Medical College of Wisconsin
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CURRICULUM VITAE

Hartmut Weiler PhD
Associate Professor
Department of Physiology

OFFICE ADDRESS:
The Blood Research Institute
8727 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
1977 - Present Abitur Humanistisches Lessing Gymnasium, Frankfurt, Germany

MILITARY SERVICE:
1985 - Present Diplom Biologe (M.S); Technische Hochschule Darmstadt, Germany
1989 - 90 Postdoctoral Fellow; Biochemistry; Technische Hochschule Darmstadt, Germany
1989 - Present Dr.rer.nat. (Ph.D.) Biology/Biochemistry; Technische Hochschule Darmstadt
1990 - 94 Postdoctoral Fellow; Department of Biology; Massachusetts Institute of Technology
1994 - 96 Research Scientist; Department of Biology; Massachusetts Institute of Technology
Hauptmann der Reserve

FACULTY APPOINTMENTS:
1 - Present Gordon Conference on Thrombolysis, 2002: Interaction of Tissue factor and Thrombomodulin in Development
2 - Present Gordon Conference on Reproductive Tract Biology; 2002: Thrombophilia and placental development
3 - Present Gordon Conference on Hemostasis, 2002: The protein C anticoagulant pathway and pregnancy maintenance.
4 - Present ITCC 2002 Kyoto, Japan: Coagulation small talk: does the placenta hear the message?
5 - Present ATVB Conference 2003, Washington: Hyperfibrinogenemia and Thrombosis: A cause-effect analysis in transgenic mice.
6 - Present 23rd International Symposium on Intensive Care and Emergency Medicine, 2003, Brussels: Does activated protein C protect by anticoagulation?
7 - Present ISTH Conference, Birmingham 2003: The thrombomodulin-protein C pathway. State of the Art Lecture.
8 - Present The Margaux V Conference on Critical Illness, 2003: APC function in sepsis: interference with factor V function.
9 - Present Gordon Conference on Plasminogen Activation And Extracellular Proteolysis, 2004: Regulation of placental cell death by fibrin degradation products.
10 - Present Gordon Research Conference on Endothelial Cell Phenotypes in Health and Disease, 2004: Endothelium and Hemostasis.
11 - Present FASEB, Experimental Biology, 2004: Coagulation activation as a protective factor in sepsis.
12 - Present Gordon Research Conference on Hemostasis, 2004: Regulation of Hemostasis
13 - Present WHITH (Women's health issues in Thrombosis and Hemostasis) 2005, February 4-7, Budapest, Hungary: Thrombophilia and fetal loss; Plenary lecture.
14 - Present German Society of Thrombosis and Hemostasis (GTH) Annual meeting, February 23-26, 2005; Mannheim, Germany: Thrombomodulin.
15 - Present FASEB conference on extracellular proteolysis, June 2005, Vermont, USA: Thrombomodulin function in development.
16 - Present ISTH 2005, Sydney, Australia: A mouse model of thrombophilia-associated fetal loss.
17 - Present WHITH 2007, February 2-5, Vienna, Austria (Women's health issues in Thrombosis and Hemostasis): Thrombophilia and fetal loss; Plenary lecture.
18 - Present ASH 2006 Orlando: Plenary Session Presentation; Mechanism of APC therapy of sepsis.
19 - Present ASH 2007 Annual Scientific Meeting. Subcommittee on Thrombosis and Vascular Biology: Pathophysiology of microangiopathies.
20 - Present Belgian Society on Thrombosis and Hemostasis, Annual Meeting November 2007; Brussels, Belgium.
21 - Present St. Louis University School of Medicine, January 21, 2009, Blood Coagulation and Innate Immunity.
22 - Present Children's Research Hospital, Cincinnati, October 2008; Protein C system and Innate Immunity
23 - Present ASH 2008. Meet the expert sessions "developmental biology of the protein C system"
24 - Present UNC-Chapel Hill, Visiting professor seminar, March 13, 2009, Protein C Pathway in Sepsis
25 - Present Symposium, Center for Medical Countermeasures Against Radiological Terrorism, Medical College of Wisconsin, April 2009: Recombinant activated protein C as a potential treatment for radiation-combined injury
26 - Present Children's Hospital of Philadelphia, Hematology Seminar Series, April 7, 2009, Variants of activated protein C for sepsis treatment
27 - Present FASEB Summer Research Conferences, Protease in Hemostasis and Vascular Biology. Arizona, June 2009, Protein C pathway in inflammation.
