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Mapping of human chromosome 5 microsatellite DNA polymorphisms. Genomics 1991 Nov;11(3):695-700

Date

11/01/1991

Pubmed ID

1774070

DOI

10.1016/0888-7543(91)90077-r

Scopus ID

2-s2.0-0026075503 (requires institutional sign-in at Scopus site)   93 Citations

Abstract

Thirteen moderately to highly informative microsatellite DNA polymorphisms based on (dC-dA)n.(dG-dT)n repeats were mapped to segments of human chromosome 5 using both linkage analysis and a panel of somatic cell hybrids which contained rearranged chromosomes. The markers were distributed throughout most of the length of the chromosome from the regions p15.3-p15.1 to q33.3-qter. Maps of the sites of meiotic recombination within the reference families proved particularly useful for the purpose of integrating new polymorphisms into the existing linkage map.

Author List

Weber JL, Polymeropoulos MH, May PE, Kwitek AE, Xiao H, McPherson JD, Wasmuth JJ

Author

Anne E. Kwitek PhD Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 5
Cloning, Molecular
DNA, Satellite
Female
Genetic Linkage
Humans
Male
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic
Recombination, Genetic