Medical College of Wisconsin
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Macrophage Expression of Inflammatory Genes in Response to EMCV Infection. Biomolecules 2015 Aug 18;5(3):1938-54

Date

08/22/2015

Pubmed ID

26295266

Pubmed Central ID

PMC4598781

DOI

10.3390/biom5031938

Scopus ID

2-s2.0-85012042916 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

The expression and production of type 1 interferon is the classic cellular response to virus infection. In addition to this antiviral response, virus infection also stimulates the production of proinflammatory mediators. In this review, the pathways controlling the induction of inflammatory genes and the roles that these inflammatory mediators contribute to host defense against viral pathogens will be discussed. Specific focus will be on the role of the chemokine receptor CCR5, as a signaling receptor controlling the activation of pathways leading to virus-induced inflammatory gene expression.

Author List

Shaheen ZR, Corbett JA

Author

John A. Corbett PhD Chair, Professor in the Biochemistry department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Encephalomyocarditis virus
Gene Expression Regulation
Humans
Inflammation
Macrophages
RNA, Double-Stranded
Signal Transduction