28 - Present ISTH 2009; Boston. State-of-the-Art Lecture: Modulation of sepsis with activated protein C variants
29 - Present Distinguished Visiting Professor Lecture, University of Toronto, Heart and Stroke Richard Lewar Center; 2010. Biological Function of the Protein C pathway.
30 - Present 54th Annual Meeting of the GTH, 1st joint meeting GTH/NVTH, February 2010, Nuernberg, Germany. Plenary Lecture: "Molecular Models for the elucidation of coagulation disorders"
31 - Present FASEB Summer Research Conferences, Protease in Hemostasis and Vascular Biology, June 2011, Arizona. APC-mediated mechanisms of host defense.
32 - Present ISTH July 2011, Kyoto, Japan. Symposium Lecture: APC-mediated host response to infection.
1985 - 88 Graduation Fellowship, Verband der Chemischen Industrie, Germany
1988 - 90 Postdoctoral Fellowship, Verband der Chemischen Industrie, Germany
1990 - 92 Liebig Fellowship, Verband der Chemischen Industrie Stipendien Fonds, Germany
1997 - Present Associate Investigator; Blood Research Institute, BloodCenter of Wisconsin
1997 - Present Assistant Professor, Department of Physiology, Medical College of Wisconsin
2001 - Present Investigator; Blood Research Institute, BloodCenter of Wisconsin
2007 - Present Ziegler Family Chair for Research; BloodCenter of Wisconsin
2009 - Present Senior Investigator; Blood Research Institute, BloodCenter of Wisconsin
Awards
SELECT OTHER ACTIVITIES
Institutional Core Facilities
- 1997 • 1997- Director, Transgenic Core Facility, Blood Research Institute / MCW
Society memberships / activities
• American Society of Hematology (ASH)
• International Society of Thrombosis and Hemostasis (ISTH)
• American Heart Association
• Organizing Committee ATVB conference, Salt Lake City, 2002
• ASH Council on Thrombosis and Hemostasis, Member. 2003-2005
• Program Committee ATVB Annual Conference 2008
• WHITH 2007, Vienna, Austria: Fetal and maternal hemostasis, Chair.
• ISTH SSC on Animal and Cellular Models of thrombosis. Chair. 2006-2008
• Abstract reviewer ASH and ATVB annual meetings
• Coordinating Abstract Reviewer / Session Coordinator ASH 2011 Annual Meeting
• Chair-elect 2015 FASEB conferences on Proteases in Hemostasis and Vascular Biology.
Editorial appointments
• Section Editor; Thrombosis and Hemostasis, 2002-2006
• Associate Editor, Physiological Genomics 2001-
• Editorial Board, Blood 2005-2009
• Editorial Board Arteriosclerosis, Thrombosis, and Vascular Biology. 2005-
• Advisory Board Journal of Thrombosis and Hemostasis. 2011-
• Board of Consulting Editors, Journal of Clinical Investigations, 2010-2011
Grant review
• American Heart Association, Northland Affiliate, Grant Reviewer, 1997-2000
• American Heart Association, Grant Reviewer, 2002-2004
• Canadian Foundation for Innovation, Reproduction & Development Expert Committee; Montreal, Canada, Ad-Hoc Grant Reviewer; 2008
• Swiss National Science Foundation. Ad-Hoc Grant Reviewer. 2010; 2011
• NHLBI Hemostasis Study Section, Permanent Member: 2009 -- 2013
Other services
• NHLBI Special Emphasis Panel (SEP) Consultant: Inflammation and Thrombosis, 2004
Division of Veterinary Resources. Consultant. Embryo derivation / transfer. 2006-2007, • NIH
• Member, Search Committee for Director of Biological Resource Center, MCW
