Molecular mechanisms underlying the memory-enhancing effects of estradiol. Horm Behav 2015 Aug;74:4-18
Date
05/12/2015Pubmed ID
25960081Pubmed Central ID
PMC4573242DOI
10.1016/j.yhbeh.2015.05.001Scopus ID
2-s2.0-84941747846 (requires institutional sign-in at Scopus site) 155 CitationsAbstract
This article is part of a Special Issue "Estradiol and cognition". Since the publication of the 1998 special issue of Hormones and Behavior on estrogens and cognition, substantial progress has been made towards understanding the molecular mechanisms through which 17β-estradiol (E2) regulates hippocampal plasticity and memory. Recent research has demonstrated that rapid effects of E2 on hippocampal cell signaling, epigenetic processes, and local protein synthesis are necessary for E2 to facilitate the consolidation of object recognition and spatial memories in ovariectomized female rodents. These effects appear to be mediated by non-classical actions of the intracellular estrogen receptors ERα and ERβ, and possibly by membrane-bound ERs such as the G-protein-coupled estrogen receptor (GPER). New findings also suggest a key role of hippocampally-synthesized E2 in regulating hippocampal memory formation. The present review discusses these findings in detail and suggests avenues for future study.
Author List
Frick KMAuthor
Karyn Frick BA,MA,PhD Professor in the Psychology department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AnimalsEpigenesis, Genetic
Estradiol
Estrogen Receptor alpha
Estrogen Receptor beta
Female
Hippocampus
Humans
Memory
Performance-Enhancing Substances
Signal Transduction
