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Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Use with Positive Blood Cultures: Methodology, Performance, and Optimization. J Clin Microbiol 2017 Dec;55(12):3328-3338

Date

09/01/2017

Pubmed ID

28855303

Pubmed Central ID

PMC5703799

DOI

10.1128/JCM.00868-17

Scopus ID

2-s2.0-85036667185 (requires institutional sign-in at Scopus site)   94 Citations

Abstract

Early initiation of effective antibiotics for septic patients is essential for patient survival. Matrix-assisted desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has revolutionized clinical microbiology for isolate identification and has the possibility to impact how blood culture testing is performed. This review discusses the various uses of MALDI-TOF MS for the identification and susceptibility testing of positive blood cultures, the performance of these methods, and the outcomes involved with its implementation.

Author List

Faron ML, Buchan BW, Ledeboer NA

Authors

Blake W. Buchan PhD Professor in the Pathology department at Medical College of Wisconsin
Nathan A. Ledeboer PhD Chief, Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Bacteria
Blood Culture
Humans
Microbial Sensitivity Tests
Sepsis
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization