Induction of plasma cell tumours with 2,6,10,14-tetramethylpentadecane (pristane) and paraffin oil (paraffinum perliquidum) in BALB/c mice simultaneously exposed to sustained antigenic stimulation with bovine serum albumin (BSA). Arch Geschwulstforsch 1987;57(1):25-30
Date
01/01/1987Pubmed ID
3566462Scopus ID
2-s2.0-0023068685 (requires institutional sign-in at Scopus site)Abstract
Plasmacytomas were readily induced in BALB/c mice by three bimonthly i.p. injections of 0.5 ml pristane or paraffin oil. Additionally, two groups of mice were simultaneously given a prolonged antigenic stimulation with bovine serum albumin (BSA). The tumour incidence found in mice treated with pristane and BSA (75%) was higher than the plasmacytoma incidence in mice subjected to paraffin oil and BSA inoculations (53.7%, p = 0.05). The sustained antigenic stimulation with BSA had no effect on cumulative plasmacytoma incidence.
Author List
Janz S, PĆ¼schel W, Raabe F, Storch HAuthor
Siegfried Janz MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntigens
Carcinogens
Female
Immunization
Male
Mice
Mice, Inbred BALB C
Mineral Oil
Oils
Paraffin
Plasmacytoma
Serum Albumin, Bovine
Terpenes
Time Factors