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Medical College of Wisconsin

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Blake W. Buchan PhD

Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Pediatric Pathology

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Publications (87)

A Multicenter Clinical Study To Demonstrate the Diagnostic Accuracy of the GenMark Dx ePlex Blood Culture Identification Gram-Negative Panel. (Wolk DM, Young S, Whitfield NN, Reid JL, Thornberg A, Carroll KC, Buchan BW, Davis TE, Salimnia H) J Clin Microbiol 2021 Aug 18;59(9):e0248420 PMID: 34232066 PMCID: PMC8373019 SCOPUS ID: 2-s2.0-85113721106 07/08/2021 8 Citations

Severe Acute Respiratory Syndrome Coronavirus 2: The Emergence of Important Genetic Variants and Testing Options for Clinical Laboratories (Buchan BW, Yao JD) Clinical Microbiology Newsletter 1 June 2021;43(11):89-96 SCOPUS ID: 2-s2.0-85106928950 06/01/2021 4 Citations

Severe Acute Respiratory Syndrome Coronavirus 2: The Emergence of Important Genetic Variants and Testing Options for Clinical Laboratories. (Buchan BW, Yao JD) Clin Microbiol Newsl 2021 Jun 01;43(11):89-96 PMID: 34035555 PMCID: PMC8138692 SCOPUS ID: 2-s2.0-85106928950 05/27/2021 4 Citations

Surveillance cultures following a regional outbreak of carbapenem-resistant Acinetobacter baumannii. (Rivera F, Reeme A, Graham MB, Buchan BW, Ledeboer NA, Valley AM, Munoz-Price LS) Infect Control Hosp Epidemiol 2022 Apr;43(4):454-460 PMID: 33985611 SCOPUS ID: 2-s2.0-85105848855 05/15/2021 1 Citation

Evaluation of a High-Definition PCR Assay for the Detection of SARS-CoV-2 in Extracted and Nonextracted Respiratory Specimens Collected in Various Transport Media. (Buchan BW, Gerstbrein D, Cruz A, Hoff J, Sievert E, Ledeboer NA, Faron ML) Am J Clin Pathol 2021 Jun 17;156(1):24-33 PMID: 33940605 PMCID: PMC8135719 SCOPUS ID: 2-s2.0-85108387082 05/04/2021

Bronchoalveolar lavage-based COVID-19 testing in patients with cancer. (Abid MB, Chhabra S, Buchan B, Graham MB, Abedin S, Thapa B, D'Souza A, George B, Hamadani M) Hematol Oncol Stem Cell Ther 2021 Mar;14(1):65-70 PMID: 33058787 PMCID: PMC7543702 SCOPUS ID: 2-s2.0-85092735525 10/16/2020 15 Citations

Racial Disparities in Incidence and Outcomes Among Patients With COVID-19. (Muñoz-Price LS, Nattinger AB, Rivera F, Hanson R, Gmehlin CG, Perez A, Singh S, Buchan BW, Ledeboer NA, Pezzin LE) JAMA Netw Open 2020 Sep 01;3(9):e2021892 PMID: 32975575 PMCID: PMC7519420 SCOPUS ID: 2-s2.0-85091807867 09/26/2020 269 Citations

Impact of an Antimicrobial Stewardship Program Pharmacist During Microbiology Rounds. (Sapozhnikov J, Huang A, Revolinski S, Ledeboer NA, Buchan BW) Am J Clin Pathol 2021 Feb 11;155(3):455-460 PMID: 32949141 SCOPUS ID: 2-s2.0-85102099001 09/20/2020 3 Citations

Toxigenic Clostridioides difficile colonization as a risk factor for development of C. difficile infection in solid-organ transplant patients. (Keegan J, Buchan BW, Ledeboer NA, Zhou Z, Hong JC, Graham MB, Munoz-Price LS) Infect Control Hosp Epidemiol 2021 Mar;42(3):287-291 PMID: 32933595 SCOPUS ID: 2-s2.0-85092160301 09/17/2020 2 Citations

Direct detection of intact Klebsiella pneumoniae carbapenemase variants from cell lysates: Identification, characterization and clinical implications (McGee WM, Faron ML, Neil JR, Kronewitter SR, Buchan BW, Ledeboer NA, Stephenson JL) Clinical Mass Spectrometry August 2020;17:12-21 SCOPUS ID: 2-s2.0-85089093667 08/01/2020 3 Citations

Distribution of SARS-CoV-2 PCR Cycle Threshold Values Provide Practical Insight Into Overall and Target-Specific Sensitivity Among Symptomatic Patients. (Buchan BW, Hoff JS, Gmehlin CG, Perez A, Faron ML, Munoz-Price LS, Ledeboer NA) Am J Clin Pathol 2020 Sep 08;154(4):479-485 PMID: 32687186 PMCID: PMC7454307 SCOPUS ID: 2-s2.0-85091263722 07/21/2020 49 Citations

Direct detection of intact Klebsiella pneumoniae carbapenemase variants from cell lysates: Identification, characterization and clinical implications. (McGee WM, Faron ML, Neil JR, Kronewitter SR, Buchan BW, Ledeboer NA, Stephenson JL Jr) Clin Mass Spectrom 2020 Aug;17:12-21 PMID: 34820520 PMCID: PMC8600995 SCOPUS ID: 2-s2.0-85089093667 07/18/2020 3 Citations

