von Willebrand's disease diagnosis and laboratory issues. Haemophilia 2010 Jul;16 Suppl 5(0 5):67-73
Date
07/16/2010Pubmed ID
20590859Pubmed Central ID
PMC4313748DOI
10.1111/j.1365-2516.2010.02296.xScopus ID
2-s2.0-77955045227 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
In this paper, the recent developments in the diagnosis and laboratory issues of von Willebrand's disease (VWD) are presented. Dr. Castaman reviews the functional tests available for the diagnosis of VWD and their pathophysiological significance, focusing on which tests are best used in the diagnosis and classification of VWD. Dr Montgomery reviews an emerging issue that is accelerated clearance of von Willebrand factor (VWF) occurring in some variants of VWD. This phenotype can be suspected by the presence of an increased ratio between the VWF propeptide and the VWF antigen. These patients have typically a robust, but short-lived increase of FVIII and VWF after desmopressin. Dr Meschengieser reviews the determinants of bleeding after surgery in patients with VWD, emphasizing the role of bleeding history in predicting this risk.
Author List
Castaman G, Montgomery RR, Meschengieser SS, Haberichter SL, Woods AI, Lazzari MAMESH terms used to index this publication - Major topics in bold
BiomarkersBlood Coagulation Tests
Clinical Laboratory Techniques
Enzyme-Linked Immunosorbent Assay
Humans
Postoperative Hemorrhage
Predictive Value of Tests
Risk Factors
von Willebrand Diseases
von Willebrand Factor
