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Medical College of Wisconsin

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Akiko Mammoto MD, PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Neonatology

Member of the Cardiovascular Center

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Publications (102)

Editorial: Organ microenvironment in vascular formation, homeostasis and engineering. (Mammoto A, Mammoto T, Song JW) Front Bioeng Biotechnol 2022;10:1130851 PMID: 36704295 PMCID: PMC9871242 SCOPUS ID: 2-s2.0-85146639145 01/28/2023

Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression. (Kyi P, Hendee K, Hunyenyiwa T, Matus K, Mammoto T, Mammoto A) Front Med (Lausanne) 2022;9:908639 PMID: 36203755 PMCID: PMC9530050 SCOPUS ID: 2-s2.0-85139235755 10/08/2022 4 Citations

Obesity in Angiogenesis and Lung Regeneration (Hunyenyiwa T, Kyi P, Hendee K, Matus K, Mammoto T, Mammoto A) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 May 2022;36 PMID: 35557429 SCOPUS ID: 2-s2.0-85130058554 05/01/2022

Mechanical Tension-induced Vascular and Alveolar Morphogenesis during Lung Regeneration (Mammoto A, Hunyenyiwa T, Kyi P, Hendee K, Matus K, Mammoto T) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 May 2022;36 PMID: 35556968 SCOPUS ID: 2-s2.0-85130056879 05/01/2022

Hydrostatic Pressure Controls Angiogenesis through Endothelial YAP1 during Lung Regeneration (Mammoto T, Hunyenyiwa T, Kyi P, Hendee K, Matus K, Mammoto A) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 May 2022;36 PMID: 35555395 SCOPUS ID: 2-s2.0-85130051023 05/01/2022

Endothelial Senescence Mediates Hypoxia-induced Vascular Remodeling in the Lung through TWIST1 Signaling (Kyi P, Hunyenyiwa T, Hendee K, Matus K, Mammoto T, Mammoto A) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 May 2022;36 PMID: 35556980 SCOPUS ID: 2-s2.0-85130017094 05/01/2022

Extracellular Matrix in Aging Aorta. (Mammoto A, Matus K, Mammoto T) Front Cell Dev Biol 2022;10:822561 PMID: 35265616 PMCID: PMC8898904 SCOPUS ID: 2-s2.0-85125870826 03/11/2022 22 Citations

Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration. (Mammoto T, Hunyenyiwa T, Kyi P, Hendee K, Matus K, Rao S, Lee SH, Tabima DM, Chesler NC, Mammoto A) Front Bioeng Biotechnol 2022;10:823642 PMID: 35252132 PMCID: PMC8896883 SCOPUS ID: 2-s2.0-85125874454 03/08/2022 3 Citations

Obesity Inhibits Angiogenesis Through TWIST1-SLIT2 Signaling. (Hunyenyiwa T, Hendee K, Matus K, Kyi P, Mammoto T, Mammoto A) Front Cell Dev Biol 2021;9:693410 PMID: 34660572 PMCID: PMC8511494 SCOPUS ID: 2-s2.0-85116933380 10/19/2021 9 Citations

Obesity Inhibits Angiogenesis Through TWIST1-SLIT2 Signaling (Hunyenyiwa T, Hendee K, Matus K, Kyi P, Mammoto T, Mammoto A) Frontiers in Cell and Developmental Biology 29 September 2021;9 SCOPUS ID: 2-s2.0-85116933380 09/29/2021 9 Citations

Twist1 signaling in age-dependent decline in angiogenesis and lung regeneration. (Hendee K, Hunyenyiwa T, Matus K, Toledo M, Mammoto A, Mammoto T) Aging (Albany NY) 2021 Mar 25;13(6):7781-7799 PMID: 33764901 PMCID: PMC8034921 SCOPUS ID: 2-s2.0-85103711251 03/26/2021 8 Citations

Vasculogenesis, Angiogenesis and Lung Alveolar Development (Mammoto T, Mammoto A) Encyclopedia of Respiratory Medicine, Second Edition 1 January 2021;1:73-76 SCOPUS ID: 2-s2.0-85143102835 01/01/2021

Molecular mapping of transmembrane mechanotransduction through the β1 integrin-CD98hc-TRPV4 axis. (Potla R, Hirano-Kobayashi M, Wu H, Chen H, Mammoto A, Matthews BD, Ingber DE) J Cell Sci 2020 Nov 02;133(20) PMID: 32989042 PMCID: PMC7657480 SCOPUS ID: 2-s2.0-85095460916 09/30/2020 19 Citations

