Medical College of Wisconsin
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David X. Zhang MD, PhD

David X. Zhang MD, PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Cardiology
Program: Administration

Member of the Cardiovascular Center

Publications (58)

  • NADPH oxidase 4 contributes to TRPV4-mediated endothelium-dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels. (Xie Y, Nishijima Y, Zinkevich NS, Korishettar A, Fang J, Mathison AJ, Zimmermann MT, Wilcox DA, Gutterman DD, Shen Y, Zhang DX) Basic Res Cardiol 2022 Apr 25;117(1):24 PMID: 35469044 PMCID: PMC9119129 SCOPUS ID: 2-s2.0-85128849246 04/27/2022    
  • Prolonged endothelial-dysfunction in human arterioles following infection with SARS-CoV-2. (Nishijima Y, Hader SN, Hanson AJ, Zhang DX, Sparapani R, Gutterman DD, Beyer AM) Cardiovasc Res 2022 01 07;118(1):18-19 PMID: 34755839 PMCID: PMC8689948 SCOPUS ID: 2-s2.0-85123651313 11/11/2021    
  • Corrigendum: Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium. (Kosuru R, Singh B, Lakshmikanthan S, Nishijima Y, Vasquez-Vivar J, Zhang DX, Chrzanowska M) Front Cell Dev Biol 2021;9:741935 PMID: 34422844 PMCID: PMC8378398 SCOPUS ID: 2-s2.0-85113218440 08/24/2021    
  • Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium. (Kosuru R, Singh B, Lakshmikanthan S, Nishijima Y, Vasquez-Vivar J, Zhang DX, Chrzanowska M) Front Cell Dev Biol 2021;9:687598 PMID: 34222255 PMCID: PMC8247587 SCOPUS ID: 2-s2.0-85109041418 07/06/2021    
  • Endothelial Rap1 (Ras-Association Proximate 1) Restricts Inflammatory Signaling to Protect From the Progression of Atherosclerosis. (Singh B, Kosuru R, Lakshmikanthan S, Sorci-Thomas MG, Zhang DX, Sparapani R, Vasquez-Vivar J, Chrzanowska M) Arterioscler Thromb Vasc Biol 2021 02;41(2):638-650 PMID: 33267664 PMCID: PMC8105264 SCOPUS ID: 2-s2.0-85104181830 12/04/2020       6 Citations
  • Endothelin-1 potentiates TRPV1-mediated vasoconstriction of human adipose arterioles in a protein kinase C-dependent manner. (Korishettar AM, Nishijima Y, Wang Z, Xie Y, Fang J, Wilcox DA, Zhang DX) Br J Pharmacol 2021 02;178(3):709-725 PMID: 33184836 PMCID: PMC9121782 SCOPUS ID: 2-s2.0-85098221966 11/14/2020       3 Citations
  • Myocardin and Kv1 Channels: A Paradigm Shift in Treating Vascular Smooth Muscle Cell-Related Proliferative Disease? (Zhang DX, Gutterman DD) Arterioscler Thromb Vasc Biol 2019 12;39(12):2454-2456 PMID: 31770031 PMCID: PMC6980742 SCOPUS ID: 2-s2.0-85075688768 11/27/2019    
  • TRPV4 regulates matrix stiffness and TGFβ1-induced epithelial-mesenchymal transition. (Sharma S, Goswami R, Zhang DX, Rahaman SO) J Cell Mol Med 2019 02;23(2):761-774 PMID: 30450767 PMCID: PMC6349341 SCOPUS ID: 2-s2.0-85056765656 11/20/2018       39 Citations
  • Endothelin receptor A and p66Shc regulate spontaneous Ca2+ oscillations in smooth muscle cells controlling renal arterial spontaneous motion. (Palygin O, Miller BS, Nishijima Y, Zhang DX, Staruschenko A, Sorokin A) FASEB J 2019 02;33(2):2636-2645 PMID: 30303741 PMCID: PMC6338658 SCOPUS ID: 2-s2.0-85061064863 10/12/2018       3 Citations
  • Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A-mediated phosphorylation. (Cao S, Anishkin A, Zinkevich NS, Nishijima Y, Korishettar A, Wang Z, Fang J, Wilcox DA, Zhang DX) J Biol Chem 2018 04 06;293(14):5307-5322 PMID: 29462784 PMCID: PMC5892583 SCOPUS ID: 2-s2.0-85045077479 02/21/2018       26 Citations
