Medical College of Wisconsin
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Gwen Lomberk PhD

Gwen Lomberk PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Administration
Program: General

Member of the Cancer Center


Research Experience

  • Cell Cycle Proteins
  • Cell Nucleus Shape
  • Chromatin
  • Chromatin Assembly and Disassembly
  • Chromatin Immunoprecipitation
  • Chromosomal Proteins, Non-Histone
  • Epigenesis, Genetic
  • Gene Expression Regulation
  • Gene Expression Regulation, Neoplastic
  • Histone Code
  • Histone-Lysine N-Methyltransferase
  • Kruppel-Like Transcription Factors
  • Nuclear Proteins
  • Pancreatic Neoplasms
  • Leadership Positions

  • Chief, Division of Research
  • Director Basic Science Research, Department of Surgery
  • Publications

  • Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss. (Kalinec GM, Lomberk G, Urrutia RA, Kalinec F) Front Cell Neurosci 2017;11:192 PMID: 28736517 PMCID: PMC5500902 07/25/2017
  • Functional validation reveals the novel missense V419L variant in TGFBR2 associated with Loeys-Dietz syndrome (LDS) impairs canonical TGF-β signaling. (Cousin MA, Zimmermann MT, Mathison AJ, Blackburn PR, Boczek NJ, Oliver GR, Lomberk GA, Urrutia RA, Deyle DR, Klee EW) Cold Spring Harb Mol Case Stud 2017 Jul;3(4) PMID: 28679693 PMCID: PMC5495030 07/07/2017
  • Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe. (Mathison A, Salmonson A, Missfeldt M, Bintz J, Williams M, Kossak S, Nair A, de Assuncao TM, Christensen T, Buttar N, Iovanna J, Huebert R, Lomberk G) Mol Cancer Res 2017 Aug;15(8):984-997 PMID: 28442587 04/27/2017
  • A novel de novo frameshift deletion in EHMT1 in a patient with Kleefstra Syndrome results in decreased H3K9 dimethylation. (Blackburn PR, Williams M, Cousin MA, Boczek NJ, Beek GJ, Lomberk GA, Urrutia RA, Babovic-Vuksanovic D, Klee EW) Mol Genet Genomic Med 2017 Mar;5(2):141-146 PMID: 28361100 PMCID: PMC5370226 04/01/2017
  • Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts. (Bian B, Bigonnet M, Gayet O, Loncle C, Maignan A, Gilabert M, Moutardier V, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Ouaissi M, Secq V, Poizat F, Nicolle R, Blum Y, Marisa L, Rubis M, Raoul JL, Bradner JE, Qi J, Lomberk G, Urrutia R, Saul A, Dusetti N, Iovanna J) EMBO Mol Med 2017 Apr;9(4):482-497 PMID: 28275007 PMCID: PMC5376755 03/10/2017
  • A Novel Kleefstra Syndrome-associated Variant That Affects the Conserved TPLX Motif within the Ankyrin Repeat of EHMT1 Leads to Abnormal Protein Folding. (Blackburn PR, Tischer A, Zimmermann MT, Kemppainen JL, Sastry S, Knight Johnson AE, Cousin MA, Boczek NJ, Oliver G, Misra VK, Gavrilova RH, Lomberk G, Auton M, Urrutia R, Klee EW) J Biol Chem 2017 Mar 03;292(9):3866-3876 PMID: 28057753 PMCID: PMC5339767 01/07/2017
  • Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion. (Jalan-Sakrikar N, De Assuncao TM, Lu J, Almada LL, Lomberk G, Fernandez-Zapico ME, Urrutia R, Huebert RC) PLoS One 2016;11(12):e0168266 PMID: 27936185 PMCID: PMC5148157 12/10/2016
  • The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes Kras(G12D)-mediated pancreatic cancer initiation. (Loncle C, Molejon MI, Lac S, Tellechea JI, Lomberk G, Gramatica L, Fernandez Zapico MF, Dusetti N, Urrutia R, Iovanna JL) Cell Death Dis 2016 Jul 14;7:e2295 PMID: 27415425 PMCID: PMC4973346 07/16/2016