Endothelial Twist1-PDGFB signaling mediates hypoxia-induced proliferation and migration of αSMA-positive cells. (Mammoto A, Hendee K, Muyleart M, Mammoto T) Sci Rep 2020 May 05;10(1):7563 PMID: 32371931 PMCID: PMC7200682 SCOPUS ID: 2-s2.0-85084328882 05/07/2020 16 Citations

Author Correction: Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. (Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE, Van der Heiden K, Ridger V, Evans PC) Sci Rep 2020 Feb 26;10(1):3870 PMID: 32099026 PMCID: PMC7042236 SCOPUS ID: 2-s2.0-85080837040 02/27/2020 1 Citation

Molecular mapping of transmembrane mechanotransduction through the β1 integrin-CD98hc-TRPV4 axis. (Potla R, Hirano-Kobayashi M, Wu H, Chen H, Mammoto A, Matthews BD, Ingber DE) J Cell Sci 2020 Jan 01 PMID: 34005341 SCOPUS ID: 2-s2.0-85095460916 01/01/2020 19 Citations

Vascular Niche in Lung Alveolar Development, Homeostasis, and Regeneration. (Mammoto A, Mammoto T) Front Bioeng Biotechnol 2019;7:318 PMID: 31781555 PMCID: PMC6861452 SCOPUS ID: 2-s2.0-85075893514 11/30/2019 42 Citations

Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1. (Mammoto T, Torisawa YS, Muyleart M, Hendee K, Anugwom C, Gutterman D, Mammoto A) Aging (Albany NY) 2019 Sep 05;11(17):7051-7069 PMID: 31487690 PMCID: PMC6756888 SCOPUS ID: 2-s2.0-85072345071 09/06/2019 20 Citations

Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models. (Papa AL, Jiang A, Korin N, Chen MB, Langan ET, Waterhouse A, Nash E, Caroff J, Graveline A, Vernet A, Mammoto A, Mammoto T, Jain A, Kamm RD, Gounis MJ, Ingber DE) Sci Transl Med 2019 Feb 13;11(479) PMID: 30760580 SCOPUS ID: 2-s2.0-85061618001 02/15/2019 54 Citations

LRP5 in age-related changes in vascular and alveolar morphogenesis in the lung. (Mammoto A, Muyleart M, Mammoto T) Aging (Albany NY) 2019 Jan 05;11(1):89-103 PMID: 30612120 PMCID: PMC6339783 SCOPUS ID: 2-s2.0-85060053785 01/07/2019 10 Citations

Endothelial YAP1 in Regenerative Lung Growth through the Angiopoietin-Tie2 Pathway. (Mammoto T, Muyleart M, Mammoto A) Am J Respir Cell Mol Biol 2019 Jan;60(1):117-127 PMID: 30156429 PMCID: PMC6348720 SCOPUS ID: 2-s2.0-85059234576 08/30/2018 27 Citations

YAP1-TEAD1 signaling controls angiogenesis and mitochondrial biogenesis through PGC1α. (Mammoto A, Muyleart M, Kadlec A, Gutterman D, Mammoto T) Microvasc Res 2018 Sep;119:73-83 PMID: 29680477 PMCID: PMC6005762 SCOPUS ID: 2-s2.0-85046667624 04/24/2018 39 Citations

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. (Musah S, Mammoto A, Ferrante TC, Jeanty SSF, Hirano-Kobayashi M, Mammoto T, Roberts K, Chung S, Novak R, Ingram M, Fatanat-Didar T, Koshy S, Weaver JC, Church GM, Ingber DE) Nat Biomed Eng 2017;1 PMID: 29038743 PMCID: PMC5639718 SCOPUS ID: 2-s2.0-85020519193 10/19/2017 367 Citations

Twist1 in Hypoxia-induced Pulmonary Hypertension through Transforming Growth Factor-β-Smad Signaling. (Mammoto T, Muyleart M, Konduri GG, Mammoto A) Am J Respir Cell Mol Biol 2018 Feb;58(2):194-207 PMID: 28915063 SCOPUS ID: 2-s2.0-85043329586 09/16/2017 65 Citations

An Engineered Human Fc-Mannose-Binding-Lectin Captures Circulating Tumor Cells (Kang JH, Driscoll H, Mammoto A, Watters AL, Melakeberhan B, Diaz A, Super M, Ingber DE) Advanced Biosystems July 2017;1(7) SCOPUS ID: 2-s2.0-85060284142 07/01/2017 9 Citations

An Engineered Human Fc-Mannose-Binding-Lectin Captures Circulating Tumor Cells. (Kang JH, Driscoll H, Mammoto A, Watters AL, Melakeberhan B, Diaz A, Super M, Ingber DE) Adv Biosyst 2017 Jul;1(7):e1700094 PMID: 32646174 SCOPUS ID: 2-s2.0-85060284142 07/01/2017 9 Citations

