Mesh term Werner Syndrome Helicase
Browse to parent terms:Exodeoxyribonucleases
Poly-ADP-Ribose Binding Proteins
RecQ Helicases
Description
A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.Search for this term in our Faculty Database
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