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Curt Sigmund PhD

Curt Sigmund PhD profile photo picture

Chair, Professor

Institution: Medical College of Wisconsin
Department: Physiology
Program: Administration

Member of the Cardiovascular Center
Member of the Center for Disease Prevention Research (CDPR)
Member of the Neuroscience Research Center


I am willing to mentor a junior faculty member.
I am willing to collaborate on research projects.


Research Experience

  • Angiotensin II
  • Animals
  • Blood Pressure
  • Brain
  • Disease Models, Animal
  • Endothelium, Vascular
  • Gene Expression Regulation
  • Hypertension
  • Kidney
  • Mice
  • Mice, Transgenic
  • Muscle, Smooth, Vascular
  • Neurons
  • Oxidative Stress
  • PPAR gamma
  • Pregnancy
  • Receptor, Angiotensin, Type 1
  • Renin
  • Renin-Angiotensin System
  • Subfornical Organ
  • Sympathetic Nervous System
  • Transcription Factors
  • Transcription, Genetic
  • Vasoconstriction
  • Vasodilation
  • Leadership Positions

  • Center Director
  • Department Chair
  • Publications (293)

  • Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage. (Nakagawa P, Nair AR, Agbor LN, Gomez J, Wu J, Zhang SY, Lu KT, Morgan DA, Rahmouni K, Grobe JL, Sigmund CD) Hypertension 2020 Aug;76(2):468-477 PMID: 32507043 PMCID: PMC7347438 SCOPUS ID: 2-s2.0-85087872461 06/09/2020    
  • Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity. (Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL) Hypertension 2020 Aug;76(2):589-597 PMID: 32507042 PMCID: PMC7347451 SCOPUS ID: 2-s2.0-85087901067 06/09/2020    
  • Failure to Vasodilate in Response to Salt Loading Blunts Renal Blood Flow and Causes Salt-Sensitive Hypertension. (Wu J, Agbor LN, Fang S, Mukohda M, Nair AR, Nakagawa P, Sharma A, Morgan DA, Grobe JL, Rahmouni K, Weiss RM, McCormick JA, Sigmund CD) Cardiovasc Res 2020 May 19 PMID: 32428209 05/20/2020    
  • Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide. (Sapouckey SA, Morselli LL, Deng G, Patil CN, Balapattabi K, Oliveira V, Claflin KE, Gomez J, Pearson NA, Potthoff MJ, Gibson-Corley KN, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2020 05 01;318(5):R855-R869 PMID: 32186897 PMCID: PMC7272763 SCOPUS ID: 2-s2.0-85083546405 03/19/2020       1 Citation
  • Report of the National Heart, Lung, and Blood Institute Working Group on Hypertension: Barriers to Translation. (Sigmund CD, Carey RM, Appel LJ, Arnett DK, Bosworth HB, Cushman WC, Galis ZS, Green Parker M, Hall JE, Harrison DG, McDonough AA, Nicastro HL, Oparil S, Osborn JW, Raizada MK, Wright JD, Oh YS) Hypertension 2020 Apr;75(4):902-917 PMID: 32063061 PMCID: PMC7067675 SCOPUS ID: 2-s2.0-85081945179 02/18/2020       1 Citation
  • A colorful view of the brain renin-angiotensin system. (Sigmund CD, Grobe JL) Hypertens Res 2020 04;43(4):357-359 PMID: 31953528 PMCID: PMC7107486 SCOPUS ID: 2-s2.0-85078310812 01/19/2020    
  • The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation. (Nakagawa P, Gomez J, Grobe JL, Sigmund CD) Curr Hypertens Rep 2020 01 10;22(1):7 PMID: 31925571 PMCID: PMC7101821 SCOPUS ID: 2-s2.0-85077710193 01/12/2020       4 Citations
  • Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice. (Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, Santillan DA, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL) Hypertension 2020 Feb;75(2):569-579 PMID: 31865781 PMCID: PMC7027931 SCOPUS ID: 2-s2.0-85077761676 12/24/2019    
  • PPARγ and RhoBTB1 in hypertension. (Fang S, Sigmund CD) Curr Opin Nephrol Hypertens 2020 Mar;29(2):161-170 PMID: 31789920 PMCID: PMC7087486 SCOPUS ID: 2-s2.0-85078693490 12/04/2019    
  • Cul3 regulates cyclin E1 protein abundance via a degron located within the N-terminal region of cyclin E. (Davidge B, Rebola KGO, Agbor LN, Sigmund CD, Singer JD) J Cell Sci 2019 11 06;132(21) PMID: 31636116 PMCID: PMC6857591 SCOPUS ID: 2-s2.0-85074673526 10/23/2019    
  • Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension. (Agbor LN, Nair AR, Wu J, Lu KT, Davis DR, Keen HL, Quelle FW, McCormick JA, Singer JD, Sigmund CD) JCI Insight 2019 06 11;5 PMID: 31184598 PMCID: PMC6675584 SCOPUS ID: 2-s2.0-85070660042 06/12/2019       4 Citations
  • Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension. (Nair AR, Silva SD Jr, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD) Hypertension 2019 07;74(1):173-183 PMID: 31104564 PMCID: PMC6561821 SCOPUS ID: 2-s2.0-85068196613 05/21/2019       3 Citations
  • RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity. (Mukohda M, Fang S, Wu J, Agbor LN, Nair AR, Ibeawuchi SC, Hu C, Liu X, Lu KT, Guo DF, Davis DR, Keen HL, Quelle FW, Sigmund CD) J Clin Invest 2019 03 21;129(6):2318-2332 PMID: 30896450 PMCID: PMC6546477 SCOPUS ID: 2-s2.0-85063644288 03/22/2019       8 Citations
  • Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-γ Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation. (Nair AR, Agbor LN, Mukohda M, Liu X, Hu C, Wu J, Sigmund CD) Hypertension 2018 11;72(5):1227-1235 PMID: 30354810 PMCID: PMC6209120 SCOPUS ID: 2-s2.0-85055599374 10/26/2018       7 Citations
  • Revised guidelines to enhance the rigor and reproducibility of research published in American Physiological Society journals. (Yosten GLC, Adams JC, Bennett CN, Bunnett NW, Scheman R, Sigmund CD, Yates BJ, Zucker IH, Samson WK) Am J Physiol Regul Integr Comp Physiol 2018 12 01;315(6):R1251-R1253 PMID: 30332303 SCOPUS ID: 2-s2.0-85058804299 10/18/2018       4 Citations
  • Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. (Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL) JCI Insight 2018 10 04;3(19) PMID: 30282823 PMCID: PMC6237463 SCOPUS ID: 2-s2.0-85063243804 10/05/2018       13 Citations
  • Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension. (Cornelius RJ, Zhang C, Erspamer KJ, Agbor LN, Sigmund CD, Singer JD, Yang CL, Ellison DH) Am J Physiol Renal Physiol 2018 10 01;315(4):F1006-F1018 PMID: 29897280 PMCID: PMC6230741 SCOPUS ID: 2-s2.0-85056000019 06/14/2018       6 Citations
  • Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology. (Forrester SJ, Booz GW, Sigmund CD, Coffman TM, Kawai T, Rizzo V, Scalia R, Eguchi S) Physiol Rev 2018 07 01;98(3):1627-1738 PMID: 29873596 PMCID: PMC6335102 SCOPUS ID: 2-s2.0-85048351338 06/07/2018       101 Citations
  • Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging. (De Silva TM, Li Y, Kinzenbaw DA, Sigmund CD, Faraci FM) Hypertension 2018 07;72(1):227-234 PMID: 29735632 PMCID: PMC6002945 SCOPUS ID: 2-s2.0-85053758174 05/08/2018       10 Citations
  • Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia. (Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK) Clin Sci (Lond) 2018 02 14;132(3):419-436 PMID: 29371289 PMCID: PMC5947858 SCOPUS ID: 2-s2.0-85046542605 01/27/2018       13 Citations
  • Angiotensin AT1A receptors expressed in vasopressin-producing cells of the supraoptic nucleus contribute to osmotic control of vasopressin. (Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2018 06 01;314(6):R770-R780 PMID: 29364700 PMCID: PMC6032302 SCOPUS ID: 2-s2.0-85048097812 01/25/2018       8 Citations
  • Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system. (Peng H, Jensen DD, Li W, Sullivan MN, Buller SA, Worker CJ, Cooper SG, Zheng S, Earley S, Sigmund CD, Feng Y) Am J Physiol Heart Circ Physiol 2018 03 01;314(3):H580-H592 PMID: 29350998 PMCID: PMC5899258 SCOPUS ID: 2-s2.0-85045437910 01/20/2018       6 Citations
  • The regulation of renal and extrarenal renin gene expression in the mouse (Jones CA, Fabian JR, Abel KJ, Sigmund CD, Gross KW) Cellular and Molecular Biology of the Renin-Angiotensin System 1 January 2018:33-57 SCOPUS ID: 2-s2.0-84995847688 01/01/2018    
  • Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects. (Ferdaus MZ, Miller LN, Agbor LN, Saritas T, Singer JD, Sigmund CD, McCormick JA) JCI Insight 2017 12 21;2(24) PMID: 29263298 PMCID: PMC5752287 12/22/2017    
  • Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism. (Sapouckey SA, Deng G, Sigmund CD, Grobe JL) Physiol Genomics 2017 Dec 01;49(12):722-732 PMID: 28986397 PMCID: PMC5814669 SCOPUS ID: 2-s2.0-85044192981 10/08/2017       7 Citations
  • PPARγ and retinol binding protein 7 form a regulatory hub promoting antioxidant properties of the endothelium. (Woll AW, Quelle FW, Sigmund CD) Physiol Genomics 2017 Nov 01;49(11):653-658 PMID: 28916634 PMCID: PMC5792137 SCOPUS ID: 2-s2.0-85033577163 09/17/2017       3 Citations
  • Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism. (Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD) Hypertension 2017 11;70(5):990-997 PMID: 28874461 PMCID: PMC5679092 SCOPUS ID: 2-s2.0-85031820971 09/07/2017       6 Citations
  • Genetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7. (De Silva TM, Hu C, Kinzenbaw DA, Modrick ML, Sigmund CD, Faraci FM) Hypertension 2017 09;70(3):559-565 PMID: 28674038 PMCID: PMC5552422 SCOPUS ID: 2-s2.0-85021825355 07/05/2017       9 Citations
  • How Is the Brain Renin-Angiotensin System Regulated? (Nakagawa P, Sigmund CD) Hypertension 2017 07;70(1):10-18 PMID: 28559391 PMCID: PMC5511499 SCOPUS ID: 2-s2.0-85020147188 06/01/2017       17 Citations
  • Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-κB p65 in Vascular Smooth Muscle. (Mukohda M, Lu KT, Guo DF, Wu J, Keen HL, Liu X, Ketsawatsomkron P, Stump M, Rahmouni K, Quelle FW, Sigmund CD) Hypertension 2017 07;70(1):174-182 PMID: 28507170 PMCID: PMC5472224 SCOPUS ID: 2-s2.0-85019598258 05/17/2017       9 Citations
  • Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice. (Agassandian K, Grobe JL, Liu X, Agassandian M, Thompson AP, Sigmund CD, Cassell MD) Am J Physiol Regul Integr Comp Physiol 2017 06 01;312(6):R973-R981 PMID: 28490451 PMCID: PMC5495920 SCOPUS ID: 2-s2.0-85020436522 05/12/2017       6 Citations