Ultrasound-sensitive nanoparticle aggregates for targeted drug delivery. (Papa AL, Korin N, Kanapathipillai M, Mammoto A, Mammoto T, Jiang A, Mannix R, Uzun O, Johnson C, Bhatta D, Cuneo G, Ingber DE) Biomaterials 2017 Sep;139:187-194 PMID: 28618348 SCOPUS ID: 2-s2.0-85020633088 06/16/2017 60 Citations

Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. (Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE, Van der Heiden K, Ridger V, Evans PC) Sci Rep 2017 Jun 13;7(1):3375 PMID: 28611395 PMCID: PMC5469771 SCOPUS ID: 2-s2.0-85020913417 06/15/2017 132 Citations

Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics. (Jain A, Barrile R, van der Meer AD, Mammoto A, Mammoto T, De Ceunynck K, Aisiku O, Otieno MA, Louden CS, Hamilton GA, Flaumenhaft R, Ingber DE) Clin Pharmacol Ther 2018 Feb;103(2):332-340 PMID: 28516446 PMCID: PMC5693794 SCOPUS ID: 2-s2.0-85023770580 05/19/2017 223 Citations

Role of Twist1 Phosphorylation in Angiogenesis and Pulmonary Fibrosis. (Mammoto T, Jiang A, Jiang E, Mammoto A) Am J Respir Cell Mol Biol 2016 Nov;55(5):633-644 PMID: 27281171 SCOPUS ID: 2-s2.0-84994417658 11/01/2016 38 Citations

TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. (Mahmoud MM, Kim HR, Xing R, Hsiao S, Mammoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R, Ariaans M, Francis SE, Weinberg PD, van der Heiden K, Jones EA, Chico TJ, Ridger V, Evans PC) Circ Res 2016 Jul 22;119(3):450-62 PMID: 27245171 PMCID: PMC4959828 SCOPUS ID: 2-s2.0-84973327121 06/02/2016 107 Citations

Modeling Hematopoiesis and Responses to Radiation Countermeasures in a Bone Marrow-on-a-Chip. (Torisawa YS, Mammoto T, Jiang E, Jiang A, Mammoto A, Watters AL, Bahinski A, Ingber DE) Tissue Eng Part C Methods 2016 May;22(5):509-15 PMID: 26993746 SCOPUS ID: 2-s2.0-84969179664 03/20/2016 51 Citations

Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation. (Huebsch N, Lippens E, Lee K, Mehta M, Koshy ST, Darnell MC, Desai RM, Madl CM, Xu M, Zhao X, Chaudhuri O, Verbeke C, Kim WS, Alim K, Mammoto A, Ingber DE, Duda GN, Mooney DJ) Nat Mater 2015 Dec;14(12):1269-77 PMID: 26366848 PMCID: PMC4654683 SCOPUS ID: 2-s2.0-84947868969 09/15/2015 384 Citations

VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells. (Yoshida A, Shimizu A, Asano H, Kadonosono T, Kondoh SK, Geretti E, Mammoto A, Klagsbrun M, Seo MK) Biol Open 2015 Jul 24;4(9):1063-76 PMID: 26209534 PMCID: PMC4582117 SCOPUS ID: 2-s2.0-84982075664 07/26/2015 32 Citations

Acceleration of Lung Regeneration by Platelet-Rich Plasma Extract through the Low-Density Lipoprotein Receptor-Related Protein 5-Tie2 Pathway. (Mammoto T, Chen Z, Jiang A, Jiang E, Ingber DE, Mammoto A) Am J Respir Cell Mol Biol 2016 Jan;54(1):103-13 PMID: 26091161 PMCID: PMC5455682 SCOPUS ID: 2-s2.0-85047289720 06/20/2015 22 Citations

Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation. (Mammoto T, Mammoto A, Jiang A, Jiang E, Hashmi B, Ingber DE) Dev Dyn 2015 Jun;244(6):713-23 PMID: 25715693 PMCID: PMC4449280 SCOPUS ID: 2-s2.0-84929952646 02/27/2015 18 Citations

Implantation of fibrin gel on mouse lung to study lung-specific angiogenesis. (Mammoto T, Mammoto A) J Vis Exp 2014 Dec 21(94) PMID: 25548859 PMCID: PMC4396947 SCOPUS ID: 2-s2.0-84921634387 12/31/2014 13 Citations

