Medical College of Wisconsin
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John W. Lough PhD


Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cardiovascular Center

Publications (71)

  • Impact of MYH6 variants in hypoplastic left heart syndrome. (Tomita-Mitchell A, Stamm KD, Mahnke DK, Kim MS, Hidestrand PM, Liang HL, Goetsch MA, Hidestrand M, Simpson P, Pelech AN, Tweddell JS, Benson DW, Lough JW, Mitchell ME) Physiol Genomics 2016 12 01;48(12):912-921 PMID: 27789736 PMCID: PMC5206387 SCOPUS ID: 2-s2.0-85006309110 10/30/2016       19 Citations
  • Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis. (Kim MS, Horst A, Blinka S, Stamm K, Mahnke D, Schuman J, Gundry R, Tomita-Mitchell A, Lough J) PLoS One 2015;10(2):e0118670 PMID: 25706534 PMCID: PMC4338295 SCOPUS ID: 2-s2.0-84923332744 02/24/2015       11 Citations
  • Allele compensation in tip60+/- mice rescues white adipose tissue function in vivo. (Gao Y, Hamers N, Rakhshandehroo M, Berger R, Lough J, Kalkhoven E) PLoS One 2014;9(5):e98343 PMID: 24870614 PMCID: PMC4037199 SCOPUS ID: 2-s2.0-84901641867 05/30/2014       3 Citations
  • Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60. (Xiao Y, Nagai Y, Deng G, Ohtani T, Zhu Z, Zhou Z, Zhang H, Ji MQ, Lough JW, Samanta A, Hancock WW, Greene MI) Cell Rep 2014 Jun 12;7(5):1471-1480 PMID: 24835996 PMCID: PMC4064594 SCOPUS ID: 2-s2.0-84902332541 05/20/2014       46 Citations
  • Comparison of cardiomyogenic potential among human ESC and iPSC lines. (Sepac A, Si-Tayeb K, Sedlic F, Barrett S, Canfield S, Duncan SA, Bosnjak ZJ, Lough JW) Cell Transplant 2012;21(11):2523-30 PMID: 22863088 PMCID: PMC3522765 SCOPUS ID: 2-s2.0-84871578911 08/07/2012       17 Citations
  • Stress-induced cell-cycle activation in Tip60 haploinsufficient adult cardiomyocytes. (Fisher JB, Kim MS, Blinka S, Ge ZD, Wan T, Duris C, Christian D, Twaroski K, North P, Auchampach J, Lough J) PLoS One 2012;7(2):e31569 PMID: 22348108 PMCID: PMC3279378 SCOPUS ID: 2-s2.0-84863165939 02/22/2012       11 Citations
  • Induction of cardiomyogenesis in human embryonic stem cells by human embryonic stem cell-derived definitive endoderm. (Van Orman JR, Si-Tayeb K, Duncan SA, Lough J) Stem Cells Dev 2012 Apr 10;21(6):987-94 PMID: 21627569 PMCID: PMC3315759 SCOPUS ID: 2-s2.0-84859414013 06/02/2011       3 Citations
  • Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model. (Gehrking KM, Andresen JM, Duvick L, Lough J, Zoghbi HY, Orr HT) Hum Mol Genet 2011 Jun 01;20(11):2204-12 PMID: 21427130 PMCID: PMC3090197 SCOPUS ID: 2-s2.0-79956017557 03/24/2011       39 Citations
  • Isoflurane preconditioning elicits competent endogenous mechanisms of protection from oxidative stress in cardiomyocytes derived from human embryonic stem cells. (Sepac A, Sedlic F, Si-Tayeb K, Lough J, Duncan SA, Bienengraeber M, Park F, Kim J, Bosnjak ZJ) Anesthesiology 2010 Oct;113(4):906-16 PMID: 20823757 PMCID: PMC2945423 SCOPUS ID: 2-s2.0-77957904668 09/09/2010       37 Citations
  • Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors. (Si-Tayeb K, Noto FK, Sepac A, Sedlic F, Bosnjak ZJ, Lough JW, Duncan SA) BMC Dev Biol 2010 Aug 03;10:81 PMID: 20682060 PMCID: PMC2923111 SCOPUS ID: 2-s2.0-77955118962 08/05/2010       147 Citations