  • Shaker-related voltage-gated K+ channel expression and vasomotor function in human coronary resistance arteries. (Nishijima Y, Korishettar A, Chabowski DS, Cao S, Zheng X, Gutterman DD, Zhang DX) Microcirculation 2018 01;25(1) PMID: 29161755 PMCID: PMC5760438 SCOPUS ID: 2-s2.0-85040240704 11/22/2017       5 Citations
  • Detection of TRPV4 channel current-like activity in Fawn Hooded hypertensive (FHH) rat cerebral arterial muscle cells. (Gebremedhin D, Zhang DX, Weihrauch D, Uche NN, Harder DR) PLoS One 2017;12(5):e0176796 PMID: 28472069 PMCID: PMC5417564 SCOPUS ID: 2-s2.0-85019077900 05/05/2017       5 Citations
  • TRPV4 ion channel is a novel regulator of dermal myofibroblast differentiation. (Sharma S, Goswami R, Merth M, Cohen J, Lei KY, Zhang DX, Rahaman SO) Am J Physiol Cell Physiol 2017 May 01;312(5):C562-C572 PMID: 28249987 PMCID: PMC6105932 SCOPUS ID: 2-s2.0-85018753321 03/03/2017       37 Citations
  • TRPV4 ION Channel Is Associated with Scleroderma. (Goswami R, Cohen J, Sharma S, Zhang DX, Lafyatis R, Bhawan J, Rahaman SO) J Invest Dermatol 2017 04;137(4):962-965 PMID: 27889423 SCOPUS ID: 2-s2.0-85015888580 11/28/2016       16 Citations
  • Contribution of KV1.5 Channel to Hydrogen Peroxide-Induced Human Arteriolar Dilation and Its Modulation by Coronary Artery Disease. (Nishijima Y, Cao S, Chabowski DS, Korishettar A, Ge A, Zheng X, Sparapani R, Gutterman DD, Zhang DX) Circ Res 2017 Feb 17;120(4):658-669 PMID: 27872049 PMCID: PMC5315616 SCOPUS ID: 2-s2.0-85000399498 11/23/2016       33 Citations
  • A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis. (Xu S, Liu B, Yin M, Koroleva M, Mastrangelo M, Ture S, Morrell CN, Zhang DX, Fisher EA, Jin ZG) Oncotarget 2016 Jun 21;7(25):37622-37635 PMID: 27191895 PMCID: PMC5122337 SCOPUS ID: 2-s2.0-84978176831 10/23/2016       45 Citations
  • Expression of CYP 4A ω-hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes. (Gebremedhin D, Zhang DX, Carver KA, Rau N, Rarick KR, Roman RJ, Harder DR) Prostaglandins Other Lipid Mediat 2016 07;124:16-26 PMID: 27174801 PMCID: PMC5287377 SCOPUS ID: 2-s2.0-84973896991 05/14/2016       18 Citations
  • Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice. (Baumgardt SL, Paterson M, Leucker TM, Fang J, Zhang DX, Bosnjak ZJ, Warltier DC, Kersten JR, Ge ZD) Circ Heart Fail 2016 Jan;9(1):e002424 PMID: 26763290 PMCID: PMC4714787 SCOPUS ID: 2-s2.0-84955258675 01/15/2016       38 Citations
  • Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol. (Ho WS, Zheng X, Zhang DX) Br J Pharmacol 2015 Nov;172(22):5251-64 PMID: 26294342 PMCID: PMC4950792 SCOPUS ID: 2-s2.0-84956789081 08/22/2015       19 Citations
  • Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function. (Lakshmikanthan S, Zheng X, Nishijima Y, Sobczak M, Szabo A, Vasquez-Vivar J, Zhang DX, Chrzanowska-Wodnicka M) EMBO Rep 2015 May;16(5):628-37 PMID: 25807985 PMCID: PMC4428051 SCOPUS ID: 2-s2.0-84928885238 03/27/2015       33 Citations
  • TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice. (Rahaman SO, Grove LM, Paruchuri S, Southern BD, Abraham S, Niese KA, Scheraga RG, Ghosh S, Thodeti CK, Zhang DX, Moran MM, Schilling WP, Tschumperlin DJ, Olman MA) J Clin Invest 2014 Dec;124(12):5225-38 PMID: 25365224 PMCID: PMC4348970 SCOPUS ID: 2-s2.0-84915748921 11/05/2014       152 Citations
  • Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure. (Lakshmikanthan S, Zieba BJ, Ge ZD, Momotani K, Zheng X, Lund H, Artamonov MV, Maas JE, Szabo A, Zhang DX, Auchampach JA, Mattson DL, Somlyo AV, Chrzanowska-Wodnicka M) Arterioscler Thromb Vasc Biol 2014 Jul;34(7):1486-94 PMID: 24790136 PMCID: PMC4224284 SCOPUS ID: 2-s2.0-84903159007 05/03/2014       34 Citations
