Medical College of Wisconsin
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Navonil De Sarkar PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Administration

Member of the Cancer Center

Research Areas of Interest

  • Aged
  • Animals
  • Biomarkers, Tumor
  • Cell Line, Tumor
  • Circulating Tumor DNA
  • DNA Repair
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Genomics
  • Genotype
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Male
  • Mice
  • Middle Aged
  • Mutation
  • Neoplasm Metastasis
  • Nucleosomes
  • Phenotype
  • Precision Medicine
  • Prostate
  • Prostatic Neoplasms
  • Prostatic Neoplasms, Castration-Resistant
  • Sequence Analysis, DNA

    • Publications (31)

  • Author Correction: A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA. (Doebley AL, Ko M, Liao H, Cruikshank AE, Santos K, Kikawa C, Hiatt JB, Patton RD, De Sarkar N, Collier KA, Hoge ACH, Chen K, Zimmer A, Weber ZT, Adil M, Reichel JB, Polak P, Adalsteinsson VA, Nelson PS, MacPherson D, Parsons HA, Stover DG, Ha G) Nat Commun 2023 Jan 25;14(1):403 PMID: 36697405 PMCID: PMC9877007 SCOPUS ID: 2-s2.0-85146766901 01/26/2023    
  • Bipolar androgen therapy plus olaparib in men with metastatic castration-resistant prostate cancer. (Schweizer MT, Gulati R, Yezefski T, Cheng HH, Mostaghel E, Haffner MC, Patel RA, De Sarkar N, Ha G, Dumpit R, Woo B, Lin A, Panlasigui P, McDonald N, Lai M, Nega K, Hammond J, Grivas P, Hsieh A, Montgomery B, Nelson PS, Yu EY) Prostate Cancer Prostatic Dis 2023 Mar;26(1):194-200 PMID: 36564459 PMCID: PMC10286318 SCOPUS ID: 2-s2.0-85144705758 12/24/2022       3 Citations
  • A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA. (Doebley AL, Ko M, Liao H, Cruikshank AE, Santos K, Kikawa C, Hiatt JB, Patton RD, De Sarkar N, Collier KA, Hoge ACH, Chen K, Zimmer A, Weber ZT, Adil M, Reichel JB, Polak P, Adalsteinsson VA, Nelson PS, MacPherson D, Parsons HA, Stover DG, Ha G) Nat Commun 2022 Dec 03;13(1):7475 PMID: 36463275 PMCID: PMC9719521 SCOPUS ID: 2-s2.0-85143230318 12/04/2022       9 Citations
  • Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes. (De Sarkar N, Patton RD, Doebley AL, Hanratty B, Adil M, Kreitzman AJ, Sarthy JF, Ko M, Brahma S, Meers MP, Janssens DH, Ang LS, Coleman IM, Bose A, Dumpit RF, Lucas JM, Nunez TA, Nguyen HM, McClure HM, Pritchard CC, Schweizer MT, Morrissey C, Choudhury AD, Baca SC, Berchuck JE, Freedman ML, Ahmad K, Haffner MC, Montgomery RB, Corey E, Henikoff S, Nelson PS, Ha G) Cancer Discov 2023 Mar 01;13(3):632-653 PMID: 36399432 PMCID: PMC9976992 SCOPUS ID: 2-s2.0-85146609116 11/19/2022       6 Citations
  • Therapeutic Implications for Intrinsic Phenotype Classification of Metastatic Castration-Resistant Prostate Cancer. (Coleman IM, DeSarkar N, Morrissey C, Xin L, Roudier MP, Sayar E, Li D, Corey E, Haffner MC, Nelson PS) Clin Cancer Res 2022 Jul 15;28(14):3127-3140 PMID: 35552660 PMCID: PMC9365375 SCOPUS ID: 2-s2.0-85134429513 05/14/2022       5 Citations
  • Genomic attributes of homology-directed DNA repair deficiency in metastatic prostate cancer. (De Sarkar N, Dasgupta S, Chatterjee P, Coleman I, Ha G, Ang LS, Kohlbrenner EA, Frank SB, Nunez TA, Salipante SJ, Corey E, Morrissey C, Van Allen E, Schweizer MT, Haffner MC, Patel R, Hanratty B, Lucas JM, Dumpit RF, Pritchard CC, Montgomery RB, Nelson PS) JCI Insight 2021 Dec 08;6(23) PMID: 34877933 PMCID: PMC8675196 SCOPUS ID: 2-s2.0-85120888453 12/09/2021       7 Citations
