Medical College of Wisconsin
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Adriano Marchese PhD

Adriano Marchese PhD profile photo picture

Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

Member of the Cancer Center
Member of the Center for Immunology

Publications (44)

  • Proximity Labeling to Identify β-Arrestin1 Binding Partners Downstream of Ligand-Activated G Protein-Coupled Receptors. (Zhuo Y, Robleto VL, Marchese A) Int J Mol Sci 2023 Feb 07;24(4) PMID: 36834700 PMCID: PMC9967311 SCOPUS ID: 2-s2.0-85148853084 02/26/2023       5 Citations
  • G protein-coupled receptor kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by chemokine receptor CXCR4. (Zhuo Y, Crecelius JM, Marchese A) J Biol Chem 2022 Sep;298(9):102351 PMID: 35940305 PMCID: PMC9465349 SCOPUS ID: 2-s2.0-85137163299 08/09/2022       9 Citations
  • Hsp70 acts as a fine-switch that controls E3 ligase CHIP-mediated TAp63 and ΔNp63 ubiquitination and degradation. (Wu HH, Wang B, Armstrong SR, Abuetabh Y, Leng S, Roa WHY, Atfi A, Marchese A, Wilson B, Sergi C, Flores ER, Eisenstat DD, Leng RP) Nucleic Acids Res 2021 Mar 18;49(5):2740-2758 PMID: 33619536 PMCID: PMC7969027 SCOPUS ID: 2-s2.0-85103228552 02/24/2021       22 Citations
  • β-Arrestin1 and β-Arrestin2 Are Required to Support the Activity of the CXCL12/HMGB1 Heterocomplex on CXCR4. (D'Agostino G, Artinger M, Locati M, Perez L, Legler DF, Bianchi ME, Rüegg C, Thelen M, Marchese A, Rocchi MBL, Cecchinato V, Uguccioni M) Front Immunol 2020;11:550824 PMID: 33072091 PMCID: PMC7533569 SCOPUS ID: 2-s2.0-85091956339 10/20/2020       25 Citations
  • The chemokine X-factor: Structure-function analysis of the CXC motif at CXCR4 and ACKR3. (Wedemeyer MJ, Mahn SA, Getschman AE, Crawford KS, Peterson FC, Marchese A, McCorvy JD, Volkman BF) J Biol Chem 2020 Oct 02;295(40):13927-13939 PMID: 32788219 PMCID: PMC7535910 SCOPUS ID: 2-s2.0-85092681956 08/14/2020       15 Citations
  • A non-GPCR-binding partner interacts with a novel surface on β-arrestin1 to mediate GPCR signaling. (Zhuo Y, Gurevich VV, Vishnivetskiy SA, Klug CS, Marchese A) J Biol Chem 2020 Oct 09;295(41):14111-14124 PMID: 32753481 PMCID: PMC7549033 SCOPUS ID: 2-s2.0-85092803357 08/06/2020       13 Citations
  • Heterologous regulation of CXCR4 lysosomal trafficking. (Caballero A, Mahn SA, Ali MS, Rogers MR, Marchese A) J Biol Chem 2019 May 17;294(20):8023-8036 PMID: 30936203 PMCID: PMC6527173 SCOPUS ID: 2-s2.0-85066114226 04/03/2019       19 Citations
  • Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation. (Boyle KA, Van Wickle J, Hill RB, Marchese A, Kalyanaraman B, Dwinell MB) J Biol Chem 2018 Sep 21;293(38):14891-14904 PMID: 30087121 PMCID: PMC6153299 SCOPUS ID: 2-s2.0-85054023214 08/09/2018       116 Citations
  • Endocytosis is required for CXC chemokine receptor type 4 (CXCR4)-mediated Akt activation and antiapoptotic signaling. (English EJ, Mahn SA, Marchese A) J Biol Chem 2018 Jul 20;293(29):11470-11480 PMID: 29899118 PMCID: PMC6065176 SCOPUS ID: 2-s2.0-85050381858 06/15/2018       37 Citations
  • Detecting Cell Surface Expression of the G Protein-Coupled Receptor CXCR4. (Nevins AM, Marchese A) Methods Mol Biol 2018;1722:151-164 PMID: 29264804 PMCID: PMC6345166 SCOPUS ID: 2-s2.0-85038862440 12/22/2017       7 Citations
  • β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4. (Alekhina O, Marchese A) J Biol Chem 2016 Dec 09;291(50):26083-26097 PMID: 27789711 PMCID: PMC5207078 SCOPUS ID: 2-s2.0-85002567012 10/30/2016       30 Citations
  • Monitoring Chemokine Receptor Trafficking by Confocal Immunofluorescence Microscopy. (Marchese A) Methods Enzymol 2016;570:281-92 PMID: 26921951 PMCID: PMC5201001 SCOPUS ID: 2-s2.0-84959135724 02/29/2016       6 Citations
