Medical College of Wisconsin
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Jong-In Park PhD

Jong-In Park PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Biochemistry
Program: Program Development

Member of the Cancer Center


  • Active ERK2 is sufficient to mediate growth arrest and differentiation signaling. (Wu PK, Hong SK, Yoon SH, Park JI) FEBS J 2015 Jan 16: PMID 25639353
  • Sp1 regulates Raf/MEK/ERK-induced p21(CIP1) transcription in TP53-mutated cancer cells. (Karkhanis M, Park JI) Cell Signal 2015 Mar;27(3):479-86 PMID 25595558
  • Kinome sequencing reveals RET G691S polymorphism in human neuroendocrine lung cancer cell lines. (Sosonkina N, Hong SK, Starenki D, Park JI) Genes Genomics 2014 Dec;36(6):829-841 PMID 25530832
  • Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells. (Starenki D, Hong SK, Lloyd RV, Park JI) Oncogene 2014 Dec 1: PMID 25435367
  • Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels. (Kim JH, Hong SK, Wu PK, Richards AL, Jackson WT, Park JI) Exp Cell Res 2014 Oct 1;327(2):340-52 PMID 25128814
  • Growth arrest signaling of the Raf/MEK/ERK pathway in cancer. (Park JI) Front Biol (Beijing) 2014 Feb;9(2):95-103 PMID 24999356
  • The Role of STAT3 in Thyroid Cancer. (Sosonkina N, Starenki D, Park JI) Cancers (Basel) 2014;6(1):526-44 PMID 24662939
  • Autophagy sensitivity of neuroendocrine lung tumor cells. (Hong SK, Kim JH, Starenki D, Park JI) Int J Oncol 2013 Dec;43(6):2031-8 PMID 24126619
  • A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase. (Wu PK, Hong SK, Veeranki S, Karkhanis M, Starenki D, Plaza JA, Park JI) Mol Cell Biol 2013 Oct;33(20):4051-67 PMID 23959801
  • Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice. (Starenki D, Singh NK, Jensen DR, Peterson FC, Park JI) Cancer Lett 2013 Oct 1;339(1):144-51 PMID 23856028
  • AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion. (Hong SK, Jeong JH, Chan AM, Park JI) Exp Cell Res 2013 Jul 15;319(12):1732-43 PMID 23701950
  • Mitochondria-targeted nitroxide, Mito-CP, suppresses medullary thyroid carcinoma cell survival in vitro and in vivo. (Starenki D, Park JI) J Clin Endocrinol Metab 2013 Apr;98(4):1529-40 PMID 23509102
  • Cooperative Cross-Talk between Neuroblastoma Subtypes Confers Resistance to Anaplastic Lymphoma Kinase Inhibition. (Yan X, Kennedy CR, Tilkens SB, Wiedemeier O, Guan H, Park JI, Chan AM) Genes Cancer 2011 May;2(5):538-49 PMID 21901167
  • The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells. (Hong SK, Kim JH, Lin MF, Park JI) Exp Cell Res 2011 Nov 1;317(18):2671-82 PMID 21871886
  • Leukemia inhibitory factor can mediate Ras/Raf/MEK/ERK-induced growth inhibitory signaling in medullary thyroid cancer cells. (Arthan D, Hong SK, Park JI) Cancer Lett 2010 Nov 1;297(1):31-41 PMID 20570039
  • Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling. (Hong SK, Yoon S, Moelling C, Arthan D, Park JI) J Biol Chem 2009 Nov 27;284(48):33006-18 PMID 19805545
  • Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. (Yin W, Park JI, Loeser RF) J Biol Chem 2009 Nov 13;284(46):31972-81 PMID 19762915
  • Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells. (Strock CJ, Park JI, Nakakura EK, Bova GS, Isaacs JT, Ball DW, Nelkin BD) Cancer Res 2006 Aug 1;66(15):7509-15 PMID 16885348
  • Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer. (Strock CJ, Park JI, Rosen DM, Ruggeri B, Denmeade SR, Ball DW, Nelkin BD) J Clin Endocrinol Metab 2006 Jan;91(1):79-84 PMID 16263812
  • The high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae is the major determinant of cAMP levels in stationary phase: involvement of different branches of the Ras-cyclic AMP pathway in stress responses. (Park JI, Grant CM, Dawes IW) Biochem Biophys Res Commun 2005 Feb 4;327(1):311-9 PMID 15629464
  • Interleukin-1beta can mediate growth arrest and differentiation via the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. (Park JI, Strock CJ, Ball DW, Nelkin BD) Cytokine 2005 Feb 7;29(3):125-34 PMID 15613280
  • Regulation and function of trefoil factor family 3 expression in the biliary tree. (Nozaki I, Lunz JG 3rd, Specht S, Park JI, Giraud AS, Murase N, Demetris AJ) Am J Pathol 2004 Dec;165(6):1907-20 PMID 15579435
  • GDNF-induced leukemia inhibitory factor can mediate differentiation via the MEK/ERK pathway in pheochromocytoma cells derived from nf1-heterozygous knockout mice. (Park JI, Powers JF, Tischler AS, Strock CJ, Ball DW, Nelkin BD) Exp Cell Res 2005 Feb 1;303(1):79-88 PMID 15572029
  • IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. (Kim EJ, Park JI, Nelkin BD) J Biol Chem 2005 Feb 11;280(6):4913-20 PMID 15572361
  • Rom2p, the Rho1 GTP/GDP exchange factor of Saccharomyces cerevisiae, can mediate stress responses via the Ras-cAMP pathway. (Park JI, Collinson EJ, Grant CM, Dawes IW) J Biol Chem 2005 Jan 28;280(4):2529-35 PMID 15545276
  • CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth. (Strock CJ, Park JI, Rosen M, Dionne C, Ruggeri B, Jones-Bolin S, Denmeade SR, Ball DW, Nelkin BD) Cancer Res 2003 Sep 1;63(17):5559-63 PMID 14500395
  • Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. (Sriuranpong V, Park JI, Amornphimoltham P, Patel V, Nelkin BD, Gutkind JS) Cancer Res 2003 Jun 1;63(11):2948-56 PMID 12782602
  • The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway. (Park JI, Strock CJ, Ball DW, Nelkin BD) Mol Cell Biol 2003 Jan;23(2):543-54 PMID 12509453
  • The cytoplasmic Cu,Zn superoxide dismutase of saccharomyces cerevisiae is required for resistance to freeze-thaw stress. Generation of free radicals during freezing and thawing. (Park JI, Grant CM, Davies MJ, Dawes IW) J Biol Chem 1998 Sep 4;273(36):22921-8 PMID 9722512
  • The freeze-thaw stress response of the yeast Saccharomyces cerevisiae is growth phase specific and is controlled by nutritional state via the RAS-cyclic AMP signal transduction pathway. (Park JI, Grant CM, Attfield PV, Dawes IW) Appl Environ Microbiol 1997 Oct;63(10):3818-24 PMID 9327544
  • Grants and Awards

  • Mechanisms of MEK/ERK Growth Arrest Signaling (#9206357 07/01/2010 - 04/30/2015) Sponsor: NIH Cancer Institute
  • MEK-Induced Growth Arrest in Small Cell Lung Cancer Cells (#9204625 07/01/2007 - 06/30/2013) Sponsor: Flight Attendant Medical Research Institute
  • Tumor Suppressive Signaling of Raf/MEK/ERK in Medullary Thyroid Carcinoma (#9206344 01/01/2011 - 12/31/2015) Sponsor: American Cancer Society National