  • Characterization of blood pressure and endothelial function in TRPV4-deficient mice with l-NAME- and angiotensin II-induced hypertension. (Nishijima Y, Zheng X, Lund H, Suzuki M, Mattson DL, Zhang DX) Physiol Rep 2014 Jan 01;2(1):e00199 PMID: 24744878 PMCID: PMC3967682 SCOPUS ID: 2-s2.0-85008930411 04/20/2014       31 Citations
  • Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteries. (Gebremedhin D, Terashvili M, Wickramasekera N, Zhang DX, Rau N, Miura H, Harder DR) PLoS One 2013;8(7):e68498 PMID: 23861911 PMCID: PMC3702596 SCOPUS ID: 2-s2.0-84879802004 07/19/2013       16 Citations
  • Arachidonic acid-induced dilation in human coronary arterioles: convergence of signaling mechanisms on endothelial TRPV4-mediated Ca2+ entry. (Zheng X, Zinkevich NS, Gebremedhin D, Gauthier KM, Nishijima Y, Fang J, Wilcox DA, Campbell WB, Gutterman DD, Zhang DX) J Am Heart Assoc 2013 Apr 25;2(3):e000080 PMID: 23619744 PMCID: PMC3698766 SCOPUS ID: 2-s2.0-84887401738 04/27/2013       57 Citations
  • H2O2-induced dilation in human coronary arterioles: role of protein kinase G dimerization and large-conductance Ca2+-activated K+ channel activation. (Zhang DX, Borbouse L, Gebremedhin D, Mendoza SA, Zinkevich NS, Li R, Gutterman DD) Circ Res 2012 Feb 03;110(3):471-80 PMID: 22158710 PMCID: PMC3272100 SCOPUS ID: 2-s2.0-84856720038 12/14/2011       123 Citations
  • Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling. (Bubolz AH, Mendoza SA, Zheng X, Zinkevich NS, Li R, Gutterman DD, Zhang DX) Am J Physiol Heart Circ Physiol 2012 Feb 01;302(3):H634-42 PMID: 22140047 PMCID: PMC3353785 SCOPUS ID: 2-s2.0-84863016934 12/06/2011       100 Citations
  • PKCα mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells. (Adapala RK, Talasila PK, Bratz IN, Zhang DX, Suzuki M, Meszaros JG, Thodeti CK) Am J Physiol Heart Circ Physiol 2011 Sep;301(3):H757-65 PMID: 21705673 PMCID: PMC3302191 SCOPUS ID: 2-s2.0-80052324633 06/28/2011       68 Citations
  • H2O2 is the transferrable factor mediating flow-induced dilation in human coronary arterioles. (Liu Y, Bubolz AH, Mendoza S, Zhang DX, Gutterman DD) Circ Res 2011 Mar 04;108(5):566-73 PMID: 21233456 PMCID: PMC3108183 SCOPUS ID: 2-s2.0-79952751560 01/15/2011       125 Citations
  • Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs. (Kopf PG, Gauthier KM, Zhang DX, Falck JR, Campbell WB) Hypertension 2011 Feb;57(2):323-9 PMID: 21199991 PMCID: PMC3034648 SCOPUS ID: 2-s2.0-79551496438 01/05/2011       17 Citations
  • Transient receptor potential channel activation and endothelium-dependent dilation in the systemic circulation. (Zhang DX, Gutterman DD) J Cardiovasc Pharmacol 2011 Feb;57(2):133-9 PMID: 20881603 PMCID: PMC3047599 SCOPUS ID: 2-s2.0-79951549829 10/01/2010       61 Citations
  • Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors. (Kopf PG, Zhang DX, Gauthier KM, Nithipatikom K, Yi XY, Falck JR, Campbell WB) Hypertension 2010 Feb;55(2):547-54 PMID: 20038752 PMCID: PMC2819927 SCOPUS ID: 2-s2.0-74949098446 12/30/2009       27 Citations
  • TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. (Mendoza SA, Fang J, Gutterman DD, Wilcox DA, Bubolz AH, Li R, Suzuki M, Zhang DX) Am J Physiol Heart Circ Physiol 2010 Feb;298(2):H466-76 PMID: 19966050 PMCID: PMC2822567 SCOPUS ID: 2-s2.0-74949090413 12/08/2009       218 Citations
  • Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. (Zhang DX, Mendoza SA, Bubolz AH, Mizuno A, Ge ZD, Li R, Warltier DC, Suzuki M, Gutterman DD) Hypertension 2009 Mar;53(3):532-8 PMID: 19188524 PMCID: PMC2694062 SCOPUS ID: 2-s2.0-61749092039 02/04/2009       145 Citations
  • Angiotensin II relaxations of bovine adrenal cortical arteries: role of angiotensin II metabolites and endothelial nitric oxide. (Gauthier KM, Zhang DX, Cui L, Nithipatikom K, Campbell WB) Hypertension 2008 Jul;52(1):150-5 PMID: 18490519 PMCID: PMC3202425 SCOPUS ID: 2-s2.0-46449115611 05/21/2008       13 Citations
  • Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles. (Liu Y, Li H, Bubolz AH, Zhang DX, Gutterman DD) Med Biol Eng Comput 2008 May;46(5):469-78 PMID: 18340474 PMCID: PMC2702135 SCOPUS ID: 2-s2.0-42549149848 03/15/2008       45 Citations
  • Epoxyeicosatrienoic acids, TRP channels, and intracellular Ca2+ in the vasculature: an endothelium-derived endothelium-hyperpolarizing factor? (Larsen BT, Zhang DX, Gutterman DD) Arterioscler Thromb Vasc Biol 2007 Dec;27(12):2496-8 PMID: 17962695 SCOPUS ID: 2-s2.0-36348935053 10/27/2007       8 Citations
  • Steroid-producing cells regulate arterial tone of adrenal cortical arteries. (Zhang DX, Gauthier KM, Falck JR, Siddam A, Campbell WB) Endocrinology 2007 Aug;148(8):3569-76 PMID: 17446179 SCOPUS ID: 2-s2.0-34547098836 04/21/2007       12 Citations
  • ACh-induced relaxations of rabbit small mesenteric arteries: role of arachidonic acid metabolites and K+. (Zhang DX, Gauthier KM, Chawengsub Y, Campbell WB) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H152-9 PMID: 17337603 SCOPUS ID: 2-s2.0-34547112024 03/06/2007       28 Citations
  • Mitochondrial reactive oxygen species-mediated signaling in endothelial cells. (Zhang DX, Gutterman DD) Am J Physiol Heart Circ Physiol 2007 May;292(5):H2023-31 PMID: 17237240 SCOPUS ID: 2-s2.0-34250825264 01/24/2007       341 Citations
  • Mechanisms of histamine-induced relaxation in bovine small adrenal cortical arteries. (Zhang DX, Gauthier KM, Campbell WB) Am J Physiol Endocrinol Metab 2005 Dec;289(6):E1058-63 PMID: 16076876 SCOPUS ID: 2-s2.0-33644678022 08/04/2005       9 Citations
  • Angiotensin II dilates bovine adrenal cortical arterioles: role of endothelial nitric oxide. (Gauthier KM, Zhang DX, Edwards EM, Holmes B, Campbell WB) Endocrinology 2005 Aug;146(8):3319-24 PMID: 15890772 SCOPUS ID: 2-s2.0-23044450565 05/14/2005       21 Citations
  • Cyclooxygenase- and lipoxygenase-dependent relaxation to arachidonic acid in rabbit small mesenteric arteries. (Zhang DX, Gauthier KM, Chawengsub Y, Holmes BB, Campbell WB) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H302-9 PMID: 15388505 SCOPUS ID: 2-s2.0-11144348685 09/25/2004       20 Citations
  • Acetylcholine-induced relaxation and hyperpolarization in small bovine adrenal cortical arteries: role of cytochrome P450 metabolites. (Zhang DX, Gauthier KM, Campbell WB) Endocrinology 2004 Oct;145(10):4532-9 PMID: 15231705 SCOPUS ID: 2-s2.0-4644284906 07/03/2004       8 Citations
  • Characterization of vasoconstrictor responses in small bovine adrenal cortical arteries in vitro. (Zhang DX, Gauthier KM, Campbell WB) Endocrinology 2004 Apr;145(4):1571-8 PMID: 14726440 SCOPUS ID: 2-s2.0-1642464969 01/17/2004       15 Citations