  • Altered cardiac function and ventricular septal defect in avian embryos exposed to low-dose trichloroethylene. (Rufer ES, Hacker TA, Flentke GR, Drake VJ, Brody MJ, Lough J, Smith SM) Toxicol Sci 2010 Feb;113(2):444-52 PMID: 19910388 PMCID: PMC2807037 SCOPUS ID: 2-s2.0-75249103978 11/17/2009       30 Citations
  • Making stem cells infarct avid. (Zhao M, Barron MR, Li Z, Koprowski S, Hall CL, Lough J) Cell Transplant 2010;19(2):245-50 PMID: 19878624 SCOPUS ID: 2-s2.0-77951444693 11/03/2009       7 Citations
  • Homozygous disruption of the Tip60 gene causes early embryonic lethality. (Hu Y, Fisher JB, Koprowski S, McAllister D, Kim MS, Lough J) Dev Dyn 2009 Nov;238(11):2912-21 PMID: 19842187 PMCID: PMC2801416 SCOPUS ID: 2-s2.0-70350743144 10/21/2009       67 Citations
  • Myocardial interstitial fluid inhibits proliferation and cardiomyocyte differentiation in pluripotent embryonic stem cells. (Van Orman JR, Weihrauch D, Warltier DC, Lough J) Am J Physiol Heart Circ Physiol 2009 Oct;297(4):H1369-76 PMID: 19633209 PMCID: PMC2770771 SCOPUS ID: 2-s2.0-70349610458 07/28/2009       1 Citation
  • Rapid single-step separation of pluripotent mouse embryonic stem cells from mouse feeder fibroblasts. (Li Z, Barron MR, Lough J, Zhao M) Stem Cells Dev 2008 Apr;17(2):383-7 PMID: 18447652 SCOPUS ID: 2-s2.0-43049149421 05/02/2008       7 Citations
  • Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. (Gorrini C, Squatrito M, Luise C, Syed N, Perna D, Wark L, Martinato F, Sardella D, Verrecchia A, Bennett S, Confalonieri S, Cesaroni M, Marchesi F, Gasco M, Scanziani E, Capra M, Mai S, Nuciforo P, Crook T, Lough J, Amati B) Nature 2007 Aug 30;448(7157):1063-7 PMID: 17728759 SCOPUS ID: 2-s2.0-34548312368 08/31/2007       223 Citations
  • Improved cardiac function in infarcted mice after treatment with pluripotent embryonic stem cells. (Nelson TJ, Ge ZD, Van Orman J, Barron M, Rudy-Reil D, Hacker TA, Misra R, Duncan SA, Auchampach JA, Lough JW) Anat Rec A Discov Mol Cell Evol Biol 2006 Nov;288(11):1216-24 PMID: 17004246 PMCID: PMC2566533 SCOPUS ID: 2-s2.0-33750532546 09/28/2006       50 Citations
  • Cardiogenic effects of trichloroethylene and trichloroacetic acid following exposure during heart specification of avian development. (Drake VJ, Koprowski SL, Hu N, Smith SM, Lough J) Toxicol Sci 2006 Nov;94(1):153-62 PMID: 16917067 SCOPUS ID: 2-s2.0-33749626274 08/19/2006       32 Citations
  • Trichloroethylene exposure during cardiac valvuloseptal morphogenesis alters cushion formation and cardiac hemodynamics in the avian embryo. (Drake VJ, Koprowski SL, Lough J, Hu N, Smith SM) Environ Health Perspect 2006 Jun;114(6):842-7 PMID: 16759982 PMCID: PMC1480523 SCOPUS ID: 2-s2.0-33745041711 06/09/2006       35 Citations
  • Co-activation of atrial natriuretic factor promoter by Tip60 and serum response factor. (Kim MS, Merlo X, Wilson C, Lough J) J Biol Chem 2006 Jun 02;281(22):15082-9 PMID: 16597624 SCOPUS ID: 2-s2.0-33744956273 04/07/2006       13 Citations