  • Regulation of GPCR Trafficking by Ubiquitin. (Kennedy JE, Marchese A) Prog Mol Biol Transl Sci 2015;132:15-38 PMID: 26055053 PMCID: PMC4699176 SCOPUS ID: 2-s2.0-84942193272 06/10/2015       47 Citations
  • The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR. (Verma R, Marchese A) J Biol Chem 2015 Mar 13;290(11):6810-24 PMID: 25605718 PMCID: PMC4358107 SCOPUS ID: 2-s2.0-84924943410 01/22/2015       24 Citations
  • The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. (Holleman J, Marchese A) Mol Biol Cell 2014 Jun 15;25(12):1892-904 PMID: 24790097 PMCID: PMC4055268 SCOPUS ID: 2-s2.0-84902668477 05/03/2014       42 Citations
  • Endocytic trafficking of chemokine receptors. (Marchese A) Curr Opin Cell Biol 2014 Apr;27:72-7 PMID: 24680433 PMCID: PMC4268779 SCOPUS ID: 2-s2.0-84890235263 04/01/2014       84 Citations
  • Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification. (Tripathi A, Saini V, Marchese A, Volkman BF, Tang WJ, Majetschak M) Biochemistry 2013 Jun 18;52(24):4184-92 PMID: 23697661 PMCID: PMC4113718 SCOPUS ID: 2-s2.0-84879247089 05/24/2013       22 Citations
  • Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling. (Marchese A, Trejo J) Cell Signal 2013 Mar;25(3):707-16 PMID: 23201781 PMCID: PMC3593103 SCOPUS ID: 2-s2.0-84872551413 12/04/2012       72 Citations
  • AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway. (Dores MR, Paing MM, Lin H, Montagne WA, Marchese A, Trejo J) Mol Biol Cell 2012 Sep;23(18):3612-23 PMID: 22833563 PMCID: PMC3442409 SCOPUS ID: 2-s2.0-84866355290 07/27/2012       48 Citations
  • Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. (Malik R, Soh UJ, Trejo J, Marchese A) J Biol Chem 2012 Mar 16;287(12):9013-27 PMID: 22275353 PMCID: PMC3308791 SCOPUS ID: 2-s2.0-84858609378 01/26/2012       43 Citations
  • Structural determinants of ubiquitin-CXC chemokine receptor 4 interaction. (Saini V, Marchese A, Tang WJ, Majetschak M) J Biol Chem 2011 Dec 23;286(51):44145-44152 PMID: 22039044 PMCID: PMC3243501 SCOPUS ID: 2-s2.0-83755162544 11/01/2011       39 Citations
  • The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactions. (Saini V, Staren DM, Ziarek JJ, Nashaat ZN, Campbell EM, Volkman BF, Marchese A, Majetschak M) J Biol Chem 2011 Sep 23;286(38):33466-77 PMID: 21757744 PMCID: PMC3190899 SCOPUS ID: 2-s2.0-80052987287 07/16/2011       86 Citations
  • Ubiquitination of GPCRs. (Caballero A, Marchese A) Methods Mol Biol 2011;746:251-9 PMID: 21607861 PMCID: PMC4699430 SCOPUS ID: 2-s2.0-80052791836 05/25/2011       5 Citations
  • Ubiquitin receptor binding and signaling in primary human leukocytes. (Saini V, Romero J, Marchese A, Majetschak M) Commun Integr Biol 2010 Nov;3(6):608-10 PMID: 21331255 PMCID: PMC3038079 02/19/2011    
  • Small ubiquitin-like modifier modification of arrestin-3 regulates receptor trafficking. (Wyatt D, Malik R, Vesecky AC, Marchese A) J Biol Chem 2011 Feb 04;286(5):3884-93 PMID: 21118812 PMCID: PMC3030389 SCOPUS ID: 2-s2.0-79952777210 12/02/2010       43 Citations
  • Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4. (Malik R, Marchese A) Mol Biol Cell 2010 Jul 15;21(14):2529-41 PMID: 20505072 PMCID: PMC2903679 SCOPUS ID: 2-s2.0-77954626403 05/28/2010       82 Citations
  • CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin. (Saini V, Marchese A, Majetschak M) J Biol Chem 2010 May 14;285(20):15566-15576 PMID: 20228059 PMCID: PMC2865327 SCOPUS ID: 2-s2.0-77952014394 03/17/2010       149 Citations
  • Ubiquitination of chemokine receptors. (Marchese A) Methods Enzymol 2009;460:413-22 PMID: 19446738 PMCID: PMC4445356 SCOPUS ID: 2-s2.0-65549095888 05/19/2009       14 Citations
  • Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes. (Hislop JN, Henry AG, Marchese A, von Zastrow M) J Biol Chem 2009 Jul 17;284(29):19361-70 PMID: 19433584 PMCID: PMC2740561 SCOPUS ID: 2-s2.0-67749127754 05/13/2009       76 Citations