  • The promise of epigenomic therapeutics in pancreatic cancer. (Lomberk GA, Iovanna J, Urrutia R) Epigenomics 2016 Jun;8(6):831-42 PMID: 27337224 PMCID: PMC5066125 06/24/2016
  • REG3β Plays a Key Role in IL17RA Protumoral Effect-Response. (Loncle C, Bonjoch L, Folch-Puy E, Lopez-Millan MB, Lac S, Molejon MI, Chuluyan E, Cordelier P, Dubus P, Lomberk G, Urrutia R, Closa D, Iovanna JL) Cancer Res 2016 04 01;76(7):2051 PMID: 26992425 03/20/2016
  • Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1γ. (Velez G, Lin M, Christensen T, Faubion WA, Lomberk G, Urrutia R) J Mol Model 2016 Jan;22(1):12 PMID: 26680990 PMCID: PMC4683166 12/19/2015
  • Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation. (Grasso D, Bintz J, Lomberk G, Molejon MI, Loncle C, Garcia MN, Lopez MB, Urrutia R, Iovanna JL) Sci Rep 2015 Nov 30;5:17549 PMID: 26617245 PMCID: PMC4663475 12/01/2015
  • Krüppel-like factor KLF10 deficiency predisposes to colitis through colonic macrophage dysregulation. (Papadakis KA, Krempski J, Svingen P, Xiong Y, Sarmento OF, Lomberk GA, Urrutia RA, Faubion WA) Am J Physiol Gastrointest Liver Physiol 2015 Dec 01;309(11):G900-9 PMID: 26472224 PMCID: PMC4669350 10/17/2015
  • Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes. (De Assuncao TM, Sun Y, Jalan-Sakrikar N, Drinane MC, Huang BQ, Li Y, Davila JI, Wang R, O'Hara SP, Lomberk GA, Urrutia RA, Ikeda Y, Huebert RC) Lab Invest 2015 Oct;95(10):1218 PMID: 26412498 09/29/2015
  • IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer. (Loncle C, Bonjoch L, Folch-Puy E, Lopez-Millan MB, Lac S, Molejon MI, Chuluyan E, Cordelier P, Dubus P, Lomberk G, Urrutia R, Closa D, Iovanna JL) Cancer Res 2015 Nov 15;75(22):4852-62 PMID: 26404002 PMCID: PMC4651828 09/26/2015
  • Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. (Guo Y, Fan Y, Zhang J, Lomberk GA, Zhou Z, Sun L, Mathison AJ, Garcia-Barrio MT, Zhang J, Zeng L, Li L, Pennathur S, Willer CJ, Rader DJ, Urrutia R, Chen YE) J Clin Invest 2015 Oct 01;125(10):3819-30 PMID: 26368306 PMCID: PMC4607137 09/15/2015
  • The Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear Structure. (Lomberk GA, Urrutia R) Surg Clin North Am 2015 Oct;95(5):935-52 PMID: 26315515 PMCID: PMC4556141 09/01/2015
  • Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes. (Mathison A, Escande C, Calvo E, Seo S, White T, Salmonson A, Faubion WA Jr, Buttar N, Iovanna J, Lomberk G, Chini EN, Urrutia R) Endocrinology 2015 Oct;156(10):3581-95 PMID: 26248217 PMCID: PMC4588811 08/08/2015
  • Restoration of epigenetically silenced SULF1 expression by 5-aza-2-deoxycytidine sensitizes hepatocellular carcinoma cells to chemotherapy-induced apoptosis. (Shire A, Lomberk G, Lai JP, Zou H, Tsuchiya N, Aderca I, Moser CD, Gulaid KH, Oseini A, Hu C, Warsame O, Jenkins RB, Roberts LR) Med Epigenet 2015 Jan-Apr;3(1):1-18 PMID: 26236329 PMCID: PMC4520440 08/04/2015
  • The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage. (Leonard PH, Grzenda A, Mathison A, Morbeck DE, Fredrickson JR, de Assuncao TM, Christensen T, Salisbury J, Calvo E, Iovanna J, Coddington CC, Urrutia R, Lomberk G) BMC Dev Biol 2015 May 29;15:23 PMID: 26021315 PMCID: PMC4448908 05/30/2015
  • Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1. (Lopez MB, Garcia MN, Grasso D, Bintz J, Molejon MI, Velez G, Lomberk G, Neira JL, Urrutia R, Iovanna J) J Cell Physiol 2015 Dec;230(12):2936-50 PMID: 25899918 PMCID: PMC4778741 04/23/2015
  • Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes. (De Assuncao TM, Sun Y, Jalan-Sakrikar N, Drinane MC, Huang BQ, Li Y, Davila JI, Wang R, O'Hara SP, Lomberk GA, Urrutia RA, Ikeda Y, Huebert RC) Lab Invest 2015 Jun;95(6):684-96 PMID: 25867762 PMCID: PMC4447567 04/14/2015
  • Evidence revealing deregulation of the KLF11-MAO A pathway in association with chronic stress and depressive disorders. (Harris S, Johnson S, Duncan JW, Udemgba C, Meyer JH, Albert PR, Lomberk G, Urrutia R, Ou XM, Stockmeier CA, Wang JM) Neuropsychopharmacology 2015 May;40(6):1373-82 PMID: 25502632 PMCID: PMC4397395 12/17/2014
  • Krüppel-like factor KLF10 regulates transforming growth factor receptor II expression and TGF-β signaling in CD8+ T lymphocytes. (Papadakis KA, Krempski J, Reiter J, Svingen P, Xiong Y, Sarmento OF, Huseby A, Johnson AJ, Lomberk GA, Urrutia RA, Faubion WA) Am J Physiol Cell Physiol 2015 Mar 01;308(5):C362-71 PMID: 25472963 PMCID: PMC4346734 12/05/2014
  • IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation. (Garcia MN, Grasso D, Lopez-Millan MB, Hamidi T, Loncle C, Tomasini R, Lomberk G, Porteu F, Urrutia R, Iovanna JL) J Clin Invest 2014 Nov;124(11):4709-22 PMID: 25250570 PMCID: PMC4347237 09/25/2014
  • Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins. (Urrutia R, Velez G, Lin M, Lomberk G, Neira JL, Iovanna J) J Mol Model 2014 Aug;20(8):2357 PMID: 25056123 PMCID: PMC4139591 07/25/2014
  • Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene. (Xiong Y, Svingen PA, Sarmento OO, Smyrk TC, Dave M, Khanna S, Lomberk GA, Urrutia RA, Faubion WA Jr) Am J Physiol Regul Integr Comp Physiol 2014 Sep 15;307(6):R608-20 PMID: 24944246 PMCID: PMC4166759 06/20/2014
  • Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence. (Grasso D, Garcia MN, Hamidi T, Cano C, Calvo E, Lomberk G, Urrutia R, Iovanna JL) Cell Death Differ 2014 Oct;21(10):1633-41 PMID: 24902898 PMCID: PMC4158688 06/07/2014
  • Single and combinatorial chromatin coupling events underlies the function of transcript factor Krüppel-like factor 11 in the regulation of gene networks. (Calvo E, Grzenda A, Lomberk G, Mathison A, Iovanna J, Urrutia R) BMC Mol Biol 2014 May 25;15:10 PMID: 24885560 PMCID: PMC4049485 06/03/2014
  • Aurora-A mitotic kinase induces endocrine resistance through down-regulation of ERα expression in initially ERα+ breast cancer cells. (Opyrchal M, Salisbury JL, Zhang S, McCubrey J, Hawse J, Goetz MP, Lomberk GA, Haddad T, Degnim A, Lange C, Ingle JN, Galanis E, D'Assoro AB) PLoS One 2014;9(5):e96995 PMID: 24816249 PMCID: PMC4016211 05/13/2014
  • New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. (de Assuncao TM, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto DA, Huebert RC, Urrutia RA, Shah VH) J Biol Chem 2014 May 30;289(22):15798-809 PMID: 24759103 PMCID: PMC4140934 04/25/2014
  • Diabetes-causing gene, kruppel-like factor 11, modulates the antinociceptive response of chronic ethanol intake. (Ou XM, Udemgba C, Wang N, Dai X, Lomberk G, Seo S, Urrutia R, Wang J, Duncan J, Harris S, Fairbanks CA, Zhang X) Alcohol Clin Exp Res 2014 Feb;38(2):401-8 PMID: 24428663 PMCID: PMC5567722 01/17/2014
  • Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1. (Grasso D, Garcia MN, Hamidi T, Cano C, Calvo E, Lomberk G, Urrutia R, Iovanna JL) Mol Cell Oncol 2014;1(1):e29913 PMID: 27308320 PMCID: PMC4905183 01/01/2014
  • Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways. (Hayashi Y, Asuzu DT, Gibbons SJ, Aarsvold KH, Bardsley MR, Lomberk GA, Mathison AJ, Kendrick ML, Shen KR, Taguchi T, Gupta A, Rubin BP, Fletcher JA, Farrugia G, Urrutia RA, Ordog T) PLoS One 2013;8(10):e76822 PMID: 24116170 PMCID: PMC3792098 10/12/2013
  • Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis. (Mathison A, Grzenda A, Lomberk G, Velez G, Buttar N, Tietz P, Hendrickson H, Liebl A, Xiong YY, Gores G, Fernandez-Zapico M, Larusso NF, Faubion W, Shah VH, Urrutia R) PLoS One 2013;8(9):e75311 PMID: 24069400 PMCID: PMC3775729 09/27/2013
  • Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis. (Cano CE, Hamidi T, Garcia MN, Grasso D, Loncle C, Garcia S, Calvo E, Lomberk G, Dusetti N, Bartholin L, Urrutia R, Iovanna JL) Gut 2014 Jun;63(6):984-95 PMID: 24026351 09/13/2013
  • Functional impact of Aurora A-mediated phosphorylation of HP1γ at serine 83 during cell cycle progression. (Grzenda A, Leonard P, Seo S, Mathison AJ, Urrutia G, Calvo E, Iovanna J, Urrutia R, Lomberk G) Epigenetics Chromatin 2013 Jul 05;6(1):21 PMID: 23829974 PMCID: PMC3707784 07/09/2013
  • Epigenetics: a promising paradigm for better understanding and managing pain. (Seo S, Grzenda A, Lomberk G, Ou XM, Cruciani RA, Urrutia R) J Pain 2013 Jun;14(6):549-57 PMID: 23602266 PMCID: PMC3672350 04/23/2013
  • Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young. (Lomberk G, Grzenda A, Mathison A, Escande C, Zhang JS, Calvo E, Miller LJ, Iovanna J, Chini EN, Fernandez-Zapico ME, Urrutia R) J Biol Chem 2013 Jun 14;288(24):17745-58 PMID: 23589285 PMCID: PMC3682574 04/17/2013
  • A novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis. (Daftary GS, Zheng Y, Tabbaa ZM, Schoolmeester JK, Gada RP, Grzenda AL, Mathison AJ, Keeney GL, Lomberk GA, Urrutia R) PLoS One 2013;8(3):e60165 PMID: 23555910 PMCID: PMC3610699 04/05/2013
  • Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs. (Gilabert M, Vaccaro MI, Fernandez-Zapico ME, Calvo EL, Turrini O, Secq V, Garcia S, Moutardier V, Lomberk G, Dusetti N, Urrutia R, Iovanna JL) J Cell Physiol 2013 Sep;228(9):1834-43 PMID: 23460482 PMCID: PMC4048029 03/06/2013
  • Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression. (Grzenda A, Lomberk G, Svingen P, Mathison A, Calvo E, Iovanna J, Xiong Y, Faubion W, Urrutia R) Epigenetics Chromatin 2013 Feb 28;6(1):3 PMID: 23448518 PMCID: PMC3606351 03/02/2013
  • Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis. (McCleary-Wheeler AL, Lomberk GA, Weiss FU, Schneider G, Fabbri M, Poshusta TL, Dusetti NJ, Baumgart S, Iovanna JL, Ellenrieder V, Urrutia R, Fernandez-Zapico ME) Cancer Lett 2013 Jan 28;328(2):212-21 PMID: 23073473 PMCID: PMC3513548 10/18/2012
  • NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells. (Hamidi T, Cano CE, Grasso D, Garcia MN, Sandi MJ, Calvo EL, Dagorn JC, Lomberk G, Goruppi S, Urrutia R, Carracedo A, Velasco G, Iovanna JL) Autophagy 2013 Jan;9(1):95-7 PMID: 23047430 PMCID: PMC3542222 10/11/2012
  • Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death. (Hamidi T, Cano CE, Grasso D, Garcia MN, Sandi MJ, Calvo EL, Dagorn JC, Lomberk G, Urrutia R, Goruppi S, Carracedo A, Velasco G, Iovanna JL) Clin Cancer Res 2012 Oct 01;18(19):5234-46 PMID: 22899799 08/18/2012
  • Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner. (Xiong Y, Khanna S, Grzenda AL, Sarmento OF, Svingen PA, Lomberk GA, Urrutia RA, Faubion WA Jr) J Biol Chem 2012 Oct 05;287(41):34372-85 PMID: 22896699 PMCID: PMC3464543 08/17/2012
  • Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer. (Cano CE, Sandí MJ, Hamidi T, Calvo EL, Turrini O, Bartholin L, Loncle C, Secq V, Garcia S, Lomberk G, Kroemer G, Urrutia R, Iovanna JL) EMBO Mol Med 2012 Sep;4(9):964-79 PMID: 22821859 PMCID: PMC3491828 07/24/2012
  • Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts. (Kitange GJ, Mladek AC, Carlson BL, Schroeder MA, Pokorny JL, Cen L, Decker PA, Wu W, Lomberk GA, Gupta SK, Urrutia RA, Sarkaria JN) Clin Cancer Res 2012 Aug 01;18(15):4070-9 PMID: 22675172 PMCID: PMC3716364 06/08/2012
  • Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression. (Grunewald M, Johnson S, Lu D, Wang Z, Lomberk G, Albert PR, Stockmeier CA, Meyer JH, Urrutia R, Miczek KA, Austin MC, Wang J, Paul IA, Woolverton WL, Seo S, Sittman DB, Ou XM) J Biol Chem 2012 Jul 13;287(29):24195-206 PMID: 22628545 PMCID: PMC3397846 05/26/2012
  • Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. (Hamidi T, Algül H, Cano CE, Sandi MJ, Molejon MI, Riemann M, Calvo EL, Lomberk G, Dagorn JC, Weih F, Urrutia R, Schmid RM, Iovanna JL) J Clin Invest 2012 Jun;122(6):2092-103 PMID: 22565310 PMCID: PMC3366404 05/09/2012
  • Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells. (Seo S, Lomberk G, Mathison A, Buttar N, Podratz J, Calvo E, Iovanna J, Brimijoin S, Windebank A, Urrutia R) J Biol Chem 2012 Apr 13;287(16):12723-35 PMID: 22375010 PMCID: PMC3339994 03/01/2012
  • Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases. (Lomberk G, Mathison AJ, Grzenda A, Seo S, DeMars CJ, Rizvi S, Bonilla-Velez J, Calvo E, Fernandez-Zapico ME, Iovanna J, Buttar NS, Urrutia R) J Biol Chem 2012 Apr 13;287(16):13026-39 PMID: 22318730 PMCID: PMC3339955 02/10/2012
  • Detailed structural-functional analysis of the Krüppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology. (Daftary GS, Lomberk GA, Buttar NS, Allen TW, Grzenda A, Zhang J, Zheng Y, Mathison AJ, Gada RP, Calvo E, Iovanna JL, Billadeau DD, Prendergast FG, Urrutia R) J Biol Chem 2012 Mar 02;287(10):7010-25 PMID: 22203677 PMCID: PMC3293586 12/29/2011
  • MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression. (Xiao TZ, Bhatia N, Urrutia R, Lomberk GA, Simpson A, Longley BJ) PLoS One 2011;6(8):e23747 PMID: 21876767 PMCID: PMC3158099 08/31/2011
  • Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid. (Singh SK, Baumgart S, Singh G, König AO, Reutlinger K, Hofbauer LC, Barth P, Gress TM, Lomberk G, Urrutia R, Fernandez-Zapico ME, Ellenrieder V) J Biol Chem 2011 Aug 19;286(33):28761-71 PMID: 21628454 PMCID: PMC3190684 06/02/2011
  • Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus. (Bonnefond A, Lomberk G, Buttar N, Busiah K, Vaillant E, Lobbens S, Yengo L, Dechaume A, Mignot B, Simon A, Scharfmann R, Neve B, Tanyolaç S, Hodoglugil U, Pattou F, Cavé H, Iovanna J, Stein R, Polak M, Vaxillaire M, Froguel P, Urrutia R) J Biol Chem 2011 Aug 12;286(32):28414-24 PMID: 21592955 PMCID: PMC3151084 05/20/2011
  • Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis. (Thabut D, Routray C, Lomberk G, Shergill U, Glaser K, Huebert R, Patel L, Masyuk T, Blechacz B, Vercnocke A, Ritman E, Ehman R, Urrutia R, Shah V) Hepatology 2011 Aug;54(2):573-85 PMID: 21567441 PMCID: PMC3145033 05/14/2011
  • Epigenetic silencing of tumor suppressor genes in pancreatic cancer. (Lomberk GA) J Gastrointest Cancer 2011 Jun;42(2):93-9 PMID: 21318291 02/15/2011
  • A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth. (Fernandez-Zapico ME, Lomberk GA, Tsuji S, DeMars CJ, Bardsley MR, Lin YH, Almada LL, Han JJ, Mukhopadhyay D, Ordog T, Buttar NS, Urrutia R) Biochem J 2011 Apr 15;435(2):529-37 PMID: 21171965 PMCID: PMC3130109 12/22/2010
  • Pancreatic stellate cell models for transcriptional studies of desmoplasia-associated genes. (Mathison A, Liebl A, Bharucha J, Mukhopadhyay D, Lomberk G, Shah V, Urrutia R) Pancreatology 2010;10(4):505-16 PMID: 20847583 PMCID: PMC3214918 09/18/2010
  • Combinatorial chemoprevention reveals a novel smoothened-independent role of GLI1 in esophageal carcinogenesis. (Rizvi S, Demars CJ, Comba A, Gainullin VG, Rizvi Z, Almada LL, Wang K, Lomberk G, Fernández-Zapico ME, Buttar NS) Cancer Res 2010 Sep 01;70(17):6787-96 PMID: 20647328 PMCID: PMC2954590 07/22/2010
  • Kitlow stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors. (Bardsley MR, Horváth VJ, Asuzu DT, Lorincz A, Redelman D, Hayashi Y, Popko LN, Young DL, Lomberk GA, Urrutia RA, Farrugia G, Rubin BP, Ordog T) Gastroenterology 2010 Sep;139(3):942-52 PMID: 20621681 PMCID: PMC2933938 07/14/2010
  • Angiogenesis. (Lomberk G) Pancreatology 2010;10(2-3):112-3 PMID: 20460942 05/13/2010
  • Conservation of the TGFbeta/Labial homeobox signaling loop in endoderm-derived cells between Drosophila and mammals. (Lomberk GA, Imoto I, Gebelein B, Urrutia R, Cook TA) Pancreatology 2010;10(1):74-84 PMID: 20339309 PMCID: PMC2865486 03/27/2010
  • The extracellular matrix and cell migration. (Lomberk G) Pancreatology 2010;10(1):4-5 PMID: 20299816 03/20/2010
  • Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis. (Buttar NS, DeMars CJ, Lomberk G, Rizvi S, Bonilla-Velez J, Achra S, Rashtak S, Wang KK, Fernandez-Zapico ME, Urrutia R) J Biol Chem 2010 Apr 09;285(15):11433-44 PMID: 20154088 PMCID: PMC2857022 02/16/2010
  • Lipid biology. (Lomberk G) Pancreatology 2009;9(6):722-3 PMID: 20016243 12/18/2009
  • Microscopy. (Lomberk G) Pancreatology 2009;9(5):554-5 PMID: 19556828 06/27/2009
  • Sin3: master scaffold and transcriptional corepressor. (Grzenda A, Lomberk G, Zhang JS, Urrutia R) Biochim Biophys Acta 2009 Jun-Aug;1789(6-8):443-50 PMID: 19505602 PMCID: PMC3686104 06/10/2009
  • Funding opportunities for rare pancreatic diseases. (Lomberk G) Pancreatology 2009;9(4):327-8 PMID: 19468246 05/27/2009
  • Primers on molecular pathways--the insulin pathway. (Lomberk G, Urrutia R) Pancreatology 2009;9(3):203-5 PMID: 19299910 03/21/2009