  • Gastrulating chick embryo as a model for evaluating teratogenicity: a comparison of three approaches. (Drake VJ, Koprowski SL, Lough JW, Smith SM) Birth Defects Res A Clin Mol Teratol 2006 Jan;76(1):66-71 PMID: 16333841 SCOPUS ID: 2-s2.0-32444440237 12/08/2005       28 Citations
  • Complete and rapid switch from light microscopy to virtual microscopy for teaching medical histology. (Krippendorf BB, Lough J) Anat Rec B New Anat 2005 Jul;285(1):19-25 PMID: 16032757 SCOPUS ID: 2-s2.0-23344441721 07/21/2005       99 Citations
  • Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes. (Barron MR, Belaguli NS, Zhang SX, Trinh M, Iyer D, Merlo X, Lough JW, Parmacek MS, Bruneau BG, Schwartz RJ) J Biol Chem 2005 Mar 25;280(12):11816-28 PMID: 15591049 SCOPUS ID: 2-s2.0-20144374695 12/14/2004       36 Citations
  • Avian precardiac endoderm/mesoderm induces cardiac myocyte differentiation in murine embryonic stem cells. (Rudy-Reil D, Lough J) Circ Res 2004 Jun 25;94(12):e107-16 PMID: 15192018 SCOPUS ID: 2-s2.0-14944382560 06/12/2004       42 Citations
  • Microarray analysis of retinoid-dependent gene activity during rat embryogenesis: increased collagen fibril production in a model of retinoid insufficiency. (Flentke GR, Baker MW, Docterman KE, Power S, Lough J, Smith SM) Dev Dyn 2004 Apr;229(4):886-98 PMID: 15042712 SCOPUS ID: 2-s2.0-1842457037 03/26/2004       14 Citations
  • What's hot in anatomy: hematopoietic progenitor cells and myocardial repair. (Lough JW) Anat Rec B New Anat 2003 Sep;274(1):147 PMID: 12964204 SCOPUS ID: 2-s2.0-0141927140 09/10/2003    
  • Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice. (Wendler CC, Schmoldt A, Flentke GR, Case LC, Quadro L, Blaner WS, Lough J, Smith SM) Circ Res 2003 May 02;92(8):920-8 PMID: 12663486 PMCID: PMC3752713 SCOPUS ID: 2-s2.0-0038304602 03/29/2003       27 Citations
  • Inhibition of the cardiac alpha-actin gene in embryonic cardiac myocytes by dominant-negative serum response factor. (Zhu X, McAllister D, Lough J) Anat Rec A Discov Mol Cell Evol Biol 2003 Apr;271(2):315-21 PMID: 12629674 SCOPUS ID: 2-s2.0-0141994725 03/12/2003       1 Citation
  • Characterization and expression of the mouse tat interactive protein 60 kD (TIP60) gene. (McAllister D, Merlo X, Lough J) Gene 2002 May 01;289(1-2):169-76 PMID: 12036595 SCOPUS ID: 2-s2.0-0036572275 05/31/2002       25 Citations
  • Transient expression of TIP60 protein during early chick heart development. (Lough JW) Dev Dyn 2002 Mar;223(3):419-25 PMID: 11891991 SCOPUS ID: 2-s2.0-0036197856 03/14/2002       17 Citations
  • FGF-2-induced imbalance in early embryonic heart cell proliferation: a potential cause of late cardiovascular anomalies. (Franciosi JP, Bolender DL, Lough J, Kolesari GL) Teratology 2000 Oct;62(4):189-94 PMID: 10992260 SCOPUS ID: 2-s2.0-0033808998 09/19/2000       11 Citations
  • Differential expression of cSmad1 and cSmad5 in the primitive streak during chick embryo gastrulation. (Gont L, Lough J) Anat Rec 2000 09 01;260(1):102-5 PMID: 10967541 SCOPUS ID: 2-s2.0-0034282940 09/01/2000       3 Citations