Responding to the Challenges of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Perspectives from the Association for Molecular Pathology Infectious Disease Subdivision Leadership. (Nolte FS, Babady NE, Buchan BW, Capraro GA, Graf EH, Leber AL, McElvania E, Yao JDC) J Mol Diagn 2020 Aug;22(8):968-974 PMID: 32565306 PMCID: PMC7303040 SCOPUS ID: 2-s2.0-85086787830 06/23/2020 9 Citations

Practical Comparison of the BioFire FilmArray Pneumonia Panel to Routine Diagnostic Methods and Potential Impact on Antimicrobial Stewardship in Adult Hospitalized Patients with Lower Respiratory Tract Infections. (Buchan BW, Windham S, Balada-Llasat JM, Leber A, Harrington A, Relich R, Murphy C, Dien Bard J, Naccache S, Ronen S, Hopp A, Mahmutoglu D, Faron ML, Ledeboer NA, Carroll A, Stone H, Akerele O, Everhart K, Bonwit A, Kwong C, Buckner R, Warren D, Fowler R, Chandrasekaran S, Huse H, Campeau S, Humphries R, Graue C, Huang A) J Clin Microbiol 2020 Jun 24;58(7) PMID: 32350045 PMCID: PMC7315039 SCOPUS ID: 2-s2.0-85086931042 05/01/2020 125 Citations

Multicenter Evaluation of the BioFire FilmArray Pneumonia/Pneumonia Plus Panel for Detection and Quantification of Agents of Lower Respiratory Tract Infection. (Murphy CN, Fowler R, Balada-Llasat JM, Carroll A, Stone H, Akerele O, Buchan B, Windham S, Hopp A, Ronen S, Relich RF, Buckner R, Warren DA, Humphries R, Campeau S, Huse H, Chandrasekaran S, Leber A, Everhart K, Harrington A, Kwong C, Bonwit A, Dien Bard J, Naccache S, Zimmerman C, Jones B, Rindlisbacher C, Buccambuso M, Clark A, Rogatcheva M, Graue C, Bourzac KM) J Clin Microbiol 2020 Jun 24;58(7) PMID: 32350043 PMCID: PMC7315029 SCOPUS ID: 2-s2.0-85086932092 05/01/2020 127 Citations

Evaluation of the WASPLab Segregation Software To Automatically Analyze Urine Cultures Using Routine Blood and MacConkey Agars. (Faron ML, Buchan BW, Relich RF, Clark J, Ledeboer NA) J Clin Microbiol 2020 Mar 25;58(4) PMID: 31941690 PMCID: PMC7098764 SCOPUS ID: 2-s2.0-85082542587 01/17/2020 19 Citations

Association Between Environmental Factors and Toxigenic Clostridioides difficile Carriage at Hospital Admission. (Muñoz-Price LS, Hanson R, Singh S, Nattinger AB, Penlesky A, Buchan BW, Ledeboer NA, Beyer K, Namin S, Zhou Y, Pezzin LE) JAMA Netw Open 2020 Jan 03;3(1):e1919132 PMID: 31922563 PMCID: PMC6991319 SCOPUS ID: 2-s2.0-85077730785 01/11/2020 7 Citations

How frequently should sink drains be disinfected? (Ramos-Castaneda JA, Faron ML, Hyke J, Bell-Key D, Buchan BW, Nanchal R, Pintar P, Graham MB, Huerta S, Munoz-Price LS) Infect Control Hosp Epidemiol 2020 Mar;41(3):358-360 PMID: 31918767 SCOPUS ID: 2-s2.0-85077885913 01/11/2020 4 Citations

A Multicenter Study of the Revogene C. difficile System for Detection of the Toxin B Gene from Unformed Stool Specimens. (Mashock MJ, Faron ML, Carroll KC, Dang C, Lewis S, Salimnia H, Lephart P, Loo VG, Schmitt BH, Young S, Buchan BW, Ledeboer NA) J Clin Microbiol 2020 Jan 28;58(2) PMID: 31776191 PMCID: PMC6989061 SCOPUS ID: 2-s2.0-85078685786 11/30/2019 3 Citations

Evaluation of WASPLab Software To Automatically Read chromID CPS Elite Agar for Reporting of Urine Cultures. (Faron ML, Buchan BW, Samra H, Ledeboer NA) J Clin Microbiol 2019 Dec 23;58(1) PMID: 31694967 PMCID: PMC6935927 SCOPUS ID: 2-s2.0-85077223772 11/07/2019 24 Citations

Multicenter Study Demonstrates Standardization Requirements for Mold Identification by MALDI-TOF MS. (Lau AF, Walchak RC, Miller HB, Slechta ES, Kamboj K, Riebe K, Robertson AE, Gilbreath JJ, Mitchell KF, Wallace MA, Bryson AL, Balada-Llasat JM, Bulman A, Buchan BW, Burnham CD, Butler-Wu S, Desai U, Doern CD, Hanson KE, Henderson CM, Kostrzewa M, Ledeboer NA, Maier T, Pancholi P, Schuetz AN, Shi G, Wengenack NL, Zhang SX, Zelazny AM, Frank KM) Front Microbiol 2019;10:2098 PMID: 31616388 PMCID: PMC6764242 SCOPUS ID: 2-s2.0-85072975776 10/17/2019 36 Citations