• Member, Appointments and Promotion Committee. Blood Research Institute, 2006-
• Faculty Mentorship Committee; Blood Research Institute; 2007-
• Chairman, Stem Cell Search Committee, Blood Research Institute. Jan 2006-2010
Training / teaching
• Graduation Committee Medical College of Wisconsin / Immunology
• Summer Student Program Blood Research Institute
• Graduate Students. Mentor/Supervisor
• MCW Graduate Student Program. Transgenic Technologies. Course Lecturer
• MCW M1 Medical Students. Blood Coagulation. Course Lecturer
• MCW Graduate Student Program. Immunology / Myeloid Differentiation. Course Lecturer
• MCW M2 Medical Students. Hematology-Blood Coagulation. Course Lecturer and Member
Curriculum Working Group
Research Grants and Contracts
Active
Title: Molecular & Cellular Mechanism in Transfusion Medicine, Core C
Source: NHLBI -- 5P01 HL44612-14
- 12/2010 Period: 12/2010 - 11/2015
Role: Core Director; (PI: Newman)
- 1 Effort: 1.2 calendar
Funds: $ 214, 352
Title: Molecular & Cellular Mechanism in Transfusion Medicine
- 2 Project 2: Protein C pathway function in Hematopoiesis
Source: NHLBI -- 5P01 HL44612-14
- 12/2010 Period: 12/2010 - 11/2011 (1 year provisional)
Role: Project Leader (PI: Newman)
- 2 Effort: 2.4 calendar
Funds: $ 200, 000
Title: Activated Protein C for Treatment of Radiation Combined Injury
Source: NIAID -- 5R33AI080557-04
- 03/2009 Period: 03/2009 - 08/2013
Role: PI
- 2 Effort: 1.8 calendar
Funds: $ 350, 501
Title: Mechanism of Activated Protein C Action in Sepsis Therapy
Source: NHLBI -- R01HL093388-015
- 07/2008 Period: 7/2008 - 6/2013
Role: PI
- 4 Effort: 4.2 calendar
Funds: $ 256, 254
Title: Imaging Vascular Phosphoethanolamine
Source: NHLBI -- R01HL102085-01
- 04/2010 Period: 4/2010 - 3/2015
Role: Co-Investigator (PI: Zhao)
- 1 Effort: 0.8 calendar
Funds: $ 19, 805
Completed
Title: Mouse model of massive thrombosis with juvenile onset
Source: American Heart Association Grant-In-Aid
- 2001 Period: 2001-03
Role: PI
Title: Thrombomodulin Function in Development and Cellular Physiology
Source: NHLBI -- R01 HL60655
- 04/1999 Period: 4/1999 - 3/2008
Role: PI
Title: Physiological Role of Fibrin Anti-Thrombin I Activities
Source: NHLBI -- R01 HL70627
- 01/2002 Period: 1/2002 - 12/2005
Role: Co-PI
Title: Genetic control of BB rat autoimmunity. Project 1: Iddm2
Source: NIAID -- P01 AI42380
- 07/2000 Period: 7/2000 - 8/2005
Role: Co-Investigator Project 1 (PI: Lernmark; Project Leader: Kwitek)
Title: Genetic control of BB rat autoimmunity. Project 2: Analysis of Ian5 function
Source: NIAID -- P01 AI42380
- 09/2005 Period: 9/2005 - 1/2010
Role: Project Leader (PI: Lernmark)
Title: Molecular & Cellular Mechanism in Transfusion Medicine, Core C
Source: NHLBI -- P01 HL44612
- 07/2005 Period: 7/2005 - 6/2010
Role: Director Core C (PI: Newman)
Title: Molecular & Cellular Mechanism in Transfusion Medicine.
- 4 Project 4: Pathophysiology of vaso-occlusion in sickle cell disease
Source: NHLBI -- P01 HL44612
- 07/2005 Period: 7/2005 - 6/2010
Role: Co-Investigator Project 4 (PI: Newman; Project Leader: Hillery)
Title: Mechanism of APC function in Sepsis: Interference with factor V function
Source: Eli Lilly Corporation / Response to call for Applications
- 01/2004 Period: 1/2004 - 12/2004
Role: PI
Selected Invited Lectures