Dusp-5 and Snrk-1 coordinately function during vascular development and disease. Blood 2009 Jan 29;113(5):1184-91
Date
10/18/2008Pubmed ID
18927432Pubmed Central ID
PMC2635084DOI
10.1182/blood-2008-06-162180Scopus ID
2-s2.0-60849096090 (requires institutional sign-in at Scopus site) 60 CitationsAbstract
Mitogen-activated protein kinases play an integral role in several cellular processes. To regulate mitogen-activated protein kinases, cells express members of a counteracting group of proteins called phosphatases. In this study, we have identified a specific role that one member of this family of phosphatases, dual-specific phosphatase-5 (Dusp-5) plays in vascular development in vivo. We have determined that dusp-5 is expressed in angioblasts and in established vasculature and that it counteracts the function of a serine threonine kinase, Snrk-1, which also plays a functional role in angioblast development. Together, Dusp-5 and Snrk-1 control angioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snrk-1. Importantly, mutations in dusp-5 and snrk-1 have been identified in affected tissues of patients with vascular anomalies, implicating the Snrk-1-Dusp-5 signaling pathway in human disease.
Author List
Pramanik K, Chun CZ, Garnaas MK, Samant GV, Li K, Horswill MA, North PE, Ramchandran RAuthors
Keguo Li MD, PhD Research Scientist I in the Surgery department at Medical College of WisconsinPaula E. North MD, PhD Professor in the Pathology department at Medical College of Wisconsin
Ramani Ramchandran PhD Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsBlood Vessels
Dual-Specificity Phosphatases
Gene Expression Regulation
Hemangioma
Humans
Mesoderm
Mutation
Neoplasm Proteins
Signal Transduction
Zebrafish
Zebrafish Proteins
