Medical College of Wisconsin
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A new key in breast cancer metastasis. Cancer Cell 2004 Nov;6(5):429-30

Date

11/16/2004

Pubmed ID

15542424

DOI

10.1016/j.ccr.2004.10.017

Scopus ID

2-s2.0-7944236603 (requires institutional sign-in at Scopus site)   38 Citations

Abstract

Unlocking the mysteries of cell metastasis, a major cause of cancer mortality, is essential in the development of novel therapies. In this issue of Cancer Cell, Li et al. (2004) identify a link between HER2 and CXCR4, two receptors previously implicated in breast cancer progression and metastasis. HER2 enhances the expression of CXCR4 by stimulating CXCR4 translation and attenuating CXCR4 degradation. Importantly, coexpression of HER2 and CXCR4 occurs in approximately 22% of human breast tumors and correlates with poor survival of breast cancer patients.

Author List

Benovic JL, Marchese A

Author

Adriano Marchese PhD Professor in the Biochemistry department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Breast Neoplasms
Cell Adhesion
Cell Movement
Humans
Models, Biological
Neoplasm Metastasis
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-akt
Receptor, ErbB-2
Receptors, CXCR4
Survival Rate
Up-Regulation