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[Histologic studies of paraproteinemic nephropathy in BALB/c mice with mineral oil-induced plasmacytoma]. Z Urol Nephrol 1989 Dec;82(12):671-8

Date

12/01/1989

Pubmed ID

2629422

Scopus ID

2-s2.0-17344384553 (requires institutional sign-in at Scopus site)

Abstract

In histological examinations of kidneys from BALB/c mice with induced plasmocytoma (n = 75) the well known morphological correlates of paraproteinemic nephropathy were found, but further changes like reactive tubular giant cells and interstitial sclerosing processes have been missing. Furthermore, in the severity of nephropathy no correlation were found between the level of paraprotein in serum and/or ascites and the duration of the disease. This may be an indirect sign of an individual nephrotoxicity of the Bence-Jones proteins.

Author List

Janz S, Rassmann B, Raabe F, Storch H

Author

Siegfried Janz MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Female
Kidney
Kidney Neoplasms
Male
Mice
Mice, Inbred BALB C
Mineral Oil
Multiple Myeloma
Paraproteinemias
Paraproteins