  • No Brain Renin-Angiotensin System: Déjà vu All Over Again? (Sigmund CD, Diz DI, Chappell MC) Hypertension 2017 06;69(6):1007-1010 PMID: 28396531 PMCID: PMC5497704 SCOPUS ID: 2-s2.0-85017447846 04/12/2017       14 Citations
  • Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin. (Hu C, Keen HL, Lu KT, Liu X, Wu J, Davis DR, Ibeawuchi SC, Vogel S, Quelle FW, Sigmund CD) JCI Insight 2017 03 23;2(6):e91738 PMID: 28352663 PMCID: PMC5358481 SCOPUS ID: 2-s2.0-85038922808 03/30/2017       9 Citations
  • Microarray Analysis of Hypertension. (Keen HL, Sigmund CD) Methods Mol Biol 2017;1527:41-52 PMID: 28116705 SCOPUS ID: 2-s2.0-85011002754 01/25/2017       3 Citations
  • Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism. (Agbor LN, Ibeawuchi SC, Hu C, Wu J, Davis DR, Keen HL, Quelle FW, Sigmund CD) JCI Insight 2016 Nov 17;1(19):e91015 PMID: 27882355 PMCID: PMC5111503 11/25/2016    
  • Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development. (Stump M, Guo DF, Lu KT, Mukohda M, Cassell MD, Norris AW, Rahmouni K, Sigmund CD) Endocrinology 2016 Nov;157(11):4266-4275 PMID: 27575030 PMCID: PMC5086539 SCOPUS ID: 2-s2.0-84994285912 11/02/2016       5 Citations
  • Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. (Shinohara K, Liu X, Morgan DA, Davis DR, Sequeira-Lopez ML, Cassell MD, Grobe JL, Rahmouni K, Sigmund CD) Hypertension 2016 12;68(6):1385-1392 PMID: 27754863 PMCID: PMC5159235 SCOPUS ID: 2-s2.0-84991696091 10/19/2016       17 Citations
  • Role of CaMKII in Ang-II-dependent small artery remodeling. (Prasad AM, Ketsawatsomkron P, Nuno DW, Koval OM, Dibbern ME, Venema AN, Sigmund CD, Lamping KG, Grumbach IM) Vascul Pharmacol 2016 12;87:172-179 PMID: 27658984 PMCID: PMC5164857 SCOPUS ID: 2-s2.0-84999885129 09/24/2016       3 Citations
  • Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. (Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, Sigmund CD, Grobe JL) Cell Rep 2016 08 09;16(6):1548-1560 PMID: 27477281 PMCID: PMC4981564 SCOPUS ID: 2-s2.0-84979752805 08/02/2016       21 Citations
  • Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury. (Song K, Stuart D, Abraham N, Wang F, Wang S, Yang T, Sigmund CD, Kohan DE, Ramkumar N) PLoS One 2016;11(7):e0159872 PMID: 27467376 PMCID: PMC4965005 SCOPUS ID: 2-s2.0-84982682387 07/29/2016       3 Citations
  • mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II. (Muta K, Morgan DA, Grobe JL, Sigmund CD, Rahmouni K) Endocrinology 2016 08;157(8):3140-8 PMID: 27254006 PMCID: PMC4967111 SCOPUS ID: 2-s2.0-84982797786 06/03/2016       4 Citations
  • Effect of selective expression of dominant-negative PPARγ in pro-opiomelanocortin neurons on the control of energy balance. (Stump M, Guo DF, Lu KT, Mukohda M, Liu X, Rahmouni K, Sigmund CD) Physiol Genomics 2016 07 01;48(7):491-501 PMID: 27199455 PMCID: PMC4967222 SCOPUS ID: 2-s2.0-85047288791 05/21/2016       8 Citations
  • Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression. (Lu KT, Keen HL, Weatherford ET, Sequeira-Lopez ML, Gomez RA, Sigmund CD) Hypertension 2016 May;67(5):992-9 PMID: 26928806 PMCID: PMC4833511 SCOPUS ID: 2-s2.0-84959310814 03/02/2016       7 Citations
  • Introduction to the American Heart Association's Hypertension Strategically Focused Research Network. (Muntner P, Becker RC, Calhoun D, Chen D, Cowley AW Jr, Flynn JT, Grobe JL, Kidambi S, Kotchen TA, Lackland DT, Leslie KK, Li Y, Liang M, Lloyd A, Mattson DL, Mendizabal B, Mitsnefes M, Nair A, Pierce GL, Pollock JS, Safford MM, Santillan MK, Sigmund CD, Thomas SJ, Urbina EM) Hypertension 2016 Apr;67(4):674-80 PMID: 26902490 PMCID: PMC5135412 SCOPUS ID: 2-s2.0-84960812805 02/24/2016       4 Citations
  • Hypertension: A Disease That Strikes Around the Clock. (Wu J, Sigmund CD) Hypertension 2016 Mar;67(3):493-5 PMID: 26781274 PMCID: PMC4819989 SCOPUS ID: 2-s2.0-84958063657 01/20/2016       3 Citations
  • Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice. (Chu Y, Lund DD, Doshi H, Keen HL, Knudtson KL, Funk ND, Shao JQ, Cheng J, Hajj GP, Zimmerman KA, Davis MK, Brooks RM, Chapleau MW, Sigmund CD, Weiss RM, Heistad DD) Arterioscler Thromb Vasc Biol 2016 Mar;36(3):466-74 PMID: 26769049 PMCID: PMC4767592 SCOPUS ID: 2-s2.0-84959540220 01/16/2016       8 Citations
  • Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension. (Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD) Hypertension 2016 Jan;67(1):214-22 PMID: 26597823 PMCID: PMC4679422 SCOPUS ID: 2-s2.0-84950335650 11/26/2015       14 Citations
  • Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress. (Mukohda M, Stump M, Ketsawatsomkron P, Hu C, Quelle FW, Sigmund CD) Am J Physiol Heart Circ Physiol 2016 Jan 01;310(1):H39-48 PMID: 26566726 PMCID: PMC4796462 SCOPUS ID: 2-s2.0-84953330749 11/15/2015       20 Citations
  • Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunction. (Hu C, Lu KT, Mukohda M, Davis DR, Faraci FM, Sigmund CD) Physiol Genomics 2016 Feb;48(2):124-34 PMID: 26534936 PMCID: PMC4729699 SCOPUS ID: 2-s2.0-84961368938 11/05/2015       24 Citations
  • PPARγ Regulation in Hypertension and Metabolic Syndrome. (Stump M, Mukohda M, Hu C, Sigmund CD) Curr Hypertens Rep 2015 Dec;17(12):89 PMID: 26462805 PMCID: PMC6766749 SCOPUS ID: 2-s2.0-84944328017 10/16/2015       16 Citations
  • Vascular versus tubular renin: role in kidney development. (Sequeira-Lopez ML, Nagalakshmi VK, Li M, Sigmund CD, Gomez RA) Am J Physiol Regul Integr Comp Physiol 2015 Sep 15;309(6):R650-7 PMID: 26246508 PMCID: PMC4591368 SCOPUS ID: 2-s2.0-84941764098 08/08/2015       15 Citations
  • Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. (Ibeawuchi SR, Agbor LN, Quelle FW, Sigmund CD) J Biol Chem 2015 Jul 31;290(31):19208-17 PMID: 26100637 PMCID: PMC4521042 SCOPUS ID: 2-s2.0-84940536795 06/24/2015       27 Citations
  • Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function. (Prasad AM, Morgan DA, Nuno DW, Ketsawatsomkron P, Bair TB, Venema AN, Dibbern ME, Kutschke WJ, Weiss RM, Lamping KG, Chapleau MW, Sigmund CD, Rahmouni K, Grumbach IM) J Am Heart Assoc 2015 Jun 15;4(6):e001949 PMID: 26077587 PMCID: PMC4599535 SCOPUS ID: 2-s2.0-85012821819 06/17/2015       19 Citations
  • Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo. (Hasan DM, Starke RM, Gu H, Wilson K, Chu Y, Chalouhi N, Heistad DD, Faraci FM, Sigmund CD) Hypertension 2015 Jul;66(1):211-20 PMID: 25916724 PMCID: PMC4465866 SCOPUS ID: 2-s2.0-84942747296 04/29/2015       16 Citations
  • Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt. (Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD) Hypertension 2015 Jun;65(6):1341-8 PMID: 25895586 PMCID: PMC4433403 SCOPUS ID: 2-s2.0-84937622096 04/22/2015       12 Citations
  • Vasopressin: the missing link for preeclampsia? (Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2015 Nov 01;309(9):R1062-4 PMID: 25810383 PMCID: PMC4666952 SCOPUS ID: 2-s2.0-84946088245 03/27/2015       18 Citations
  • Endothelial PPAR-γ protects against vascular thrombosis by downregulating P-selectin expression. (Jin H, Gebska MA, Blokhin IO, Wilson KM, Ketsawatsomkron P, Chauhan AK, Keen HL, Sigmund CD, Lentz SR) Arterioscler Thromb Vasc Biol 2015 Apr;35(4):838-44 PMID: 25675995 PMCID: PMC4376629 SCOPUS ID: 2-s2.0-84933497865 02/14/2015       20 Citations
  • Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. (Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD) Physiol Rep 2015 Jan 01;3(1) PMID: 25602015 PMCID: PMC4387753 01/21/2015    
  • Molecular mechanisms regulating vascular tone by peroxisome proliferator activated receptor gamma. (Ketsawatsomkron P, Sigmund CD) Curr Opin Nephrol Hypertens 2015 Mar;24(2):123-30 PMID: 25587903 PMCID: PMC4384504 SCOPUS ID: 2-s2.0-84922671172 01/15/2015       19 Citations
  • Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ. (Coble JP, Grobe JL, Johnson AK, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2015 Feb 15;308(4):R238-49 PMID: 25519738 PMCID: PMC4347751 SCOPUS ID: 2-s2.0-84923163679 12/19/2014       42 Citations
  • The earliest metanephric arteriolar progenitors and their role in kidney vascular development. (Sequeira-Lopez ML, Lin EE, Li M, Hu Y, Sigmund CD, Gomez RA) Am J Physiol Regul Integr Comp Physiol 2015 Jan 15;308(2):R138-49 PMID: 25427768 PMCID: PMC4297861 SCOPUS ID: 2-s2.0-84921530247 11/28/2014       49 Citations
  • Genetic interference with peroxisome proliferator-activated receptor γ in smooth muscle enhances myogenic tone in the cerebrovasculature via A Rho kinase-dependent mechanism. (De Silva TM, Ketsawatsomkron P, Pelham C, Sigmund CD, Faraci FM) Hypertension 2015 Feb;65(2):345-51 PMID: 25385762 PMCID: PMC4289099 SCOPUS ID: 2-s2.0-84921598861 11/12/2014       12 Citations
  • Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants. (Grobe JL, Sigmund CD) Hypertension 2014 Dec;64(6):1182-3 PMID: 25225201 SCOPUS ID: 2-s2.0-84927797099 09/17/2014       2 Citations
  • Role of peroxisome proliferator-activated receptor-γ in vascular muscle in the cerebral circulation. (De Silva TM, Modrick ML, Ketsawatsomkron P, Lynch C, Chu Y, Pelham CJ, Sigmund CD, Faraci FM) Hypertension 2014 Nov;64(5):1088-93 PMID: 25185134 PMCID: PMC4192060 SCOPUS ID: 2-s2.0-84925770086 09/04/2014       15 Citations
  • Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension. (Ramkumar N, Stuart D, Rees S, Hoek AV, Sigmund CD, Kohan DE) Am J Physiol Renal Physiol 2014 Oct 15;307(8):F931-8 PMID: 25122048 PMCID: PMC4200300 SCOPUS ID: 2-s2.0-84908079996 08/15/2014       31 Citations
  • Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. (Carrillo-Sepulveda MA, Keen HL, Davis DR, Grobe JL, Sigmund CD) PLoS One 2014;9(8):e103786 PMID: 25122005 PMCID: PMC4133177 SCOPUS ID: 2-s2.0-84905989058 08/15/2014       10 Citations
  • Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake. (Coble JP, Cassell MD, Davis DR, Grobe JL, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2014 Aug 15;307(4):R376-86 PMID: 24965793 PMCID: PMC4137154 SCOPUS ID: 2-s2.0-84907637962 06/27/2014       13 Citations
  • Interference with peroxisome proliferator-activated receptor-γ in vascular smooth muscle causes baroreflex impairment and autonomic dysfunction. (Borges GR, Morgan DA, Ketsawatsomkron P, Mickle AD, Thompson AP, Cassell MD, Mohapatra DP, Rahmouni K, Sigmund CD) Hypertension 2014 Sep;64(3):590-6 PMID: 24914194 PMCID: PMC4134389 SCOPUS ID: 2-s2.0-84907598119 06/11/2014       9 Citations
  • Activity of protein kinase C-α within the subfornical organ is necessary for fluid intake in response to brain angiotensin. (Coble JP, Johnson RF, Cassell MD, Johnson AK, Grobe JL, Sigmund CD) Hypertension 2014 Jul;64(1):141-8 PMID: 24777977 PMCID: PMC4057298 SCOPUS ID: 2-s2.0-84902551083 04/30/2014       16 Citations
  • Differential control of calcium homeostasis and vascular reactivity by Ca2+/calmodulin-dependent kinase II. (Prasad AM, Nuno DW, Koval OM, Ketsawatsomkron P, Li W, Li H, Shen FY, Joiner ML, Kutschke W, Weiss RM, Sigmund CD, Anderson ME, Lamping KG, Grumbach IM) Hypertension 2013 Aug;62(2):434-41 PMID: 23753415 PMCID: PMC3868483 SCOPUS ID: 2-s2.0-84880935755 06/12/2013       19 Citations
  • Allele-specific expression of angiotensinogen in human subcutaneous adipose tissue. (Park S, Lu KT, Liu X, Chatterjee TK, Rudich SM, Weintraub NL, Kwitek AE, Sigmund CD) Hypertension 2013 Jul;62(1):41-7 PMID: 23648704 PMCID: PMC3718031 SCOPUS ID: 2-s2.0-84880725776 05/08/2013       7 Citations
  • Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent. (Littlejohn NK, Siel RB Jr, Ketsawatsomkron P, Pelham CJ, Pearson NA, Hilzendeger AM, Buehrer BA, Weidemann BJ, Li H, Davis DR, Thompson AP, Liu X, Cassell MD, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2013 May 15;304(10):R818-28 PMID: 23535460 PMCID: PMC3652167 SCOPUS ID: 2-s2.0-84878651210 03/29/2013       43 Citations
  • A clinical link between peroxisome proliferator-activated receptor γ and the renin-angiotensin system. (Sigmund CD) Arterioscler Thromb Vasc Biol 2013 Apr;33(4):676-8 PMID: 23486770 PMCID: PMC3905617 SCOPUS ID: 2-s2.0-84875340383 03/15/2013       5 Citations
  • Dominant negative PPARγ promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle. (Pelham CJ, Keen HL, Lentz SR, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2013 May 01;304(9):R690-701 PMID: 23447133 PMCID: PMC3652079 SCOPUS ID: 2-s2.0-84878649995 03/01/2013       30 Citations
  • PPARγ: no SirT, no service. (Quelle FW, Sigmund CD) Circ Res 2013 Feb 01;112(3):411-4 PMID: 23371897 PMCID: PMC3580855 02/02/2013    
  • Pioglitazone attenuates valvular calcification induced by hypercholesterolemia. (Chu Y, Lund DD, Weiss RM, Brooks RM, Doshi H, Hajj GP, Sigmund CD, Heistad DD) Arterioscler Thromb Vasc Biol 2013 Mar;33(3):523-32 PMID: 23288158 PMCID: PMC3573264 SCOPUS ID: 2-s2.0-84874388376 01/05/2013       32 Citations
  • Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension. (Hilzendeger AM, Cassell MD, Davis DR, Stauss HM, Mark AL, Grobe JL, Sigmund CD) Hypertension 2013 Mar;61(3):716-22 PMID: 23266541 PMCID: PMC3573251 SCOPUS ID: 2-s2.0-84874360680 12/26/2012       38 Citations
  • Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase. (Pelham CJ, Ketsawatsomkron P, Groh S, Grobe JL, de Lange WJ, Ibeawuchi SR, Keen HL, Weatherford ET, Faraci FM, Sigmund CD) Cell Metab 2012 Oct 03;16(4):462-72 PMID: 23040068 PMCID: PMC3474846 SCOPUS ID: 2-s2.0-84867084491 10/09/2012       60 Citations
  • PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity. (Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham CJ, Grobe JL, Faraci FM, England SK, Sigmund CD) Circ Res 2012 Nov 09;111(11):1446-58 PMID: 22962432 PMCID: PMC3494760 SCOPUS ID: 2-s2.0-84870039725 09/11/2012       43 Citations
  • Coex-Rank: An approach incorporating co-expression information for combined analysis of microarray data. (Cai J, Keen HL, Sigmund CD, Casavant TL) J Integr Bioinform 2012 Jul 30;9(1):208 PMID: 22842118 PMCID: PMC3482100 SCOPUS ID: 2-s2.0-84868239989 07/31/2012       3 Citations
  • Decreased expression of neuronal nitric oxide synthase in the nucleus tractus solitarii inhibits sympathetically mediated baroreflex responses in rat. (Lin LH, Nitschke Dragon D, Jin J, Tian X, Chu Y, Sigmund C, Talman WT) J Physiol 2012 Aug 01;590(15):3545-59 PMID: 22687614 PMCID: PMC3547269 06/13/2012    
  • A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity. (Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, Grobe JL, Rahmouni K, Sigmund CD, Mark AL) Am J Physiol Heart Circ Physiol 2012 Jul 15;303(2):H197-206 PMID: 22610169 PMCID: PMC3404702 SCOPUS ID: 2-s2.0-84864011880 05/23/2012       81 Citations
  • Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression. (Park S, Liu X, Davis DR, Sigmund CD) Hypertension 2012 Jun;59(6):1212-9 PMID: 22547438 PMCID: PMC3357008 SCOPUS ID: 2-s2.0-84861532238 05/02/2012       11 Citations
  • Metabolic rate regulation by the renin-angiotensin system: brain vs. body. (Grobe JL, Rahmouni K, Liu X, Sigmund CD) Pflugers Arch 2013 Jan;465(1):167-75 PMID: 22491893 PMCID: PMC3569511 SCOPUS ID: 2-s2.0-84873056337 04/12/2012       18 Citations
  • Peroxisome proliferator-activated receptor-γ protects against vascular aging. (Modrick ML, Kinzenbaw DA, Chu Y, Sigmund CD, Faraci FM) Am J Physiol Regul Integr Comp Physiol 2012 May 15;302(10):R1184-90 PMID: 22461176 PMCID: PMC3362146 SCOPUS ID: 2-s2.0-84861158340 03/31/2012       19 Citations
  • Regulation of renin expression by the orphan nuclear receptors Nr2f2 and Nr2f6. (Weatherford ET, Liu X, Sigmund CD) Am J Physiol Renal Physiol 2012 Apr 15;302(8):F1025-33 PMID: 22278040 PMCID: PMC3330716 SCOPUS ID: 2-s2.0-84859771697 01/27/2012       8 Citations
  • A second chance for a PPARγ targeted therapy? (Norris AW, Sigmund CD) Circ Res 2012 Jan 06;110(1):8-11 PMID: 22223206 PMCID: PMC3583552 SCOPUS ID: 2-s2.0-84855405202 01/10/2012       8 Citations
  • Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. (He BJ, Joiner ML, Singh MV, Luczak ED, Swaminathan PD, Koval OM, Kutschke W, Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR, Sigmund CD, Blankesteijn WM, Heymans S, Mohler PJ, Anderson ME) Nat Med 2011 Nov 13;17(12):1610-8 PMID: 22081025 PMCID: PMC3332099 SCOPUS ID: 2-s2.0-84856100794 11/15/2011       143 Citations
  • Divergent mechanism regulating fluid intake and metabolism by the brain renin-angiotensin system. (Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2012 Feb 01;302(3):R313-20 PMID: 22049229 PMCID: PMC3289263 SCOPUS ID: 2-s2.0-84857001776 11/04/2011       16 Citations
  • Renal proximal tubule angiotensin AT1A receptors regulate blood pressure. (Li H, Weatherford ET, Davis DR, Keen HL, Grobe JL, Daugherty A, Cassis LA, Allen AM, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2011 Oct;301(4):R1067-77 PMID: 21753145 PMCID: PMC3197336 SCOPUS ID: 2-s2.0-80053655134 07/15/2011       48 Citations
  • Inflaming hypothalamic neurons raises blood pressure. (Rahmouni K, Davisson RL, Sigmund CD) Cell Metab 2011 Jul 06;14(1):3-4 PMID: 21723497 PMCID: PMC3131053 07/05/2011    
  • Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation. (Harlan SM, Morgan DA, Agassandian K, Guo DF, Cassell MD, Sigmund CD, Mark AL, Rahmouni K) Circ Res 2011 Apr 01;108(7):808-12 PMID: 21311043 PMCID: PMC3072835 SCOPUS ID: 2-s2.0-79954701326 02/12/2011       102 Citations
  • Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR-/- mice. (Ostedgaard LS, Meyerholz DK, Vermeer DW, Karp PH, Schneider L, Sigmund CD, Welsh MJ) Proc Natl Acad Sci U S A 2011 Feb 15;108(7):2921-6 PMID: 21285372 PMCID: PMC3041073 SCOPUS ID: 2-s2.0-79952582209 02/03/2011       10 Citations
  • Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice. (Grobe JL, Buehrer BA, Hilzendeger AM, Liu X, Davis DR, Xu D, Sigmund CD) Hypertension 2011 Mar;57(3):600-7 PMID: 21263123 PMCID: PMC3144490 SCOPUS ID: 2-s2.0-79953191408 01/26/2011       52 Citations
  • Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism. (Xu D, Borges GR, Davis DR, Agassandian K, Sequeira Lopez ML, Gomez RA, Cassell MD, Grobe JL, Sigmund CD) Physiol Genomics 2011 Mar 29;43(6):286-94 PMID: 21189370 PMCID: PMC3068515 SCOPUS ID: 2-s2.0-79955774465 12/30/2010       16 Citations
  • Structural biology: On stress and pressure. (Sigmund CD) Nature 2010 Nov 04;468(7320):46-7 PMID: 21048758 SCOPUS ID: 2-s2.0-78149256566 11/05/2010       7 Citations
  • The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. (Grobe JL, Grobe CL, Beltz TG, Westphal SG, Morgan DA, Xu D, de Lange WJ, Li H, Sakai K, Thedens DR, Cassis LA, Rahmouni K, Mark AL, Johnson AK, Sigmund CD) Cell Metab 2010 Nov 03;12(5):431-42 PMID: 21035755 PMCID: PMC2994017 SCOPUS ID: 2-s2.0-78049448391 11/03/2010       92 Citations
  • Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice. (Grobe JL, Dickson ME, Park S, Davis DR, Born EJ, Sigmund CD) Hypertension 2010 Nov;56(5):981-7 PMID: 20823378 PMCID: PMC2959143 SCOPUS ID: 2-s2.0-78149258856 09/09/2010       8 Citations
  • Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure. (Redding KM, Chen BL, Singh A, Re RN, Navar LG, Seth DM, Sigmund CD, Tang WW, Cook JL) Am J Physiol Heart Circ Physiol 2010 Jun;298(6):H1807-18 PMID: 20363893 PMCID: PMC2886647 SCOPUS ID: 2-s2.0-77952623456 04/07/2010       35 Citations
  • Twists and turns in the search for the elusive renin processing enzyme: focus on "Cathepsin B is not the processing enzyme for mouse prorenin". (Gross KW, Gomez RA, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2010 May;298(5):R1209-11 PMID: 20237305 PMCID: PMC3597226 SCOPUS ID: 2-s2.0-77951742389 03/20/2010       4 Citations
  • Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the vasculature? (Ketsawatsomkron P, Pelham CJ, Groh S, Keen HL, Faraci FM, Sigmund CD) J Biol Chem 2010 Mar 26;285(13):9311-6 PMID: 20129921 PMCID: PMC2843178 SCOPUS ID: 2-s2.0-77951221502 02/05/2010       49 Citations
  • From molecules to medicine: a future cure for preeclampsia? (Santillan MK, Santillan DA, Sigmund CD, Hunter SK) Drug News Perspect 2009 Nov;22(9):531-41 PMID: 20072730 SCOPUS ID: 2-s2.0-76749125403 01/15/2010       13 Citations
  • Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells. (Desch M, Schreiber A, Schweda F, Madsen K, Friis UG, Weatherford ET, Sigmund CD, Sequeira Lopez ML, Gomez RA, Todorov VT) Hypertension 2010 Mar;55(3):660-6 PMID: 20065157 PMCID: PMC2907524 SCOPUS ID: 2-s2.0-77149177984 01/13/2010       23 Citations
  • The microRNA-processing enzyme dicer maintains juxtaglomerular cells. (Sequeira-Lopez ML, Weatherford ET, Borges GR, Monteagudo MC, Pentz ES, Harfe BD, Carretero O, Sigmund CD, Gomez RA) J Am Soc Nephrol 2010 Mar;21(3):460-7 PMID: 20056748 PMCID: PMC2831866 SCOPUS ID: 2-s2.0-77949905292 01/09/2010       112 Citations
  • Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency. (Sigmund CD) Hypertension 2010 Feb;55(2):437-44 PMID: 20038751 PMCID: PMC2819308 SCOPUS ID: 2-s2.0-74949126382 12/30/2009       33 Citations
  • Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta. (Keen HL, Halabi CM, Beyer AM, de Lange WJ, Liu X, Maeda N, Faraci FM, Casavant TL, Sigmund CD) Arterioscler Thromb Vasc Biol 2010 Mar;30(3):518-25 PMID: 20018933 PMCID: PMC2850258 SCOPUS ID: 2-s2.0-77649134985 12/19/2009       20 Citations
  • Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. (Feng Y, Xia H, Cai Y, Halabi CM, Becker LK, Santos RA, Speth RC, Sigmund CD, Lazartigues E) Circ Res 2010 Feb 05;106(2):373-82 PMID: 19926873 PMCID: PMC2818798 SCOPUS ID: 2-s2.0-76349095332 11/21/2009       127 Citations
  • Team exercise. (Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2010 Jan;298(1):R1 PMID: 19923356 SCOPUS ID: 2-s2.0-73549117199 11/20/2009    
  • Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. (Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD) Hypertension 2009 Dec;54(6):1240-7 PMID: 19822797 PMCID: PMC2783841 SCOPUS ID: 2-s2.0-73349119699 10/14/2009       30 Citations
  • Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice. (Chen S, Li G, Zhang W, Wang J, Sigmund CD, Olson JE, Chen Y) Am J Physiol Regul Integr Comp Physiol 2009 Nov;297(5):R1526-31 PMID: 19759335 PMCID: PMC2777773 SCOPUS ID: 2-s2.0-70449659424 09/18/2009       33 Citations
  • Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase. (Bianco RA, Agassandian K, Cassell MD, Spector AA, Sigmund CD) Brain Res 2009 Sep 29;1291:60-72 PMID: 19643090 PMCID: PMC2745107 SCOPUS ID: 2-s2.0-69249205387 08/01/2009       16 Citations
  • Regulation of renin gene expression by oxidative stress. (Itani H, Liu X, Sarsour EH, Goswami PC, Born E, Keen HL, Sigmund CD) Hypertension 2009 Jun;53(6):1070-6 PMID: 19433777 PMCID: PMC2740736 SCOPUS ID: 2-s2.0-67049115480 05/13/2009       18 Citations
  • Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging. (Modrick ML, Didion SP, Sigmund CD, Faraci FM) Am J Physiol Heart Circ Physiol 2009 Jun;296(6):H1914-9 PMID: 19395552 PMCID: PMC2716103 SCOPUS ID: 2-s2.0-66949114376 04/28/2009       76 Citations
  • PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake". (Grobe JL, Venegas-Pont M, Sigmund CD, Ryan MJ) Am J Physiol Regul Integr Comp Physiol 2009 May;296(5):R1325-6 PMID: 19261916 PMCID: PMC3597227 SCOPUS ID: 2-s2.0-66149112458 03/06/2009       4 Citations
  • Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. (Rahmouni K, Sigmund CD, Haynes WG, Mark AL) Diabetes 2009 Mar;58(3):536-42 PMID: 19066310 PMCID: PMC2646051 SCOPUS ID: 2-s2.0-62749109421 12/11/2008       128 Citations
  • A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension: focus on "a haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G," by Jain et al. (Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2008 Dec;295(6):R1846-8 PMID: 18971347 PMCID: PMC3597228 SCOPUS ID: 2-s2.0-57749084506 10/31/2008       1 Citation
  • Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice. (Harlan SM, Reiter RS, Sigmund CD, Lin JL, Lin JJ) Anat Rec (Hoboken) 2008 Dec;291(12):1574-86 PMID: 18951515 PMCID: PMC2592506 SCOPUS ID: 2-s2.0-58149383867 10/28/2008       6 Citations
  • AJP: Regulatory, Integrative and Comparative Physiology: 1 Year later.... (Sigmund CD) American Journal of Physiology - Regulatory Integrative and Comparative Physiology October 2008;295(4) SCOPUS ID: 2-s2.0-57349152315 10/01/2008    
  • Upstream stimulatory factor is required for human angiotensinogen expression and differential regulation by the A-20C polymorphism. (Dickson ME, Tian X, Liu X, Davis DR, Sigmund CD) Circ Res 2008 Oct 24;103(9):940-7 PMID: 18802024 PMCID: PMC2678906 SCOPUS ID: 2-s2.0-55449090345 09/20/2008       16 Citations
  • Id3, E47, and SREBP-1c: fat factors controlling adiponectin expression. (Rahmouni K, Sigmund CD) Circ Res 2008 Sep 12;103(6):565-7 PMID: 18796641 PMCID: PMC2728444 SCOPUS ID: 2-s2.0-53249103670 09/18/2008       14 Citations
  • An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy. (Grobe JL, Xu D, Sigmund CD) Physiology (Bethesda) 2008 Aug;23:187-93 PMID: 18697992 PMCID: PMC2538674 SCOPUS ID: 2-s2.0-53749104976 08/14/2008       105 Citations
  • Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. (Beyer AM, de Lange WJ, Halabi CM, Modrick ML, Keen HL, Faraci FM, Sigmund CD) Circ Res 2008 Sep 12;103(6):654-61 PMID: 18676352 PMCID: PMC2583077 SCOPUS ID: 2-s2.0-53249111805 08/05/2008       73 Citations
  • Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus. (Zhou X, Weatherford ET, Liu X, Born E, Keen HL, Sigmund CD) Am J Physiol Renal Physiol 2008 Sep;295(3):F642-53 PMID: 18632798 PMCID: PMC2536869 SCOPUS ID: 2-s2.0-54449093668 07/18/2008       3 Citations
  • Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles. (de Lange WJ, Halabi CM, Beyer AM, Sigmund CD) Physiol Genomics 2008 Sep 17;35(1):1-4 PMID: 18612081 PMCID: PMC2574738 SCOPUS ID: 2-s2.0-56149117324 07/10/2008       47 Citations
  • Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. (Shi PP, Cao XR, Sweezer EM, Kinney TS, Williams NR, Husted RF, Nair R, Weiss RM, Williamson RA, Sigmund CD, Snyder PM, Staub O, Stokes JB, Yang B) Am J Physiol Renal Physiol 2008 Aug;295(2):F462-70 PMID: 18524855 PMCID: PMC2519178 SCOPUS ID: 2-s2.0-52449104628 06/06/2008       113 Citations
  • An androgen-inducible proximal tubule-specific Cre recombinase transgenic model. (Li H, Zhou X, Davis DR, Xu D, Sigmund CD) Am J Physiol Renal Physiol 2008 Jun;294(6):F1481-6 PMID: 18385272 PMCID: PMC3584705 SCOPUS ID: 2-s2.0-48249150356 04/04/2008       17 Citations
  • Interference with PPARγ signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling (Hypertension (2008) 51, (867-871)) (Beyer AM, Baumbach GL, Halabi CM, Modrick ML, Lynch CM, Gerhold TD, Ghoneim SM, De Lange WJ, Keen HL, Tsai YS, Maeda N, Sigmund CD, Faraci FM) Hypertension April 2008;51(4) SCOPUS ID: 2-s2.0-43249123388 04/01/2008    
  • Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. (Halabi CM, Beyer AM, de Lange WJ, Keen HL, Baumbach GL, Faraci FM, Sigmund CD) Cell Metab 2008 Mar;7(3):215-26 PMID: 18316027 PMCID: PMC2275166 SCOPUS ID: 2-s2.0-39649100393 03/05/2008       120 Citations
  • Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage. (Wakisaka Y, Miller JD, Chu Y, Baumbach GL, Wilson S, Faraci FM, Sigmund CD, Heistad DD) J Cereb Blood Flow Metab 2008 Jun;28(6):1175-85 PMID: 18301433 PMCID: PMC3153951 SCOPUS ID: 2-s2.0-44349143538 02/28/2008       23 Citations
  • Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. (Beyer AM, Baumbach GL, Halabi CM, Modrick ML, Lynch CM, Gerhold TD, Ghoneim SM, de Lange WJ, Keen HL, Tsai YS, Maeda N, Sigmund CD, Faraci FM) Hypertension 2008 Apr;51(4):867-71 PMID: 18285614 PMCID: PMC2408877 SCOPUS ID: 2-s2.0-42049101837 02/21/2008       95 Citations
  • Chorionic enhancer is dispensable for regulated expression of the human renin gene. (Zhou X, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2008 Feb;294(2):R279-87 PMID: 18077515 PMCID: PMC2408876 SCOPUS ID: 2-s2.0-38949153407 12/14/2007       9 Citations
  • Is peroxisome proliferator-activated receptor-gamma a new "pal" of renin? (Weatherford ET, Itani H, Keen HL, Sigmund CD) Hypertension 2007 Nov;50(5):844-6 PMID: 17785627 SCOPUS ID: 2-s2.0-35848946144 09/06/2007       8 Citations
  • Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice. (Kobori H, Ozawa Y, Satou R, Katsurada A, Miyata K, Ohashi N, Hase N, Suzaki Y, Sigmund CD, Navar LG) Am J Physiol Renal Physiol 2007 Sep;293(3):F938-45 PMID: 17634399 PMCID: PMC2000297 SCOPUS ID: 2-s2.0-34548655306 07/20/2007       76 Citations
  • AJP: Regulatory, Integrative and Comparative Physiology: 2007 And beyond (Sigmund CD) American Journal of Physiology - Regulatory Integrative and Comparative Physiology July 2007;293(1) SCOPUS ID: 2-s2.0-34447622633 07/01/2007    
  • Editors' note (Sigmund CD) Hypertension June 2007;49(6):1195 SCOPUS ID: 2-s2.0-34249341381 06/01/2007    
  • Local production of angiotensin II in the subfornical organ causes elevated drinking. (Sakai K, Agassandian K, Morimoto S, Sinnayah P, Cassell MD, Davisson RL, Sigmund CD) J Clin Invest 2007 Apr;117(4):1088-95 PMID: 17404622 PMCID: PMC1838949 SCOPUS ID: 2-s2.0-34147153376 04/04/2007       103 Citations
  • Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. (Driskell RR, Goodheart M, Neff T, Liu X, Luo M, Moothart C, Sigmund CD, Hosokawa R, Chai Y, Engelhardt JF) Dev Biol 2007 May 01;305(1):90-102 PMID: 17335794 PMCID: PMC1892170 SCOPUS ID: 2-s2.0-34247130562 03/06/2007       40 Citations
  • The -20 and -217 promoter variants dominate differential angiotensinogen haplotype regulation in angiotensinogen-expressing cells. (Dickson ME, Zimmerman MB, Rahmouni K, Sigmund CD) Hypertension 2007 Mar;49(3):631-9 PMID: 17200439 SCOPUS ID: 2-s2.0-33847041494 01/04/2007       29 Citations
  • Functional characterization of polymorphisms in the kidney enhancer of the human renin gene. (Itani HA, Liu X, Pratt JH, Sigmund CD) Endocrinology 2007 Mar;148(3):1424-30 PMID: 17158202 SCOPUS ID: 2-s2.0-33847062962 12/13/2006       17 Citations
  • Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. (McCray PB Jr, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L, Netland J, Jia HP, Halabi C, Sigmund CD, Meyerholz DK, Kirby P, Look DC, Perlman S) J Virol 2007 Jan;81(2):813-21 PMID: 17079315 PMCID: PMC1797474 SCOPUS ID: 2-s2.0-33846067199 11/03/2006       156 Citations
  • Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response. (Sinnayah P, Lazartigues E, Sakai K, Sharma RV, Sigmund CD, Davisson RL) Circ Res 2006 Nov 10;99(10):1125-31 PMID: 17053195 SCOPUS ID: 2-s2.0-33750896096 10/21/2006       35 Citations
  • The human renin kidney enhancer is required to maintain base-line renin expression but is dispensable for tissue-specific, cell-specific, and regulated expression. (Zhou X, Davis DR, Sigmund CD) J Biol Chem 2006 Nov 17;281(46):35296-304 PMID: 16990260 SCOPUS ID: 2-s2.0-33845954722 09/23/2006       28 Citations
  • Interleukin-1beta attenuates renin gene expression via a mitogen-activated protein kinase kinase-extracellular signal-regulated kinase and signal transducer and activator of transcription 3-dependent mechanism in As4.1 cells. (Liu X, Shi Q, Sigmund CD) Endocrinology 2006 Dec;147(12):6011-8 PMID: 16959849 SCOPUS ID: 2-s2.0-33751524067 09/09/2006       16 Citations
  • Genetic basis of hypertension: revisiting angiotensinogen. (Dickson ME, Sigmund CD) Hypertension 2006 Jul;48(1):14-20 PMID: 16754793 SCOPUS ID: 2-s2.0-33745994900 06/07/2006       80 Citations
  • Angiotensinogen modulates renal vasculature growth. (Brand M, Lamandé N, Sigmund CD, Larger E, Corvol P, Gasc JM) Hypertension 2006 Jun;47(6):1067-74 PMID: 16636191 SCOPUS ID: 2-s2.0-33745003459 04/26/2006       14 Citations
  • Mice heterozygous for beta-ENaC deletion have defective potassium excretion. (Cao XR, Shi PP, Sigmund RD, Husted RF, Sigmund CD, Williamson RA, Stokes JB, Yang B) Am J Physiol Renal Physiol 2006 Jul;291(1):F107-15 PMID: 16571596 PMCID: PMC2818793 SCOPUS ID: 2-s2.0-33745397263 03/31/2006       11 Citations
  • RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. (Sachetelli S, Liu Q, Zhang SL, Liu F, Hsieh TJ, Brezniceanu ML, Guo DF, Filep JG, Ingelfinger JR, Sigmund CD, Hamet P, Chan JS) Kidney Int 2006 Mar;69(6):1016-23 PMID: 16528251 SCOPUS ID: 2-s2.0-33644853998 03/11/2006       104 Citations
  • Renal thrombotic microangiopathy in a genetic model of hypertension in mice. (Sethi S, Iida S, Sigmund CD, Heistad DD) Exp Biol Med (Maywood) 2006 Feb;231(2):196-203 PMID: 16446496 SCOPUS ID: 2-s2.0-32244442964 02/01/2006       8 Citations
  • Evidence supporting a functional role for intracellular renin in the brain. (Lavoie JL, Liu X, Bianco RA, Beltz TG, Johnson AK, Sigmund CD) Hypertension 2006 Mar;47(3):461-6 PMID: 16446393 SCOPUS ID: 2-s2.0-33644983130 02/01/2006       59 Citations
  • Inactivation of NADPH oxidase organizer 1 results in severe imbalance. (Kiss PJ, Knisz J, Zhang Y, Baltrusaitis J, Sigmund CD, Thalmann R, Smith RJ, Verpy E, Bánfi B) Curr Biol 2006 Jan 24;16(2):208-13 PMID: 16431374 SCOPUS ID: 2-s2.0-30944460667 01/25/2006       76 Citations
  • Targeting brain AT1 receptors by RNA interference. (Sigmund CD, Davisson RL) Hypertension 2006 Feb;47(2):145-6 PMID: 16380514 SCOPUS ID: 2-s2.0-31944442656 12/29/2005       5 Citations
  • Peroxisome proliferator-activated receptor-gamma and its agonists in hypertension and atherosclerosis : mechanisms and clinical implications. (Halabi CM, Sigmund CD) Am J Cardiovasc Drugs 2005;5(6):389-98 PMID: 16259527 SCOPUS ID: 2-s2.0-27744434609 11/02/2005       14 Citations
  • Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice. (Sherrod M, Davis DR, Zhou X, Cassell MD, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2005 Dec;289(6):R1763-9 PMID: 16109805 SCOPUS ID: 2-s2.0-27844439395 08/20/2005       24 Citations
  • Cerebral vascular effects of angiotensin II: new insights from genetic models. (Faraci FM, Lamping KG, Modrick ML, Ryan MJ, Sigmund CD, Didion SP) J Cereb Blood Flow Metab 2006 Apr;26(4):449-55 PMID: 16094317 SCOPUS ID: 2-s2.0-33645849538 08/12/2005       73 Citations
  • Spontaneous stroke in a genetic model of hypertension in mice. (Iida S, Baumbach GL, Lavoie JL, Faraci FM, Sigmund CD, Heistad DD) Stroke 2005 Jun;36(6):1253-8 PMID: 15914769 SCOPUS ID: 2-s2.0-20444372244 05/26/2005       42 Citations
  • Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome. (Fath MA, Mullins RF, Searby C, Nishimura DY, Wei J, Rahmouni K, Davis RE, Tayeh MK, Andrews M, Yang B, Sigmund CD, Stone EM, Sheffield VC) Hum Mol Genet 2005 May 01;14(9):1109-18 PMID: 15772095 SCOPUS ID: 2-s2.0-20944445215 03/18/2005       136 Citations
  • Molecular evidence of tissue renin-angiotensin systems: a focus on the brain. (Sakai K, Sigmund CD) Curr Hypertens Rep 2005 Apr;7(2):135-40 PMID: 15748539 PMCID: PMC7088661 SCOPUS ID: 2-s2.0-20444372993 03/08/2005       34 Citations
  • Differential modulation of baroreflex control of heart rate by neuron- vs. glia-derived angiotensin II. (Sakai K, Chapleau MW, Morimoto S, Cassell MD, Sigmund CD) Physiol Genomics 2004 Dec 15;20(1):66-72 PMID: 15467015 SCOPUS ID: 2-s2.0-15244340172 10/07/2004       31 Citations
  • Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase. (Baumbach GL, Sigmund CD, Faraci FM) Circ Res 2004 Oct 15;95(8):822-9 PMID: 15388643 SCOPUS ID: 2-s2.0-6344241908 09/25/2004       52 Citations
  • Nuclear localization of angiotensinogen in astrocytes. (Sherrod M, Liu X, Zhang X, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2005 Feb;288(2):R539-46 PMID: 15388495 09/25/2004       48 Citations
  • Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin. (Rahmouni K, Morgan DA, Morgan GM, Liu X, Sigmund CD, Mark AL, Haynes WG) J Clin Invest 2004 Sep;114(5):652-8 PMID: 15343383 PMCID: PMC514588 SCOPUS ID: 2-s2.0-85047693533 09/03/2004       151 Citations
  • Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture. (Stunz LL, Busch LK, Munroe ME, Sigmund CD, Tygrett LT, Waldschmidt TJ, Bishop GA) Immunity 2004 Aug;21(2):255-66 PMID: 15308105 SCOPUS ID: 2-s2.0-4143124227 08/17/2004       48 Citations
  • Transgenic mice for studies of the renin-angiotensin system in hypertension. (Lavoie JL, Bianco RA, Sakai K, Keen HL, Ryan MJ, Sigmund CD) Acta Physiol Scand 2004 Aug;181(4):571-7 PMID: 15283772 SCOPUS ID: 2-s2.0-4043174157 07/31/2004       20 Citations
  • Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin. (Liu X, Driskell RR, Luo M, Abbott D, Filali M, Cheng N, Sigmund CD, Engelhardt JF) J Invest Dermatol 2004 Aug;123(2):264-74 PMID: 15245424 PMCID: PMC1803077 SCOPUS ID: 2-s2.0-3242675802 07/13/2004       21 Citations
  • Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis. (Driskell RR, Liu X, Luo M, Filali M, Zhou W, Abbott D, Cheng N, Moothart C, Sigmund CD, Engelhardt JF) Am J Physiol Lung Cell Mol Physiol 2004 Oct;287(4):L752-63 PMID: 15194563 SCOPUS ID: 2-s2.0-4544225539 06/15/2004       24 Citations
  • Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. (Dayal S, Arning E, Bottiglieri T, Böger RH, Sigmund CD, Faraci FM, Lentz SR) Stroke 2004 Aug;35(8):1957-62 PMID: 15178827 SCOPUS ID: 2-s2.0-3242746092 06/05/2004       135 Citations
  • Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. (Li WG, Gavrila D, Liu X, Wang L, Gunnlaugsson S, Stoll LL, McCormick ML, Sigmund CD, Tang C, Weintraub NL) Circulation 2004 May 11;109(18):2221-6 PMID: 15117840 SCOPUS ID: 2-s2.0-2442419837 05/01/2004       422 Citations
  • Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. (Lavoie JL, Lake-Bruse KD, Sigmund CD) Am J Physiol Renal Physiol 2004 May;286(5):F965-71 PMID: 15075192 SCOPUS ID: 2-s2.0-1942535146 04/13/2004       91 Citations
  • Gene expression profiling of potential PPARgamma target genes in mouse aorta. (Keen HL, Ryan MJ, Beyer A, Mathur S, Scheetz TE, Gackle BD, Faraci FM, Casavant TL, Sigmund CD) Physiol Genomics 2004 Jun 17;18(1):33-42 PMID: 15054141 SCOPUS ID: 2-s2.0-4243120941 04/01/2004       42 Citations
  • Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model. (Lavoie JL, Cassell MD, Gross KW, Sigmund CD) Hypertension 2004 May;43(5):1116-9 PMID: 15037561 SCOPUS ID: 2-s2.0-2342479957 03/24/2004       51 Citations
  • Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice. (Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD) Hypertension 2004 May;43(5):1074-9 PMID: 15007032 SCOPUS ID: 2-s2.0-2342586810 03/10/2004       62 Citations
  • Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. (Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, Welsh MJ) Proc Natl Acad Sci U S A 2004 Mar 09;101(10):3621-6 PMID: 14988500 PMCID: PMC373512 SCOPUS ID: 2-s2.0-1542723399 02/28/2004       150 Citations