  • Urotensin II is a nitric oxide-dependent vasodilator and natriuretic peptide in the rat kidney. (Zhang AY, Chen YF, Zhang DX, Yi FX, Qi J, Andrade-Gordon P, de Garavilla L, Li PL, Zou AP) Am J Physiol Renal Physiol 2003 Oct;285(4):F792-8 PMID: 12783779 SCOPUS ID: 2-s2.0-0141590352 06/05/2003       97 Citations
  • Cyclic ADP-ribose contributes to contraction and Ca2+ release by M1 muscarinic receptor activation in coronary arterial smooth muscle. (Ge ZD, Zhang DX, Chen YF, Yi FX, Zou AP, Campbell WB, Li PL) J Vasc Res 2003 Jan-Feb;40(1):28-36 PMID: 12644723 SCOPUS ID: 2-s2.0-0037227424 03/20/2003       48 Citations
  • Ceramide-induced activation of NADPH oxidase and endothelial dysfunction in small coronary arteries. (Zhang DX, Zou AP, Li PL) Am J Physiol Heart Circ Physiol 2003 Feb;284(2):H605-12 PMID: 12424096 SCOPUS ID: 2-s2.0-0037306287 11/09/2002       95 Citations
  • Role of ceramide in TNF-alpha-induced impairment of endothelium-dependent vasorelaxation in coronary arteries. (Zhang DX, Yi FX, Zou AP, Li PL) Am J Physiol Heart Circ Physiol 2002 Nov;283(5):H1785-94 PMID: 12384455 SCOPUS ID: 2-s2.0-0036838876 10/18/2002       61 Citations
  • Calcium-induced calcium release and cyclic ADP-ribose-mediated signaling in the myocytes from small coronary arteries. (Zhang DX, Harrison MD, Li PL) Microvasc Res 2002 Sep;64(2):339-48 PMID: 12204658 SCOPUS ID: 2-s2.0-0036384195 09/03/2002       12 Citations
  • Effects of homocysteine on intracellular nitric oxide and superoxide levels in the renal arterial endothelium. (Li N, Yi FX, Rute E, Zhang DX, Slocum GR, Zou AP) Am J Physiol Heart Circ Physiol 2002 Sep;283(3):H1237-43 PMID: 12181155 SCOPUS ID: 2-s2.0-0036351855 08/16/2002       25 Citations
  • Role of ADP-ribose in 11,12-EET-induced activation of K(Ca) channels in coronary arterial smooth muscle cells. (Li PL, Zhang DX, Ge ZD, Campbell WB) Am J Physiol Heart Circ Physiol 2002 Apr;282(4):H1229-36 PMID: 11893556 SCOPUS ID: 2-s2.0-0036084912 03/15/2002       39 Citations
  • Characteristics and superoxide-induced activation of reconstituted myocardial mitochondrial ATP-sensitive potassium channels. (Zhang DX, Chen YF, Campbell WB, Zou AP, Gross GJ, Li PL) Circ Res 2001 Dec 07;89(12):1177-83 PMID: 11739283 SCOPUS ID: 2-s2.0-0035824922 12/12/2001       176 Citations
  • Production and metabolism of ceramide in normal and ischemic-reperfused myocardium of rats. (Zhang DX, Fryer RM, Hsu AK, Zou AP, Gross GJ, Campbell WB, Li PL) Basic Res Cardiol 2001 May-Jun;96(3):267-74 PMID: 11403420 SCOPUS ID: 2-s2.0-0035040978 06/14/2001       71 Citations
  • Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries. (Zhang DX, Zou AP, Li PL) Circ Res 2001 Apr 27;88(8):824-31 PMID: 11325875 SCOPUS ID: 2-s2.0-0035957592 04/28/2001       66 Citations
  • Adenosine diphosphate ribose dilates bovine coronary small arteries through apyrase- and 5'-nucleotidase-mediated metabolism. (Zhang DX, Zou AP, Li PL) J Vasc Res 2001 Jan-Feb;38(1):64-72 PMID: 11173996 SCOPUS ID: 2-s2.0-0035105095 02/15/2001       14 Citations
  • Nitric oxide inhibits Ca(2+) mobilization through cADP-ribose signaling in coronary arterial smooth muscle cells. (Yu JZ, Zhang DX, Zou AP, Campbell WB, Li PL) Am J Physiol Heart Circ Physiol 2000 Sep;279(3):H873-81 PMID: 10993745 SCOPUS ID: 2-s2.0-0033826526 09/20/2000       51 Citations
  • Effect of ceramide on KCa channel activity and vascular tone in coronary arteries. (Li PL, Zhang DX, Zou AP, Campbell WB) Hypertension 1999 Jun;33(6):1441-6 PMID: 10373230 SCOPUS ID: 2-s2.0-0032588253 06/18/1999       47 Citations
  • Last update: 04/27/2022