Medical College of Wisconsin
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Joy Lincoln PhD

Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Cardiology

Member of the Cardiovascular Center


Publications (58)

  • Constructing and evaluating caspase-activatable adeno-associated virus vector for gene delivery to the injured heart. (Brun MJ, Song K, Kang B, Lueck C, Chen W, Thatcher K, Gao E, Koch WJ, Lincoln J, Rajan S, Suh J) J Control Release 2020 Dec 10;328:834-845 PMID: 33157191 PMCID: PMC7770761 SCOPUS ID: 2-s2.0-85096157735 11/07/2020    
  • Disruption of foxc1 genes in zebrafish results in dosage-dependent phenotypes overlapping Axenfeld-Rieger syndrome. (Ferre-Fernández JJ, Sorokina EA, Thompson S, Collery RF, Nordquist E, Lincoln J, Semina EV) Hum Mol Genet 2020 Sep 29;29(16):2723-2735 PMID: 32720677 PMCID: PMC7530528 SCOPUS ID: 2-s2.0-85092681312 07/29/2020       1 Citation
  • The Endocardium and Heart Valves. (Dye B, Lincoln J) Cold Spring Harb Perspect Biol 2020 Dec 01;12(12) PMID: 31988139 PMCID: PMC7382980 SCOPUS ID: 2-s2.0-85083345940 01/29/2020       2 Citations
  • Effect of Left and Right Coronary Flow Waveforms on Aortic Sinus Hemodynamics and Leaflet Shear Stress: Correlation with Calcification Locations (Flemister DC, Hatoum H, Guhan V, Zebhi B, Lincoln J, Crestanello J, Dasi LP) Annals of Biomedical Engineering 2020 SCOPUS ID: 2-s2.0-85094883942 01/01/2020    
  • Loss of ADAMTS19 causes progressive non-syndromic heart valve disease. (Wünnemann F, Ta-Shma A, Preuss C, Leclerc S, van Vliet PP, Oneglia A, Thibeault M, Nordquist E, Lincoln J, Scharfenberg F, Becker-Pauly C, Hofmann P, Hoff K, Audain E, Kramer HH, Makalowski W, Nir A, Gerety SS, Hurles M, Comes J, Fournier A, Osinska H, Robins J, Pucéat M, MIBAVA Leducq Consortium principal investigators, Elpeleg O, Hitz MP, Andelfinger G) Nat Genet 2020 01;52(1):40-47 PMID: 31844321 PMCID: PMC7197892 SCOPUS ID: 2-s2.0-85076909295 12/18/2019       10 Citations
  • Corrigendum: Postnatal and Adult Aortic Heart Valves Have Distinctive Transcriptional Profiles Associated With Valve Tissue Growth and Maintenance Respectively. (Nordquist E, LaHaye S, Nagel C, Lincoln J) Front Cardiovasc Med 2019;6:164 PMID: 31799279 PMCID: PMC6874012 12/05/2019    
  • miR-486 is modulated by stretch and increases ventricular growth. (Lange S, Banerjee I, Carrion K, Serrano R, Habich L, Kameny R, Lengenfelder L, Dalton N, Meili R, Börgeson E, Peterson K, Ricci M, Lincoln J, Ghassemian M, Fineman J, Del Álamo JC, Nigam V) JCI Insight 2019 09 12;4(19) PMID: 31513548 PMCID: PMC6795397 SCOPUS ID: 2-s2.0-85072970284 09/13/2019       2 Citations
  • Molecular and cellular developments in heart valve development and disease (Anstine LJ, Baker AS, Lincoln J) Advances in Heart Valve Biomechanics: Valvular Physiology, Mechanobiology, and Bioengineering 8 April 2019:207-239 SCOPUS ID: 2-s2.0-85084805169 04/08/2019    
  • MG 53 Protein Protects Aortic Valve Interstitial Cells From Membrane Injury and Fibrocalcific Remodeling. (Adesanya TMA, Russell M, Park KH, Zhou X, Sermersheim MA, Gumpper K, Koenig SN, Tan T, Whitson BA, Janssen PML, Lincoln J, Zhu H, Ma J) J Am Heart Assoc 2019 02 19;8(4):e009960 PMID: 30741589 PMCID: PMC6405656 SCOPUS ID: 2-s2.0-85061251064 02/12/2019       6 Citations
