Medical College of Wisconsin
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Hui-Zi Chen MD, PhD

Hui-Zi Chen MD, PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology - Medicine
Program: Hematology

Member of the Cancer Center


Publications (25)

  • Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance. (Krook MA, Reeser JW, Ernst G, Barker H, Wilberding M, Li G, Chen HZ, Roychowdhury S) Br J Cancer 2021 Mar;124(5):880-892 PMID: 33268819 PMCID: PMC7921129 12/04/2020       2 Citations
  • Characterization of Clonal Evolution in Microsatellite Unstable Metastatic Cancers through Multiregional Tumor Sequencing. (Bonneville R, Paruchuri A, Wing MR, Krook MA, Reeser JW, Chen HZ, Dao T, Samorodnitsky E, Smith AM, Yu L, Nowacki N, Chen W, Roychowdhury S) Mol Cancer Res 2021 Mar;19(3):465-474 PMID: 33229401 PMCID: PMC7939074 11/25/2020    
  • Research Autopsy Demonstrates Polyclonal Acquired Resistance in a Patient With Metastatic GI Stromal Tumor. (Paruchuri A, Chen HZ, Bonneville R, Reeser JW, Wing MR, Krook MA, Samorodnitsky E, Miya J, Dao T, Smith A, Freud AG, Allenby P, Roychowdhury S) JCO Precis Oncol 2020;4 PMID: 32923900 PMCID: PMC7446505 09/15/2020    
  • Efficacy of FGFR Inhibitors and Combination Therapies for Acquired Resistance in FGFR2-Fusion Cholangiocarcinoma. (Krook MA, Lenyo A, Wilberding M, Barker H, Dantuono M, Bailey KM, Chen HZ, Reeser JW, Wing MR, Miya J, Samorodnitsky E, Smith AM, Dao T, Martin DM, Ciombor KK, Hays J, Freud AG, Roychowdhury S) Mol Cancer Ther 2020 03;19(3):847-857 PMID: 31911531 PMCID: PMC7359896 01/09/2020       21 Citations
  • Detection of Microsatellite Instability Biomarkers via Next-Generation Sequencing. (Bonneville R, Krook MA, Chen HZ, Smith A, Samorodnitsky E, Wing MR, Reeser JW, Roychowdhury S) Methods Mol Biol 2020;2055:119-132 PMID: 31502149 PMCID: PMC7010320 09/11/2019       3 Citations
  • Tumor heterogeneity and acquired drug resistance in FGFR2-fusion-positive cholangiocarcinoma through rapid research autopsy. (Krook MA, Bonneville R, Chen HZ, Reeser JW, Wing MR, Martin DM, Smith AM, Dao T, Samorodnitsky E, Paruchuri A, Miya J, Baker KR, Yu L, Timmers C, Dittmar K, Freud AG, Allenby P, Roychowdhury S) Cold Spring Harb Mol Case Stud 2019 08;5(4) PMID: 31371345 PMCID: PMC6672025 08/03/2019       15 Citations
  • Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer. (Krook MA, Barker H, Chen HZ, Reeser JW, Wing MR, Martin D, Smith AM, Dao T, Bonneville R, Samorodnitsky E, Miya J, Freud AG, Monk JP, Clinton SK, Roychowdhury S) Prostate Cancer Prostatic Dis 2019 12;22(4):624-632 PMID: 31043681 PMCID: PMC6824932 05/03/2019       3 Citations
  • Genomic characterization of metastatic ultra-hypermutated interdigitating dendritic cell sarcoma through rapid research autopsy. (Chen HZ, Bonneville R, Yu L, Wing MR, Reeser JW, Krook MA, Miya J, Samorodnitsky E, Smith A, Martin D, Dao T, Guo Q, Liebner D, Freud AG, Allenby P, Roychowdhury S) Oncotarget 2019 Jan 08;10(3):277-288 PMID: 30719225 PMCID: PMC6349455 02/06/2019    
  • Rapid Research Autopsy: Piecing the Puzzle of Tumor Heterogeneity. (Krook MA, Chen HZ, Bonneville R, Allenby P, Roychowdhury S) Trends Cancer 2019 01;5(1):1-5 PMID: 30616752 01/09/2019       5 Citations
  • Metastatic Calcinosis Cutis Associated With a Selective FGFR Inhibitor. (Carr DR, Pootrakul L, Chen HZ, Chung CG) JAMA Dermatol 2019 Jan 01;155(1):122-123 PMID: 30476938 11/27/2018       7 Citations
  • Implementing precision cancer medicine in the genomic era. (Chen HZ, Bonneville R, Roychowdhury S) Semin Cancer Biol 2019 04;55:16-27 PMID: 29857039 06/02/2018       7 Citations
  • Tumor spread through air space (STAS) is an important predictor of clinical outcome in stage IA lung adenocarcinoma. (Chen HZ, Bertino EM, He K) J Thorac Dis 2017 Aug;9(8):2283-2285 PMID: 28932525 PMCID: PMC5594112 09/22/2017    
  • Landscape of Microsatellite Instability Across 39 Cancer Types. (Bonneville R, Krook MA, Kautto EA, Miya J, Wing MR, Chen HZ, Reeser JW, Yu L, Roychowdhury S) JCO Precis Oncol 2017;2017 PMID: 29850653 PMCID: PMC5972025 01/01/2017    