  • Diabetes. (Lomberk G) Pancreatology 2009;9(3):200-2 PMID: 19299909 03/21/2009
  • The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer research. (Lomberk G, Mathison AJ, Grzenda A, Urrutia R) Curr Opin Gastroenterol 2008 Sep;24(5):597-602 PMID: 19122501 PMCID: PMC2941574 01/06/2009
  • Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling. (Truty MJ, Lomberk G, Fernandez-Zapico ME, Urrutia R) J Biol Chem 2009 Mar 06;284(10):6291-300 PMID: 19088080 PMCID: PMC2649086 12/18/2008
  • Primers on molecular pathways--caspase pathway. (Lomberk G, Urrutia R) Pancreatology 2009;9(1-2):6-8 PMID: 19077449 12/17/2008
  • Educational websites--Bioinformatics Tools II. (Lomberk G) Pancreatology 2009;9(1-2):4-5 PMID: 19077448 12/17/2008
  • Primers on molecular pathways--pain and opioid receptors, I. (Lomberk G, Cruciani R, Urrutia R) Pancreatology 2008;8(6):544-5 PMID: 18818506 09/27/2008
  • Pain management. (Lomberk G) Pancreatology 2008;8(6):542-3 PMID: 18818505 09/27/2008
  • Patient advocacy. (Lomberk G) Pancreatology 2008;8(4-5):420-1 PMID: 18714174 08/21/2008
  • Societies. (Lomberk G) Pancreatology 2008;8(3):225-6 PMID: 18497535 05/24/2008
  • Primers on molecular pathways--notch. (Lomberk G, Urrutia R) Pancreatology 2008;8(2):103-4 PMID: 18382095 04/03/2008
  • Pharmacogenomics. (Lomberk G) Pancreatology 2008;8(1):4-5 PMID: 18235210 02/01/2008
  • Epigenetics. (Lomberk G) Pancreatology 2007;7(5-6):396-7 PMID: 17898528 09/28/2007
  • Stem cells. (Lomberk G) Pancreatology 2007;7(4):314-6 PMID: 17627095 07/14/2007
  • Alcohol and pancreas. (Lomberk G) Pancreatology 2007;7(2-3):96-7 PMID: 17570953 06/16/2007
  • Laboratory skills. (Lomberk G) Pancreatology 2007;7(1):7-8 PMID: 17259745 01/30/2007
  • The Heterochromatin Protein 1 family. (Lomberk G, Wallrath L, Urrutia R) Genome Biol 2006;7(7):228 PMID: 17224041 PMCID: PMC1779566 01/17/2007
  • Animal models. (Lomberk G) Pancreatology 2006;6(5):427-8 PMID: 16847379 07/19/2006
  • Evidence for the existence of an HP1-mediated subcode within the histone code. (Lomberk G, Bensi D, Fernandez-Zapico ME, Urrutia R) Nat Cell Biol 2006 Apr;8(4):407-15 PMID: 16531993 03/15/2006
  • The family feud: turning off Sp1 by Sp1-like KLF proteins. (Lomberk G, Urrutia R) Biochem J 2005 Nov 15;392(Pt 1):1-11 PMID: 16266294 PMCID: PMC1317658 11/04/2005
  • When developmental signaling pathways go wrong and their impact on pancreatic cancer development. (Lomberk G, Fernandez-Zapico ME, Urrutia R) Curr Opin Gastroenterol 2005 Sep;21(5):555-60 PMID: 16093769 08/12/2005
  • Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer. (Denison SR, Callahan G, Becker NA, Phillips LA, Smith DI) Genes Chromosomes Cancer 2003 Sep;38(1):40-52 PMID: 12874785 07/23/2003
  • Characterization of the common fragile site FRA9E and its potential role in ovarian cancer. (Callahan G, Denison SR, Phillips LA, Shridhar V, Smith DI) Oncogene 2003 Jan 30;22(4):590-601 PMID: 12555072 01/30/2003
  • Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer. (Huang H, Reed CP, Mordi A, Lomberk G, Wang L, Shridhar V, Hartmann L, Jenkins R, Smith DI) Genes Chromosomes Cancer 1999 Jan;24(1):48-55 PMID: 9892108 01/19/1999
  • Last update: 08/16/2017
    jenkins-FCD Prod-130 96200611f8481f0aa4f84230b11dd74d063847a3