  • Transgenesis and gene targeting in the mouse; tools for studying genetic determinants of hypertension. (Stec DE, Davisson RL, Sigmund CD) Trends Cardiovasc Med 1998 Aug;8(6):256-64 PMID: 14987561 02/28/2004    
  • Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity. (Rahmouni K, Mark AL, Haynes WG, Sigmund CD) Am J Physiol Endocrinol Metab 2004 Jun;286(6):E891-5 PMID: 14749209 SCOPUS ID: 2-s2.0-2442646800 01/30/2004       93 Citations
  • PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. (Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD) Hypertension 2004 Mar;43(3):661-6 PMID: 14744930 SCOPUS ID: 2-s2.0-1442288375 01/28/2004       172 Citations
  • ACE, ACE inhibitors, and other JNK. (Ryan MJ, Sigmund CD) Circ Res 2004 Jan 09;94(1):1-3 PMID: 14715529 SCOPUS ID: 2-s2.0-0347320773 01/13/2004       14 Citations
  • Differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice. (Nistala R, Zhang X, Sigmund CD) Physiol Genomics 2004 Mar 12;17(1):4-10 PMID: 14709678 SCOPUS ID: 2-s2.0-3142690560 01/08/2004       9 Citations
  • Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice. (Ma X, Sigmund CD, Hingtgen SD, Tian X, Davisson RL, Abboud FM, Chapleau MW) Hypertension 2004 Feb;43(2):312-6 PMID: 14699002 SCOPUS ID: 2-s2.0-0842311512 12/31/2003       23 Citations
  • Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. (Chen CC, Lamping KG, Nuno DW, Barresi R, Prouty SJ, Lavoie JL, Cribbs LL, England SK, Sigmund CD, Weiss RM, Williamson RA, Hill JA, Campbell KP) Science 2003 Nov 21;302(5649):1416-8 PMID: 14631046 SCOPUS ID: 2-s2.0-0344875643 11/25/2003       273 Citations
  • Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model. (Lavoie JL, Cassell MD, Gross KW, Sigmund CD) Physiol Genomics 2004 Jan 15;16(2):240-6 PMID: 14625376 SCOPUS ID: 2-s2.0-1842587534 11/20/2003       58 Citations
  • HPRT targeting: "Ets" a powerful tool for investigating endothelial-cell specific gene expression. (Ryan MJ, Sigmund CD) Arterioscler Thromb Vasc Biol 2003 Nov 01;23(11):1960-2 PMID: 14617618 SCOPUS ID: 2-s2.0-0242492004 11/18/2003       1 Citation
  • Untraditional methods for targeting the kidney in transgenic mice. (Bianco RA, Keen HL, Lavoie JL, Sigmund CD) Am J Physiol Renal Physiol 2003 Dec;285(6):F1027-33 PMID: 14600026 SCOPUS ID: 2-s2.0-0242582133 11/06/2003       10 Citations
  • Minireview: overview of the renin-angiotensin system--an endocrine and paracrine system. (Lavoie JL, Sigmund CD) Endocrinology 2003 Jun;144(6):2179-83 PMID: 12746271 SCOPUS ID: 2-s2.0-0037901037 05/15/2003       366 Citations
  • Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription. (Liu X, Huang X, Sigmund CD) Circ Res 2003 May 16;92(9):1033-40 PMID: 12690040 SCOPUS ID: 2-s2.0-0037687975 04/12/2003       46 Citations
  • Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay. (Tran ND, Liu X, Yan Z, Abbote D, Jiang Q, Kmiec EB, Sigmund CD, Engelhardt JF) Mol Ther 2003 Feb;7(2):248-53 PMID: 12597913 SCOPUS ID: 2-s2.0-0037302819 02/25/2003       34 Citations
  • Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen. (Baumbach GL, Sigmund CD, Faraci FM) Hypertension 2003 Jan;41(1):50-5 PMID: 12511529 SCOPUS ID: 2-s2.0-0037217448 01/04/2003       76 Citations
  • Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. (Didion SP, Ryan MJ, Didion LA, Fegan PE, Sigmund CD, Faraci FM) Circ Res 2002 Nov 15;91(10):938-44 PMID: 12433839 SCOPUS ID: 2-s2.0-0037112407 11/16/2002       188 Citations
  • Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice. (Baumbach GL, Sigmund CD, Bottiglieri T, Lentz SR) Circ Res 2002 Nov 15;91(10):931-7 PMID: 12433838 SCOPUS ID: 2-s2.0-0037112386 11/16/2002       57 Citations
  • Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse. (Cvetkovic B, Keen HL, Zhang X, Davis D, Yang B, Sigmund CD) Physiol Genomics 2002 Dec 03;11(3):253-62 PMID: 12388794 SCOPUS ID: 2-s2.0-0141816961 10/22/2002       21 Citations
  • Angiotensin mutant mice: a focus on the brain renin-angiotensin system. (Morimoto S, Sigmund CD) Neuropeptides 2002 Apr-Jun;36(2-3):194-200 PMID: 12359509 SCOPUS ID: 2-s2.0-0036552412 10/03/2002       27 Citations
  • Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen. (Didion SP, Ryan MJ, Baumbach GL, Sigmund CD, Faraci FM) Am J Physiol Heart Circ Physiol 2002 Oct;283(4):H1569-76 PMID: 12234811 SCOPUS ID: 2-s2.0-0036783627 09/18/2002       60 Citations
  • Regulation of renin expression and blood pressure by vitamin D(3). (Sigmund CD) J Clin Invest 2002 Jul;110(2):155-6 PMID: 12122105 PMCID: PMC151071 SCOPUS ID: 2-s2.0-0036074357 07/18/2002       55 Citations
  • Glia- and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference. (Morimoto S, Cassell MD, Sigmund CD) J Biol Chem 2002 Sep 06;277(36):33235-41 PMID: 12080069 SCOPUS ID: 2-s2.0-0037031825 06/25/2002       95 Citations
  • Meeting report: Physiological Genomics of Cardiovascular Disease: from Technology to Physiology. (Glueck SB, Sigmund CD) Physiol Genomics 2002;9(3):135-6 PMID: 12045293 SCOPUS ID: 2-s2.0-0036365819 06/05/2002       1 Citation
  • Neuron-specific expression of human angiotensinogen in brain causes increased salt appetite. (Morimoto S, Cassell MD, Sigmund CD) Physiol Genomics 2002;9(2):113-20 PMID: 12006677 SCOPUS ID: 2-s2.0-0036359970 05/15/2002       32 Citations
  • A reliable and efficient method for deleting operational sequences in PACs and BACs. (Nistala R, Sigmund CD) Nucleic Acids Res 2002 May 15;30(10):e41 PMID: 12000846 PMCID: PMC115295 SCOPUS ID: 2-s2.0-0037095745 05/10/2002       11 Citations
  • Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice. (Lazartigues E, Dunlay SM, Loihl AK, Sinnayah P, Lang JA, Espelund JJ, Sigmund CD, Davisson RL) Circ Res 2002 Mar 22;90(5):617-24 PMID: 11909827 SCOPUS ID: 2-s2.0-0037155772 03/23/2002       64 Citations
  • Use of transgenic and knockout strategies in mice. (Ryan MJ, Sigmund CD) Semin Nephrol 2002 Mar;22(2):154-60 PMID: 11891509 SCOPUS ID: 2-s2.0-0036124346 03/14/2002       3 Citations
  • Lower blood pressure in floxed angiotensinogen mice after adenoviral delivery of Cre-recombinase. (Stec DE, Keen HL, Sigmund CD) Hypertension 2002 Feb;39(2 Pt 2):629-33 PMID: 11882621 SCOPUS ID: 2-s2.0-0036176433 03/08/2002       23 Citations
  • Endothelial dysfunction and blood pressure variability in selected inbred mouse strains. (Ryan MJ, Didion SP, Davis DR, Faraci FM, Sigmund CD) Arterioscler Thromb Vasc Biol 2002 Jan;22(1):42-8 PMID: 11788459 SCOPUS ID: 2-s2.0-0036144727 01/15/2002       62 Citations
  • The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene. (Morimoto S, Cassell MD, Sigmund CD) Circ Res 2002 Jan 11;90(1):80-6 PMID: 11786522 SCOPUS ID: 2-s2.0-0037059564 01/12/2002       40 Citations
  • Differential requirement for SLP-76 domains in T cell development and function. (Myung PS, Derimanov GS, Jordan MS, Punt JA, Liu QH, Judd BA, Meyers EE, Sigmund CD, Freedman BD, Koretzky GA) Immunity 2001 Dec;15(6):1011-26 PMID: 11754821 SCOPUS ID: 2-s2.0-18244408051 01/05/2002       84 Citations
  • Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice. (Wilson K, Fry GL, Chappell DA, Sigmund CD, Medh JD) Arterioscler Thromb Vasc Biol 2001 Nov;21(11):1809-15 PMID: 11701470 PMCID: PMC2768479 SCOPUS ID: 2-s2.0-0035571614 11/10/2001       54 Citations
  • Genetic manipulation of the renin-angiotensin system in the kidney. (Sigmund CD) Acta Physiol Scand 2001 Sep;173(1):67-73 PMID: 11678728 SCOPUS ID: 2-s2.0-0034796748 10/27/2001       7 Citations
  • NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors. (Shi Q, Gross KW, Sigmund CD) Hypertension 2001 Sep;38(3):332-6 PMID: 11566900 SCOPUS ID: 2-s2.0-0035571531 09/22/2001       30 Citations
  • Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. (Pan L, Black TA, Shi Q, Jones CA, Petrovic N, Loudon J, Kane C, Sigmund CD, Gross KW) J Biol Chem 2001 Dec 07;276(49):45530-8 PMID: 11564732 SCOPUS ID: 2-s2.0-0035824520 09/21/2001       106 Citations
  • Vectors for high-level expression of cDNAs controlled by tissue-specific promoters in transgenic mice. (Stec DE, Morimoto S, Sigmund CD) Biotechniques 2001 Aug;31(2):256-8, 260 PMID: 11515356 SCOPUS ID: 2-s2.0-0034891892 08/23/2001       15 Citations
  • Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. (Morimoto S, Cassell MD, Beltz TG, Johnson AK, Davisson RL, Sigmund CD) Circ Res 2001 Aug 17;89(4):365-72 PMID: 11509454 SCOPUS ID: 2-s2.0-0035903241 08/18/2001       89 Citations
  • Genetic manipulation of the renin-angiotensin system: targeted expression of the renin-angiotensin system in the kidney. (Sigmund CD) Am J Hypertens 2001 Jun;14(6 Pt 2):33S-37S PMID: 11411763 SCOPUS ID: 2-s2.0-0034987538 06/20/2001       16 Citations
  • Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. (Dayal S, Bottiglieri T, Arning E, Maeda N, Malinow MR, Sigmund CD, Heistad DD, Faraci FM, Lentz SR) Circ Res 2001 Jun 08;88(11):1203-9 PMID: 11397788 SCOPUS ID: 2-s2.0-0035827728 06/09/2001       181 Citations
  • Physiological insights from genetic manipulation of the renin-angiotensin system. (Stec DE, Sigmund CD) News Physiol Sci 2001 Apr;16:80-4 PMID: 11390954 SCOPUS ID: 2-s2.0-0035316924 06/08/2001       7 Citations
  • Paradoxical regulation of short promoter human renin transgene by angiotensin ii. (Keen HL, Sigmund CD) Hypertension 2001 Feb;37(2 Pt 2):403-7 PMID: 11230308 SCOPUS ID: 2-s2.0-0035090179 03/07/2001       10 Citations
  • Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice. (Ding Y, Sigmund CD) Am J Physiol Renal Physiol 2001 Jan;280(1):F54-60 PMID: 11133514 SCOPUS ID: 2-s2.0-0034997199 01/03/2001       46 Citations
