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Publications indexed to the term Allosteric Regulation

FacultyTitle
4Extrahelical Binding Site for a 1H-Imidazo[4,5-c]quinolin-4-amine A3 Adenosine Receptor Positive Allosteric Modulator on Helix 8 and Distal Portions of Transmembrane Domains 1 and 7. (Fisher CL, Pavan M, Salmaso V, Keyes RF, Wan TC, Pradhan B, Gao ZG, Smith BC, Jacobson KA, Auchampach JA) Mol Pharmacol 2024 Feb 15;105(3):213-223       2 Citations
1Structure-Activity Studies of 1H-Imidazo[4,5-c]quinolin-4-amine Derivatives as A3 Adenosine Receptor Positive Allosteric Modulators. (Fallot LB, Suresh RR, Fisher CL, Salmaso V, O'Connor RD, Kaufman N, Gao ZG, Auchampach JA, Jacobson KA) J Med Chem 2022 Nov 24;65(22):15238-15262       7 Citations
3Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor. (Kleist AB, Jenjak S, Sente A, Laskowski LJ, Szpakowska M, Calkins MM, Anderson EI, McNally LM, Heukers R, Bobkov V, Peterson FC, Thomas MA, Chevigné A, Smit MJ, McCorvy JD, Babu MM, Volkman BF) Science 2022 Jul 08;377(6602):222-228       14 Citations
1Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor. (Olson LJ, Misra SK, Ishihara M, Battaile KP, Grant OC, Sood A, Woods RJ, Kim JP, Tiemeyer M, Ren G, Sharp JS, Dahms NM) Commun Biol 2020 Sep 09;3(1):498       19 Citations
1PTPσ inhibitors promote hematopoietic stem cell regeneration. (Zhang Y, Roos M, Himburg H, Termini CM, Quarmyne M, Li M, Zhao L, Kan J, Fang T, Yan X, Pohl K, Diers E, Jin Gim H, Damoiseaux R, Whitelegge J, McBride W, Jung ME, Chute JP) Nat Commun 2019 Aug 14;10(1):3667       24 Citations
3The parmodulin NRD-21 is an allosteric inhibitor of PAR1 Gq signaling with improved anti-inflammatory activity and stability. (Gandhi DM, Rosas R Jr, Greve E, Kentala K, D-R Diby N, Snyder VA, Stephans A, Yeung THW, Subramaniam S, DiMilo E, Kurtenbach KE, Arnold LA, Weiler H, Dockendorff C) Bioorg Med Chem 2019 Sep 01;27(17):3788-3796       9 Citations
1An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABAA receptors. (Methuku KR, Li X, Cerne R, Gleason SD, Schkeryantz JM, Tiruveedhula VVNPB, Golani LK, Li G, Poe MM, Rahman MT, Cook JM, Fisher JL, Witkin JM) Pharmacol Biochem Behav 2018 Jul;170:9-13       14 Citations
1Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells. (Gandhi DM, Majewski MW, Rosas R Jr, Kentala K, Foster TJ, Greve E, Dockendorff C) Bioorg Med Chem 2018 May 15;26(9):2514-2529       13 Citations
1Allosteric regulation alters carrier domain translocation in pyruvate carboxylase. (Liu Y, Budelier MM, Stine K, St Maurice M) Nat Commun 2018 Apr 11;9(1):1384       12 Citations
1Calmodulin-induced Conformational Control and Allostery Underlying Neuronal Nitric Oxide Synthase Activation. (Hanson QM, Carley JR, Gilbreath TJ, Smith BC, Underbakke ES) J Mol Biol 2018 Mar 30;430(7):935-947       17 Citations
1Negative allosteric modulation of alpha 5-containing GABAA receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice. (Xu NZ, Ernst M, Treven M, Cerne R, Wakulchik M, Li X, Jones TM, Gleason SD, Morrow D, Schkeryantz JM, Rahman MT, Li G, Poe MM, Cook JM, Witkin JM) Psychopharmacology (Berl) 2018 Apr;235(4):1151-1161       19 Citations
1Analgesic effect of ADX71441, a positive allosteric modulator (PAM) of GABAB receptor in a rat model of bladder pain. (Kannampalli P, Poli SM, Boléa C, Sengupta JN) Neuropharmacology 2017 Nov;126:1-11       7 Citations
1Positive modulation of α5 GABAA receptors in preadolescence prevents reduced locomotor response to amphetamine in adult female but not male rats prenatally exposed to lipopolysaccharide. (Batinić B, Santrač A, Jančić I, Li G, Vidojević A, Marković B, Cook JM, Savić MM) Int J Dev Neurosci 2017 Oct;61:31-39       14 Citations
1Antinociceptive Effects of a Novel α2/α3-Subtype Selective GABAA Receptor Positive Allosteric Modulator. (Lewter LA, Fisher JL, Siemian JN, Methuku KR, Poe MM, Cook JM, Li JX) ACS Chem Neurosci 2017 Jun 21;8(6):1305-1312       34 Citations
2Characterization of GABAA receptor ligands with automated patch-clamp using human neurons derived from pluripotent stem cells. (Yuan NY, Poe MM, Witzigmann C, Cook JM, Stafford D, Arnold LA) J Pharmacol Toxicol Methods 2016;82:109-114       12 Citations
1Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. (Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH) EBioMedicine 2016 Jun;8:117-131       75 Citations
1Allosteric activation of ADAMTS13 by von Willebrand factor. (Muia J, Zhu J, Gupta G, Haberichter SL, Friedman KD, Feys HB, Deforche L, Vanhoorelbeke K, Westfield LA, Roth R, Tolia NH, Heuser JE, Sadler JE) Proc Natl Acad Sci U S A 2014 Dec 30;111(52):18584-9       110 Citations
