Jong-In Park PhD
Associate Professor
Institution: Medical College of Wisconsin
Department: Biochemistry
Program: Program Development
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Publications
Autophagy sensitivity of neuroendocrine lung tumor cells. (Hong SK, Kim JH, Starenki D, Park JI) Int J Oncol 2013 Dec;43(6):2031-8 PMID 24126619 A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase. (Wu PK, Hong SK, Veeranki S, Karkhanis M, Starenki D, Plaza JA, Park JI) Mol Cell Biol 2013 Oct;33(20):4051-67 PMID 23959801 Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice. (Starenki D, Singh NK, Jensen DR, Peterson FC, Park JI) Cancer Lett 2013 Oct 1;339(1):144-51 PMID 23856028 AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion. (Hong SK, Jeong JH, Chan AM, Park JI) Exp Cell Res 2013 Jul 15;319(12):1732-43 PMID 23701950 Mitochondria-targeted nitroxide, Mito-CP, suppresses medullary thyroid carcinoma cell survival in vitro and in vivo. (Starenki D, Park JI) J Clin Endocrinol Metab 2013 Apr;98(4):1529-40 PMID 23509102 Cooperative Cross-Talk between Neuroblastoma Subtypes Confers Resistance to Anaplastic Lymphoma Kinase Inhibition. (Yan X, Kennedy CR, Tilkens SB, Wiedemeier O, Guan H, Park JI, Chan AM) Genes Cancer 2011 May;2(5):538-49 PMID 21901167 The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells. (Hong SK, Kim JH, Lin MF, Park JI) Exp Cell Res 2011 Nov 1;317(18):2671-82 PMID 21871886 Leukemia inhibitory factor can mediate Ras/Raf/MEK/ERK-induced growth inhibitory signaling in medullary thyroid cancer cells. (Arthan D, Hong SK, Park JI) Cancer Lett 2010 Nov 1;297(1):31-41 PMID 20570039 Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling. (Hong SK, Yoon S, Moelling C, Arthan D, Park JI) J Biol Chem 2009 Nov 27;284(48):33006-18 PMID 19805545 Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. (Yin W, Park JI, Loeser RF) J Biol Chem 2009 Nov 13;284(46):31972-81 PMID 19762915 Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells. (Strock CJ, Park JI, Nakakura EK, Bova GS, Isaacs JT, Ball DW, Nelkin BD) Cancer Res 2006 Aug 1;66(15):7509-15 PMID 16885348 Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer. (Strock CJ, Park JI, Rosen DM, Ruggeri B, Denmeade SR, Ball DW, Nelkin BD) J Clin Endocrinol Metab 2006 Jan;91(1):79-84 PMID 16263812 The high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae is the major determinant of cAMP levels in stationary phase: involvement of different branches of the Ras-cyclic AMP pathway in stress responses. (Park JI, Grant CM, Dawes IW) Biochem Biophys Res Commun 2005 Feb 4;327(1):311-9 PMID 15629464 Interleukin-1beta can mediate growth arrest and differentiation via the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. (Park JI, Strock CJ, Ball DW, Nelkin BD) Cytokine 2005 Feb 7;29(3):125-34 PMID 15613280 Regulation and function of trefoil factor family 3 expression in the biliary tree. (Nozaki I, Lunz JG 3rd, Specht S, Park JI, Giraud AS, Murase N, Demetris AJ) Am J Pathol 2004 Dec;165(6):1907-20 PMID 15579435 IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. (Kim EJ, Park JI, Nelkin BD) J Biol Chem 2005 Feb 11;280(6):4913-20 PMID 15572361 GDNF-induced leukemia inhibitory factor can mediate differentiation via the MEK/ERK pathway in pheochromocytoma cells derived from nf1-heterozygous knockout mice. (Park JI, Powers JF, Tischler AS, Strock CJ, Ball DW, Nelkin BD) Exp Cell Res 2005 Feb 1;303(1):79-88 PMID 15572029 Rom2p, the Rho1 GTP/GDP exchange factor of Saccharomyces cerevisiae, can mediate stress responses via the Ras-cAMP pathway. (Park JI, Collinson EJ, Grant CM, Dawes IW) J Biol Chem 2005 Jan 28;280(4):2529-35 PMID 15545276 CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth. (Strock CJ, Park JI, Rosen M, Dionne C, Ruggeri B, Jones-Bolin S, Denmeade SR, Ball DW, Nelkin BD) Cancer Res 2003 Sep 1;63(17):5559-63 PMID 14500395 Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. (Sriuranpong V, Park JI, Amornphimoltham P, Patel V, Nelkin BD, Gutkind JS) Cancer Res 2003 Jun 1;63(11):2948-56 PMID 12782602 The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway. (Park JI, Strock CJ, Ball DW, Nelkin BD) Mol Cell Biol 2003 Jan;23(2):543-54 PMID 12509453 The cytoplasmic Cu,Zn superoxide dismutase of saccharomyces cerevisiae is required for resistance to freeze-thaw stress. Generation of free radicals during freezing and thawing. (Park JI, Grant CM, Davies MJ, Dawes IW) J Biol Chem 1998 Sep 4;273(36):22921-8 PMID 9722512 The freeze-thaw stress response of the yeast Saccharomyces cerevisiae is growth phase specific and is controlled by nutritional state via the RAS-cyclic AMP signal transduction pathway. (Park JI, Grant CM, Attfield PV, Dawes IW) Appl Environ Microbiol 1997 Oct;63(10):3818-24 PMID 9327544 Grants and Awards
MEK-Induced Growth Arrest in Small Cell Lung Cancer Cells (#9204625 07/01/2007 - 06/30/2013) Sponsor: Flight Attendant Medical Research InstituteTumor Suppressive Signaling of Raf/MEK/ERK in Medullary Thyroid Carcinoma (#9206344 01/01/2011 - 12/31/2015) Sponsor: American Cancer Society NationalMechanisms of MEK/ERK Growth Arrest Signaling (#9206357 07/01/2010 - 04/30/2015) Sponsor: NIH Cancer Institute
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