  • The Genetic Regulation of Aortic Valve Development and Calcific Disease. (Menon V, Lincoln J) Front Cardiovasc Med 2018;5:162 PMID: 30460247 PMCID: PMC6232166 11/22/2018    
  • Dynamic Expression Profiles of Sox9 in Embryonic, Post Natal, and Adult Heart Valve Cell Populations. (Gallina D, Lincoln J) Anat Rec (Hoboken) 2019 01;302(1):108-116 PMID: 30412364 PMCID: PMC6312467 SCOPUS ID: 2-s2.0-85056317523 11/10/2018       3 Citations
  • Corrigendum to "Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease" [J. Mol. Cell. Cardiol. 60 (2013) 27-35]. (Bosse K, Hans CP, Zhao N, Koenig SN, Huang N, Guggilam A, LaHaye S, Tao G, Lucchesi PA, Lincoln J, Lilly B, Garg V) J Mol Cell Cardiol 2018 08;121:307 PMID: 29778253 SCOPUS ID: 2-s2.0-85046864667 05/21/2018    
  • Postnatal and Adult Aortic Heart Valves Have Distinctive Transcriptional Profiles Associated With Valve Tissue Growth and Maintenance Respectively. (Nordquist E, LaHaye S, Nagel C, Lincoln J) Front Cardiovasc Med 2018;5:30 PMID: 29740591 PMCID: PMC5928323 05/10/2018    
  • Calcific Aortic Valve Disease: a Developmental Biology Perspective. (Dutta P, Lincoln J) Curr Cardiol Rep 2018 03 08;20(4):21 PMID: 29520694 PMCID: PMC5842494 SCOPUS ID: 2-s2.0-85043328653 03/10/2018       18 Citations
  • Macrophage Transitions in Heart Valve Development and Myxomatous Valve Disease. (Hulin A, Anstine LJ, Kim AJ, Potter SJ, DeFalco T, Lincoln J, Yutzey KE) Arterioscler Thromb Vasc Biol 2018 03;38(3):636-644 PMID: 29348122 PMCID: PMC5823761 SCOPUS ID: 2-s2.0-85047924908 01/20/2018       19 Citations
  • Contribution of Extra-Cardiac Cells in Murine Heart Valves is Age-Dependent. (Anstine LJ, Horne TE, Horwitz EM, Lincoln J) J Am Heart Assoc 2017 Oct 20;6(10) PMID: 29054843 PMCID: PMC5721893 SCOPUS ID: 2-s2.0-85032224175 10/22/2017       11 Citations
  • HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development. (Laurent F, Girdziusaite A, Gamart J, Barozzi I, Osterwalder M, Akiyama JA, Lincoln J, Lopez-Rios J, Visel A, Zuniga A, Zeller R) Cell Rep 2017 05 23;19(8):1602-1613 PMID: 28538179 PMCID: PMC5523860 SCOPUS ID: 2-s2.0-85019679275 05/26/2017       21 Citations
  • Genetic basis of aortic valvular disease. (Koenig SN, Lincoln J, Garg V) Curr Opin Cardiol 2017 May;32(3):239-245 PMID: 28157139 PMCID: PMC5783785 SCOPUS ID: 2-s2.0-85011672989 02/06/2017       15 Citations
  • Growth and maturation of heart valves leads to changes in endothelial cell distribution, impaired function, decreased metabolism and reduced cell proliferation. (Anstine LJ, Bobba C, Ghadiali S, Lincoln J) J Mol Cell Cardiol 2016 Nov;100:72-82 PMID: 27756541 PMCID: PMC5154817 SCOPUS ID: 2-s2.0-84992222005 10/25/2016       15 Citations
  • Rbfox2 function in RNA metabolism is impaired in hypoplastic left heart syndrome patient hearts. (Verma SK, Deshmukh V, Nutter CA, Jaworski E, Jin W, Wadhwa L, Abata J, Ricci M, Lincoln J, Martin JF, Yeo GW, Kuyumcu-Martinez MN) Sci Rep 2016 08 03;6:30896 PMID: 27485310 PMCID: PMC4971515 SCOPUS ID: 2-s2.0-84981341832 08/04/2016       17 Citations
