Medical College of Wisconsin
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Calvin B. Williams MD, PhD

Calvin B. Williams MD, PhD

Chief, Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Rheumatology

Member of the Cancer Center

Leadership Positions

  • Professor of Pediatrics, Mirobiology and Molecular Genetics
  • Chief Scientific Officer, Children's Research Institute
  • Section Chief, Pediatric Rheumatology
  • Publications

  • Platelet Gene Therapy Promotes Targeted Peripheral Tolerance by Clonal Deletion and Induction of Antigen-Specific Regulatory T Cells. (Luo X, Chen J, Schroeder JA, Allen KP, Baumgartner CK, Malarkannan S, Hu J, Williams CB, Shi Q) Front Immunol 2018;9:1950 PMID: 30237796 PMCID: PMC6136275 09/22/2018       1 Citations
  • A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis. (Jeschke JC, Mayne CG, Ziegelbauer J, DeCiantis CL, Singh S, Kumar SN, Suchi M, Iwakura Y, Drobyski WR, Salzman NH, Williams CB) Mucosal Immunol 2018 07;11(4):1127-1137 PMID: 29728642 05/08/2018    
  • Risk, Timing, and Predictors of Disease Flare After Discontinuation of Anti-Tumor Necrosis Factor Therapy in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis With Clinically Inactive Disease. (Lovell DJ, Johnson AL, Huang B, Gottlieb BS, Morris PW, Kimura Y, Onel K, Li SC, Grom AA, Taylor J, Brunner HI, Huggins JL, Nocton JJ, Haines KA, Edelheit BS, Shishov M, Jung LK, Williams CB, Tesher MS, Costanzo DM, Zemel LS, Dare JA, Passo MH, Ede KC, Olson JC, Cassidy EA, Griffin TA, Wagner-Weiner L, Weiss JE, Vogler LB, Rouster-Stevens KA, Beukelman T, Cron RQ, Kietz D, Schikler K, Schmidt KM, Mehta J, Wahezi DM, Ting TV, Verbsky JW, Eberhard BA, Spalding S, Chen C, Giannini EH) Arthritis Rheumatol 2018 Sep;70(9):1508-1518 PMID: 29604189 PMCID: PMC6115300 04/01/2018    
  • TGF-β1 along with other platelet contents augments Treg cells to suppress anti-FVIII immune responses in hemophilia A mice. (Haribhai D, Luo X, Chen J, Jia S, Shi L, Schroeder JA, Weiler H, Aster RH, Hessner MJ, Hu J, Williams CB, Shi Q) Blood Adv 2016 Dec 13;1(2):139-151 PMID: 28164173 PMCID: PMC5288643 02/07/2017    
  • A colitogenic memory CD4+ T cell population mediates gastrointestinal graft-versus-host disease. (Zhou V, Agle K, Chen X, Beres A, Komorowski R, Belle L, Taylor C, Zhu F, Haribhai D, Williams CB, Verbsky J, Blumenschein W, Sadekova S, Bowman E, Ballantyne C, Weaver C, Serody DA, Vincent B, Serody J, Cua DJ, Drobyski WR) J Clin Invest 2016 09 01;126(9):3541-55 PMID: 27500496 PMCID: PMC5004941 08/09/2016       4 Citations
  • Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression. (Belle L, Agle K, Zhou V, Yin-Yuan C, Komorowski R, Eastwood D, Logan B, Sun J, Ghilardi N, Cua D, Williams CB, Gaignage M, Marillier R, van Snick J, Drobyski WR) Blood 2016 10 20;128(16):2068-2082 PMID: 27488350 PMCID: PMC5073185 08/05/2016       8 Citations
  • Editorial: Treg potency and the importance of being fit. (Jeschke JC, Williams CB) J Leukoc Biol 2016 07;100(1):1-3 PMID: 27365526 07/02/2016       1 Citations
  • Immunotherapy with iTreg and nTreg Cells in a Murine Model of Inflammatory Bowel Disease. (Haribhai D, Chatila TA, Williams CB) Methods Mol Biol 2016;1422:197-211 PMID: 27246035 06/02/2016       6 Citations
  • Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis. (Haribhai D, Ziegelbauer J, Jia S, Upchurch K, Yan K, Schmitt EG, Salzman NH, Simpson P, Hessner MJ, Chatila TA, Williams CB) J Immunol 2016 Apr 15;196(8):3305-17 PMID: 26927797 PMCID: PMC4851766 03/02/2016       14 Citations
  • Editorial: Crossing the divide: a novel Cd8 enhancer with activity in CTLs and CD8αα+ dendritic cells. (Jeschke JC, Williams CB) J Leukoc Biol 2015 Apr;97(4):623-5 PMID: 25828836 04/02/2015    