  • Requirement for BMP and FGF signaling during cardiogenic induction in non-precardiac mesoderm is specific, transient, and cooperative. (Barron M, Gao M, Lough J) Dev Dyn 2000 Jun;218(2):383-93 PMID: 10842364 SCOPUS ID: 2-s2.0-0034093126 06/08/2000       132 Citations
  • Endoderm and heart development. (Lough J, Sugi Y) Dev Dyn 2000 Apr;217(4):327-42 PMID: 10767078 SCOPUS ID: 2-s2.0-0034111134 04/15/2000       178 Citations
  • Evidence that FGF receptor signaling is necessary for endoderm-regulated development of precardiac mesoderm. (Zhu X, Sasse J, Lough J) Mech Ageing Dev 1999 Apr 01;108(1):77-85 PMID: 10366041 SCOPUS ID: 2-s2.0-0033119062 06/12/1999       17 Citations
  • Expression of retinol binding protein and transthyretin during early embryogenesis. (Barron M, McAllister D, Smith SM, Lough J) Dev Dyn 1998 Jul;212(3):413-22 PMID: 9671945 SCOPUS ID: 2-s2.0-0031750873 07/22/1998       20 Citations
  • Teratogenic effects of implanting fibroblast growth factor-2-soaked beads in the cardiac region of the stage 24 chick embryo. (Watkins BP, Bolender DL, Lough J, Kolesari GL) Teratology 1998 Mar;57(3):140-5 PMID: 9587967 SCOPUS ID: 2-s2.0-0031946950 05/20/1998       1 Citation
  • Evidence that fibroblast growth factors 1 and 4 participate in regulation of cardiogenesis. (Zhu X, Sasse J, McAllister D, Lough J) Dev Dyn 1996 Dec;207(4):429-38 PMID: 8950517 SCOPUS ID: 2-s2.0-0029860034 12/01/1996       57 Citations
  • Insulin-like growth factor-II/mannose-6-phosphate receptor expression during early heart development. (McCormick KM, Dahms NM, Lough J) Dev Dyn 1996 Oct;207(2):195-203 PMID: 8906422 SCOPUS ID: 2-s2.0-0029853236 10/01/1996       8 Citations
  • Combined BMP-2 and FGF-4, but neither factor alone, induces cardiogenesis in non-precardiac embryonic mesoderm. (Lough J, Barron M, Brogley M, Sugi Y, Bolender DL, Zhu X) Dev Biol 1996 Aug 25;178(1):198-202 PMID: 8812122 SCOPUS ID: 2-s2.0-0030601359 08/25/1996       188 Citations
  • Avian serum response factor expression restricted primarily to muscle cell lineages is required for alpha-actin gene transcription. (Croissant JD, Kim JH, Eichele G, Goering L, Lough J, Prywes R, Schwartz RJ) Dev Biol 1996 Jul 10;177(1):250-64 PMID: 8660892 SCOPUS ID: 2-s2.0-0030578427 07/10/1996       150 Citations
  • Expression of alternatively spliced and canonical basic fibroblast growth factor mRNAs in the early embryo and developing heart. (Zhu X, Lough J) Dev Dyn 1996 Jun;206(2):139-45 PMID: 8725281 SCOPUS ID: 2-s2.0-0029999250 06/01/1996       12 Citations
  • Activin-A and FGF-2 mimic the inductive effects of anterior endoderm on terminal cardiac myogenesis in vitro. (Sugi Y, Lough J) Dev Biol 1995 Apr;168(2):567-74 PMID: 7729588 SCOPUS ID: 2-s2.0-0028905441 04/01/1995       113 Citations
  • Developmental expression of fibroblast growth factor receptor-1 (cek-1; flg) during heart development. (Sugi Y, Sasse J, Barron M, Lough J) Dev Dyn 1995 Feb;202(2):115-25 PMID: 7734730 SCOPUS ID: 2-s2.0-0028796767 02/01/1995       48 Citations
  • Anterior endoderm is a specific effector of terminal cardiac myocyte differentiation of cells from the embryonic heart forming region. (Sugi Y, Lough J) Dev Dyn 1994 Jun;200(2):155-62 PMID: 7919501 SCOPUS ID: 2-s2.0-0028292426 06/01/1994       122 Citations