  • The cardiac matrix revolution: Post-translational modification of Scleraxis. (Lincoln J) J Mol Cell Cardiol 2016 04;93:106-7 PMID: 26964702 SCOPUS ID: 2-s2.0-84960337303 03/12/2016       2 Citations
  • Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification. (Huk DJ, Austin BF, Horne TE, Hinton RB, Ray WC, Heistad DD, Lincoln J) Arterioscler Thromb Vasc Biol 2016 Feb;36(2):328-38 PMID: 26634652 PMCID: PMC4732913 SCOPUS ID: 2-s2.0-84955616856 12/05/2015       33 Citations
  • Dynamic Heterogeneity of the Heart Valve Interstitial Cell Population in Mitral Valve Health and Disease. (Horne TE, VandeKopple M, Sauls K, Koenig SN, Anstine LJ, Garg V, Norris RA, Lincoln J) J Cardiovasc Dev Dis 2015 Sep;2(3):214-232 PMID: 26527432 PMCID: PMC4625550 11/04/2015    
  • Hemodynamic Characterization of a Mouse Model for Investigating the Cellular and Molecular Mechanisms of Neotissue Formation in Tissue-Engineered Heart Valves. (James IA, Yi T, Tara S, Best CA, Stuber AJ, Shah KV, Austin BF, Sugiura T, Lee YU, Lincoln J, Trask AJ, Shinoka T, Breuer CK) Tissue Eng Part C Methods 2015 Sep;21(9):987-94 PMID: 25915105 PMCID: PMC4553370 SCOPUS ID: 2-s2.0-84940101539 04/29/2015       8 Citations
  • Cost-benefit analysis of robotic versus nonrobotic minimally invasive mitral valve surgery. (Hassan M, Miao Y, Lincoln J, Ricci M) Innovations (Phila) 2015 Mar-Apr;10(2):90-5 PMID: 25811708 SCOPUS ID: 2-s2.0-84930349723 03/27/2015       6 Citations
  • To 'cell' and back! (Lincoln J) J Mol Cell Cardiol 2015 Apr;81:94-5 PMID: 25681583 SCOPUS ID: 2-s2.0-84922998621 02/15/2015    
  • A microfluidic shear device that accommodates parallel high and low stress zones within the same culturing chamber. (Zhang X, Huk DJ, Wang Q, Lincoln J, Zhao Y) Biomicrofluidics 2014 Sep;8(5):054106 PMID: 25332743 PMCID: PMC4189595 10/22/2014    
  • Isolation of murine valve endothelial cells. (Miller LJ, Lincoln J) J Vis Exp 2014 Aug 21(90) PMID: 25177896 PMCID: PMC4758760 09/02/2014    
  • Etiology of valvular heart disease-genetic and developmental origins. (Lincoln J, Garg V) Circ J 2014;78(8):1801-7 PMID: 24998280 PMCID: PMC7313685 SCOPUS ID: 2-s2.0-84904965491 07/08/2014       27 Citations
  • RNA-seq analysis to identify novel roles of scleraxis during embryonic mouse heart valve remodeling. (Barnette DN, VandeKopple M, Wu Y, Willoughby DA, Lincoln J) PLoS One 2014;9(7):e101425 PMID: 24983472 PMCID: PMC4077804 SCOPUS ID: 2-s2.0-84903587948 07/02/2014       7 Citations
  • Genetics of valvular heart disease. (LaHaye S, Lincoln J, Garg V) Curr Cardiol Rep 2014;16(6):487 PMID: 24743897 PMCID: PMC4531840 SCOPUS ID: 2-s2.0-84901336620 04/20/2014       38 Citations
  • Tgfβ-Smad and MAPK signaling mediate scleraxis and proteoglycan expression in heart valves. (Barnette DN, Hulin A, Ahmed AS, Colige AC, Azhar M, Lincoln J) J Mol Cell Cardiol 2013 Dec;65:137-46 PMID: 24157418 PMCID: PMC3869408 SCOPUS ID: 2-s2.0-84887141758 10/26/2013       29 Citations
  • Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease. (Bosse K, Hans CP, Zhao N, Koenig SN, Huang N, Guggilam A, LaHaye S, Tao G, Lucchesi PA, Lincoln J, Lilly B, Garg V) J Mol Cell Cardiol 2013 Jul;60:27-35 PMID: 23583836 PMCID: PMC4058883 04/16/2013    