Evaluation of a Novel Multiplex High-Definition PCR Assay for Detection of Tick-Borne Pathogens in Whole-Blood Specimens. (Buchan BW, Jobe DA, Mashock M, Gerstbrein D, Faron ML, Ledeboer NA, Callister SM) J Clin Microbiol 2019 Nov;57(11) PMID: 31484700 PMCID: PMC6812998 SCOPUS ID: 2-s2.0-85074119071 09/06/2019 20 Citations

Patient-to-Patient Transmission of Klebsiella pneumoniae Carbapenemase Variants with Reduced Ceftazidime-Avibactam Susceptibility. (Munoz-Price LS, Reeme AE, Buchan BW, Mettus RT, Mustapha MM, Van Tyne D, Shields RK, Doi Y) Antimicrob Agents Chemother 2019 Oct;63(10) PMID: 31332070 PMCID: PMC6761506 SCOPUS ID: 2-s2.0-85072570497 07/25/2019 17 Citations

Use of a cohorting-unit and systematic surveillance cultures to control a Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae outbreak. (Reeme AE, Bowler SL, Buchan BW, Graham MB, Behrens E, Singh S, Hong JC, Arvan J, Hyke JW, Palen L, Savage S, Seliger H, Huerta S, Ledeboer NA, Kotay S, Mathers AJ, Cooper VS, Mustapha MM, Mettus RT, Doi Y, Munoz-Price LS) Infect Control Hosp Epidemiol 2019 Jul;40(7):767-773 PMID: 31084655 SCOPUS ID: 2-s2.0-85065637314 05/16/2019 5 Citations

Effectiveness of a hydrogen peroxide foam against bleach for the disinfection of sink drains. (Buchan BW, Arvan JA, Graham MB, Tarima S, Faron ML, Nanchal R, Munoz-Price LS) Infect Control Hosp Epidemiol 2019 Jun;40(6):724-726 PMID: 30992089 SCOPUS ID: 2-s2.0-85065244760 04/18/2019 14 Citations

Campylobacter culture fails to correctly detect Campylobacter in 30% of positive patient stool specimens compared to non-cultural methods. (Buss JE, Cresse M, Doyle S, Buchan BW, Craft DW, Young S) Eur J Clin Microbiol Infect Dis 2019 Jun;38(6):1087-1093 PMID: 30783889 PMCID: PMC6520473 SCOPUS ID: 2-s2.0-85066051911 02/21/2019 36 Citations

Immediate impact of healthcare-facility-onset Clostridium difficile laboratory-identified events reporting methodology change on standardized infection ratios. (Figueroa Castro CE, Palen L, Johnson C, Graham MB, Letzer D, Ledeboer N, Buchan B, Block T, Seliger H, Singh S, Behrens E, Huerta S, Munoz-Price LS) Infect Control Hosp Epidemiol 2018 Dec;39(12):1484-1486 PMID: 30348236 SCOPUS ID: 2-s2.0-85055537816 10/24/2018 1 Citation

The relevance of sink proximity to toilets on the detection of Klebsiella pneumoniae carbapenemase inside sink drains. (Buchan BW, Graham MB, Lindmair-Snell J, Arvan J, Ledeboer NA, Nanchal R, Munoz-Price LS) Am J Infect Control 2019 Jan;47(1):98-100 PMID: 30172608 SCOPUS ID: 2-s2.0-85052737901 09/03/2018 17 Citations

Avoiding the Headache: Laboratory Considerations for Implementation, Utilization, and Interpretation of Multiplex Molecular Panels for the Diagnosis of Meningitis and Encephalitis, Part II (Buchan BW) Clinical Microbiology Newsletter 1 August 2018;40(15):123-127 SCOPUS ID: 2-s2.0-85050161016 08/01/2018 1 Citation

Avoiding the Headache: Laboratory Considerations for Implementation, Utilization, and Interpretation of Multiplex Molecular Panels for the Diagnosis of Meningitis and Encephalitis, Part I (Buchan BW) Clinical Microbiology Newsletter 15 July 2018;40(14):115-121 SCOPUS ID: 2-s2.0-85049566091 07/15/2018 1 Citation

Clinical Evaluation of the iCubate iC-GPC Assay for Detection of Gram-Positive Bacteria and Resistance Markers from Positive Blood Cultures. (Granato PA, Unz MM, Widen RH, Silbert S, Young S, Heflin KL, Conover MS, Buchan BW, Ledeboer NA) J Clin Microbiol 2018 Sep;56(9) PMID: 29899000 PMCID: PMC6113461 SCOPUS ID: 2-s2.0-85052491577 06/15/2018 9 Citations

Elizabethkingia anophelis: Clinical Experience of an Academic Health System in Southeastern Wisconsin. (Figueroa Castro CE, Johnson C, Williams M, VanDerSlik A, Graham MB, Letzer D, Ledeboer N, Buchan BW, Block T, Borlaug G, Munoz-Price LS) Open Forum Infect Dis 2017;4(4):ofx251 PMID: 29308406 PMCID: PMC5751080 SCOPUS ID: 2-s2.0-85056804311 01/09/2018 28 Citations

