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Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. J Biomed Mater Res A 2018 Nov;106(11):2881-2890

Date

10/29/2018

Pubmed ID

30369055

Pubmed Central ID

PMC6366942

DOI

10.1002/jbm.a.36477

Scopus ID

2-s2.0-85055703769 (requires institutional sign-in at Scopus site)   21 Citations

Abstract

An urgent need to deliver therapeutics across the blood-brain barrier (BBB) underlies a paucity of effective therapies currently available for treatment of degenerative, infectious, traumatic, chemical, and metabolic disorders of the nervous system. With an eye toward achieving this goal, an in vitro BBB model was employed to simulate biodegradable polyanhydride nanoparticle-based drug delivery to the brain. Using a combination of confocal microscopy, flow cytometry, and high performance liquid chromatography, we examined the potential of polyanhydride nanoparticles containing the anti-oxidant, mito-apocynin, to be internalized and then transferred from monocytes to human brain microvascular endothelial cells. The efficacy of this nanoparticle-based delivery platform was demonstrated by neuronal protection against oxidative stress. Taken together, this polyanhydride nanoparticle-based delivery system holds promise for enhancing neuroprotection by facilitating drug transport across the BBB. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2881-2890, 2018.

Author List

Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG, McMillan JM, Kalyanaraman B, Gendelman HE, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B, Kanmogne GD

Author

Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Antioxidants
Biological Transport
Blood-Brain Barrier
Brain
Cells, Cultured
Drug Carriers
Drug Delivery Systems
Endothelial Cells
Humans
Monocytes
Nanoparticles
Polyanhydrides
Quantum Dots