  • Efficacy of systemic therapies in men with metastatic castration resistant prostate cancer harboring germline ATM versus BRCA2 mutations. (Sokolova AO, Marshall CH, Lozano R, Gulati R, Ledet EM, De Sarkar N, Grivas P, Higano CS, Montgomery B, Nelson PS, Olmos D, Sokolov V, Schweizer MT, Yezefski TA, Yu EY, Paller CJ, Sartor O, Castro E, Antonarakis ES, Cheng HH) Prostate 2021 Dec;81(16):1382-1389 PMID: 34516663 PMCID: PMC8563438 SCOPUS ID: 2-s2.0-85114718067 09/14/2021       7 Citations
  • Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth. (Nyquist MD, Ang LS, Corella A, Coleman IM, Meers MP, Christiani AJ, Pierce C, Janssens DH, Meade HE, Bose A, Brady L, Howard T, De Sarkar N, Frank SB, Dumpit RF, Dalton JT, Corey E, Plymate SR, Haffner MC, Mostaghel EA, Nelson PS) J Clin Invest 2021 Jun 15;131(12) PMID: 34128479 PMCID: PMC8203444 SCOPUS ID: 2-s2.0-85108237474 06/16/2021    
  • Concordance of DNA Repair Gene Mutations in Paired Primary Prostate Cancer Samples and Metastatic Tissue or Cell-Free DNA. (Schweizer MT, Sivakumar S, Tukachinsky H, Coleman I, De Sarkar N, Yu EY, Konnick EQ, Nelson PS, Pritchard CC, Montgomery B) JAMA Oncol 2021 Jun 04;7(9):1-5 PMID: 34086042 PMCID: PMC8446811 SCOPUS ID: 2-s2.0-85108061848 06/05/2021       25 Citations
  • Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth. (Nyquist MD, Ang LS, Corella A, Coleman IM, Meers MP, Christiani AJ, Pierce C, Janssens DH, Meade HE, Bose A, Brady L, Howard T, De Sarkar N, Frank SB, Dumpit RF, Dalton JT, Corey E, Plymate SR, Haffner MC, Mostaghel EA, Nelson PS) J Clin Invest 2021 May 17;131(10) PMID: 33998604 PMCID: PMC8121509 SCOPUS ID: 2-s2.0-85106609999 05/18/2021       18 Citations
  • Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer. (Baca SC, Takeda DY, Seo JH, Hwang J, Ku SY, Arafeh R, Arnoff T, Agarwal S, Bell C, O'Connor E, Qiu X, Alaiwi SA, Corona RI, Fonseca MAS, Giambartolomei C, Cejas P, Lim K, He M, Sheahan A, Nassar A, Berchuck JE, Brown L, Nguyen HM, Coleman IM, Kaipainen A, De Sarkar N, Nelson PS, Morrissey C, Korthauer K, Pomerantz MM, Ellis L, Pasaniuc B, Lawrenson K, Kelly K, Zoubeidi A, Hahn WC, Beltran H, Long HW, Brown M, Corey E, Freedman ML) Nat Commun 2021 Mar 30;12(1):1979 PMID: 33785741 PMCID: PMC8010057 SCOPUS ID: 2-s2.0-85103682911 04/01/2021       44 Citations
  • Regulation of CEACAM5 and Therapeutic Efficacy of an Anti-CEACAM5-SN38 Antibody-drug Conjugate in Neuroendocrine Prostate Cancer. (DeLucia DC, Cardillo TM, Ang L, Labrecque MP, Zhang A, Hopkins JE, De Sarkar N, Coleman I, da Costa RMG, Corey E, True LD, Haffner MC, Schweizer MT, Morrissey C, Nelson PS, Lee JK) Clin Cancer Res 2021 Feb 01;27(3):759-774 PMID: 33199493 PMCID: PMC7854497 SCOPUS ID: 2-s2.0-85100427026 11/18/2020       23 Citations
  • A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients. (Saha G, Singh R, Mandal A, Das S, Chattopadhyay E, Panja P, Roy P, DeSarkar N, Gulati S, Ghatak S, Ghosh S, Banerjee S, Roy B, Ghosh S, Chaudhuri D, Arora N, Biswas NK, Sikdar N) Mol Med 2020 Jun 17;26(1):59 PMID: 32552660 PMCID: PMC7302128 SCOPUS ID: 2-s2.0-85086694366 06/20/2020       7 Citations
  • Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress. (Nyquist MD, Corella A, Coleman I, De Sarkar N, Kaipainen A, Ha G, Gulati R, Ang L, Chatterjee P, Lucas J, Pritchard C, Risbridger G, Isaacs J, Montgomery B, Morrissey C, Corey E, Nelson PS) Cell Rep 2020 May 26;31(8):107669 PMID: 32460015 PMCID: PMC7453577 SCOPUS ID: 2-s2.0-85085319793 05/28/2020       107 Citations