Multicenter Evaluation of the Accelerate PhenoTest BC Kit for Rapid Identification and Phenotypic Antimicrobial Susceptibility Testing Using Morphokinetic Cellular Analysis. (Pancholi P, Carroll KC, Buchan BW, Chan RC, Dhiman N, Ford B, Granato PA, Harrington AT, Hernandez DR, Humphries RM, Jindra MR, Ledeboer NA, Miller SA, Mochon AB, Morgan MA, Patel R, Schreckenberger PC, Stamper PD, Simner PJ, Tucci NE, Zimmerman C, Wolk DM) J Clin Microbiol 2018 Apr;56(4) PMID: 29305546 PMCID: PMC5869823 SCOPUS ID: 2-s2.0-85044779516 01/07/2018 127 Citations

Effective utilization of C. difficile PCR and identification of clinicopathologic factors associated with conversion to a positive result in symptomatic patients. (Mostafa ME, Flynn T, Hartley CP, Ledeboer NA, Buchan BW) Diagn Microbiol Infect Dis 2018 Apr;90(4):307-310 PMID: 29290473 SCOPUS ID: 2-s2.0-85039550113 01/02/2018 1 Citation

Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Use with Positive Blood Cultures: Methodology, Performance, and Optimization. (Faron ML, Buchan BW, Ledeboer NA) J Clin Microbiol 2017 Dec;55(12):3328-3338 PMID: 28855303 PMCID: PMC5703799 SCOPUS ID: 2-s2.0-85036667185 09/01/2017 78 Citations

Evaluation of Copan FecalSwab as Specimen Type for Use in Xpert C. difficile Assay. (Mashock MJ, Faron ML, Buchan BW, Ledeboer NA) J Clin Microbiol 2017 Oct;55(10):3123-3129 PMID: 28794179 PMCID: PMC5625397 SCOPUS ID: 2-s2.0-85030127876 08/11/2017 8 Citations

Multicenter Evaluation of the Bruker MALDI Biotyper CA System for the Identification of Clinically Important Bacteria and Yeasts. (Wilson DA, Young S, Timm K, Novak-Weekley S, Marlowe EM, Madisen N, Lillie JL, Ledeboer NA, Smith R, Hyke J, Griego-Fullbright C, Jim P, Granato PA, Faron ML, Cumpio J, Buchan BW, Procop GW) Am J Clin Pathol 2017 Jun 01;147(6):623-631 PMID: 28505220 SCOPUS ID: 2-s2.0-85031705467 05/16/2017 22 Citations

Multicenter Evaluation of the Portrait Staph ID/R Blood Culture Panel for Rapid Identification of Staphylococci and Detection of the mecA Gene. (Denys GA, Collazo-Velez V, Young S, Daly JA, Couturier MR, Faron ML, Buchan BW, Ledeboer N) J Clin Microbiol 2017 Apr;55(4):1140-1146 PMID: 28122871 PMCID: PMC5377841 SCOPUS ID: 2-s2.0-85016173124 01/27/2017 3 Citations

Clinical Evaluation and Cost Analysis of Great Basin Shiga Toxin Direct Molecular Assay for Detection of Shiga Toxin-Producing Escherichia coli in Diarrheal Stool Specimens. (Faron ML, Ledeboer NA, Connolly J, Granato PA, Alkins BR, Dien Bard J, Daly JA, Young S, Buchan BW) J Clin Microbiol 2017 Feb;55(2):519-525 PMID: 27927919 PMCID: PMC5277522 SCOPUS ID: 2-s2.0-85011977894 12/09/2016 6 Citations

Automatic Digital Analysis of Chromogenic Media for Vancomycin-Resistant-Enterococcus Screens Using Copan WASPLab. (Faron ML, Buchan BW, Coon C, Liebregts T, van Bree A, Jansz AR, Soucy G, Korver J, Ledeboer NA) J Clin Microbiol 2016 Oct;54(10):2464-9 PMID: 27413193 PMCID: PMC5035414 SCOPUS ID: 2-s2.0-84991216241 07/15/2016 41 Citations

Treatment of Paecilomyces variotii pneumonia with posaconazole: case report and literature review. (Feldman R, Cockerham L, Buchan BW, Lu Z, Huang AM) Mycoses 2016 Dec;59(12):746-750 PMID: 27401982 SCOPUS ID: 2-s2.0-84978191719 07/13/2016 28 Citations

Multicenter Evaluation of the Solana Group A Streptococcus Assay: Comparison with Culture. (Uphoff TS, Buchan BW, Ledeboer NA, Granato PA, Daly JA, Marti TN) J Clin Microbiol 2016 Sep;54(9):2388-90 PMID: 27358464 PMCID: PMC5005512 SCOPUS ID: 2-s2.0-84983593764 07/01/2016 13 Citations

Multicenter Evaluation of Meridian Bioscience HSV 1&2 Molecular Assay for Detection of Herpes Simplex Virus 1 and 2 from Clinical Cutaneous and Mucocutaneous Specimens. (Faron ML, Ledeboer NA, Patel A, Beqa SH, Yen-Lieberman B, Kohn D, Leber AL, Mayne D, Northern WI, Buchan BW) J Clin Microbiol 2016 Aug;54(8):2008-13 PMID: 27194690 PMCID: PMC4963491 SCOPUS ID: 2-s2.0-84979502519 05/20/2016 9 Citations