  • Inhibition of precardiac mesoderm cell proliferation by antisense oligodeoxynucleotide complementary to fibroblast growth factor-2 (FGF-2). (Sugi Y, Sasse J, Lough J) Dev Biol 1993 May;157(1):28-37 PMID: 8482417 SCOPUS ID: 2-s2.0-0027238422 05/01/1993       84 Citations
  • Onset of expression and regional deposition of alpha-smooth and sarcomeric actin during avian heart development. (Sugi Y, Lough J) Dev Dyn 1992 Feb;193(2):116-24 PMID: 1581600 SCOPUS ID: 2-s2.0-0026521724 02/01/1992       56 Citations
  • Localization of bFGF-like proteins as punctate inclusions in the preseptation myocardium of the chicken embryo. (Parlow MH, Bolender DL, Kokan-Moore NP, Lough J) Dev Biol 1991 Jul;146(1):139-47 PMID: 1647988 SCOPUS ID: 2-s2.0-0025812005 07/01/1991       67 Citations
  • Secretion of inhibin beta A by endoderm cultured from early embryonic chicken. (Kokan-Moore NP, Bolender DL, Lough J) Dev Biol 1991 Jul;146(1):242-5 PMID: 2060706 SCOPUS ID: 2-s2.0-0025762279 07/01/1991       37 Citations
  • Normal transitions in synthesis of replacement histones H2A.Z and H3.3 during differentiation of dystrophic myotube cells. A brief note. (Wunsch AM, Reinhardt K, Lough J) Mech Ageing Dev 1991 Jun 28;59(3):299-305 PMID: 1921519 SCOPUS ID: 2-s2.0-0025912482 06/28/1991       8 Citations
  • Affinity isolation of active murine erythroleukemia cell chromatin: uniform distribution of ubiquitinated histone H2A between active and inactive fractions. (Dawson BA, Herman T, Haas AL, Lough J) J Cell Biochem 1991 Jun;46(2):166-73 PMID: 1655820 SCOPUS ID: 2-s2.0-0025904349 06/01/1991       21 Citations
  • Arabinosylcytosine-induced accumulation of DNA nicks in myotube nuclei detected by in situ nick translation. (Masuck TM, Taylor AR, Lough J) J Cell Physiol 1990 Jul;144(1):12-7 PMID: 2365739 SCOPUS ID: 2-s2.0-0025316415 07/01/1990       12 Citations
  • Enrichment of ubiquitinated histone H2A in a low salt extract of micrococcal nuclease-digested myotube nuclei. (Parlow MH, Haas AL, Lough J) J Biol Chem 1990 May 05;265(13):7507-12 PMID: 2159002 SCOPUS ID: 2-s2.0-0025344438 05/05/1990       16 Citations
  • Histone variant patterns during vertebrate embryogenesis and limb development. (Wunsch AM, Lough J) Cell Differ Dev 1990 Apr;30(1):19-25 PMID: 2350733 SCOPUS ID: 2-s2.0-0025283787 04/01/1990       8 Citations
  • Histones synthesized at different stages of myogenesis are differentially degraded in myotube cells. (Wunsch AM, Lough J) J Cell Physiol 1989 Oct;141(1):97-102 PMID: 2777905 SCOPUS ID: 2-s2.0-0024440726 10/01/1989       8 Citations
  • Affinity isolation of transcriptionally active murine erythroleukemia cell DNA using a cleavable biotinylated nucleotide analog. (Dawson BA, Herman T, Lough J) J Biol Chem 1989 Aug 05;264(22):12830-7 PMID: 2753891 SCOPUS ID: 2-s2.0-0024389329 08/05/1989       9 Citations
  • Immunocytochemical localization of transient DNA strand breaks in differentiating myotubes using in situ nick-translation. (Dawson BA, Lough J) Dev Biol 1988 Jun;127(2):362-7 PMID: 3378668 SCOPUS ID: 2-s2.0-0023904340 06/01/1988       36 Citations
