Faculty Collaboration Database

Philip Mosier PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: School of Pharmacy Operations

Publications (47)

Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ₁) receptor ligands with potent anti-amnesic effect. (Abatematteo FS, Mosier PD, Niso M, Brunetti L, Berardi F, Loiodice F, Contino M, Delprat B, Maurice T, Laghezza A, Abate C) Eur J Med Chem 2022 Jan 15;228:114038 PMID: 34902734 SCOPUS ID: 2-s2.0-85120886359 12/14/2021 5 Citations

High-affinity sigma-1 (σ₁) receptor ligands based on the σ₁ antagonist PB212. (Niso M, Mosier PD, Marottoli R, Ferorelli S, Cassano G, Gasparre G, Leopoldo M, Berardi F, Abate C) Future Med Chem 2019 Oct;11(19):2547-2562 PMID: 31633399 SCOPUS ID: 2-s2.0-85073634435 10/22/2019 6 Citations

"Methylene Bridge" to 5-HT₃ Receptor Antagonists: Conformationally Constrained Phenylguanidines. (Abdelkhalek AS, Alley GS, Alwassil OI, Khatri S, Mosier PD, Nyce HL, White MM, Schulte MK, Dukat M) ACS Chem Neurosci 2019 Mar 20;10(3):1380-1389 PMID: 30375852 SCOPUS ID: 2-s2.0-85056457396 10/31/2018 5 Citations

Discovery and Biochemical Characterization of PlyP56, PlyN74, and PlyTB40-Bacillus Specific Endolysins. (Etobayeva I, Linden SB, Alem F, Harb L, Rizkalla L, Mosier PD, Johnson AA, Temple L, Hakami RM, Nelson DC) Viruses 2018 May 21;10(5) PMID: 29883383 PMCID: PMC5977269 SCOPUS ID: 2-s2.0-85047499157 06/09/2018 29 Citations

Complete Genome Sequences of Bacillus Phages Janet and OTooleKemple52. (Kent B, Raymond T, Mosier PD, Johnson AA, the 2016–2017 VCU Phage Hunters) Genome Announc 2018 May 10;6(19) PMID: 29748396 PMCID: PMC5946042 05/12/2018

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. (Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll FI, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL) Cell 2018 Jan 11;172(1-2):55-67.e15 PMID: 29307491 PMCID: PMC5802374 SCOPUS ID: 2-s2.0-85039900111 01/09/2018 318 Citations

Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication. (Chiang MJ, Musayev FN, Kosikova M, Lin Z, Gao Y, Mosier PD, Althufairi B, Ye Z, Zhou Q, Desai UR, Xie H, Safo MK) Emerg Microbes Infect 2017 Dec 06;6(12):e108 PMID: 29209052 PMCID: PMC5750462 SCOPUS ID: 2-s2.0-85052600391 12/07/2017 11 Citations

A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II. (Sankarayanarayanan NV, Strebel TR, Boothello RS, Sheerin K, Raghuraman A, Sallas F, Mosier PD, Watermeyer ND, Oscarson S, Desai UR) Angew Chem Int Ed Engl 2017 Feb 20;56(9):2312-2317 PMID: 28124818 PMCID: PMC5347859 SCOPUS ID: 2-s2.0-85011340770 01/27/2017 56 Citations

Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1. (Mosier PD, Chiang MJ, Lin Z, Gao Y, Althufairi B, Zhou Q, Musayev F, Safo MK, Xie H, Desai UR) Sci Rep 2016 Aug 30;6:32340 PMID: 27573445 PMCID: PMC5004101 SCOPUS ID: 2-s2.0-84984688523 08/31/2016 13 Citations

Superagonist, Full Agonist, Partial Agonist, and Antagonist Actions of Arylguanidines at 5-Hydroxytryptamine-3 (5-HT₃) Subunit A Receptors. (Alix K, Khatri S, Mosier PD, Casterlow S, Yan D, Nyce HL, White MM, Schulte MK, Dukat M) ACS Chem Neurosci 2016 Nov 16;7(11):1565-1574 PMID: 27533595 SCOPUS ID: 2-s2.0-84996554544 08/18/2016 14 Citations

Estimating glycosaminoglycan-protein interaction affinity: water dominates the specific antithrombin-heparin interaction. (Sarkar A, Yu W, Desai UR, MacKerell AD, Mosier PD) Glycobiology 2016 Oct;26(10):1041-1047 PMID: 27496757 PMCID: PMC5072149 SCOPUS ID: 2-s2.0-84994831305 08/09/2016 20 Citations

