Faculty Collaboration Database

PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science 1990 Mar 09;247(4947):1219-22

Date

03/09/1990

Pubmed ID

1690453

DOI

10.1126/science.1690453

Scopus ID

2-s2.0-0025274020 (requires institutional sign-in at Scopus site)   902 Citations

Abstract

An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracellular immunoglobulin (Ig)-like domains and was most similar to the cell adhesion molecule (CAM) subgroup of the Ig superfamily. This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events.

Author List

Newman PJ, Berndt MC, Gorski J, White GC 2nd, Lyman S, Paddock C, Muller WA

Author

Gilbert C. White MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Amino Acid Sequence
Antibodies, Monoclonal
Antigens, Differentiation, Myelomonocytic
Cell Adhesion Molecules
Cloning, Molecular
DNA
Endothelium, Vascular
Epitopes
Genes, Immunoglobulin
Humans
Immunoblotting
Immunoglobulins
Immunosorbent Techniques
Molecular Sequence Data
Platelet Endothelial Cell Adhesion Molecule-1
Platelet Membrane Glycoproteins
Protein Conformation
Repetitive Sequences, Nucleic Acid
Sequence Homology, Nucleic Acid
Signal Transduction