Mapping of human chromosome 5 microsatellite DNA polymorphisms. Genomics 1991 Nov;11(3):695-700
Date
11/01/1991Pubmed ID
1774070DOI
10.1016/0888-7543(91)90077-rScopus ID
2-s2.0-0026075503 (requires institutional sign-in at Scopus site) 93 CitationsAbstract
Thirteen moderately to highly informative microsatellite DNA polymorphisms based on (dC-dA)n.(dG-dT)n repeats were mapped to segments of human chromosome 5 using both linkage analysis and a panel of somatic cell hybrids which contained rearranged chromosomes. The markers were distributed throughout most of the length of the chromosome from the regions p15.3-p15.1 to q33.3-qter. Maps of the sites of meiotic recombination within the reference families proved particularly useful for the purpose of integrating new polymorphisms into the existing linkage map.
Author List
Weber JL, Polymeropoulos MH, May PE, Kwitek AE, Xiao H, McPherson JD, Wasmuth JJAuthor
Anne E. Kwitek PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Base SequenceChromosome Mapping
Chromosomes, Human, Pair 5
Cloning, Molecular
DNA, Satellite
Female
Genetic Linkage
Humans
Male
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic
Recombination, Genetic