  • Randomized, double-blind, dose-escalation trial of triptorelin for ovary protection in childhood-onset systemic lupus erythematosus. (Brunner HI, Silva CA, Reiff A, Higgins GC, Imundo L, Williams CB, Wallace CA, Aikawa NE, Nelson S, Klein-Gitelman MS, Rose SR) Arthritis Rheumatol 2015 May;67(5):1377-85 PMID: 25676588 PMCID: PMC4414812 02/14/2015       13 Citations
  • Regulatory T cells: exosomes deliver tolerance. (Chatila TA, Williams CB) Immunity 2014 Jul 17;41(1):3-5 PMID: 25035945 PMCID: PMC4130330 07/19/2014       11 Citations
  • Mice with an absent stress response are protected against ischemic renal injury. (Sreedharan R, Chen S, Miller M, Haribhai D, Williams CB, Van Why SK) Kidney Int 2014 Sep;86(3):515-24 PMID: 24805105 PMCID: PMC4149847 05/09/2014       5 Citations
  • Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo. (Wu X, Schulte BC, Zhou Y, Haribhai D, Mackinnon AC, Plaza JA, Williams CB, Hwang ST) J Invest Dermatol 2014 Nov;134(11):2814-2822 PMID: 24780929 05/02/2014       40 Citations
  • Editorial: Optimizing iTreg differentiation: STATs in the balance. (Williams CB, Chatila TA) J Leukoc Biol 2014 Feb;95(2):197-8 PMID: 24482484 02/01/2014    
  • Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. (Schmitt EG, Haribhai D, Jeschke JC, Co DO, Ziegelbauer J, Yan K, Iwakura Y, Mishra MK, Simpson P, Salzman NH, Williams CB) J Immunol 2013 Dec 01;191(11):5460-76 PMID: 24163409 PMCID: PMC3893829 10/29/2013    
  • Generation and function of induced regulatory T cells. (Schmitt EG, Williams CB) Front Immunol 2013;4:152 PMID: 23801990 PMCID: PMC3685796 06/27/2013    
  • Induced and natural regulatory T cells in the development of inflammatory bowel disease. (Mayne CG, Williams CB) Inflamm Bowel Dis 2013 Jul;19(8):1772-88 PMID: 23656897 PMCID: PMC3690174 05/10/2013       54 Citations
  • Fox family ties. (Williams CB, Chatila TA) Cell Res 2013 Apr;23(4):452-4 PMID: 23318581 PMCID: PMC3616439 01/16/2013    
  • IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy. (Schmitt EG, Haribhai D, Williams JB, Aggarwal P, Jia S, Charbonnier LM, Yan K, Lorier R, Turner A, Ziegelbauer J, Georgiev P, Simpson P, Salzman NH, Hessner MJ, Broeckel U, Chatila TA, Williams CB) J Immunol 2012 Dec 15;189(12):5638-48 PMID: 23125413 PMCID: PMC3537488 11/06/2012       56 Citations
  • The TCR repertoires of regulatory and conventional T cells specific for the same foreign antigen are distinct. (Relland LM, Williams JB, Relland GN, Haribhai D, Ziegelbauer J, Yassai M, Gorski J, Williams CB) J Immunol 2012 Oct 01;189(7):3566-74 PMID: 22933635 PMCID: PMC3538134 08/31/2012       16 Citations
  • CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity. (Beres AJ, Haribhai D, Chadwick AC, Gonyo PJ, Williams CB, Drobyski WR) J Immunol 2012 Jul 01;189(1):464-74 PMID: 22649199 PMCID: PMC3381996 06/01/2012       58 Citations
  • Foxp3: shades of tolerance. (Chatila TA, Williams CB) Immunity 2012 May 25;36(5):693-4 PMID: 22633453 PMCID: PMC3868336 05/29/2012    
  • Requirements for growth and IL-10 expression of highly purified human T regulatory cells. (Bonacci B, Edwards B, Jia S, Williams CB, Hessner MJ, Gauld SB, Verbsky JW) J Clin Immunol 2012 Oct;32(5):1118-28 PMID: 22562448 PMCID: PMC4271826 05/09/2012       5 Citations
  • A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand. (Ray A, Basu S, Williams CB, Salzman NH, Dittel BN) J Immunol 2012 Apr 01;188(7):3188-98 PMID: 22368274 PMCID: PMC3311743 03/01/2012       148 Citations
  • A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. (Haribhai D, Williams JB, Jia S, Nickerson D, Schmitt EG, Edwards B, Ziegelbauer J, Yassai M, Li SH, Relland LM, Wise PM, Chen A, Zheng YQ, Simpson PM, Gorski J, Salzman NH, Hessner MJ, Chatila TA, Williams CB) Immunity 2011 Jul 22;35(1):109-22 PMID: 21723159 PMCID: PMC3295638 07/05/2011       256 Citations
