Allele-specific expression of the murine Ren-1 genes. J Biol Chem 1989 Oct 15;264(29):17589-94
Date
10/15/1989Pubmed ID
2677011Scopus ID
2-s2.0-0024341987 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
Inbred strains of mice carry either one of two alleles for the Ren-1 gene on chromosome 1; Ren-1c or Ren-1d. The Ren-1d allele is found in association with a tightly linked duplicated locus, Ren-2. The relative accumulations of renin transcripts derived from each locus were found to differ between mice with one or two renin loci in three extra renal tissues, the adrenal gland, testis, and sex accessory gland tissue. We find that the two Ren-1 alleles exhibit characteristic expression patterns in these tissues. Using genetic analyses and an allele-specific dideoxynucleotide primer extension assay we have further characterized the expression differences in these tissues. The results suggest that the allele-specific expression patterns observed for the Ren-1 genes are regulated by closely associated sequences in cis.
Author List
Fabian JR, Field LJ, McGowan RA, Mullins JJ, Sigmund CD, Gross KWAuthor
Curt Sigmund PhD Chair, Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adrenal GlandsAlleles
Animals
Base Sequence
Female
Gene Expression
Genitalia
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred DBA
Molecular Sequence Data
RNA, Messenger
Renin
Testis
Transcription, Genetic