Endothelial TWIST1 promotes pathological ocular angiogenesis. (Li J, Liu CH, Sun Y, Gong Y, Fu Z, Evans LP, Tian KT, Juan AM, Hurst CG, Mammoto A, Chen J) Invest Ophthalmol Vis Sci 2014 Nov 20;55(12):8267-77 PMID: 25414194 PMCID: PMC4541480 SCOPUS ID: 2-s2.0-84919360479 11/22/2014 37 Citations

An extracorporeal blood-cleansing device for sepsis therapy. (Kang JH, Super M, Yung CW, Cooper RM, Domansky K, Graveline AR, Mammoto T, Berthet JB, Tobin H, Cartwright MJ, Watters AL, Rottman M, Waterhouse A, Mammoto A, Gamini N, Rodas MJ, Kole A, Jiang A, Valentin TM, Diaz A, Takahashi K, Ingber DE) Nat Med 2014 Oct;20(10):1211-6 PMID: 25216635 SCOPUS ID: 2-s2.0-84911445227 09/14/2014 245 Citations

Platelet-rich plasma extract prevents pulmonary edema through angiopoietin-Tie2 signaling. (Mammoto T, Jiang A, Jiang E, Mammoto A) Am J Respir Cell Mol Biol 2015 Jan;52(1):56-64 PMID: 24960457 PMCID: PMC5455304 SCOPUS ID: 2-s2.0-84920278242 06/25/2014 18 Citations

RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity. (Kawasaki J, Aegerter S, Fevurly RD, Mammoto A, Mammoto T, Sahin M, Mably JD, Fishman SJ, Chan J) J Clin Invest 2014 Jun;124(6):2774-84 PMID: 24837431 PMCID: PMC4089464 SCOPUS ID: 2-s2.0-84902180002 05/20/2014 64 Citations

Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and demonstrates elevated expression in tumor tissue and urine of patients with pediatric medulloblastoma. (Akino T, Han X, Nakayama H, McNeish B, Zurakowski D, Mammoto A, Klagsbrun M, Smith E) Cancer Res 2014 Jul 15;74(14):3716-26 PMID: 24812271 PMCID: PMC4123751 SCOPUS ID: 2-s2.0-84904247223 05/09/2014 54 Citations

Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro. (Torisawa YS, Spina CS, Mammoto T, Mammoto A, Weaver JC, Tat T, Collins JJ, Ingber DE) Nat Methods 2014 Jun;11(6):663-9 PMID: 24793454 SCOPUS ID: 2-s2.0-84901823942 05/06/2014 341 Citations

Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation. (Hashmi B, Zarzar LD, Mammoto T, Mammoto A, Jiang A, Aizenberg J, Ingber DE) Adv Mater 2014 May 28;26(20):3253-7 PMID: 24550068 PMCID: PMC4146397 SCOPUS ID: 2-s2.0-84901485098 02/20/2014 24 Citations

Mechanotransduction of fluid stresses governs 3D cell migration. (Polacheck WJ, German AE, Mammoto A, Ingber DE, Kamm RD) Proc Natl Acad Sci U S A 2014 Feb 18;111(7):2447-52 PMID: 24550267 PMCID: PMC3932905 SCOPUS ID: 2-s2.0-84894380551 02/20/2014 198 Citations

Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression. (German AE, Mammoto T, Jiang E, Ingber DE, Mammoto A) J Cell Sci 2014 Apr 15;127(Pt 8):1672-83 PMID: 24522185 PMCID: PMC3986673 SCOPUS ID: 2-s2.0-84898913240 02/14/2014 36 Citations

Biospleen device for extracorporeal sepsis therapy (Kang JH, Super M, Yung CW, Cooper RM, Domansky K, Graveline AR, Mammoto T, Berthet JB, Tobin H, Cartwright MJ, Watters AL, Rottman M, Waterhouse A, Mammoto A, Gamini N, Rodas MJ, Kole A, Jiang A, Valentin TM, Diaz A, Ingber DE) 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 2014:2516-2517 SCOPUS ID: 2-s2.0-84941696089 01/01/2014

Mechanobiology and developmental control. (Mammoto T, Mammoto A, Ingber DE) Annu Rev Cell Dev Biol 2013;29:27-61 PMID: 24099083 SCOPUS ID: 2-s2.0-84904240136 10/09/2013 314 Citations

Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression. (Mammoto T, Jiang E, Jiang A, Lu Y, Juan AM, Chen J, Mammoto A) PLoS One 2013;8(9):e73407 PMID: 24023872 PMCID: PMC3759405 SCOPUS ID: 2-s2.0-84897402975 09/12/2013 28 Citations

Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression. (Mammoto T, Jiang A, Jiang E, Panigrahy D, Kieran MW, Mammoto A) Am J Pathol 2013 Oct;183(4):1293-1305 PMID: 23928381 PMCID: PMC3791684 SCOPUS ID: 2-s2.0-84884545390 08/10/2013 125 Citations