  • E2f8 mediates tumor suppression in postnatal liver development. (Kent LN, Rakijas JB, Pandit SK, Westendorp B, Chen HZ, Huntington JT, Tang X, Bae S, Srivastava A, Senapati S, Koivisto C, Martin CK, Cuitino MC, Perez M, Clouse JM, Chokshi V, Shinde N, Kladney R, Sun D, Perez-Castro A, Matondo RB, Nantasanti S, Mokry M, Huang K, Machiraju R, Fernandez S, Rosol TJ, Coppola V, Pohar KS, Pipas JM, Schmidt CR, de Bruin A, Leone G) J Clin Invest 2016 08 01;126(8):2955-69 PMID: 27454291 PMCID: PMC4966321 SCOPUS ID: 2-s2.0-84987814871 07/28/2016       33 Citations
  • Canonical and atypical E2Fs regulate the mammalian endocycle. (Chen HZ, Ouseph MM, Li J, Pécot T, Chokshi V, Kent L, Bae S, Byrne M, Duran C, Comstock G, Trikha P, Mair M, Senapati S, Martin CK, Gandhi S, Wilson N, Liu B, Huang YW, Thompson JC, Raman S, Singh S, Leone M, Machiraju R, Huang K, Mo X, Fernandez S, Kalaszczynska I, Wolgemuth DJ, Sicinski P, Huang T, Jin V, Leone G) Nat Cell Biol 2012 Nov;14(11):1192-202 PMID: 23064266 PMCID: PMC3616487 SCOPUS ID: 2-s2.0-84869079592 10/16/2012       87 Citations
  • Atypical E2F repressors and activators coordinate placental development. (Ouseph MM, Li J, Chen HZ, Pécot T, Wenzel P, Thompson JC, Comstock G, Chokshi V, Byrne M, Forde B, Chong JL, Huang K, Machiraju R, de Bruin A, Leone G) Dev Cell 2012 Apr 17;22(4):849-62 PMID: 22516201 PMCID: PMC3483796 SCOPUS ID: 2-s2.0-84859872654 04/21/2012       59 Citations
  • Cell proliferation in the absence of E2F1-3. (Wenzel PL, Chong JL, Sáenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, Robinson ML, Leone G) Dev Biol 2011 Mar 01;351(1):35-45 PMID: 21185283 PMCID: PMC3868453 12/28/2010    
  • Allele-specific tumor spectrum in pten knockin mice. (Wang H, Karikomi M, Naidu S, Rajmohan R, Caserta E, Chen HZ, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Weinstein M, Wang D, Sadee W, La Perle K, Stromberg P, Rosol TJ, Eng C, Ostrowski MC, Leone G) Proc Natl Acad Sci U S A 2010 Mar 16;107(11):5142-7 PMID: 20194734 PMCID: PMC2841921 SCOPUS ID: 2-s2.0-77950419842 03/03/2010       43 Citations
  • E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. (Chong JL, Wenzel PL, Sáenz-Robles MT, Nair V, Ferrey A, Hagan JP, Gomez YM, Sharma N, Chen HZ, Ouseph M, Wang SH, Trikha P, Culp B, Mezache L, Winton DJ, Sansom OJ, Chen D, Bremner R, Cantalupo PG, Robinson ML, Pipas JM, Leone G) Nature 2009 Dec 17;462(7275):930-4 PMID: 20016602 PMCID: PMC2806193 SCOPUS ID: 2-s2.0-72449177341 12/18/2009       167 Citations
  • E2F3 is a mediator of DNA damage-induced apoptosis. (Martinez LA, Goluszko E, Chen HZ, Leone G, Post S, Lozano G, Chen Z, Chauchereau A) Mol Cell Biol 2010 Jan;30(2):524-36 PMID: 19917728 PMCID: PMC2798461 SCOPUS ID: 2-s2.0-73549095168 11/18/2009       51 Citations
  • Emerging roles of E2Fs in cancer: an exit from cell cycle control. (Chen HZ, Tsai SY, Leone G) Nat Rev Cancer 2009 Nov;9(11):785-97 PMID: 19851314 PMCID: PMC3616489 SCOPUS ID: 2-s2.0-70350518233 10/24/2009       597 Citations
  • Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement. (Wang D, Chen H, Momary KM, Cavallari LH, Johnson JA, Sadée W) Blood 2008 Aug 15;112(4):1013-21 PMID: 18523153 PMCID: PMC2515137 06/05/2008       160 Citations
  • Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. (Li J, Ran C, Li E, Gordon F, Comstock G, Siddiqui H, Cleghorn W, Chen HZ, Kornacker K, Liu CG, Pandit SK, Khanizadeh M, Weinstein M, Leone G, de Bruin A) Dev Cell 2008 Jan;14(1):62-75 PMID: 18194653 PMCID: PMC2253677 SCOPUS ID: 2-s2.0-37749005850 01/16/2008       142 Citations
  • Activation of the Nrf2/antioxidant response pathway increases IL-8 expression. (Zhang X, Chen X, Song H, Chen HZ, Rovin BH) Eur J Immunol 2005 Nov;35(11):3258-67 PMID: 16220540 10/13/2005       71 Citations
  • Unexpected sensitivity of synthetic Renilla luciferase control vectors to treatment with a cyclopentenone prostaglandin. (Zhang X, Chen HZ, Rovin BH) Biotechniques 2003 Dec;35(6):1144-6, 1148 PMID: 14682047 12/20/2003       4 Citations
  • Last update: 03/31/2021