  • Combination therapy with methotrexate and etanercept for refractory chronic recurrent multifocal osteomyelitis. (Eisenstein EM, Syverson GD, Vora SS, Williams CB) J Rheumatol 2011 Apr;38(4):782-3 PMID: 21459961 04/05/2011       17 Citations
  • 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. (Mayne CG, Spanier JA, Relland LM, Williams CB, Hayes CE) Eur J Immunol 2011 Mar;41(3):822-32 PMID: 21287548 02/03/2011       94 Citations
  • Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance. (Fu G, Chen Y, Yu M, Podd A, Schuman J, He Y, Di L, Yassai M, Haribhai D, North PE, Gorski J, Williams CB, Wang D, Wen R) J Exp Med 2010 Feb 15;207(2):309-18 PMID: 20123962 PMCID: PMC2822604 02/04/2010       67 Citations
  • Enteric defensins are essential regulators of intestinal microbial ecology. (Salzman NH, Hung K, Haribhai D, Chu H, Karlsson-Sjöberg J, Amir E, Teggatz P, Barman M, Hayward M, Eastwood D, Stoel M, Zhou Y, Sodergren E, Weinstock GM, Bevins CL, Williams CB, Bos NA) Nat Immunol 2010 Jan;11(1):76-83 PMID: 19855381 PMCID: PMC2795796 10/27/2009       631 Citations
  • The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression. (Jana S, Jailwala P, Haribhai D, Waukau J, Glisic S, Grossman W, Mishra M, Wen R, Wang D, Williams CB, Ghosh S) Eur J Immunol 2009 Sep;39(9):2571-83 PMID: 19701891 08/25/2009       37 Citations
  • A central role for induced regulatory T cells in tolerance induction in experimental colitis. (Haribhai D, Lin W, Edwards B, Ziegelbauer J, Salzman NH, Carlson MR, Li SH, Simpson PM, Chatila TA, Williams CB) J Immunol 2009 Mar 15;182(6):3461-8 PMID: 19265124 PMCID: PMC2763205 03/07/2009       151 Citations
  • The T(reg)/Th17 cell balance: a new paradigm for autoimmunity. (Eisenstein EM, Williams CB) Pediatr Res 2009 May;65(5 Pt 2):26R-31R PMID: 19218879 02/17/2009       105 Citations
  • Affinity-based selection of regulatory T cells occurs independent of agonist-mediated induction of Foxp3 expression. (Relland LM, Mishra MK, Haribhai D, Edwards B, Ziegelbauer J, Williams CB) J Immunol 2009 Feb 01;182(3):1341-50 PMID: 19155480 PMCID: PMC2818884 01/22/2009       16 Citations
  • Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. (Schulteis RD, Chu H, Dai X, Chen Y, Edwards B, Haribhai D, Williams CB, Malarkannan S, Hessner MJ, Glisic-Milosavljevic S, Jana S, Kerschen EJ, Ghosh S, Wang D, Kwitek AE, Lernmark A, Gorski J, Weiler H) Blood 2008 Dec 15;112(13):4905-14 PMID: 18796632 PMCID: PMC2597598 09/18/2008       41 Citations
  • Regulatory T cells dynamically control the primary immune response to foreign antigen. (Haribhai D, Lin W, Relland LM, Truong N, Williams CB, Chatila TA) J Immunol 2007 Mar 01;178(5):2961-72 PMID: 17312141 02/22/2007       150 Citations
  • Regulatory T cell development in the absence of functional Foxp3. (Lin W, Haribhai D, Relland LM, Truong N, Carlson MR, Williams CB, Chatila TA) Nat Immunol 2007 Apr;8(4):359-68 PMID: 17273171 02/03/2007       297 Citations
  • Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. (Lin W, Truong N, Grossman WJ, Haribhai D, Williams CB, Wang J, Martín MG, Chatila TA) J Allergy Clin Immunol 2005 Nov;116(5):1106-15 PMID: 16275384 11/09/2005       161 Citations
  • Functional reprogramming of the primary immune response by T cell receptor antagonism. (Haribhai D, Edwards B, Williams ML, Williams CB) J Exp Med 2004 Dec 06;200(11):1371-82 PMID: 15557350 PMCID: PMC2211957 11/24/2004       10 Citations
  • Talo-patello-scaphoid osteolysis, synovitis, and short fourth metacarpals in sisters: a new syndrome? (Singh JA, Williams CB, McAlister WH) Am J Med Genet A 2003 Aug 30;121A(2):118-25 PMID: 12910489 08/12/2003       2 Citations
