Rho signaling and mechanical control of vascular development. Curr Opin Hematol 2008 May;15(3):228-34
Date
04/09/2008Pubmed ID
18391790DOI
10.1097/MOH.0b013e3282fa7445Scopus ID
2-s2.0-41949104623 (requires institutional sign-in at Scopus site) 56 CitationsAbstract
PURPOSE OF REVIEW: To discuss how mechanical cues and Rho signaling contribute to control of vascular development and hematopoiesis.
RECENT FINDINGS: Rho guanine trinucleotide phosphatases are ubiquitious regulators of cytoskeletal structure and tension generation. Recent work shows that Rho-dependent mechanical interactions between cells and extracellular matrix regulate cell fate switching in capillary endothelial cells and megakaryocytes in vitro, as well as angiogenesis, vascular permeability, leukocyte migration and platelet formation in vivo. Signaling pathways that link integrins and tension-dependent changes in cytoskeletal structure to Rho have also begun to be delineated.
SUMMARY: Mechanical force generation by cells and simultaneous sensing of these physical forces play critical roles in vascular development by estimating whether individual cells will grow, differentiate, move or undergo apoptosis in the local tissue microenvironment. Future work in the vascular field therefore needs to incorporate physical control mechanisms into existing biochemical concepts of cell and tissue regulation.
Author List
Mammoto A, Mammoto T, Ingber DEAuthors
Akiko Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of WisconsinTadanori Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Biomechanical PhenomenaCytoskeleton
Endothelium, Vascular
Hematopoiesis
Humans
Neovascularization, Physiologic
Rho Factor
Signal Transduction
rho GTP-Binding Proteins