  • Synthesis and ubiquitination of histones during myogenesis. (Wunsch AM, Haas AL, Lough J) Dev Biol 1987 Jan;119(1):85-93 PMID: 3025034 SCOPUS ID: 2-s2.0-0023103138 01/01/1987       26 Citations
  • Modulation of histone H3 variant synthesis during the myoblast-myotube transition of chicken myogenesis. (Wunsch AM, Lough J) Dev Biol 1987 Jan;119(1):94-9 PMID: 3792638 SCOPUS ID: 2-s2.0-0023118959 01/01/1987       26 Citations
  • Affinity isolation of transcriptionally active DNA. (Roseman B, Lough J, Houkom E, Herman T) Biochem Biophys Res Commun 1986 May 29;137(1):474-9 PMID: 3718516 SCOPUS ID: 2-s2.0-0022506841 05/29/1986       7 Citations
  • Interferon-mediated inhibition of differentiation in a murine myoblast cell line. (Multhauf C, Lough J) J Cell Physiol 1986 Feb;126(2):211-5 PMID: 3944205 SCOPUS ID: 2-s2.0-0022631655 02/01/1986       15 Citations
  • Differential sensitivity of chicken MM-creatine kinase to trypsin and proteinase-K. (Lough J, Wrenn DS, Miziorko HM, Auer HE) Int J Biochem 1985;17(3):309-18 PMID: 3891449 SCOPUS ID: 2-s2.0-0021840560 01/01/1985       11 Citations
  • Spermine-induced phosphorylation of myotube histones by endogenous nuclear protein kinases. (Lough J) Exp Cell Res 1984 Jan;150(1):23-8 PMID: 6692846 SCOPUS ID: 2-s2.0-0021353433 01/01/1984       6 Citations
  • Declining histone phosphorylation during myogenesis revealed by in vivo and in vitro labeling. (Lough J) Exp Cell Res 1983 Oct 15;148(2):437-47 PMID: 6628565 SCOPUS ID: 2-s2.0-0021016772 10/15/1983       5 Citations
  • DNA synthesis and accumulation of acetylated histone in butyrate-treated myogenic cultures. (Lough J) Cell Biol Int Rep 1981 Jul;5(7):691-8 PMID: 6168401 SCOPUS ID: 2-s2.0-0019468931 07/01/1981       2 Citations
  • Change in a nuclear phosphoprotein during in vitro myogenesis. (Lough J, Ingram VM) Exp Cell Res 1978 Jul;114(2):349-56 PMID: 679987 SCOPUS ID: 2-s2.0-0018101559 07/01/1978       10 Citations
  • Differentiation of creatine phosphokinase during myogenesis: quantitative fractionation of isozymes. (Lough J, Bischoff R) Dev Biol 1977 Jun;57(2):330-44 PMID: 559598 SCOPUS ID: 2-s2.0-0017713095 06/01/1977       54 Citations
  • Differential sensitivity to 5-bromodeoxyuridine during the S phase of synchronized myogenic cells. (Lough J, Bischoff R) Dev Biol 1976 Jun;50(2):457-75 PMID: 1278597 SCOPUS ID: 2-s2.0-0017143247 06/01/1976       29 Citations
  • The effects of chloroquine on chick skeletal muscle in vitro. (Bossen EH, Lough JW Jr, Hansen JL) Toxicol Appl Pharmacol 1973 Feb;24(2):197-205 PMID: 4696304 02/01/1973       3 Citations
  • Calcium accumulation by isolated sarcoplasmic reticulum of skeletal muscle during development in tissue culture. (Lough JW, Entman ML, Bossen EH, Hansen JL) J Cell Physiol 1972 Dec;80(3):431-6 PMID: 4265139 12/01/1972       9 Citations
  • Physiology of the large milkweed bug after laser irradiation. (Feir D, Lough JW Jr) Comp Biochem Physiol 1969 Feb;28(2):759-64 PMID: 5778263 02/01/1969       2 Citations
  • Last update: 10/31/2016
    jenkins-FCD Prod-480 9a4deaf152b0b06dd18151814fff2e18f6c05280