  • Genomic distinctions between metastatic lower and upper tract urothelial carcinoma revealed through rapid autopsy. (Winters BR, De Sarkar N, Arora S, Bolouri H, Jana S, Vakar-Lopez F, Cheng HH, Schweizer MT, Yu EY, Grivas P, Lee JK, Kollath L, Holt SK, McFerrin L, Ha G, Nelson PS, Montgomery RB, Wright JL, Lam HM, Hsieh AC) JCI Insight 2019 May 30;5(13) PMID: 31145100 PMCID: PMC6629128 SCOPUS ID: 2-s2.0-85070658429 05/31/2019       26 Citations
  • Genomic correlates of clinical outcome in advanced prostate cancer. (Abida W, Cyrta J, Heller G, Prandi D, Armenia J, Coleman I, Cieslik M, Benelli M, Robinson D, Van Allen EM, Sboner A, Fedrizzi T, Mosquera JM, Robinson BD, De Sarkar N, Kunju LP, Tomlins S, Wu YM, Nava Rodrigues D, Loda M, Gopalan A, Reuter VE, Pritchard CC, Mateo J, Bianchini D, Miranda S, Carreira S, Rescigno P, Filipenko J, Vinson J, Montgomery RB, Beltran H, Heath EI, Scher HI, Kantoff PW, Taplin ME, Schultz N, deBono JS, Demichelis F, Nelson PS, Rubin MA, Chinnaiyan AM, Sawyers CL) Proc Natl Acad Sci U S A 2019 Jun 04;116(23):11428-11436 PMID: 31061129 PMCID: PMC6561293 SCOPUS ID: 2-s2.0-85066600927 05/08/2019       614 Citations
  • Genome-wide miRNA methylome analysis in oral cancer: possible biomarkers associated with patient survival. (Roy R, Chatterjee A, Das D, Ray A, Singh R, Chattopadhyay E, Sarkar N, Eccles M, Pal M, Maitra A, Roy B) Epigenomics 2019 Apr;11(5):473-487 PMID: 30875235 SCOPUS ID: 2-s2.0-85063613443 03/16/2019       10 Citations
  • Clinical determinants for successful circulating tumor DNA analysis in prostate cancer. (Schweizer MT, Gulati R, Beightol M, Konnick EQ, Cheng HH, Klemfuss N, De Sarkar N, Yu EY, Montgomery RB, Nelson PS, Pritchard CC) Prostate 2019 May;79(7):701-708 PMID: 30865311 PMCID: PMC6589085 SCOPUS ID: 2-s2.0-85062990636 03/14/2019       14 Citations
  • Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer. (Wu YM, Cieślik M, Lonigro RJ, Vats P, Reimers MA, Cao X, Ning Y, Wang L, Kunju LP, de Sarkar N, Heath EI, Chou J, Feng FY, Nelson PS, de Bono JS, Zou W, Montgomery B, Alva A, PCF/SU2C International Prostate Cancer Dream Team, Robinson DR, Chinnaiyan AM) Cell 2018 Jun 14;173(7):1770-1782.e14 PMID: 29906450 PMCID: PMC6084431 SCOPUS ID: 2-s2.0-85047481697 06/16/2018       341 Citations
  • Targeted Gene Sequencing of Gallbladder Carcinoma Identifies High-impact Somatic and Rare Germline Mutations. (Yadav S, DE Sarkar N, Kumari N, Krishnani N, Kumar A, Mittal B) Cancer Genomics Proteomics 2017;14(6):495-506 PMID: 29109099 PMCID: PMC6070325 SCOPUS ID: 2-s2.0-85046630667 11/08/2017       19 Citations
  • Analysis of the whole transcriptome from gingivo-buccal squamous cell carcinoma reveals deregulated immune landscape and suggests targets for immunotherapy. (Singh R, De Sarkar N, Sarkar S, Roy R, Chattopadhyay E, Ray A, Biswas NK, Maitra A, Roy B) PLoS One 2017;12(9):e0183606 PMID: 28886030 PMCID: PMC5590820 SCOPUS ID: 2-s2.0-85029295065 09/09/2017       5 Citations
  • Genome-wide mitochondrial DNA sequence variations and lower expression of OXPHOS genes predict mitochondrial dysfunction in oral cancer tissue. (Chattopadhyay E, De Sarkar N, Singh R, Ray A, Roy R, Paul RR, Pal M, Ghose S, Ghosh S, Kabiraj D, Banerjee R, Roy B) Tumour Biol 2016 Sep;37(9):11861-11871 PMID: 27055661 SCOPUS ID: 2-s2.0-84964038436 10/27/2016       10 Citations
