Transgenic models as tools for studying the regulation of human renin expression. Regul Pept 2000 Jan 29;86(1-3):77-82
Date
02/15/2000Pubmed ID
10672905DOI
10.1016/s0167-0115(99)00097-xScopus ID
2-s2.0-0033987144 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
Transgenic mice and rats have become popular tools to study the regulation of gene expression and the consequences of protein over-production. Over the past decade, numerous transgenic models have been developed to study the mechanisms of human renin gene expression and the participation of the renin-angiotensin system in the development of hypertension. Herein we will provide an overview of what has been learned from the use of transgenic models for studying the human renin gene.
Author List
Sinn PL, Sigmund CDAuthor
Curt Sigmund PhD Chair, Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnimals, Genetically Modified
Antigens, Viral, Tumor
Disease Models, Animal
Gene Expression Regulation, Enzymologic
Humans
Hypertension
Mice
Rats
Renin
Renin-Angiotensin System