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions. (Joseph PR, Mosier PD, Desai UR, Rajarathnam K) Biochem J 2015 Nov 15;472(1):121-33 PMID: 26371375 PMCID: PMC4692082 SCOPUS ID: 2-s2.0-84945917798 09/16/2015 99 Citations

Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. (Vardy E, Sassano MF, Rennekamp AJ, Kroeze WK, Mosier PD, Westkaemper RB, Stevens CW, Katritch V, Stevens RC, Peterson RT, Roth BL) Chem Biol 2015 Jun 18;22(6):764-75 PMID: 26091169 PMCID: PMC4507497 SCOPUS ID: 2-s2.0-84934953131 06/20/2015 14 Citations

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. (Vardy E, Robinson JE, Li C, Olsen RHJ, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, Mosier PD, Song J, Kash TL, Malanga CJ, Krashes MJ, Roth BL) Neuron 2015 May 20;86(4):936-946 PMID: 25937170 PMCID: PMC4441592 SCOPUS ID: 2-s2.0-84930244375 05/06/2015 324 Citations

Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands. (Yuan Y, Zaidi SA, Stevens DL, Scoggins KL, Mosier PD, Kellogg GE, Dewey WL, Selley DE, Zhang Y) Bioorg Med Chem 2015 Apr 15;23(8):1701-15 PMID: 25783191 PMCID: PMC4380750 SCOPUS ID: 2-s2.0-84925668837 03/19/2015 31 Citations

Steric parameters, molecular modeling and hydropathic interaction analysis of the pharmacology of para-substituted methcathinone analogues. (Sakloth F, Kolanos R, Mosier PD, Bonano JS, Banks ML, Partilla JS, Baumann MH, Negus SS, Glennon RA) Br J Pharmacol 2015 May;172(9):2210-8 PMID: 25522019 PMCID: PMC4403088 SCOPUS ID: 2-s2.0-84926673612 12/19/2014 39 Citations

Designing "high-affinity, high-specificity" glycosaminoglycan sequences through computerized modeling. (Sankaranarayanan NV, Sarkar A, Desai UR, Mosier PD) Methods Mol Biol 2015;1229:289-314 PMID: 25325961 PMCID: PMC4452111 SCOPUS ID: 2-s2.0-84921739794 10/19/2014 18 Citations

Crystal structures of influenza A virus matrix protein M1: variations on a theme. (Safo MK, Musayev FN, Mosier PD, Zhou Q, Xie H, Desai UR) PLoS One 2014;9(10):e109510 PMID: 25295515 PMCID: PMC4190115 SCOPUS ID: 2-s2.0-84907720555 10/09/2014 32 Citations

Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor. (Polepally PR, Huben K, Vardy E, Setola V, Mosier PD, Roth BL, Zjawiony JK) Eur J Med Chem 2014 Oct 06;85:818-29 PMID: 25193297 PMCID: PMC4162805 SCOPUS ID: 2-s2.0-84930245171 09/07/2014 25 Citations

Chemotype-selective modes of action of κ-opioid receptor agonists. (Vardy E, Mosier PD, Frankowski KJ, Wu H, Katritch V, Westkaemper RB, Aubé J, Stevens RC, Roth BL) J Biol Chem 2013 Nov 29;288(48):34470-83 PMID: 24121503 PMCID: PMC3843062 10/15/2013

Binding mode characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: application of the 'message-address' concept in development of mu opioid receptor selective antagonists. (Zaidi SA, Arnatt CK, He H, Selley DE, Mosier PD, Kellogg GE, Zhang Y) Bioorg Med Chem 2013 Nov 01;21(21):6405-13 PMID: 24055076 PMCID: PMC3831368 SCOPUS ID: 2-s2.0-84885186318 09/24/2013 26 Citations

On scaffold hopping: challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans. (Sidhu PS, Mosier PD, Zhou Q, Desai UR) Bioorg Med Chem Lett 2013 Jan 01;23(1):355-9 PMID: 23164711 PMCID: PMC3525718 SCOPUS ID: 2-s2.0-84871030760 11/21/2012 14 Citations

