Medical College of Wisconsin
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Jong-In Park PhD

Jong-In Park PhD

Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

Member of the Cancer Center
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)

View Curriculum Vitae

Publications

  • A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses. (Hong SK, Wu PK, Park JI) Cell Signal 2018 Jan;42:11-20 PMID: 28986121 PMCID: PMC5732048 10/08/2017    
  • Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in and Tumor Cells. (Wu PK, Hong SK, Park JI) Mol Cell Biol 2017 Sep 15;37(18) PMID: 28674184 PMCID: PMC5574043 07/05/2017       1 Citations
  • Vandetanib and cabozantinib potentiate mitochondria-targeted agents to suppress medullary thyroid carcinoma cells. (Starenki D, Hong SK, Wu PK, Park JI) Cancer Biol Ther 2017 Jul 03;18(7):473-483 PMID: 28475408 PMCID: PMC5639831 05/06/2017       2 Citations
  • Suppression of B-Raf melanoma cell survival by targeting mitochondria using triphenyl-phosphonium-conjugated nitroxide or ubiquinone. (Hong SK, Starenki D, Wu PK, Park JI) Cancer Biol Ther 2017 02;18(2):106-114 PMID: 27786591 PMCID: PMC5362989 10/28/2016       4 Citations
  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). (Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfane) Autophagy 2016;12(1):1-222 PMID: 26799652 PMCID: PMC4835977 01/23/2016       1559 Citations
  • MEK1/2 Inhibitors: Molecular Activity and Resistance Mechanisms. (Wu PK, Park JI) Semin Oncol 2015 Dec;42(6):849-62 PMID: 26615130 PMCID: PMC4663016 11/29/2015       13 Citations
  • Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo. (Starenki D, Park JI) Endocrinol Metab (Seoul) 2015 Dec;30(4):593-603 PMID: 26485469 PMCID: PMC4722416 10/21/2015    
  • ERK1/2 can feedback-regulate cellular MEK1/2 levels. (Hong SK, Wu PK, Karkhanis M, Park JI) Cell Signal 2015 Oct;27(10):1939-48 PMID: 26163823 PMCID: PMC4540659 07/15/2015       4 Citations
  • Phosphoinositide and Erk signaling pathways mediate activity-driven rodent olfactory sensory neuronal survival and stress mitigation. (Kim SY, Mammen A, Yoo SJ, Cho B, Kim EK, Park JI, Moon C, Ronnett GV) J Neurochem 2015 Aug;134(3):486-98 PMID: 25903517 PMCID: PMC4496289 04/24/2015       8 Citations
  • Active ERK2 is sufficient to mediate growth arrest and differentiation signaling. (Wu PK, Hong SK, Yoon SH, Park JI) FEBS J 2015 Mar;282(6):1017-30 PMID: 25639353 PMCID: PMC4368470 02/03/2015       6 Citations
  • Sp1 regulates Raf/MEK/ERK-induced p21(CIP1) transcription in TP53-mutated cancer cells. (Karkhanis M, Park JI) Cell Signal 2015 Mar;27(3):479-86 PMID: 25595558 PMCID: PMC4333010 01/18/2015       10 Citations
  • Pediatric Medullary Thyroid Carcinoma. (Starenki D, Park JI) J Pediatr Oncol 2015;3(2):29-37 PMID: 27014708 PMCID: PMC4803041 01/01/2015    
  • Kinome sequencing reveals RET G691S polymorphism in human neuroendocrine lung cancer cell lines. (Sosonkina N, Hong SK, Starenki D, Park JI) Genes Genomics 2014 Dec;36(6):829-841 PMID: 25530832 PMCID: PMC4270057 12/23/2014    
  • Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells. (Starenki D, Hong SK, Lloyd RV, Park JI) Oncogene 2015 Aug 27;34(35):4624-34 PMID: 25435367 PMCID: PMC4451452 12/02/2014       21 Citations
  • Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels. (Kim JH, Hong SK, Wu PK, Richards AL, Jackson WT, Park JI) Exp Cell Res 2014 Oct 01;327(2):340-52 PMID: 25128814 PMCID: PMC4164593 08/17/2014       34 Citations
  • Growth arrest signaling of the Raf/MEK/ERK pathway in cancer. (Park JI) Front Biol (Beijing) 2014 Feb;9(2):95-103 PMID: 24999356 PMCID: PMC4079089 07/08/2014    
  • The Role of STAT3 in Thyroid Cancer. (Sosonkina N, Starenki D, Park JI) Cancers (Basel) 2014 Mar 06;6(1):526-44 PMID: 24662939 PMCID: PMC3980610 03/26/2014    
  • Autophagy sensitivity of neuroendocrine lung tumor cells. (Hong SK, Kim JH, Starenki D, Park JI) Int J Oncol 2013 Dec;43(6):2031-8 PMID: 24126619 PMCID: PMC3834067 10/16/2013       6 Citations
  • A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase. (Wu PK, Hong SK, Veeranki S, Karkhanis M, Starenki D, Plaza JA, Park JI) Mol Cell Biol 2013 Oct;33(20):4051-67 PMID: 23959801 PMCID: PMC3811686 08/21/2013       29 Citations
  • Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice. (Starenki D, Singh NK, Jensen DR, Peterson FC, Park JI) Cancer Lett 2013 Oct 01;339(1):144-51 PMID: 23856028 PMCID: PMC3771534 07/17/2013       9 Citations
  • AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion. (Hong SK, Jeong JH, Chan AM, Park JI) Exp Cell Res 2013 Jul 15;319(12):1732-43 PMID: 23701950 PMCID: PMC3699957 05/25/2013    
  • Mitochondria-targeted nitroxide, Mito-CP, suppresses medullary thyroid carcinoma cell survival in vitro and in vivo. (Starenki D, Park JI) J Clin Endocrinol Metab 2013 Apr;98(4):1529-40 PMID: 23509102 PMCID: PMC3615196 03/20/2013       23 Citations
