The Endocannabinoid Signaling System in the CNS: A Primer. Int Rev Neurobiol 2015;125:1-47
Date
12/08/2015Pubmed ID
26638763Pubmed Central ID
PMC6813823DOI
10.1016/bs.irn.2015.10.001Scopus ID
2-s2.0-84949035273 (requires institutional sign-in at Scopus site) 120 CitationsAbstract
The purpose of this chapter is to provide an introduction to the mechanisms for the regulation of endocannabinoid signaling through CB1 cannabinoid receptors in the central nervous system. The processes involved in the synthesis and degradation of the two most well-studied endocannabinoids, 2-arachidonoylglycerol and N-arachidonylethanolamine are outlined along with information regarding the regulation of the proteins involved. Signaling mechanisms and pharmacology of the CB1 cannabinoid receptor are outlined, as is the paradigm of endocannabinoid/CB1 receptor regulation of neurotransmitter release. The reader is encouraged to appreciate the importance of the endocannabinoid/CB1 receptor signaling system in the regulation of synaptic activity in the brain.
Author List
Hillard CJAuthor
Cecilia J. Hillard PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCentral Nervous System
Endocannabinoids
Humans
Signal Transduction