On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different. (Mosier PD, Krishnasamy C, Kellogg GE, Desai UR) PLoS One 2012;7(11):e48632 PMID: 23152789 PMCID: PMC3495972 SCOPUS ID: 2-s2.0-84869073602 11/16/2012 55 Citations

The compensatory G88R change is essential in restoring the normal functions of influenza A/WSN/33 virus matrix protein 1 with a disrupted nuclear localization signal. (Xie H, Lin Z, Mosier PD, Desai UR, Gao Y) J Virol 2013 Jan;87(1):345-53 PMID: 23077315 PMCID: PMC3536423 SCOPUS ID: 2-s2.0-84871982938 10/19/2012 9 Citations

Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition. (Abdel Aziz MH, Sidhu PS, Liang A, Kim JY, Mosier PD, Zhou Q, Farrell DH, Desai UR) J Med Chem 2012 Aug 09;55(15):6888-97 PMID: 22788964 PMCID: PMC3416887 SCOPUS ID: 2-s2.0-84864953109 07/14/2012 38 Citations

Structure of the human κ-opioid receptor in complex with JDTic. (Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC) Nature 2012 Mar 21;485(7398):327-32 PMID: 22437504 PMCID: PMC3356457 SCOPUS ID: 2-s2.0-84862777742 03/23/2012 813 Citations

Identification of the site of binding of sulfated, low molecular weight lignins on thrombin. (Abdel Aziz MH, Mosier PD, Desai UR) Biochem Biophys Res Commun 2011 Sep 23;413(2):348-52 PMID: 21893043 PMCID: PMC3183121 SCOPUS ID: 2-s2.0-80053109628 09/07/2011 24 Citations

Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers. (Abate C, Niso M, Lacivita E, Mosier PD, Toscano A, Perrone R) J Med Chem 2011 Feb 24;54(4):1022-32 PMID: 21229979 SCOPUS ID: 2-s2.0-79951840503 01/15/2011 54 Citations

Understanding Dermatan Sulfate-Heparin Cofactor II Interaction through Virtual Library Screening. (Raghuraman A, Mosier PD, Desai UR) ACS Med Chem Lett 2010 Sep 09;1(6):281-285 PMID: 20835364 PMCID: PMC2936258 SCOPUS ID: 2-s2.0-77956521262 09/14/2010 37 Citations

CoMFA analyses of C-2 position salvinorin A analogs at the kappa-opioid receptor provides insights into epimer selectivity. (McGovern DL, Mosier PD, Roth BL, Westkaemper RB) J Mol Graph Model 2010 Apr;28(7):612-25 PMID: 20083418 PMCID: PMC2859180 SCOPUS ID: 2-s2.0-76549096825 01/20/2010 16 Citations

9-Aminomethyl-9,10-dihydroanthracene (AMDA) analogs as structural probes for steric tolerance in 5-HT2A and H1 receptor binding sites. (Shah JR, Mosier PD, Peddi S, Roth BL, Westkaemper RB) Bioorg Med Chem Lett 2010 Feb 01;20(3):935-8 PMID: 20045641 PMCID: PMC3252747 SCOPUS ID: 2-s2.0-74049127386 01/05/2010 8 Citations

A structure-affinity and comparative molecular field analysis of sigma-2 (sigma2) receptor ligands. (Abate C, Mosier PD, Berardi F, Glennon RA) Cent Nerv Syst Agents Med Chem 2009 Sep;9(3):246-57 PMID: 20021358 SCOPUS ID: 2-s2.0-69249154176 12/22/2009 34 Citations

Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. (Shah JR, Mosier PD, Roth BL, Kellogg GE, Westkaemper RB) Bioorg Med Chem 2009 Sep 15;17(18):6496-504 PMID: 19700330 PMCID: PMC3088504 SCOPUS ID: 2-s2.0-69249122527 08/25/2009 21 Citations

Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. (Yan F, Bikbulatov RV, Mocanu V, Dicheva N, Parker CE, Wetsel WC, Mosier PD, Westkaemper RB, Allen JA, Zjawiony JK, Roth BL) Biochemistry 2009 Jul 28;48(29):6898-908 PMID: 19555087 PMCID: PMC2752672 SCOPUS ID: 2-s2.0-67651204566 06/27/2009 75 Citations

Toward the three-dimensional structure and lysophosphatidic acid binding characteristics of the LPA(4)/p2y(9)/GPR23 receptor: a homology modeling study. (Li G, Mosier PD, Fang X, Zhang Y) J Mol Graph Model 2009 Aug;28(1):70-9 PMID: 19423373 PMCID: PMC4373609 SCOPUS ID: 2-s2.0-69249215410 05/09/2009 8 Citations

Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation. (Runyon SP, Mosier PD, Roth BL, Glennon RA, Westkaemper RB) J Med Chem 2008 Nov 13;51(21):6808-28 PMID: 18847250 PMCID: PMC3088499 SCOPUS ID: 2-s2.0-56249148224 10/14/2008 37 Citations

Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT(2A) receptor. (Dewkar GK, Peddi S, Mosier PD, Roth BL, Westkaemper RB) Bioorg Med Chem Lett 2008 Oct 01;18(19):5268-71 PMID: 18774714 PMCID: PMC3082371 SCOPUS ID: 2-s2.0-52249112061 09/09/2008 10 Citations

Tom1l2 hypomorphic mice exhibit increased incidence of infections and tumors and abnormal immunologic response. (Girirajan S, Hauck PM, Williams S, Vlangos CN, Szomju BB, Solaymani-Kohal S, Mosier PD, White KL Jr, McCoy K, Elsea SH) Mamm Genome 2008 Apr;19(4):246-62 PMID: 18343975 SCOPUS ID: 2-s2.0-42449119665 03/18/2008 22 Citations

Galpha-subunits differentially alter the conformation and agonist affinity of kappa-opioid receptors. (Yan F, Mosier PD, Westkaemper RB, Roth BL) Biochemistry 2008 Feb 12;47(6):1567-78 PMID: 18205395 SCOPUS ID: 2-s2.0-38949112855 01/22/2008 50 Citations

Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. (Dukat M, Mosier PD, Kolanos R, Roth BL, Glennon RA) J Med Chem 2008 Feb 14;51(3):603-11 PMID: 18201064 PMCID: PMC5994921 SCOPUS ID: 2-s2.0-39149119649 01/19/2008 38 Citations

Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor. (Vortherms TA, Mosier PD, Westkaemper RB, Roth BL) J Biol Chem 2007 Feb 02;282(5):3146-56 PMID: 17121830 SCOPUS ID: 2-s2.0-34047253035 11/24/2006 36 Citations

Finding a needle in a haystack: development of a combinatorial virtual screening approach for identifying high specificity heparin/heparan sulfate sequence(s). (Raghuraman A, Mosier PD, Desai UR) J Med Chem 2006 Jun 15;49(12):3553-62 PMID: 16759098 PMCID: PMC2516555 SCOPUS ID: 2-s2.0-33745119433 06/09/2006 66 Citations

Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors. (Yan F, Mosier PD, Westkaemper RB, Stewart J, Zjawiony JK, Vortherms TA, Sheffler DJ, Roth BL) Biochemistry 2005 Jun 21;44(24):8643-51 PMID: 15952771 SCOPUS ID: 2-s2.0-20544441511 06/15/2005 89 Citations

Predicting the genotoxicity of thiophene derivatives from molecular structure. (Mosier PD, Jurs PC, Custer LL, Durham SK, Pearl GM) Chem Res Toxicol 2003 Jun;16(6):721-32 PMID: 12807355 SCOPUS ID: 2-s2.0-0037903058 06/17/2003 48 Citations

QSAR/QSPR studies using probabilistic neural networks and generalized regression neural networks. (Mosier PD, Jurs PC) J Chem Inf Comput Sci 2002;42(6):1460-70 PMID: 12444744 SCOPUS ID: 2-s2.0-0036827084 11/26/2002 66 Citations

Discovery of imidazole glycerol phosphate dehydratase inhibitors through 3-D database searching. (Schweitzer BA, Loida PJ, CaJacob CA, Chott RC, Collantes EM, Hegde SG, Mosier PD, Profeta S) Bioorg Med Chem Lett 2002 Jul 08;12(13):1743-6 PMID: 12067551 SCOPUS ID: 2-s2.0-0037042771 06/18/2002 21 Citations

Prediction of peptide ion collision cross sections from topological molecular structure and amino acid parameters. (Mosier PD, Counterman AE, Jurs PC, Clemmer DE) Anal Chem 2002 Mar 15;74(6):1360-70 PMID: 11922305 SCOPUS ID: 2-s2.0-0037086062 04/02/2002 47 Citations

Last update: 05/06/2026

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Philip Mosier PhD

Assistant Professor

Publications (47)