  • Snai1 is important for avian epicardial cell transformation and motility. (Tao G, Miller LJ, Lincoln J) Dev Dyn 2013 Jun;242(6):699-708 PMID: 23553854 PMCID: PMC3668562 SCOPUS ID: 2-s2.0-84878156641 04/05/2013       6 Citations
  • Increased dietary intake of vitamin A promotes aortic valve calcification in vivo. (Huk DJ, Hammond HL, Kegechika H, Lincoln J) Arterioscler Thromb Vasc Biol 2013 Feb;33(2):285-93 PMID: 23202364 PMCID: PMC3557503 SCOPUS ID: 2-s2.0-84872978085 12/04/2012       21 Citations
  • Collagen XIV is important for growth and structural integrity of the myocardium. (Tao G, Levay AK, Peacock JD, Huk DJ, Both SN, Purcell NH, Pinto JR, Galantowicz ML, Koch M, Lucchesi PA, Birk DE, Lincoln J) J Mol Cell Cardiol 2012 Nov;53(5):626-38 PMID: 22906538 PMCID: PMC3472103 SCOPUS ID: 2-s2.0-84867404775 08/22/2012       27 Citations
  • Heart valve development, maintenance, and disease: the role of endothelial cells. (Tao G, Kotick JD, Lincoln J) Curr Top Dev Biol 2012;100:203-32 PMID: 22449845 SCOPUS ID: 2-s2.0-84858766326 03/28/2012       42 Citations
  • Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse. (Dillon LM, Williams SL, Hida A, Peacock JD, Prolla TA, Lincoln J, Moraes CT) Hum Mol Genet 2012 May 15;21(10):2288-97 PMID: 22357654 PMCID: PMC3335313 SCOPUS ID: 2-s2.0-84860445228 02/24/2012       59 Citations
  • Myocardial alternative RNA splicing and gene expression profiling in early stage hypoplastic left heart syndrome. (Ricci M, Xu Y, Hammond HL, Willoughby DA, Nathanson L, Rodriguez MM, Vatta M, Lipshultz SE, Lincoln J) PLoS One 2012;7(1):e29784 PMID: 22299024 PMCID: PMC3267718 SCOPUS ID: 2-s2.0-84863048063 02/03/2012       17 Citations
  • Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. (Peacock JD, Huk DJ, Ediriweera HN, Lincoln J) PLoS One 2011;6(10):e26769 PMID: 22046352 PMCID: PMC3202586 SCOPUS ID: 2-s2.0-80055026826 11/03/2011       26 Citations
  • FGF23 induces left ventricular hypertrophy. (Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-O M, Kusek JW, Keane MG, Wolf M) J Clin Invest 2011 Nov;121(11):4393-408 PMID: 21985788 PMCID: PMC3204831 SCOPUS ID: 2-s2.0-80555148939 10/12/2011       1193 Citations
  • Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development. (Tao G, Levay AK, Gridley T, Lincoln J) Dev Biol 2011 Nov 15;359(2):209-21 PMID: 21920357 PMCID: PMC3202673 09/17/2011    
  • Is aviation a good model to study human errors in health care? (Ricci M, Panos AL, Lincoln J, Salerno TA, Warshauer L) Am J Surg 2012 Jun;203(6):798-801 PMID: 21890103 SCOPUS ID: 2-s2.0-84861635935 09/06/2011       12 Citations
  • Molecular markers of cardiomyopathy in cyanotic pediatric heart disease (Ricci M, Lincoln J) Progress in Pediatric Cardiology August 2011;32(1):19-23 SCOPUS ID: 2-s2.0-79961171026 08/01/2011    
  • Molecular and developmental mechanisms of congenital heart valve disease. (Lincoln J, Yutzey KE) Birth Defects Res A Clin Mol Teratol 2011 Jun;91(6):526-34 PMID: 21538813 SCOPUS ID: 2-s2.0-79958124564 05/04/2011       38 Citations