  • Genetic Manipulation of the Renin-Angiotensin System Using Cre-loxP-Recombinase. (Sigmund CD, Stec DE) Methods Mol Med 2001;51:53-65 PMID: 21331709 01/01/2001    
  • Genetic evidence that lethality in angiotensinogen-deficient mice is due to loss of systemic but not renal angiotensinogen. (Ding Y, Stec DE, Sigmund CD) J Biol Chem 2001 Mar 09;276(10):7431-6 PMID: 11096065 SCOPUS ID: 2-s2.0-0035831441 11/30/2000       17 Citations
  • Retinoic acid-mediated activation of the mouse renin enhancer. (Shi Q, Gross KW, Sigmund CD) J Biol Chem 2001 Feb 02;276(5):3597-603 PMID: 11058598 SCOPUS ID: 2-s2.0-0035793588 11/04/2000       54 Citations
  • Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle. (Khan AH, Thurmond DC, Yang C, Ceresa BP, Sigmund CD, Pessin JE) J Biol Chem 2001 Feb 09;276(6):4063-9 PMID: 11054418 PMCID: PMC5540311 SCOPUS ID: 2-s2.0-0035830868 10/31/2000       66 Citations
  • Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation. (Sinn PL, Sigmund CD) Physiol Genomics 2000 Jun 29;3(1):25-31 PMID: 11015597 SCOPUS ID: 2-s2.0-0034729573 10/04/2000       82 Citations
  • Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. (Davisson RL, Ding Y, Stec DE, Catterall JF, Sigmund CD) Physiol Genomics 1999 Jul 15;1(1):3-9 PMID: 11015555 SCOPUS ID: 2-s2.0-0033564984 10/04/2000       102 Citations
  • Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways. (Lake-Bruse KD, Sigmund CD) Curr Hypertens Rep 2000 Apr;2(2):211-6 PMID: 10981151 SCOPUS ID: 2-s2.0-0034169792 09/12/2000       9 Citations
  • Divergent functions of angiotensin II receptor isoforms in the brain. (Davisson RL, Oliverio MI, Coffman TM, Sigmund CD) J Clin Invest 2000 Jul;106(1):103-6 PMID: 10880053 PMCID: PMC314366 SCOPUS ID: 2-s2.0-0033916897 07/06/2000       144 Citations
  • Viewpoint: are studies in genetically altered mice out of control? (Sigmund CD) Arterioscler Thromb Vasc Biol 2000 Jun;20(6):1425-9 PMID: 10845854 SCOPUS ID: 2-s2.0-0034091586 06/10/2000       99 Citations
  • Understanding hypertension through genetic manipulation in mice. (Cvetkovic B, Sigmund CD) Kidney Int 2000 Mar;57(3):863-74 PMID: 10720939 SCOPUS ID: 2-s2.0-0033917514 03/18/2000       37 Citations
  • Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. (Mark AL, Shaffer RA, Correia ML, Morgan DA, Sigmund CD, Haynes WG) J Hypertens 1999 Dec;17(12 Pt 2):1949-53 PMID: 10703894 SCOPUS ID: 2-s2.0-0033512117 03/07/2000       219 Citations
  • Impaired endothelial function in transgenic mice expressing both human renin and human angiotensinogen. (Didion SP, Sigmund CD, Faraci FM) Stroke 2000 Mar;31(3):760-4; discussion 765 PMID: 10700516 SCOPUS ID: 2-s2.0-0034056523 03/04/2000       51 Citations
  • Identification of cis elements in the cardiac troponin T gene conferring specific expression in cardiac muscle of transgenic mice. (Wang Q, Sigmund CD, Lin JJ) Circ Res 2000 Mar 03;86(4):478-84 PMID: 10700454 SCOPUS ID: 2-s2.0-0034599035 03/04/2000       28 Citations
  • Transgenic models as tools for studying the regulation of human renin expression. (Sinn PL, Sigmund CD) Regul Pept 2000 Jan 29;86(1-3):77-82 PMID: 10672905 SCOPUS ID: 2-s2.0-0033987144 02/15/2000       9 Citations
  • Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination. (Cvetkovic B, Yang B, Williamson RA, Sigmund CD) J Biol Chem 2000 Jan 14;275(2):1073-8 PMID: 10625648 SCOPUS ID: 2-s2.0-0033955101 01/08/2000       41 Citations
  • Vascular biology in genetically altered mice : smaller vessels, bigger insight. (Faraci FM, Sigmund CD) Circ Res 1999 Dec 3-17;85(12):1214-25 PMID: 10590250 SCOPUS ID: 2-s2.0-0033533988 12/11/1999       67 Citations
  • Highly regulated cell type-restricted expression of human renin in mice containing 140- or 160-kilobase pair P1 phage artificial chromosome transgenes. (Sinn PL, Davis DR, Sigmund CD) J Biol Chem 1999 Dec 10;274(50):35785-93 PMID: 10585461 SCOPUS ID: 2-s2.0-0033544875 12/10/1999       50 Citations
  • JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter. (Sinn PL, Zhang X, Sigmund CD) Am J Physiol 1999 10;277(4):F634-42 PMID: 10516288 SCOPUS ID: 2-s2.0-0032742484 10/12/1999       19 Citations
  • Species-specific differences in positive and negative regulatory elements in the renin gene enhancer. (Shi Q, Black TA, Gross KW, Sigmund CD) Circ Res 1999 Sep 17;85(6):479-88 PMID: 10488050 SCOPUS ID: 2-s2.0-0033578852 09/17/1999       44 Citations
  • Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice. (Lake-Bruse KD, Faraci FM, Shesely EG, Maeda N, Sigmund CD, Heistad DD) Am J Physiol 1999 08;277(2):H770-6 PMID: 10444505 SCOPUS ID: 2-s2.0-0032879970 08/13/1999       50 Citations
  • Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo. (Stec DE, Davisson RL, Haskell RE, Davidson BL, Sigmund CD) J Biol Chem 1999 Jul 23;274(30):21285-90 PMID: 10409686 SCOPUS ID: 2-s2.0-0033597775 07/20/1999       69 Citations
  • Human renin mRNA stability is increased in response to cAMP in Calu-6 cells. (Sinn PL, Sigmund CD) Hypertension 1999 Mar;33(3):900-5 PMID: 10082506 SCOPUS ID: 2-s2.0-0033000013 03/19/1999       35 Citations
  • The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system. (Yang G, Gray TS, Sigmund CD, Cassell MD) Brain Res 1999 Jan 30;817(1-2):123-31 PMID: 9889347 SCOPUS ID: 2-s2.0-0033616351 01/16/1999       66 Citations
  • Kidney is the only source of human plasma renin in 45-kb human renin transgenic mice. (Yan Y, Chen R, Pitarresi T, Sigmund CD, Gross KW, Sealey JE, Laragh JH, Catanzaro DF) Circ Res 1998 Dec 14-28;83(12):1279-88 PMID: 9851945 SCOPUS ID: 2-s2.0-0032576601 12/16/1998       25 Citations
  • The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes. (Davisson RL, Yang G, Beltz TG, Cassell MD, Johnson AK, Sigmund CD) Circ Res 1998 Nov 16;83(10):1047-58 PMID: 9815152 SCOPUS ID: 2-s2.0-0032538972 11/14/1998       119 Citations
  • Modifiable gene expression in mice: kidney-specific deletion of a target gene via the cre-loxP system. (Stec DE, Sigmund CD) Exp Nephrol 1998 Nov-Dec;6(6):568-75 PMID: 9807030 SCOPUS ID: 2-s2.0-0031797909 11/10/1998       16 Citations
  • Developmental expression of human angiotensinogen in transgenic mice. (Yang G, Sigmund CD) Am J Physiol 1998 05;274(5):F932-9 PMID: 9612331 SCOPUS ID: 2-s2.0-0031804598 06/05/1998       13 Citations
  • Differential regulation of human renin gene expression during the estrous cycle in transgenic mice (Merrill DC, Smith SB, Sigmund CD) FASEB Journal 20 March 1998;12(5) SCOPUS ID: 2-s2.0-33749227218 03/20/1998    
  • Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice. (Yang G, Sigmund CD) Hypertension 1998 Mar;31(3):734-40 PMID: 9495255 SCOPUS ID: 2-s2.0-0031910886 03/12/1998       20 Citations
  • Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. (Faraci FM, Sigmund CD, Shesely EG, Maeda N, Heistad DD) Am J Physiol 1998 02;274(2):H564-70 PMID: 9486260 SCOPUS ID: 2-s2.0-0031952267 03/05/1998       115 Citations
  • Transgenesis and gene targeting in the mouse: Tools for studying genetic determinants of hypertension (Stec DE, Davisson RL, Sigmund CD) Trends in Cardiovascular Medicine August 1998;8(6):256-264 SCOPUS ID: 2-s2.0-0031691649 01/01/1998    
  • Use of transgenic and gene-targeted mice to model the genetic basis of hypertensive disorders. (Merrill DC, Granwehr BP, Davis DR, Sigmund CD) Proc Assoc Am Physicians 1997 Nov;109(6):533-46 PMID: 9394415 SCOPUS ID: 2-s2.0-0030695283 12/12/1997       10 Citations
  • Post-transcriptional regulation of human renin messenger RNA in Calu-6 cells (Sinn PL, Lang JA, Sigmund CD) FASEB Journal 1997;11(3) SCOPUS ID: 2-s2.0-33750275037 12/01/1997    
  • Evidence for vascular remodeling but not enhanced sympathetic drive in the chronic hypertension exhibited by transgenic mice containing both the human renin and human angiotensinogen genes (RA+) (Davisson RL, Merrill DC, Sigmund CD) FASEB Journal 1997;11(3) SCOPUS ID: 2-s2.0-33750147863 12/01/1997    
  • Inducible hypertension in transgenic mice containing the human angiotensinogen gene under the control of the kidney androgen-regulated protein promoter (Ding Y, Davisson RL, Hardy DO, Zhu LJ, Catterall JF, Sigmund CD) FASEB Journal 1997;11(3) SCOPUS ID: 2-s2.0-33750191282 12/01/1997    
  • The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. (Ding Y, Davisson RL, Hardy DO, Zhu LJ, Merrill DC, Catterall JF, Sigmund CD) J Biol Chem 1997 Oct 31;272(44):28142-8 PMID: 9346970 SCOPUS ID: 2-s2.0-0030736087 11/05/1997       110 Citations
  • Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells. (Yan Y, Jones CA, Sigmund CD, Gross KW, Catanzaro DF) Circ Res 1997 Oct;81(4):558-66 PMID: 9314837 SCOPUS ID: 2-s2.0-0013127779 10/07/1997       51 Citations
  • Downregulation of renin gene expression by interleukin-1. (Petrovic N, Kane CM, Sigmund CD, Gross KW) Hypertension 1997 Aug;30(2 Pt 1):230-5 PMID: 9260985 SCOPUS ID: 2-s2.0-0030791443 08/01/1997       24 Citations
  • Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. (Davisson RL, Kim HS, Krege JH, Lager DJ, Smithies O, Sigmund CD) J Clin Invest 1997 Mar 15;99(6):1258-64 PMID: 9077534 PMCID: PMC507940 SCOPUS ID: 2-s2.0-0030952323 03/15/1997       65 Citations
  • Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 (CREB)-dependent and CREB-independent mechanisms in Calu-6 cells. (Ying L, Morris BJ, Sigmund CD) J Biol Chem 1997 Jan 24;272(4):2412-20 PMID: 8999953 SCOPUS ID: 2-s2.0-0031026633 01/24/1997       65 Citations
  • Biosynthesis of renin in mouse kidney tumor As4.1 cells. (Jones CA, Petrovic N, Novak EK, Swank RT, Sigmund CD, Gross KW) Eur J Biochem 1997 Jan 15;243(1-2):181-90 PMID: 9030738 SCOPUS ID: 2-s2.0-0031019662 01/15/1997       26 Citations
