Mesh term Colorectal Neoplasms, Hereditary Nonpolyposis
Browse to parent terms:Colorectal Neoplasms
DNA Repair-Deficiency Disorders
Neoplastic Syndromes, Hereditary
Description
A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.Browse to child terms:
Lynch Syndrome II
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