Faculty Collaboration Database

Persistence and progression of immunologic abnormalities in haemophilia. Thromb Haemost 1985 Jun 24;53(3):328-31

Date

06/24/1985

Pubmed ID

3931282

DOI

10.1055/s-0038-1661308

Scopus ID

2-s2.0-0021878480 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

Immunologic parameters in 51 patients with haemophilia treated with cryoprecipitate from volunteer donors or with commercial lyophilized concentrate were studied on 2-7 occasions. Concentrate users had significantly decreased mean T4 (helper)/T8 (suppressor) lymphocyte ratios when the initial (1.5 +/- .43) and most recent (1.25 +/- .60) values were compared (p less than .001), whereas in cryoprecipitate users mean values remained normal. Of the 22 concentrate users with initially normal T4/T8 ratios, 10 became abnormal during the study, an incidence of 45%. Fifteen of 28 (54%) patients with abnormal T4/T8 ratios had elevated circulating immune complexes (CIC), whereas all 16 patients with normal T4/T8 ratios had normal levels of CIC. Six patients have persistent lymphadenopathy.

Author List

Gill JC, Wheeler D, Menitove JE, Aster RH, Casper JT, Kirchner P, Montgomery RR

Author

Robert R. Montgomery MD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Antigens, Surface
Blood Cell Count
Blood Preservation
Blood Transfusion
Factor VIII
Fluorescent Antibody Technique
Freezing
Hemophilia A
Humans
Immune System Diseases
Immunoglobulin G
Lymphocytes
Male
Platelet Count