Resistance Mechanisms, Epidemiology, and Approaches to Screening for Vancomycin-Resistant Enterococcus in the Health Care Setting. (Faron ML, Ledeboer NA, Buchan BW) J Clin Microbiol 2016 Oct;54(10):2436-47 PMID: 27147728 PMCID: PMC5035425 SCOPUS ID: 2-s2.0-84991208719 05/06/2016 144 Citations

Comparison of ESwab and Wound Fiber Swab Specimen Collection Devices for Use with Xpert SA Nasal Complete Assay. (Beck ET, Buchan BW, Reymann GC, Ledeboer NA) J Clin Microbiol 2016 Jul;54(7):1904-1906 PMID: 27122376 PMCID: PMC4922099 SCOPUS ID: 2-s2.0-84976345917 04/29/2016 5 Citations

Is Staphylococcal Screening and Suppression an Effective Interventional Strategy for Reduction of Surgical Site Infection? (Edmiston CE Jr, Ledeboer NA, Buchan BW, Spencer M, Seabrook GR, Leaper D) Surg Infect (Larchmt) 2016 Apr;17(2):158-66 PMID: 26836053 SCOPUS ID: 2-s2.0-84962549354 02/03/2016 17 Citations

Verification and validation of matrix-assisted laser desorption ionization time of flight mass spectrometry-based protocols (Faron ML, Buchan BW, Ledeboer NA) Molecular Microbiology: Diagnostic Principles and Practice 27 January 2016:784-796 SCOPUS ID: 2-s2.0-85102324545 01/27/2016

Automated Scoring of Chromogenic Media for Detection of Methicillin-Resistant Staphylococcus aureus by Use of WASPLab Image Analysis Software. (Faron ML, Buchan BW, Vismara C, Lacchini C, Bielli A, Gesu G, Liebregts T, van Bree A, Jansz A, Soucy G, Korver J, Ledeboer NA) J Clin Microbiol 2016 Mar;54(3):620-4 PMID: 26719443 PMCID: PMC4767952 SCOPUS ID: 2-s2.0-84959505663 01/01/2016 51 Citations

Multicenter Evaluation of MRSASelect II Chromogenic Agar for Identification of Methicillin-Resistant Staphylococcus aureus from Wound and Nasal Specimens. (Hernandez DR, Newton DW, Ledeboer NA, Buchan B, Young C, Clark AE, Connoly J, Wolk DM) J Clin Microbiol 2016 Feb;54(2):305-11 PMID: 26582836 PMCID: PMC4733205 SCOPUS ID: 2-s2.0-84956690099 11/20/2015 10 Citations

Multicenter Evaluation of the Xpert Norovirus Assay for Detection of Norovirus Genogroups I and II in Fecal Specimens. (Gonzalez MD, Langley LC, Buchan BW, Faron ML, Maier M, Templeton K, Walker K, Popowitch EB, Miller MB, Rao A, Liebert UG, Ledeboer NA, Vinjé J, Burnham CA) J Clin Microbiol 2016 Jan;54(1):142-7 PMID: 26560532 PMCID: PMC4702714 SCOPUS ID: 2-s2.0-84954319782 11/13/2015 34 Citations

Multicenter Evaluation of the Bruker MALDI Biotyper CA System for the Identification of Clinical Aerobic Gram-Negative Bacterial Isolates. (Faron ML, Buchan BW, Hyke J, Madisen N, Lillie JL, Granato PA, Wilson DA, Procop GW, Novak-Weekley S, Marlowe E, Cumpio J, Griego-Fullbright C, Kindig S, Timm K, Young S, Ledeboer NA) PLoS One 2015;10(11):e0141350 PMID: 26529504 PMCID: PMC4631355 SCOPUS ID: 2-s2.0-84951851740 11/04/2015 31 Citations

Preliminary Evaluation of the Research-Use-Only (RUO) iCubate iC-GPC Assay for Identification of Select Gram-Positive Bacteria and Their Resistance Determinants in Blood Culture Broths. (Buchan BW, Reymann GC, Granato PA, Alkins BR, Jim P, Young S) J Clin Microbiol 2015 Dec;53(12):3931-4 PMID: 26468498 PMCID: PMC4652113 SCOPUS ID: 2-s2.0-84947731492 10/16/2015 5 Citations

Comparative Evaluation of AmpliVue HSV 1+2 Assay with ELVIS Culture for Detecting Herpes Simplex Virus 1 (HSV-1) and HSV-2 in Clinical Specimens. (Granato PA, Alkins BR, Yen-Lieberman B, Greene WH, Connolly J, Buchan BW, Ledeboer NA) J Clin Microbiol 2015 Dec;53(12):3922-5 PMID: 26468497 PMCID: PMC4652092 SCOPUS ID: 2-s2.0-84947764664 10/16/2015 17 Citations