  • Expression deregulation of mir31 and CXCL12 in two types of oral precancers and cancer: importance in progression of precancer and cancer. (Chattopadhyay E, Singh R, Ray A, Roy R, De Sarkar N, Paul RR, Pal M, Aich R, Roy B) Sci Rep 2016 Sep 06;6:32735 PMID: 27597234 PMCID: PMC5011738 SCOPUS ID: 2-s2.0-84986296776 09/07/2016       24 Citations
  • Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. (Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, Garofalo A, Gulati R, Carreira S, Eeles R, Elemento O, Rubin MA, Robinson D, Lonigro R, Hussain M, Chinnaiyan A, Vinson J, Filipenko J, Garraway L, Taplin ME, AlDubayan S, Han GC, Beightol M, Morrissey C, Nghiem B, Cheng HH, Montgomery B, Walsh T, Casadei S, Berger M, Zhang L, Zehir A, Vijai J, Scher HI, Sawyers C, Schultz N, Kantoff PW, Solit D, Robson M, Van Allen EM, Offit K, de Bono J, Nelson PS) N Engl J Med 2016 Aug 04;375(5):443-53 PMID: 27433846 PMCID: PMC4986616 SCOPUS ID: 2-s2.0-84982797286 07/20/2016       1043 Citations
  • Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer. (Kumar A, Coleman I, Morrissey C, Zhang X, True LD, Gulati R, Etzioni R, Bolouri H, Montgomery B, White T, Lucas JM, Brown LG, Dumpit RF, DeSarkar N, Higano C, Yu EY, Coleman R, Schultz N, Fang M, Lange PH, Shendure J, Vessella RL, Nelson PS) Nat Med 2016 Apr;22(4):369-78 PMID: 26928463 PMCID: PMC5045679 SCOPUS ID: 2-s2.0-84959255550 03/02/2016       484 Citations
  • Sequence and expression variations in 23 genes involved in mitochondrial and non-mitochondrial apoptotic pathways and risk of oral leukoplakia and cancer. (Datta S, Ray A, Singh R, Mondal P, Basu A, De Sarkar N, Majumder M, Maiti G, Baral A, Jha GN, Mukhopadhyay I, Panda C, Chowdhury S, Ghosh S, Roychoudhury S, Roy B) Mitochondrion 2015 Nov;25:28-33 PMID: 26403071 SCOPUS ID: 2-s2.0-84942568949 09/26/2015       10 Citations
  • A quest for miRNA bio-marker: a track back approach from gingivo buccal cancer to two different types of precancers. (De Sarkar N, Roy R, Mitra JK, Ghose S, Chakraborty A, Paul RR, Mukhopadhyay I, Roy B) PLoS One 2014;9(8):e104839 PMID: 25126847 PMCID: PMC4134240 SCOPUS ID: 2-s2.0-84940270877 08/16/2014       30 Citations
  • Association between risk of oral precancer and genetic variations in microRNA and related processing genes. (Roy R, De Sarkar N, Ghose S, Paul RR, Ray A, Mukhopadhyay I, Roy B) J Biomed Sci 2014 May 17;21(1):48 PMID: 24885463 PMCID: PMC4035900 SCOPUS ID: 2-s2.0-84901688781 06/03/2014       17 Citations
  • Genetic variations at microRNA and processing genes and risk of oral cancer. (Roy R, De Sarkar N, Ghose S, Paul RR, Pal M, Bhattacharya C, Chowdhury SK, Ghosh S, Roy B) Tumour Biol 2014 Apr;35(4):3409-14 PMID: 24297336 SCOPUS ID: 2-s2.0-84898794275 12/04/2013       28 Citations
  • Differential haplotype amplification leads to misgenotyping of heterozygote as homozygote when using single nucleotide mismatch primer. (De Sarkar N, Majumder M, Roy B) Electrophoresis 2012 Dec;33(23):3564-73 PMID: 23161286 SCOPUS ID: 2-s2.0-84870575023 11/20/2012       2 Citations
  • Oral suffering and antimicrobial susceptibility of Staphylococcus aureus in a dental hospital in Kolkata, India (Batabyal B, Biswas S, Mandal B, Desai PD, De Sarkar N) International Journal of Pharma and Bio Sciences October 2012;3(4):620-629 SCOPUS ID: 2-s2.0-84873804362 10/01/2012       1 Citation
    • Last update: 07/20/2023