  • Transgenic animal models as tools for studying renal developmental physiology. (Davisson RL, Sigmund CD) Pediatr Nephrol 1996 Dec;10(6):798-803 PMID: 8971910 SCOPUS ID: 2-s2.0-0029801107 12/01/1996       1 Citation
  • Cardiovascular control in conscious transgenic mice carrying human renin and human angiotensinogen genes (Merrill DC, Carney CL, Granwehr BP, Schlager G, Robillard JE, Sigmund CD) FASEB Journal 1996;10(3) SCOPUS ID: 2-s2.0-33748967222 12/01/1996    
  • Kidney-specific expression of the human angiotenslnogen gene under the control of the kidney androgenregulated protein promoter in transgenic mice (Ding Y, Davisson RL, Hardy PO, Sinclair NE, Robbins L, Catterall JF, Sigmund CD) FASEB Journal 1996;10(3) SCOPUS ID: 2-s2.0-10544220900 12/01/1996    
  • Inappropriate splicing of a chimeric gene containing a large internal exon results in exon skipping in transgenic mice. (Davisson RL, Nuutinen N, Coleman ST, Sigmund CD) Nucleic Acids Res 1996 Oct 15;24(20):4023-8 PMID: 8918807 PMCID: PMC146210 SCOPUS ID: 2-s2.0-0029808775 10/15/1996       10 Citations
  • Role of proximal promoter elements in regulation of renin gene transcription. (Petrovic N, Black TA, Fabian JR, Kane C, Jones CA, Loudon JA, Abonia JP, Sigmund CD, Gross KW) J Biol Chem 1996 Sep 13;271(37):22499-505 PMID: 8798416 SCOPUS ID: 2-s2.0-0029808405 09/13/1996       94 Citations
  • Regulation of human renin mRNA expression and protein release in transgenic mice. (Thompson MW, Smith SB, Sigmund CD) Hypertension 1996 Aug;28(2):290-6 PMID: 8707396 SCOPUS ID: 2-s2.0-0029743370 08/01/1996       25 Citations
  • Transcriptional and posttranscriptional mechanisms regulate human renin gene expression in Calu-6 cells. (Lang JA, Ying LH, Morris BJ, Sigmund CD) Am J Physiol 1996 Jul;271(1 Pt 2):F94-100 PMID: 8760248 SCOPUS ID: 2-s2.0-0029759107 07/01/1996       48 Citations
  • Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. (Merrill DC, Thompson MW, Carney CL, Granwehr BP, Schlager G, Robillard JE, Sigmund CD) J Clin Invest 1996 Feb 15;97(4):1047-55 PMID: 8613528 PMCID: PMC507152 SCOPUS ID: 2-s2.0-0030049446 02/15/1996       152 Citations
  • Transgenic animals in the study of blood pressure regulation and hypertension. (Thompson MW, Merrill DC, Yang G, Robillard JE, Sigmund CD) Am J Physiol 1995 Nov;269(5 Pt 1):E793-803 PMID: 7491928 SCOPUS ID: 2-s2.0-0028881235 11/01/1995       16 Citations
  • Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). (Thompson HA, Burson JM, Lang JA, Gross KW, Sigmund CD) Endocrinology 1995 Jul;136(7):3037-45 PMID: 7789330 SCOPUS ID: 2-s2.0-0029003401 07/01/1995       9 Citations
  • Endogenous human renin expression and promoter activity in CALU-6, a pulmonary carcinoma cell line. (Lang JA, Yang G, Kern JA, Sigmund CD) Hypertension 1995 Apr;25(4 Pt 2):704-10 PMID: 7721420 SCOPUS ID: 2-s2.0-0028900531 04/01/1995       38 Citations
  • Human renin 5'-flanking DNA to nucleotide-2750. (Smith DL, Jeyapalan S, Lang JA, Guo XH, Sigmund CD, Morris BJ) DNA Seq 1995;5(5):319-21 PMID: 7579588 SCOPUS ID: 2-s2.0-0028873963 01/01/1995       3 Citations
  • Functional expression of the human angiotensinogen gene in transgenic mice. (Yang G, Merrill DC, Thompson MW, Robillard JE, Sigmund CD) J Biol Chem 1994 Dec 23;269(51):32497-502 PMID: 7798251 SCOPUS ID: 2-s2.0-0028608104 12/23/1994       105 Citations
  • Chromosome 8 alterations accompany tumorigenesis in renin-SV40 T antigen transgenic mice. (Held WA, O'Brien JG, Kerns K, Gallagher JF, Sigmund CD, Gross KW) Cancer Res 1994 Dec 15;54(24):6496-9 PMID: 7987848 SCOPUS ID: 2-s2.0-0028624686 12/15/1994       5 Citations
  • A Pit-1 binding site in the human renin gene promoter stimulates activity in pituitary, placental and juxtaglomerular cells. (Catanzaro DF, Sun J, Gilbert MT, Yan Y, Black T, Sigmund C, Gross KW) Kidney Int 1994 Dec;46(6):1513-5 PMID: 7699993 SCOPUS ID: 2-s2.0-0027948408 12/01/1994       15 Citations
  • Differential expression of angiotensin receptor 1A and 1B in mouse. (Burson JM, Aguilera G, Gross KW, Sigmund CD) Am J Physiol 1994 Aug;267(2 Pt 1):E260-7 PMID: 8074205 SCOPUS ID: 2-s2.0-0028005235 08/01/1994       202 Citations
  • Transgenic animals as tools in hypertension research. (Lang JA, Sinclair NL, Burson JM, Sigmund CD) Proc Soc Exp Biol Med 1994 Feb;205(2):106-18 PMID: 8108459 SCOPUS ID: 2-s2.0-0028345370 02/01/1994       4 Citations
  • Major approaches for generating and analyzing transgenic mice. An overview. (Sigmund CD) Hypertension 1993 Oct;22(4):599-607 PMID: 8406666 SCOPUS ID: 2-s2.0-0027386012 10/01/1993       40 Citations
  • Expression of the human renin gene in transgenic mice throughout ontogeny. (Sigmund CD) Pediatr Nephrol 1993 Oct;7(5):639-45 PMID: 8251339 SCOPUS ID: 2-s2.0-0027361720 10/01/1993       15 Citations
  • Expression and regulation of the renin gene. (Sigmund CD, Fabian JR, Gross KW) Trends Cardiovasc Med 1992 Nov-Dec;2(6):237-45 PMID: 21239248 11/01/1992    
  • Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice. (Sigmund CD, Jones CA, Kane CM, Wu C, Lang JA, Gross KW) Circ Res 1992 May;70(5):1070-9 PMID: 1568298 SCOPUS ID: 2-s2.0-0026514648 05/01/1992       92 Citations
  • Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products. (Lim SK, Sigmund CD, Gross KW, Maquat LE) Mol Cell Biol 1992 Mar;12(3):1149-61 PMID: 1545796 PMCID: PMC369546 SCOPUS ID: 2-s2.0-0026583873 03/01/1992       100 Citations
  • Structure, expression, and regulation of the murine renin genes. (Sigmund CD, Gross KW) Hypertension 1991 Oct;18(4):446-57 PMID: 1916990 SCOPUS ID: 2-s2.0-0025948361 10/01/1991       106 Citations
  • Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia. (Jacob HJ, Sigmund CD, Shockley TR, Gross KW, Dzau VJ) Hypertension 1991 Jun;17(6 Pt 2):1167-62 PMID: 2045162 SCOPUS ID: 2-s2.0-0026095260 06/01/1991       14 Citations
  • Pathophysiology of vascular smooth muscle in renin promoter-T-antigen transgenic mice. (Sigmund CD, Jones CA, Jacob HJ, Ingelfinger J, Kim U, Gamble D, Dzau VJ, Gross KW) Am J Physiol 1991 Feb;260(2 Pt 2):F249-57 PMID: 1996675 SCOPUS ID: 2-s2.0-0026022214 02/01/1991       25 Citations
  • Differential expression of the murine and rat renin genes in peripheral subcutaneous tissue. (Sigmund CD, Gross KW) Biochem Biophys Res Commun 1990 Nov 30;173(1):218-23 PMID: 1979487 SCOPUS ID: 2-s2.0-0025686098 11/30/1990       9 Citations
  • Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct. (Sigmund CD, Okuyama K, Ingelfinger J, Jones CA, Mullins JJ, Kane C, Kim U, Wu CZ, Kenny L, Rustum Y) J Biol Chem 1990 Nov 15;265(32):19916-22 PMID: 2174057 SCOPUS ID: 2-s2.0-0025201726 11/15/1990       141 Citations
  • Expression of murine renin genes in subcutaneous connective tissue. (Sigmund CD, Jones CA, Mullins JJ, Kim U, Gross KW) Proc Natl Acad Sci U S A 1990 Oct;87(20):7993-7 PMID: 2172970 PMCID: PMC54878 SCOPUS ID: 2-s2.0-0025089378 10/01/1990       25 Citations
  • Tissue and cell specific expression of a renin promoter-reporter gene construct in transgenic mice. (Sigmund CD, Jones CA, Fabian JR, Mullins JJ, Gross KW) Biochem Biophys Res Commun 1990 Jul 16;170(1):344-50 PMID: 1695507 SCOPUS ID: 2-s2.0-0025108262 07/16/1990       64 Citations
  • Expression of murine renin genes during fetal development. (Jones CA, Sigmund CD, McGowan RA, Kane-Haas CM, Gross KW) Mol Endocrinol 1990 Mar;4(3):375-83 PMID: 2188116 SCOPUS ID: 2-s2.0-0025270518 03/01/1990       99 Citations
  • Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice. (Mullins JJ, Sigmund CD, Kane-Haas C, Gross KW, McGowan RA) EMBO J 1989 Dec 20;8(13):4065-72 PMID: 2480233 PMCID: PMC401583 SCOPUS ID: 2-s2.0-0024789525 12/20/1989       65 Citations
  • Allele-specific expression of the murine Ren-1 genes. (Fabian JR, Field LJ, McGowan RA, Mullins JJ, Sigmund CD, Gross KW) J Biol Chem 1989 Oct 15;264(29):17589-94 PMID: 2677011 SCOPUS ID: 2-s2.0-0024341987 10/15/1989       40 Citations
  • Effects of Escherichia coli Nus A protein on transcription termination in vitro are not increased or decreased by DNA sequences sufficient for antitermination in vivo. (Sigmund CD, Morgan EA) Biochemistry 1988 Jul 26;27(15):5628-35 PMID: 2846045 SCOPUS ID: 2-s2.0-0023711908 07/26/1988       5 Citations
  • Nus A protein affects transcriptional pausing and termination in vitro by binding to different sites on the transcription complex. (Sigmund CD, Morgan EA) Biochemistry 1988 Jul 26;27(15):5622-7 PMID: 2846044 SCOPUS ID: 2-s2.0-0023721890 07/26/1988       24 Citations
  • Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli. (Sigmund CD, Ettayebi M, Borden A, Morgan EA) Methods Enzymol 1988;164:673-90 PMID: 3071688 SCOPUS ID: 2-s2.0-0024271795 01/01/1988       159 Citations
  • Studies on the regulation of renin genes using transgenic mice. (Mullins JJ, Sigmund CD, Kane-Haas C, Wu CZ, Pacholec F, Zeng Q, Gross KW) Clin Exp Hypertens A 1988;10(6):1157-67 PMID: 3066526 SCOPUS ID: 2-s2.0-0024264773 01/01/1988       17 Citations
  • Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli. (Sigmund CD, Ettayebi M, Morgan EA) Nucleic Acids Res 1984 Jun 11;12(11):4653-63 PMID: 6330677 PMCID: PMC318865 SCOPUS ID: 2-s2.0-0021760461 06/11/1984       163 Citations
  • Spectinomycin resistance due to a mutation in an rRNA operon of Escherichia coli. (Mark LG, Sigmund CD, Morgan EA) J Bacteriol 1983 Sep;155(3):989-94 PMID: 6193099 PMCID: PMC217790 SCOPUS ID: 2-s2.0-0020520046 09/01/1983       18 Citations
  • Erythromycin resistance due to a mutation in a ribosomal RNA operon of Escherichia coli. (Sigmund CD, Morgan EA) Proc Natl Acad Sci U S A 1982 Sep;79(18):5602-6 PMID: 6752954 PMCID: PMC346952 SCOPUS ID: 2-s2.0-0343417099 09/01/1982       37 Citations
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