Epoxyeicosanoids promote organ and tissue regeneration. (Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW) Proc Natl Acad Sci U S A 2013 Aug 13;110(33):13528-33 PMID: 23898174 PMCID: PMC3746918 SCOPUS ID: 2-s2.0-84882380783 07/31/2013 120 Citations

GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2. (Coma S, Allard-Ratick M, Akino T, van Meeteren LA, Mammoto A, Klagsbrun M) Angiogenesis 2013 Oct;16(4):939-52 PMID: 23892628 PMCID: PMC3793839 SCOPUS ID: 2-s2.0-84884815240 07/31/2013 44 Citations

Extracellular matrix structure and tissue stiffness control postnatal lung development through the lipoprotein receptor-related protein 5/Tie2 signaling system. (Mammoto T, Jiang E, Jiang A, Mammoto A) Am J Respir Cell Mol Biol 2013 Dec;49(6):1009-18 PMID: 23841513 SCOPUS ID: 2-s2.0-84890045883 07/12/2013 55 Citations

Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan. (Bischof AG, Yüksel D, Mammoto T, Mammoto A, Krause S, Ingber DE) Integr Biol (Camb) 2013 Aug;5(8):1045-56 PMID: 23817524 SCOPUS ID: 2-s2.0-84893450991 07/03/2013 33 Citations

Low urine vascular endothelial growth factor levels are associated with mechanical ventilation, bronchopulmonary dysplasia and retinopathy of prematurity. (Levesque BM, Kalish LA, Winston AB, Parad RB, Hernandez-Diaz S, Phillips M, Zolit A, Morey J, Gupta M, Mammoto A, Ingber DE, Van Marter LJ) Neonatology 2013;104(1):56-64 PMID: 23711562 SCOPUS ID: 2-s2.0-84878038265 05/29/2013 28 Citations

Platelet rich plasma extract promotes angiogenesis through the angiopoietin1-Tie2 pathway. (Mammoto T, Jiang A, Jiang E, Mammoto A) Microvasc Res 2013 Sep;89:15-24 PMID: 23660186 SCOPUS ID: 2-s2.0-84883172376 05/11/2013 85 Citations

Control of lung vascular permeability and endotoxin-induced pulmonary oedema by changes in extracellular matrix mechanics. (Mammoto A, Mammoto T, Kanapathipillai M, Wing Yung C, Jiang E, Jiang A, Lofgren K, Gee EP, Ingber DE) Nat Commun 2013;4:1759 PMID: 23612300 SCOPUS ID: 2-s2.0-84877773940 04/25/2013 104 Citations

Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. (Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, Coma S, Italiano JE Jr, Mammoto A, Bielenberg DR, Klagsbrun M) J Biol Chem 2013 Jan 25;288(4):2210-22 PMID: 23195957 PMCID: PMC3554894 SCOPUS ID: 2-s2.0-84873813207 12/01/2012 83 Citations

Paxillin controls directional cell motility in response to physical cues. (Sero JE, German AE, Mammoto A, Ingber DE) Cell Adh Migr 2012;6(6):502-8 PMID: 23076140 PMCID: PMC3547894 SCOPUS ID: 2-s2.0-84872070258 10/19/2012 16 Citations

LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. (Mammoto T, Chen J, Jiang E, Jiang A, Smith LE, Ingber DE, Mammoto A) PLoS One 2012;7(7):e41596 PMID: 22848540 PMCID: PMC3404972 SCOPUS ID: 2-s2.0-84864355628 08/01/2012 26 Citations

Mechanosensitive mechanisms in transcriptional regulation. (Mammoto A, Mammoto T, Ingber DE) J Cell Sci 2012 Jul 01;125(Pt 13):3061-73 PMID: 22797927 PMCID: PMC3434847 SCOPUS ID: 2-s2.0-84868111953 07/17/2012 346 Citations

Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix. (Kanapathipillai M, Mammoto A, Mammoto T, Kang JH, Jiang E, Ghosh K, Korin N, Gibbs A, Mannix R, Ingber DE) Nano Lett 2012 Jun 13;12(6):3213-7 PMID: 22554317 SCOPUS ID: 2-s2.0-84862301989 05/05/2012 100 Citations

A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells. (Kang JH, Krause S, Tobin H, Mammoto A, Kanapathipillai M, Ingber DE) Lab Chip 2012 Jun 21;12(12):2175-81 PMID: 22453808 SCOPUS ID: 2-s2.0-84862234603 03/29/2012 250 Citations

Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning. (Sero JE, Thodeti CK, Mammoto A, Bakal C, Thomas S, Ingber DE) PLoS One 2011;6(12):e28303 PMID: 22194823 PMCID: PMC3237434 SCOPUS ID: 2-s2.0-83355173170 12/24/2011 37 Citations

Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. (Panigrahy D, Edin ML, Lee CR, Huang S, Bielenberg DR, Butterfield CE, Barnés CM, Mammoto A, Mammoto T, Luria A, Benny O, Chaponis DM, Dudley AC, Greene ER, Vergilio JA, Pietramaggiori G, Scherer-Pietramaggiori SS, Short SM, Seth M, Lih FB, Tomer KB, Yang J, Schwendener RA, Hammock BD, Falck JR, Manthati VL, Ingber DE, Kaipainen A, D'Amore PA, Kieran MW, Zeldin DC) J Clin Invest 2012 Jan;122(1):178-91 PMID: 22182838 PMCID: PMC3248288 SCOPUS ID: 2-s2.0-84855453198 12/21/2011 243 Citations

Wnt signaling mediates pathological vascular growth in proliferative retinopathy. (Chen J, Stahl A, Krah NM, Seaward MR, Dennison RJ, Sapieha P, Hua J, Hatton CJ, Juan AM, Aderman CM, Willett KL, Guerin KI, Mammoto A, Campbell M, Smith LE) Circulation 2011 Oct 25;124(17):1871-81 PMID: 21969016 PMCID: PMC3326389 SCOPUS ID: 2-s2.0-80054993016 10/05/2011 103 Citations

Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. (Mammoto T, Mammoto A, Torisawa YS, Tat T, Gibbs A, Derda R, Mannix R, de Bruijn M, Yung CW, Huh D, Ingber DE) Dev Cell 2011 Oct 18;21(4):758-69 PMID: 21924961 PMCID: PMC3199351 SCOPUS ID: 2-s2.0-80054744142 09/20/2011 152 Citations

Multizone paper platform for 3D cell cultures. (Derda R, Tang SK, Laromaine A, Mosadegh B, Hong E, Mwangi M, Mammoto A, Ingber DE, Whitesides GM) PLoS One 2011 May 06;6(5):e18940 PMID: 21573103 PMCID: PMC3089608 SCOPUS ID: 2-s2.0-79955856918 05/17/2011 184 Citations

Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. (Xu Y, Bismar TA, Su J, Xu B, Kristiansen G, Varga Z, Teng L, Ingber DE, Mammoto A, Kumar R, Alaoui-Jamali MA) J Exp Med 2010 Oct 25;207(11):2421-37 PMID: 20937704 PMCID: PMC2964581 SCOPUS ID: 2-s2.0-78149314610 10/13/2010 135 Citations

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. (Matthews BD, Thodeti CK, Tytell JD, Mammoto A, Overby DR, Ingber DE) Integr Biol (Camb) 2010 Sep;2(9):435-42 PMID: 20725677 PMCID: PMC3147167 SCOPUS ID: 2-s2.0-77956329847 08/21/2010 209 Citations

Reconstituting organ-level lung functions on a chip. (Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE) Science 2010 Jun 25;328(5986):1662-8 PMID: 20576885 PMCID: PMC8335790 SCOPUS ID: 2-s2.0-77954038080 06/26/2010 3021 Citations

Paper-supported 3D cell culture for tissue-based bioassays. (Derda R, Laromaine A, Mammoto A, Tang SK, Mammoto T, Ingber DE, Whitesides GM) Proc Natl Acad Sci U S A 2009 Nov 03;106(44):18457-62 PMID: 19846768 PMCID: PMC2773961 SCOPUS ID: 2-s2.0-73249131798 10/23/2009 377 Citations

Cytoskeletal control of growth and cell fate switching. (Mammoto A, Ingber DE) Curr Opin Cell Biol 2009 Dec;21(6):864-70 PMID: 19740640 SCOPUS ID: 2-s2.0-70549098542 09/11/2009 180 Citations

Discovery of potent and practical antiangiogenic agents inspired by cortistatin A. (Czakó B, Kürti L, Mammoto A, Ingber DE, Corey EJ) J Am Chem Soc 2009 Jul 01;131(25):9014-9 PMID: 19469509 SCOPUS ID: 2-s2.0-67649576730 05/28/2009 55 Citations

TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. (Thodeti CK, Matthews B, Ravi A, Mammoto A, Ghosh K, Bracha AL, Ingber DE) Circ Res 2009 May 08;104(9):1123-30 PMID: 19359599 PMCID: PMC2754067 SCOPUS ID: 2-s2.0-66149088448 04/11/2009 298 Citations

