Calcific Aortic Valve Disease: a Developmental Biology Perspective. Curr Cardiol Rep 2018 Mar 08;20(4):21
Date
03/10/2018Pubmed ID
29520694Pubmed Central ID
PMC5842494DOI
10.1007/s11886-018-0968-9Scopus ID
2-s2.0-85043328653 (requires institutional sign-in at Scopus site) 54 CitationsAbstract
PURPOSE OF REVIEW: This review aims to highlight the past and more current literature related to the multifaceted pathogenic programs that contribute to calcific aortic valve disease (CAVD) with a focus on the contribution of developmental programs.
RECENT FINDINGS: Calcification of the aortic valve is an active process characterized by calcific nodule formation on the aortic surface leading to a less supple and more stiffened cusp, thereby limiting movement and causing clinical stenosis. The mechanisms underlying these pathogenic changes are largely unknown, but emerging studies have suggested that signaling pathways common to valvulogenesis and bone development play significant roles and include Transforming Growth Factor-β (TGF-β), bone morphogenetic protein (BMP), Wnt, Notch, and Sox9. This comprehensive review of the literature highlights the complex nature of CAVD but concurrently identifies key regulators that can be targeted in the development of mechanistic-based therapies beyond surgical intervention to improve patient outcome.
Author List
Dutta P, Lincoln JAuthor
Joy Lincoln PhD Chief, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Aortic ValveAortic Valve Stenosis
Developmental Biology
Extracellular Matrix
Humans
Signal Transduction
Vascular Calcification