Identification of Gram-Negative Bacteria and Genetic Resistance Determinants from Positive Blood Culture Broths by Use of the Verigene Gram-Negative Blood Culture Multiplex Microarray-Based Molecular Assay. (Ledeboer NA, Lopansri BK, Dhiman N, Cavagnolo R, Carroll KC, Granato P, Thomson R Jr, Butler-Wu SM, Berger H, Samuel L, Pancholi P, Swyers L, Hansen GT, Tran NK, Polage CR, Thomson KS, Hanson ND, Winegar R, Buchan BW) J Clin Microbiol 2015 Aug;53(8):2460-72 PMID: 25994165 PMCID: PMC4508435 SCOPUS ID: 2-s2.0-84938118582 05/23/2015 124 Citations

Detection of Group A Streptococcus in Pharyngeal Swab Specimens by Use of the AmpliVue GAS Isothermal Helicase-Dependent Amplification Assay. (Faron ML, Ledeboer NA, Granato P, Daly JA, Pierce K, Pancholi P, Uphoff TS, Buchan BW) J Clin Microbiol 2015 Jul;53(7):2365-7 PMID: 25972419 PMCID: PMC4473221 SCOPUS ID: 2-s2.0-84932620912 05/15/2015 11 Citations

Multicenter evaluation of the BD max enteric bacterial panel PCR assay for rapid detection of Salmonella spp., Shigella spp., Campylobacter spp. (C. jejuni and C. coli), and Shiga toxin 1 and 2 genes. (Harrington SM, Buchan BW, Doern C, Fader R, Ferraro MJ, Pillai DR, Rychert J, Doyle L, Lainesse A, Karchmer T, Mortensen JE) J Clin Microbiol 2015 May;53(5):1639-47 PMID: 25740779 PMCID: PMC4400754 SCOPUS ID: 2-s2.0-84928036946 03/06/2015 73 Citations

Comparison of the next-generation Xpert MRSA/SA BC assay and the GeneOhm StaphSR assay to routine culture for identification of Staphylococcus aureus and methicillin-resistant S. aureus in positive-blood-culture broths. (Buchan BW, Allen S, Burnham CA, McElvania TeKippe E, Davis T, Levi M, Mayne D, Pancholi P, Relich RF, Thomson R, Ledeboer NA) J Clin Microbiol 2015 Mar;53(3):804-9 PMID: 25540397 PMCID: PMC4390651 SCOPUS ID: 2-s2.0-84923351710 12/30/2014 61 Citations

Multicenter clinical evaluation of the Xpert GBS LB assay for detection of group B Streptococcus in prenatal screening specimens. (Buchan BW, Faron ML, Fuller D, Davis TE, Mayne D, Ledeboer NA) J Clin Microbiol 2015 Feb;53(2):443-8 PMID: 25411176 PMCID: PMC4298547 SCOPUS ID: 2-s2.0-84921778191 11/21/2014 33 Citations

Emerging technologies for the clinical microbiology laboratory. (Buchan BW, Ledeboer NA) Clin Microbiol Rev 2014 Oct;27(4):783-822 PMID: 25278575 PMCID: PMC4187641 SCOPUS ID: 2-s2.0-84907798849 10/04/2014 218 Citations

Multicenter evaluation of the Quidel Lyra Direct C. difficile nucleic acid amplification assay. (Beck ET, Buchan BW, Riebe KM, Alkins BR, Pancholi P, Granato PA, Ledeboer NA) J Clin Microbiol 2014 Jun;52(6):1998-2002 PMID: 24671790 PMCID: PMC4042815 SCOPUS ID: 2-s2.0-84901650235 03/29/2014 16 Citations

Clinical evaluation of the walk-away specimen processor and ESwab for recovery of Streptococcus agalactiae isolates in prenatal screening specimens. (Buchan BW, Olson WJ, Mackey TL, Ledeboer NA) J Clin Microbiol 2014 Jun;52(6):2166-8 PMID: 24622104 PMCID: PMC4042734 SCOPUS ID: 2-s2.0-84901675733 03/14/2014 12 Citations

Comparison of the BD MAX enteric bacterial panel to routine culture methods for detection of Campylobacter, enterohemorrhagic Escherichia coli (O157), Salmonella, and Shigella isolates in preserved stool specimens. (Anderson NW, Buchan BW, Ledeboer NA) J Clin Microbiol 2014 Apr;52(4):1222-4 PMID: 24430460 PMCID: PMC3993502 SCOPUS ID: 2-s2.0-84897133136 01/17/2014 49 Citations

Comparison of MALDI-TOF MS with HPLC and nucleic acid sequencing for the identification of Mycobacterium species in cultures using solid medium and broth. (Buchan BW, Riebe KM, Timke M, Kostrzewa M, Ledeboer NA) Am J Clin Pathol 2014 Jan;141(1):25-34 PMID: 24343734 SCOPUS ID: 2-s2.0-84894470655 12/18/2013 64 Citations

Light microscopy, culture, molecular, and serologic methods for detection of herpes simplex virus. (Anderson NW, Buchan BW, Ledeboer NA) J Clin Microbiol 2014 Jan;52(1):2-8 PMID: 24131689 PMCID: PMC3911428 SCOPUS ID: 2-s2.0-84891418459 10/18/2013 47 Citations