  • A threshold for central T cell tolerance to an inducible serum protein. (Haribhai D, Engle D, Meyer M, Donermeyer D, White JM, Williams CB) J Immunol 2003 Mar 15;170(6):3007-14 PMID: 12626554 03/11/2003       17 Citations
  • Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold. (Raman V, Blaeser F, Ho N, Engle DL, Williams CB, Chatila TA) J Immunol 2001 Dec 01;167(11):6270-8 PMID: 11714790 11/21/2001       18 Citations
  • Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture. (Kersh GJ, Engle DL, Williams CB, Allen PM) J Immunol 2000 Jun 01;164(11):5675-82 PMID: 10820243 05/23/2000       10 Citations
  • CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. (Marcelino J, Carpten JD, Suwairi WM, Gutierrez OM, Schwartz S, Robbins C, Sood R, Makalowska I, Baxevanis A, Johnstone B, Laxer RM, Zemel L, Kim CA, Herd JK, Ihle J, Williams C, Johnson M, Raman V, Alonso LG, Brunoni D, Gerstein A, Papadopoulos N, Bahabri SA, Trent JM, Warman ML) Nat Genet 1999 Nov;23(3):319-22 PMID: 10545950 11/05/1999       191 Citations
  • A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex. (Williams CB, Engle DL, Kersh GJ, Michael White J, Allen PM) J Exp Med 1999 May 17;189(10):1531-44 PMID: 10330432 PMCID: PMC2193645 05/20/1999       91 Citations
  • Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection. (Plas DR, Williams CB, Kersh GJ, White LS, White JM, Paust S, Ulyanova T, Allen PM, Thomas ML) J Immunol 1999 May 15;162(10):5680-4 PMID: 10229799 05/07/1999       45 Citations
  • In vivo antagonism of a T cell response by an endogenously expressed ligand. (Basu D, Williams CB, Allen PM) Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14332-6 PMID: 9826700 PMCID: PMC24373 11/25/1998       35 Citations
  • The study of self-tolerance using murine haemoglobin as a model self antigen. (Williams CB, Allen PM) Novartis Found Symp 1998;215:41-6; discussion 46-53 PMID: 9760570 10/07/1998       2 Citations
  • In vivo expression of a TCR antagonist: T cells escape central tolerance but are antagonized in the periphery. (Williams CB, Vidal K, Donermeyer D, Peterson DA, White JM, Allen PM) J Immunol 1998 Jul 01;161(1):128-37 PMID: 9647216 07/01/1998       30 Citations
  • Endogenous altered peptide ligands can affect peripheral T cell responses. (Vidal K, Hsu BL, Williams CB, Allen PM) J Exp Med 1996 Apr 01;183(4):1311-21 PMID: 8666889 PMCID: PMC2192490 04/01/1996       60 Citations
  • Alleles of the rat T-cell receptor beta chain gene complex. (Blankenhorn EP, Smith PD, Williams CB, Gutman GA) Immunogenetics 1992;35(5):324-31 PMID: 1348495 01/01/1992       10 Citations
  • Organization and nucleotide sequence of the rat T cell receptor beta-chain complex. (Williams CB, Blankenhorn EP, Byrd KE, Levinson G, Gutman GA) J Immunol 1991 Jun 15;146(12):4406-13 PMID: 1828265 06/15/1991       42 Citations
  • A family of three mouse potassium channel genes with intronless coding regions. (Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, Gutman GA) Science 1990 Feb 23;247(4945):973-5 PMID: 2305265 02/23/1990       123 Citations
  • Duplication of Tcra-V gene segments in the rat. (Williams CB, Khurana S, Gutman GA) Immunogenetics 1990;32(2):134-7 PMID: 1975798 01/01/1990       1 Citations
  • T cell receptor beta-chain genes in the rat. Availability and pattern of utilization of V gene segments differs from that in the mouse. (Williams CB, Gutman GA) J Immunol 1989 Feb 01;142(3):1027-35 PMID: 2563271 02/01/1989       24 Citations
  • Sonography of the internal capsule and basal ganglia in infants. Part II. Localization of pathologic processes in the sagittal section through the caudothalamic groove. (Naidich TP, Yousefzadeh DK, Gusnard DA, Naidich JB) Radiology 1986 Dec;161(3):615-21 PMID: 3538134 12/01/1986       7 Citations
  • Last update: 03/27/2017
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