1The N-terminal domain allosterically regulates cleavage and activation of the epithelial sodium channel. (Kota P, Buchner G, Chakraborty H, Dang YL, He H, Garcia GJM, Kubelka J, Gentzsch M, Stutts MJ, Dokholyan NV) J Biol Chem 2014 Aug 15;289(33):23029-23042       13 Citations
1Prior antipsychotic drug treatment prevents response to novel antipsychotic agent in the methylazoxymethanol acetate model of schizophrenia. (Gill KM, Cook JM, Poe MM, Grace AA) Schizophr Bull 2014 Mar;40(2):341-50       54 Citations
1The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor. (Gutiérrez-de-Terán H, Massink A, Rodríguez D, Liu W, Han GW, Joseph JS, Katritch I, Heitman LH, Xia L, Ijzerman AP, Cherezov V, Katritch V, Stevens RC) Structure 2013 Dec 03;21(12):2175-85       105 Citations
1Two-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-cap. (Corbi-Verge C, Marinelli F, Zafra-Ruano A, Ruiz-Sanz J, Luque I, Faraldo-Gómez JD) Proc Natl Acad Sci U S A 2013 Sep 03;110(36):E3372-80       32 Citations
2Allosteric activation of the Par-6 PDZ via a partial unfolding transition. (Whitney DS, Peterson FC, Kovrigin EL, Volkman BF) J Am Chem Soc 2013 Jun 26;135(25):9377-83       8 Citations
1On scaffold hopping: challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans. (Sidhu PS, Mosier PD, Zhou Q, Desai UR) Bioorg Med Chem Lett 2013 Jan 01;23(1):355-9       13 Citations
1Structural basis for allosteric regulation of GPCRs by sodium ions. (Liu W, Chun E, Thompson AA, Chubukov P, Xu F, Katritch V, Han GW, Roth CB, Heitman LH, IJzerman AP, Cherezov V, Stevens RC) Science 2012 Jul 13;337(6091):232-6       776 Citations
1Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition. (Abdel Aziz MH, Sidhu PS, Liang A, Kim JY, Mosier PD, Zhou Q, Farrell DH, Desai UR) J Med Chem 2012 Aug 09;55(15):6888-97       35 Citations
1Low NO concentration dependence of reductive nitrosylation reaction of hemoglobin. (Tejero J, Basu S, Helms C, Hogg N, King SB, Kim-Shapiro DB, Gladwin MT) J Biol Chem 2012 May 25;287(22):18262-74       36 Citations
1Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound. (Mueller R, Dawson ES, Meiler J, Rodriguez AL, Chauder BA, Bates BS, Felts AS, Lamb JP, Menon UN, Jadhav SB, Kane AS, Jones CK, Gregory KJ, Niswender CM, Conn PJ, Olsen CM, Winder DG, Emmitte KA, Lindsley CW) ChemMedChem 2012 Mar 05;7(3):406-14       39 Citations
2A conformational switch in the CRIB-PDZ module of Par-6. (Whitney DS, Peterson FC, Volkman BF) Structure 2011 Nov 09;19(11):1711-22       21 Citations
1An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing. (Yang J, Krishnamoorthy G, Saxena A, Zhang G, Shi J, Yang H, Delaloye K, Sept D, Cui J) Neuron 2010 Jun 24;66(6):871-83       91 Citations
1The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating. (Krishnamoorthy G, Shi J, Sept D, Cui J) J Gen Physiol 2005 Sep;126(3):227-41       29 Citations
1Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. (Huang Z, Shiva S, Kim-Shapiro DB, Patel RP, Ringwood LA, Irby CE, Huang KT, Ho C, Hogg N, Schechter AN, Gladwin MT) J Clin Invest 2005 Aug;115(8):2099-107       447 Citations
1Allosteric modulation of the presynaptic Ca2+ sensor for vesicle fusion. (Lou X, Scheuss V, Schneggenburger R) Nature 2005 May 26;435(7041):497-501       225 Citations
2The reaction between nitrite and deoxyhemoglobin. Reassessment of reaction kinetics and stoichiometry. (Huang KT, Keszler A, Patel N, Patel RP, Gladwin MT, Kim-Shapiro DB, Hogg N) J Biol Chem 2005 Sep 02;280(35):31126-31       233 Citations
2Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition. (Peterson FC, Penkert RR, Volkman BF, Prehoda KE) Mol Cell 2004 Mar 12;13(5):665-76       125 Citations
1Two-state allosteric behavior in a single-domain signaling protein. (Volkman BF, Lipson D, Wemmer DE, Kern D) Science 2001 Mar 23;291(5512):2429-33       549 Citations
2Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosation. (Patel RP, Hogg N, Spencer NY, Kalyanaraman B, Matalon S, Darley-Usmar VM) J Biol Chem 1999 May 28;274(22):15487-92       125 Citations
1PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. (Mizumura T, Auchampach JA, Linden J, Bruns RF, Gross GJ) Circ Res 1996 Sep;79(3):415-23    
1Block of cardiac ATP-sensitive K+ channels by external divalent cations is modulated by intracellular ATP. Evidence for allosteric regulation of the channel protein. (Kwok WM, Kass RS) J Gen Physiol 1993 Oct;102(4):693-712       17 Citations