Multicenter evaluation of the Verigene Clostridium difficile nucleic acid assay. (Carroll KC, Buchan BW, Tan S, Stamper PD, Riebe KM, Pancholi P, Kelly C, Rao A, Fader R, Cavagnolo R, Watson W, Goering RV, Trevino EA, Weissfeld AS, Ledeboer NA) J Clin Microbiol 2013 Dec;51(12):4120-5 PMID: 24088862 PMCID: PMC3838056 SCOPUS ID: 2-s2.0-84889856754 10/04/2013 33 Citations

Clinical evaluation of a real-time PCR assay for identification of Salmonella, Shigella, Campylobacter (Campylobacter jejuni and C. coli), and shiga toxin-producing Escherichia coli isolates in stool specimens. (Buchan BW, Olson WJ, Pezewski M, Marcon MJ, Novicki T, Uphoff TS, Chandramohan L, Revell P, Ledeboer NA) J Clin Microbiol 2013 Dec;51(12):4001-7 PMID: 24048539 PMCID: PMC3838069 SCOPUS ID: 2-s2.0-84889869928 09/21/2013 60 Citations

Multiplex identification of gram-positive bacteria and resistance determinants directly from positive blood culture broths: evaluation of an automated microarray-based nucleic acid test. (Buchan BW, Ginocchio CC, Manii R, Cavagnolo R, Pancholi P, Swyers L, Thomson RB Jr, Anderson C, Kaul K, Ledeboer NA) PLoS Med 2013;10(7):e1001478 PMID: 23843749 PMCID: PMC3699453 SCOPUS ID: 2-s2.0-84881261591 07/12/2013 103 Citations

Multicenter clinical evaluation of VRESelect agar for identification of vancomycin-resistant Enterococcus faecalis and Enterococcus faecium. (Anderson NW, Buchan BW, Young CL, Newton DW, Brenke C, Lapsley L, Granato PA, Ledeboer NA) J Clin Microbiol 2013 Aug;51(8):2758-60 PMID: 23761153 PMCID: PMC3719601 SCOPUS ID: 2-s2.0-84880637996 06/14/2013 14 Citations

Multicenter clinical evaluation of the illumigene group A Streptococcus DNA amplification assay for detection of group A Streptococcus from pharyngeal swabs. (Anderson NW, Buchan BW, Mayne D, Mortensen JE, Mackey TL, Ledeboer NA) J Clin Microbiol 2013 May;51(5):1474-7 PMID: 23447639 PMCID: PMC3647941 SCOPUS ID: 2-s2.0-84876761270 03/01/2013 40 Citations

Advances in identification of clinical yeast isolates by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry. (Buchan BW, Ledeboer NA) J Clin Microbiol 2013 May;51(5):1359-66 PMID: 23426924 PMCID: PMC3647935 SCOPUS ID: 2-s2.0-84876705043 02/22/2013 65 Citations

Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation. (Ulland TK, Janowski AM, Buchan BW, Faron M, Cassel SL, Jones BD, Sutterwala FS) Infect Immun 2013 Jan;81(1):201-8 PMID: 23115038 PMCID: PMC3536133 SCOPUS ID: 2-s2.0-84871886258 11/02/2012 13 Citations

Multicenter clinical evaluation of the portrait toxigenic C. difficile assay for detection of toxigenic Clostridium difficile strains in clinical stool specimens. (Buchan BW, Mackey TL, Daly JA, Alger G, Denys GA, Peterson LR, Kehl SC, Ledeboer NA) J Clin Microbiol 2012 Dec;50(12):3932-6 PMID: 23015667 PMCID: PMC3502949 SCOPUS ID: 2-s2.0-84869217890 09/28/2012 36 Citations

Comparison of BD Phoenix and bioMérieux Vitek 2 automated systems for the detection of macrolide-lincosamide-streptogramin B resistance among clinical isolates of Staphylococcus. (Buchan BW, Anderson NW, Ledeboer NA) Diagn Microbiol Infect Dis 2012 Mar;72(3):291-4 PMID: 22322000 SCOPUS ID: 2-s2.0-84856612590 02/11/2012 9 Citations

Comparison of the MALDI Biotyper system using Sepsityper specimen processing to routine microbiological methods for identification of bacteria from positive blood culture bottles. (Buchan BW, Riebe KM, Ledeboer NA) J Clin Microbiol 2012 Feb;50(2):346-52 PMID: 22162549 PMCID: PMC3264150 SCOPUS ID: 2-s2.0-84856206216 12/14/2011 158 Citations

Effects of solid-medium type on routine identification of bacterial isolates by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry. (Anderson NW, Buchan BW, Riebe KM, Parsons LN, Gnacinski S, Ledeboer NA) J Clin Microbiol 2012 Mar;50(3):1008-13 PMID: 22162546 PMCID: PMC3295166 SCOPUS ID: 2-s2.0-84857423338 12/14/2011 75 Citations

Evaluation of a microarray-based genotyping assay for the rapid detection of cytochrome P450 2C19 *2 and *3 polymorphisms from whole blood using nanoparticle probes. (Buchan BW, Peterson JF, Cogbill CH, Anderson DK, Ledford JS, White MN, Quigley NB, Jannetto PJ, Ledeboer NA) Am J Clin Pathol 2011 Oct;136(4):604-8 PMID: 21917683 SCOPUS ID: 2-s2.0-80053464779 09/16/2011 21 Citations