  • The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. (Bhandari D, Robia SL, Marchese A) Mol Biol Cell 2009 Mar;20(5):1324-39 PMID: 19116316 PMCID: PMC2649280 SCOPUS ID: 2-s2.0-65249115360 01/01/2009       77 Citations
  • Cross-talk between Notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches (Cancer Research (July 1, 2008) 68 (5226-5235)) (Rizzo P, Miao H, D'Souza G, Osipo C, Song LL, Yun J, Zhao H, Mascarenhas J, Wyatt D, Antico G, Hao L, Yao K, Rajan P, Hicks C, Siziopikou K, Selvaggi S, Bashir A, Bhandari D, Marchese A, Lendahl U, Qin JZ, Tonetti DA, Albain K, Nickoloff BJ, Miele L) Cancer Research 1 September 2008;68(17):7246 SCOPUS ID: 2-s2.0-54749147146 09/01/2008       1 Citation
  • Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. (Rizzo P, Miao H, D'Souza G, Osipo C, Song LL, Yun J, Zhao H, Mascarenhas J, Wyatt D, Antico G, Hao L, Yao K, Rajan P, Hicks C, Siziopikou K, Selvaggi S, Bashir A, Bhandari D, Marchese A, Lendahl U, Qin JZ, Tonetti DA, Albain K, Nickoloff BJ, Miele L) Cancer Res 2008 Jul 01;68(13):5226-35 PMID: 18593923 PMCID: PMC4445363 SCOPUS ID: 2-s2.0-48549103124 07/03/2008       310 Citations
  • G protein-coupled receptor sorting to endosomes and lysosomes. (Marchese A, Paing MM, Temple BR, Trejo J) Annu Rev Pharmacol Toxicol 2008;48:601-29 PMID: 17995450 PMCID: PMC2869288 SCOPUS ID: 2-s2.0-41149154050 11/13/2007       380 Citations
  • Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. (Bhandari D, Trejo J, Benovic JL, Marchese A) J Biol Chem 2007 Dec 21;282(51):36971-9 PMID: 17947233 SCOPUS ID: 2-s2.0-37549035071 10/20/2007       176 Citations
  • Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1. (Wolfe BL, Marchese A, Trejo J) J Cell Biol 2007 Jun 04;177(5):905-16 PMID: 17535965 PMCID: PMC2064289 SCOPUS ID: 2-s2.0-34249905192 05/31/2007       90 Citations
  • CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4. (Slagsvold T, Marchese A, Brech A, Stenmark H) EMBO J 2006 Aug 23;25(16):3738-49 PMID: 16888620 PMCID: PMC1553197 SCOPUS ID: 2-s2.0-33748041667 08/05/2006       61 Citations
  • Assessment of degradation and ubiquitination of CXCR4, a GPCR regulated by EGFR family members. (Marchese A) Methods Mol Biol 2006;327:139-45 PMID: 16780218 SCOPUS ID: 2-s2.0-33745969459 06/20/2006       8 Citations
  • A new key in breast cancer metastasis. (Benovic JL, Marchese A) Cancer Cell 2004 Nov;6(5):429-30 PMID: 15542424 SCOPUS ID: 2-s2.0-7944236603 11/16/2004       38 Citations
  • Ubiquitination of G-protein-coupled receptors. (Marchese A, Benovic JL) Methods Mol Biol 2004;259:299-305 PMID: 15250500 SCOPUS ID: 2-s2.0-4043140225 07/15/2004       15 Citations
  • The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. (Marchese A, Raiborg C, Santini F, Keen JH, Stenmark H, Benovic JL) Dev Cell 2003 Nov;5(5):709-22 PMID: 14602072 SCOPUS ID: 2-s2.0-0242362743 11/07/2003       334 Citations
  • The ins and outs of G protein-coupled receptor trafficking. (Marchese A, Chen C, Kim YM, Benovic JL) Trends Biochem Sci 2003 Jul;28(7):369-76 PMID: 12878004 SCOPUS ID: 2-s2.0-0038487327 07/25/2003       178 Citations
  • The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. (Vecchione A, Marchese A, Henry P, Rotin D, Morrione A) Mol Cell Biol 2003 May;23(9):3363-72 PMID: 12697834 PMCID: PMC153198 SCOPUS ID: 2-s2.0-0345381737 04/17/2003       220 Citations
  • Novel orphan g protein-coupled receptors (O'Dowd BF, Marchese A, Lee D, Nguyen T, George SR) Proceedings of the Western Pharmacology Society 1999;42:135 SCOPUS ID: 2-s2.0-33748199571 12/01/1999    
  • Discovery, cloning, and characterization of a novel human G protein-coupled receptor genes (Kolakqwsk LF, Casares J, Marchese A, Johnson MP, Nguyen T, Lynch KR, George SR, O'Dowd B) FASEB Journal 1997;11(9) SCOPUS ID: 2-s2.0-33750258222 12/01/1997    
    • Last update: 10/07/2023