A mechanosensitive transcriptional mechanism that controls angiogenesis. (Mammoto A, Connor KM, Mammoto T, Yung CW, Huh D, Aderman CM, Mostoslavsky G, Smith LE, Ingber DE) Nature 2009 Feb 26;457(7233):1103-8 PMID: 19242469 PMCID: PMC2708674 SCOPUS ID: 2-s2.0-61349168351 02/27/2009 435 Citations

Methods for studying mechanical control of angiogenesis by the cytoskeleton and extracellular matrix. (Mammoto A, Sero JE, Mammoto T, Ingber DE) Methods Enzymol 2008;443:227-59 PMID: 18772019 SCOPUS ID: 2-s2.0-52049085563 09/06/2008 8 Citations

Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. (Ghosh K, Thodeti CK, Dudley AC, Mammoto A, Klagsbrun M, Ingber DE) Proc Natl Acad Sci U S A 2008 Aug 12;105(32):11305-10 PMID: 18685096 PMCID: PMC2516246 SCOPUS ID: 2-s2.0-49649125325 08/08/2008 175 Citations

ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells. (Shimizu A, Mammoto A, Italiano JE Jr, Pravda E, Dudley AC, Ingber DE, Klagsbrun M) J Biol Chem 2008 Oct 03;283(40):27230-8 PMID: 18660502 PMCID: PMC2555994 SCOPUS ID: 2-s2.0-55249110412 07/29/2008 87 Citations

Rho signaling and mechanical control of vascular development. (Mammoto A, Mammoto T, Ingber DE) Curr Opin Hematol 2008 May;15(3):228-34 PMID: 18391790 SCOPUS ID: 2-s2.0-41949104623 04/09/2008 55 Citations

Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. (Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP) J Biol Chem 2007 Aug 17;282(33):23910-8 PMID: 17562701 SCOPUS ID: 2-s2.0-34447627607 06/15/2007 150 Citations

The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. (Chen Z, Naveiras O, Balduini A, Mammoto A, Conti MA, Adelstein RS, Ingber D, Daley GQ, Shivdasani RA) Blood 2007 Jul 01;110(1):171-9 PMID: 17392504 PMCID: PMC1896110 SCOPUS ID: 2-s2.0-34347390082 03/30/2007 134 Citations

Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. (Mammoto A, Huang S, Ingber DE) J Cell Sci 2007 Feb 01;120(Pt 3):456-67 PMID: 17227794 SCOPUS ID: 2-s2.0-33847419281 01/18/2007 89 Citations

Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition. (Mammoto A, Huang S, Moore K, Oh P, Ingber DE) J Biol Chem 2004 Jun 18;279(25):26323-30 PMID: 15096506 SCOPUS ID: 2-s2.0-2942707853 04/21/2004 192 Citations

Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF. (Nanba D, Mammoto A, Hashimoto K, Higashiyama S) J Cell Biol 2003 Nov 10;163(3):489-502 PMID: 14597771 PMCID: PMC2173632 SCOPUS ID: 2-s2.0-0242425875 11/05/2003 139 Citations

Intravenous anesthetic, propofol inhibits invasion of cancer cells. (Mammoto T, Mukai M, Mammoto A, Yamanaka Y, Hayashi Y, Mashimo T, Kishi Y, Nakamura H) Cancer Lett 2002 Oct 28;184(2):165-70 PMID: 12127688 SCOPUS ID: 2-s2.0-0037190808 07/20/2002 147 Citations

Infiltration anesthetic lidocaine inhibits cancer cell invasion by modulating ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF). (Mammoto T, Higashiyama S, Mukai M, Mammoto A, Ayaki M, Mashimo T, Hayashi Y, Kishi Y, Nakamura H, Akedo H) J Cell Physiol 2002 Sep;192(3):351-8 PMID: 12124780 SCOPUS ID: 2-s2.0-0036321571 07/19/2002 52 Citations

Stimulation of Rho GDI release by ERM proteins. (Mammoto A, Takahashi K, Sasaki T, Takai Y) Methods Enzymol 2000;325:91-101 PMID: 11036595 SCOPUS ID: 2-s2.0-0033780416 10/19/2000 11 Citations

Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2. (Fujiwara T, Mammoto A, Kim Y, Takai Y) Biochem Biophys Res Commun 2000 May 19;271(3):626-9 PMID: 10814512 SCOPUS ID: 2-s2.0-0034685631 05/18/2000 71 Citations

Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking. (Mammoto A, Sasaki T, Kim Y, Takai Y) J Biol Chem 2000 May 05;275(18):13167-70 PMID: 10747849 SCOPUS ID: 2-s2.0-0034607642 04/05/2000 17 Citations

Rab11BP/Rabphilin-11, a downstream target of rab11 small G protein implicated in vesicle recycling. (Mammoto A, Ohtsuka T, Hotta I, Sasaki T, Takai Y) J Biol Chem 1999 Sep 03;274(36):25517-24 PMID: 10464283 SCOPUS ID: 2-s2.0-0033520460 08/28/1999 83 Citations

Distinct actions and cooperative roles of ROCK and mDia in Rho small G protein-induced reorganization of the actin cytoskeleton in Madin-Darby canine kidney cells. (Nakano K, Takaishi K, Kodama A, Mammoto A, Shiozaki H, Monden M, Takai Y) Mol Biol Cell 1999 Aug;10(8):2481-91 PMID: 10436006 PMCID: PMC25478 SCOPUS ID: 2-s2.0-0032784388 08/06/1999 139 Citations

Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl. (Takahashi K, Sasaki T, Mammoto A, Hotta I, Takaishi K, Imamura H, Nakano K, Kodama A, Takai Y) Oncogene 1998 Jun 25;16(25):3279-84 PMID: 9681826 SCOPUS ID: 2-s2.0-0032566011 07/29/1998 104 Citations

Interactions of drebrin and gephyrin with profilin. (Mammoto A, Sasaki T, Asakura T, Hotta I, Imamura H, Takahashi K, Matsuura Y, Shirao T, Takai Y) Biochem Biophys Res Commun 1998 Feb 04;243(1):86-9 PMID: 9473484 SCOPUS ID: 2-s2.0-0032481298 02/25/1998 125 Citations

Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein. (Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S, Takai Y) J Biol Chem 1997 Sep 12;272(37):23371-5 PMID: 9287351 SCOPUS ID: 2-s2.0-0030846295 09/12/1997 369 Citations

Involvement of a sperm protein sensitive to sulfhydryl-depleting reagents in mouse sperm-egg fusion. (Mammoto A, Masumoto N, Tahara M, Yoneda M, Nishizaki T, Tasaka K, Miyake A) J Exp Zool 1997 Jun 15;278(3):178-88 PMID: 9181696 SCOPUS ID: 2-s2.0-0031570766 06/15/1997 12 Citations

Involvement of Rabphilin-3A in cortical granule exocytosis in mouse eggs. (Masumoto N, Sasaki T, Tahara M, Mammoto A, Ikebuchi Y, Tasaka K, Tokunaga M, Takai Y, Miyake A) J Cell Biol 1996 Dec;135(6 Pt 2):1741-7 PMID: 8991087 PMCID: PMC2133937 SCOPUS ID: 2-s2.0-0030461545 12/01/1996 43 Citations

Reactive oxygen species block sperm-egg fusion via oxidation of sperm sulfhydryl proteins in mice. (Mammoto A, Masumoto N, Tahara M, Ikebuchi Y, Ohmichi M, Tasaka K, Miyake A) Biol Reprod 1996 Nov;55(5):1063-8 PMID: 8902218 SCOPUS ID: 2-s2.0-0029908454 11/01/1996 54 Citations

Dynamics of cortical granule exocytosis at fertilization in living mouse eggs. (Tahara M, Tasaka K, Masumoto N, Mammoto A, Ikebuchi Y, Miyake A) Am J Physiol 1996 May;270(5 Pt 1):C1354-61 PMID: 8967435 SCOPUS ID: 2-s2.0-0030008499 05/01/1996 47 Citations

Inhibition of mouse placental lactogen-II release from placental cells by interleukin-1 after mid-pregnancy. (Yamaguchi M, Sakata M, Ogura K, Adachi K, Mammoto A, Miyake A) J Endocrinol 1995 Dec;147(3):423-9 PMID: 8543912 SCOPUS ID: 2-s2.0-0028834308 12/01/1995 3 Citations

Regulation of mouse soluble interleukin-6 receptor secretion by decidua. (Yamaguchi M, Mammoto A, Taga T, Kishimoto T, Miyake A) Biochem Biophys Res Commun 1995 Jun 26;211(3):1077-82 PMID: 7598695 SCOPUS ID: 2-s2.0-0029010178 06/26/1995 6 Citations

Scanning electron microscope assessment of exocytotic changes in purified gonadotropes. (Mizuki J, Masumoto N, Tahara M, Fukami K, Mammoto A, Tasaka K, Miyake A) J Endocrinol 1995 Feb;144(2):193-200 PMID: 7706972 SCOPUS ID: 2-s2.0-0028955663 02/01/1995 2 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Akiko Mammoto MD, PhD

Associate Professor

Publications (102)