Medical College of Wisconsin
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Linda J. Olson PhD

Linda J. Olson PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Cancer Center

View Curriculum Vitae

Research Experience

  • Cells, Cultured
  • Crystallography, X-Ray
  • Protein Structure, Tertiary
  • Recombinant Proteins
  • Sf9 Cells
  • Surface Plasmon Resonance

    • Publications (28)

  • Tissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate. (Miller JJ, Bohnsack RN, Olson LJ, Ishihara M, Aoki K, Tiemeyer M, Dahms NM) Sci Rep 2021 Apr 15;11(1):8213 PMID: 33859256 PMCID: PMC8050316 SCOPUS ID: 2-s2.0-85104287178 04/17/2021       2 Citations
  • Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor. (Olson LJ, Misra SK, Ishihara M, Battaile KP, Grant OC, Sood A, Woods RJ, Kim JP, Tiemeyer M, Ren G, Sharp JS, Dahms NM) Commun Biol 2020 Sep 09;3(1):498 PMID: 32908216 PMCID: PMC7481795 SCOPUS ID: 2-s2.0-85090384984 09/11/2020       18 Citations
  • Cloning, Expression, and Purification of the Glycosylated Transmembrane Protein, Cation-Dependent Mannose 6-Phosphate Receptor, from Sf9 Cells Using the Baculovirus System. (Olson LJ, Dahms NM) Methods Mol Biol 2018;1722:105-116 PMID: 29264801 PMCID: PMC6202031 SCOPUS ID: 2-s2.0-85038831305 12/22/2017       2 Citations
  • Crystal Structure and Functional Analyses of the Lectin Domain of Glucosidase II: Insights into Oligomannose Recognition. (Olson LJ, Orsi R, Peterson FC, Parodi AJ, Kim JJ, D'Alessio C, Dahms NM) Biochemistry 2015 Jul 07;54(26):4097-111 PMID: 26062005 PMCID: PMC6202027 SCOPUS ID: 2-s2.0-84936769044 06/11/2015       14 Citations
  • Bacterial expression of the phosphodiester-binding site of the cation-independent mannose 6-phosphate receptor for crystallographic and NMR studies. (Olson LJ, Jensen DR, Volkman BF, Kim JJ, Peterson FC, Gundry RL, Dahms NM) Protein Expr Purif 2015 Jul;111:91-7 PMID: 25863146 PMCID: PMC4417374 SCOPUS ID: 2-s2.0-84927727743 04/12/2015       1 Citation
  • Identification of a fourth mannose 6-phosphate binding site in the cation-independent mannose 6-phosphate receptor. (Olson LJ, Castonguay AC, Lasanajak Y, Peterson FC, Cummings RD, Smith DF, Dahms NM) Glycobiology 2015 Jun;25(6):591-606 PMID: 25573276 PMCID: PMC4410830 SCOPUS ID: 2-s2.0-84930944628 01/13/2015       24 Citations
  • Mannose 6-Phosphate Receptors (Olson LJ, Dahms NM) Glycoscience: Biology and Medicine 1 January 2015:1037-1048 SCOPUS ID: 2-s2.0-84943616477 01/01/2015       2 Citations
  • Structure of the lectin mannose 6-phosphate receptor homology (MRH) domain of glucosidase II, an enzyme that regulates glycoprotein folding quality control in the endoplasmic reticulum. (Olson LJ, Orsi R, Alculumbre SG, Peterson FC, Stigliano ID, Parodi AJ, D'Alessio C, Dahms NM) J Biol Chem 2013 Jun 07;288(23):16460-16475 PMID: 23609449 PMCID: PMC3675582 SCOPUS ID: 2-s2.0-84878756888 04/24/2013       26 Citations
  • The glycan-binding properties of the cation-independent mannose 6-phosphate receptor are evolutionary conserved in vertebrates. (Castonguay AC, Lasanajak Y, Song X, Olson LJ, Cummings RD, Smith DF, Dahms NM) Glycobiology 2012 Jul;22(7):983-96 PMID: 22369936 PMCID: PMC3355666 SCOPUS ID: 2-s2.0-84861409583 03/01/2012       17 Citations
  • Mannose 6-phosphate receptor homology (MRH) domain-containing lectins in the secretory pathway. (Castonguay AC, Olson LJ, Dahms NM) Biochim Biophys Acta 2011 Sep;1810(9):815-26 PMID: 21723917 PMCID: PMC3150748 SCOPUS ID: 2-s2.0-79960702536 07/05/2011       26 Citations
  • Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor. (Olson LJ, Peterson FC, Castonguay A, Bohnsack RN, Kudo M, Gotschall RR, Canfield WM, Volkman BF, Dahms NM) Proc Natl Acad Sci U S A 2010 Jul 13;107(28):12493-8 PMID: 20615935 PMCID: PMC2906551 SCOPUS ID: 2-s2.0-77955444897 07/10/2010       38 Citations
  • Residues essential for plasminogen binding by the cation-independent mannose 6-phosphate receptor. (Bohnsack RN, Patel M, Olson LJ, Twining SS, Dahms NM) Biochemistry 2010 Jan 26;49(3):635-44 PMID: 20028034 PMCID: PMC2814163 SCOPUS ID: 2-s2.0-74949084342 12/24/2009       11 Citations
  • Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor. (Olson LJ, Sun G, Bohnsack RN, Peterson FC, Dahms NM, Kim JJ) Biochemistry 2010 Jan 12;49(1):236-46 PMID: 19928875 PMCID: PMC2802658 SCOPUS ID: 2-s2.0-73449127633 11/26/2009       8 Citations
  • Cation-independent mannose 6-phosphate receptor: a composite of distinct phosphomannosyl binding sites. (Bohnsack RN, Song X, Olson LJ, Kudo M, Gotschall RR, Canfield WM, Cummings RD, Smith DF, Dahms NM) J Biol Chem 2009 Dec 11;284(50):35215-26 PMID: 19840944 PMCID: PMC2787381 SCOPUS ID: 2-s2.0-71749085682 10/21/2009       57 Citations
  • Glycan microarray analysis of P-type lectins reveals distinct phosphomannose glycan recognition. (Song X, Lasanajak Y, Olson LJ, Boonen M, Dahms NM, Kornfeld S, Cummings RD, Smith DF) J Biol Chem 2009 Dec 11;284(50):35201-14 PMID: 19801653 PMCID: PMC2787380 SCOPUS ID: 2-s2.0-70349879814 10/06/2009       58 Citations
  • Carbohydrate recognition by the mannose-6-phosphate receptors. (Kim JJ, Olson LJ, Dahms NM) Curr Opin Struct Biol 2009 Oct;19(5):534-42 PMID: 19801188 PMCID: PMC2771201 SCOPUS ID: 2-s2.0-70349882101 10/06/2009       62 Citations
  • Strategies for carbohydrate recognition by the mannose 6-phosphate receptors. (Dahms NM, Olson LJ, Kim JJ) Glycobiology 2008 Sep;18(9):664-78 PMID: 18621992 PMCID: PMC2733771 SCOPUS ID: 2-s2.0-58149107948 07/16/2008       86 Citations
  • Structural insights into the mechanism of pH-dependent ligand binding and release by the cation-dependent mannose 6-phosphate receptor. (Olson LJ, Hindsgaul O, Dahms NM, Kim JJ) J Biol Chem 2008 Apr 11;283(15):10124-34 PMID: 18272523 PMCID: PMC2442308 SCOPUS ID: 2-s2.0-44349171796 02/15/2008       30 Citations
  • P-Type Lectins and Lysosomal Enzyme Targeting (Dahms NM, Olson LJ, Kim JJP) Animal Lectins: A Functional View 1 January 2008:147-164 SCOPUS ID: 2-s2.0-85131992811 01/01/2008       1 Citation
  • The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor. (Olson LJ, Dahms NM, Kim JJ) J Biol Chem 2004 Aug 06;279(32):34000-9 PMID: 15169779 SCOPUS ID: 2-s2.0-4043147868 06/01/2004       50 Citations
  • Structure of uPAR, plasminogen, and sugar-binding sites of the 300 kDa mannose 6-phosphate receptor. (Olson LJ, Yammani RD, Dahms NM, Kim JJ) EMBO J 2004 May 19;23(10):2019-28 PMID: 15085180 PMCID: PMC424385 SCOPUS ID: 2-s2.0-2942558373 04/16/2004       55 Citations
  • Twists and turns of the cation-dependent mannose 6-phosphate receptor. Ligand-bound versus ligand-free receptor. (Olson LJ, Zhang J, Dahms NM, Kim JJ) J Biol Chem 2002 Mar 22;277(12):10156-61 PMID: 11786557 SCOPUS ID: 2-s2.0-0037155883 01/12/2002       42 Citations
  • Mutational analysis of the binding site residues of the bovine cation-dependent mannose 6-phosphate receptor. (Olson LJ, Hancock MK, Dix D, Kim JJ, Dahms NM) J Biol Chem 1999 Dec 24;274(52):36905-11 PMID: 10601243 SCOPUS ID: 2-s2.0-0033601324 12/22/1999       29 Citations
  • Structural basis for recognition of phosphorylated high mannose oligosaccharides by the cation-dependent mannose 6-phosphate receptor. (Olson LJ, Zhang J, Lee YC, Dahms NM, Kim JJ) J Biol Chem 1999 Oct 15;274(42):29889-96 PMID: 10514470 SCOPUS ID: 2-s2.0-0033569876 10/09/1999       56 Citations
  • Functionally active catalytic domain is essential for guanylyl cyclase-linked receptor mediated inhibition of human aldosterone synthesis. (Olson LJ, Ho BY, Cashdollar LW, Drewett JG) Mol Pharmacol 1998 Nov;54(5):761-9 PMID: 9804611 SCOPUS ID: 2-s2.0-0031753505 11/06/1998       10 Citations
  • Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation. (Olson LJ, Knych ET Jr, Herzig TC, Drewett JG) Hypertension 1997 Jan;29(1 Pt 2):254-61 PMID: 9039111 SCOPUS ID: 2-s2.0-0031028506 01/01/1997       69 Citations
  • Novel natriuretic peptide receptor/guanylyl cyclase A-selective agonist inhibits angiotensin II- and forskolin-evoked aldosterone synthesis in a human zona glomerulosa cell line. (Olson LJ, Lowe DG, Drewett JG) Mol Pharmacol 1996 Aug;50(2):430-5 PMID: 8700153 SCOPUS ID: 2-s2.0-0029789839 08/01/1996       21 Citations
  • Interaction of the bHLH-zip domain of c-Myc with H1-type peptides. Characterization of helicity in the H1 peptides by NMR. (Draeger LJ, Mullen GP) J Biol Chem 1994 Jan 21;269(3):1785-93 PMID: 8294427 SCOPUS ID: 2-s2.0-0028125659 01/21/1994       45 Citations
    • Last update: 08/09/2023