  • Reduced sox9 function promotes heart valve calcification phenotypes in vivo. (Peacock JD, Levay AK, Gillaspie DB, Tao G, Lincoln J) Circ Res 2010 Mar 05;106(4):712-9 PMID: 20056916 PMCID: PMC2863131 SCOPUS ID: 2-s2.0-77949388887 01/09/2010       87 Citations
  • Temporal and spatial expression of collagens during murine atrioventricular heart valve development and maintenance. (Peacock JD, Lu Y, Koch M, Kadler KE, Lincoln J) Dev Dyn 2008 Oct;237(10):3051-8 PMID: 18816857 PMCID: PMC2579967 SCOPUS ID: 2-s2.0-54549095893 09/26/2008       45 Citations
  • Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo. (Levay AK, Peacock JD, Lu Y, Koch M, Hinton RB Jr, Kadler KE, Lincoln J) Circ Res 2008 Oct 24;103(9):948-56 PMID: 18802027 PMCID: PMC2743952 SCOPUS ID: 2-s2.0-55449128620 09/20/2008       77 Citations
  • Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development. (Lincoln J, Kist R, Scherer G, Yutzey KE) Dev Biol 2007 May 01;305(1):120-32 PMID: 17350610 PMCID: PMC1920559 SCOPUS ID: 2-s2.0-34247249338 03/14/2007       128 Citations
  • ColVa1 and ColXIa1 are required for myocardial morphogenesis and heart valve development. (Lincoln J, Florer JB, Deutsch GH, Wenstrup RJ, Yutzey KE) Dev Dyn 2006 Dec;235(12):3295-305 PMID: 17029294 SCOPUS ID: 2-s2.0-33845362872 10/10/2006       43 Citations
  • BMP and FGF regulatory pathways control cell lineage diversification of heart valve precursor cells. (Lincoln J, Alfieri CM, Yutzey KE) Dev Biol 2006 Apr 15;292(2):292-302 PMID: 16680829 SCOPUS ID: 2-s2.0-33646924001 05/09/2006       86 Citations
  • Extracellular matrix remodeling and organization in developing and diseased aortic valves. (Hinton RB Jr, Lincoln J, Deutsch GH, Osinska H, Manning PB, Benson DW, Yutzey KE) Circ Res 2006 Jun 09;98(11):1431-8 PMID: 16645142 SCOPUS ID: 2-s2.0-33745400942 04/29/2006       273 Citations
  • Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development. (Lincoln J, Lange AW, Yutzey KE) Dev Biol 2006 Jun 15;294(2):292-302 PMID: 16643886 SCOPUS ID: 2-s2.0-33745102721 04/29/2006       138 Citations
  • Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. (Lincoln J, Alfieri CM, Yutzey KE) Dev Dyn 2004 Jun;230(2):239-50 PMID: 15162503 SCOPUS ID: 2-s2.0-2442639010 05/27/2004       181 Citations
  • Characterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing haematopoietic differentiation. (Lako M, Lindsay S, Lincoln J, Cairns PM, Armstrong L, Hole N) Mech Dev 2001 May;103(1-2):49-59 PMID: 11335111 SCOPUS ID: 2-s2.0-0035018077 05/04/2001       67 Citations
  • mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells (Armstromg L, Lako M, Lincoln J, Cairns PM, Hole N) Blood 2000;96(11 PART II) SCOPUS ID: 2-s2.0-33748557231 12/01/2000    
  • Involvement of wnt genes in early haematopoiesis and identification of wnt3 as a regulator of haematopoietic commitment (Lako M, Lindsay S, Cairns PM, Lincoln J, Armstrong L, Hole N) Blood 2000;96(11 PART II) SCOPUS ID: 2-s2.0-33748556230 12/01/2000    
  • mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells. (Armstrong L, Lako M, Lincoln J, Cairns PM, Hole N) Mech Dev 2000 Oct;97(1-2):109-16 PMID: 11025212 SCOPUS ID: 2-s2.0-0342359187 10/12/2000       99 Citations
  • Last update: 01/12/2021