Acinetobacter infections - Epidemiology and pathogenesis of a significant healthcare-associated pathogen (Buchan BW, Ledeboer NA, Edmiston CE) Healthcare Infection March 2011;16(1):6-17 SCOPUS ID: 2-s2.0-79953165771 01/01/2011 2 Citations

Identification of two borderline oxacillin-resistant strains of Staphylococcus aureus from routine nares swab specimens by one of three chromogenic agars evaluated for the detection of MRSA. (Buchan BW, Ledeboer NA) Am J Clin Pathol 2010 Dec;134(6):921-7 PMID: 21088156 SCOPUS ID: 2-s2.0-78649655793 11/23/2010 11 Citations

Real-time detection of influenza a, influenza B, and respiratory syncytial virus a and B in respiratory specimens by use of nanoparticle probes. (Jannetto PJ, Buchan BW, Vaughan KA, Ledford JS, Anderson DK, Henley DC, Quigley NB, Ledeboer NA) J Clin Microbiol 2010 Nov;48(11):3997-4002 PMID: 20826644 PMCID: PMC3020893 SCOPUS ID: 2-s2.0-78049514476 09/10/2010 36 Citations

Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence. (Ulland TK, Buchan BW, Ketterer MR, Fernandes-Alnemri T, Meyerholz DK, Apicella MA, Alnemri ES, Jones BD, Nauseef WM, Sutterwala FS) J Immunol 2010 Sep 01;185(5):2670-4 PMID: 20679532 PMCID: PMC2953561 SCOPUS ID: 2-s2.0-78049394393 08/04/2010 67 Citations

Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis. (McCaffrey RL, Schwartz JT, Lindemann SR, Moreland JG, Buchan BW, Jones BD, Allen LA) J Leukoc Biol 2010 Oct;88(4):791-805 PMID: 20610796 PMCID: PMC2974429 SCOPUS ID: 2-s2.0-77957887794 07/09/2010 78 Citations

Identification of migR, a regulatory element of the Francisella tularensis live vaccine strain iglABCD virulence operon required for normal replication and trafficking in macrophages. (Buchan BW, McCaffrey RL, Lindemann SR, Allen LA, Jones BD) Infect Immun 2009 Jun;77(6):2517-29 PMID: 19349423 PMCID: PMC2687360 SCOPUS ID: 2-s2.0-66549085340 04/08/2009 56 Citations

Francisella tularensis genes required for inhibition of the neutrophil respiratory burst and intramacrophage growth identified by random transposon mutagenesis of strain LVS. (Schulert GS, McCaffrey RL, Buchan BW, Lindemann SR, Hollenback C, Jones BD, Allen LA) Infect Immun 2009 Apr;77(4):1324-36 PMID: 19204089 PMCID: PMC2663180 SCOPUS ID: 2-s2.0-63149103523 02/11/2009 59 Citations

Identification of differentially regulated francisella tularensis genes by use of a newly developed Tn5-based transposon delivery system. (Buchan BW, McLendon MK, Jones BD) Appl Environ Microbiol 2008 May;74(9):2637-45 PMID: 18344342 PMCID: PMC2394869 SCOPUS ID: 2-s2.0-43049087013 03/18/2008 29 Citations

Light-induced exacerbation of retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. (Vaughan DK, Peachey NS, Richards MJ, Buchan B, Fliesler SJ) Exp Eye Res 2006 Mar;82(3):496-504 PMID: 16360150 PMCID: PMC2844790 SCOPUS ID: 2-s2.0-31344439518 12/20/2005 35 Citations

X-ray structure of Arabidopsis At1g77680, 12-oxophytodienoate reductase isoform 1. (Fox BG, Malone TE, Johnson KA, Madson SE, Aceti D, Bingman CA, Blommel PG, Buchan B, Burns B, Cao J, Cornilescu C, Doreleijers J, Ellefson J, Frederick R, Geetha H, Hruby D, Jeon WB, Kimball T, Kunert J, Markley JL, Newman C, Olson A, Peterson FC, Phillips GN Jr, Primm J, Ramirez B, Rosenberg NS, Runnels M, Seder K, Shaw J, Smith DW, Sreenath H, Song J, Sussman MR, Thao S, Troestler D, Tyler E, Tyler R, Ulrich E, Vinarov D, Vojtik F, Volkman BF, Wesenberg G, Wrobel RL, Zhang J, Zhao Q, Zolnai Z) Proteins 2005 Oct 01;61(1):206-8 PMID: 16080145 SCOPUS ID: 2-s2.0-24344437685 08/05/2005 9 Citations

Protocols for production of selenomethionine-labeled proteins in 2-L polyethylene terephthalate bottles using auto-induction medium. (Sreenath HK, Bingman CA, Buchan BW, Seder KD, Burns BT, Geetha HV, Jeon WB, Vojtik FC, Aceti DJ, Frederick RO, Phillips GN Jr, Fox BG) Protein Expr Purif 2005 Apr;40(2):256-67 PMID: 15766867 SCOPUS ID: 2-s2.0-20044376278 03/16/2005 100 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Blake W. Buchan PhD

Professor

Publications (87)