  • Cooperative Cross-Talk between Neuroblastoma Subtypes Confers Resistance to Anaplastic Lymphoma Kinase Inhibition. (Yan X, Kennedy CR, Tilkens SB, Wiedemeier O, Guan H, Park JI, Chan AM) Genes Cancer 2011 May;2(5):538-49 PMID: 21901167 PMCID: PMC3161418 09/09/2011    
  • The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells. (Hong SK, Kim JH, Lin MF, Park JI) Exp Cell Res 2011 Nov 01;317(18):2671-82 PMID: 21871886 PMCID: PMC3189339 08/30/2011    
  • Leukemia inhibitory factor can mediate Ras/Raf/MEK/ERK-induced growth inhibitory signaling in medullary thyroid cancer cells. (Arthan D, Hong SK, Park JI) Cancer Lett 2010 Nov 01;297(1):31-41 PMID: 20570039 06/24/2010       30 Citations
  • Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling. (Hong SK, Yoon S, Moelling C, Arthan D, Park JI) J Biol Chem 2009 Nov 27;284(48):33006-18 PMID: 19805545 PMCID: PMC2785141 10/07/2009       50 Citations
  • Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. (Yin W, Park JI, Loeser RF) J Biol Chem 2009 Nov 13;284(46):31972-81 PMID: 19762915 PMCID: PMC2797269 09/19/2009       107 Citations
  • Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells. (Strock CJ, Park JI, Nakakura EK, Bova GS, Isaacs JT, Ball DW, Nelkin BD) Cancer Res 2006 Aug 01;66(15):7509-15 PMID: 16885348 08/04/2006       105 Citations
  • Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer. (Strock CJ, Park JI, Rosen DM, Ruggeri B, Denmeade SR, Ball DW, Nelkin BD) J Clin Endocrinol Metab 2006 Jan;91(1):79-84 PMID: 16263812 11/03/2005       39 Citations
  • The high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae is the major determinant of cAMP levels in stationary phase: involvement of different branches of the Ras-cyclic AMP pathway in stress responses. (Park JI, Grant CM, Dawes IW) Biochem Biophys Res Commun 2005 Feb 04;327(1):311-9 PMID: 15629464 01/05/2005       46 Citations
  • Interleukin-1beta can mediate growth arrest and differentiation via the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. (Park JI, Strock CJ, Ball DW, Nelkin BD) Cytokine 2005 Feb 07;29(3):125-34 PMID: 15613280 12/23/2004       23 Citations
  • Regulation and function of trefoil factor family 3 expression in the biliary tree. (Nozaki I, Lunz JG 3rd, Specht S, Park JI, Giraud AS, Murase N, Demetris AJ) Am J Pathol 2004 Dec;165(6):1907-20 PMID: 15579435 PMCID: PMC1618723 12/08/2004       33 Citations
  • GDNF-induced leukemia inhibitory factor can mediate differentiation via the MEK/ERK pathway in pheochromocytoma cells derived from nf1-heterozygous knockout mice. (Park JI, Powers JF, Tischler AS, Strock CJ, Ball DW, Nelkin BD) Exp Cell Res 2005 Feb 01;303(1):79-88 PMID: 15572029 12/02/2004    
  • IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. (Kim EJ, Park JI, Nelkin BD) J Biol Chem 2005 Feb 11;280(6):4913-20 PMID: 15572361 12/02/2004       35 Citations
  • Rom2p, the Rho1 GTP/GDP exchange factor of Saccharomyces cerevisiae, can mediate stress responses via the Ras-cAMP pathway. (Park JI, Collinson EJ, Grant CM, Dawes IW) J Biol Chem 2005 Jan 28;280(4):2529-35 PMID: 15545276 11/17/2004       34 Citations
  • CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth. (Strock CJ, Park JI, Rosen M, Dionne C, Ruggeri B, Jones-Bolin S, Denmeade SR, Ball DW, Nelkin BD) Cancer Res 2003 Sep 01;63(17):5559-63 PMID: 14500395 09/23/2003       83 Citations
  • Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. (Sriuranpong V, Park JI, Amornphimoltham P, Patel V, Nelkin BD, Gutkind JS) Cancer Res 2003 Jun 01;63(11):2948-56 PMID: 12782602 06/05/2003       199 Citations
  • The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway. (Park JI, Strock CJ, Ball DW, Nelkin BD) Mol Cell Biol 2003 Jan;23(2):543-54 PMID: 12509453 PMCID: PMC151536 01/02/2003       99 Citations
  • The cytoplasmic Cu,Zn superoxide dismutase of saccharomyces cerevisiae is required for resistance to freeze-thaw stress. Generation of free radicals during freezing and thawing. (Park JI, Grant CM, Davies MJ, Dawes IW) J Biol Chem 1998 Sep 04;273(36):22921-8 PMID: 9722512 08/29/1998       109 Citations
  • The freeze-thaw stress response of the yeast Saccharomyces cerevisiae is growth phase specific and is controlled by nutritional state via the RAS-cyclic AMP signal transduction pathway. (Park JI, Grant CM, Attfield PV, Dawes IW) Appl Environ Microbiol 1997 Oct;63(10):3818-24 PMID: 9327544 PMCID: PMC168690 11/05/1997       87 Citations
  • Cell biological study of the effect of 5-hydroxytryptamine (serotonin) on chick embryogenesis (Joo CN, Park JI, Lee SY, Hwang WI) BMB Reports 23 (1): 142-150 12/29/1990    
    • Last update: 06/07/2018
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6