Medical College of Wisconsin
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Jong-In Park PhD

Jong-In Park PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Biochemistry
Program: Program Development

Member of the Cancer Center


  • MEK1/2 Inhibitors: Molecular Activity and Resistance Mechanisms. (Wu PK, Park JI) Semin Oncol 2015 Dec;42(6):849-62 PMID: 26615130 PMCID: PMC4663016 11/29/2015
  • Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo. (Starenki D, Park JI) Endocrinol Metab (Seoul) 2015 Dec;30(4):593-603 PMID: 26485469 PMCID: PMC4722416 10/21/2015
  • ERK1/2 can feedback-regulate cellular MEK1/2 levels. (Hong SK, Wu PK, Karkhanis M, Park JI) Cell Signal 2015 Oct;27(10):1939-48 PMID: 26163823 PMCID: PMC4540659 07/15/2015
  • Phosphoinositide and Erk signaling pathways mediate activity-driven rodent olfactory sensory neuronal survival and stress mitigation. (Kim SY, Mammen A, Yoo SJ, Cho B, Kim EK, Park JI, Moon C, Ronnett GV) J Neurochem 2015 Aug;134(3):486-98 PMID: 25903517 PMCID: PMC4496289 04/24/2015
  • Active ERK2 is sufficient to mediate growth arrest and differentiation signaling. (Wu PK, Hong SK, Yoon SH, Park JI) FEBS J 2015 Mar;282(6):1017-30 PMID: 25639353 PMCID: PMC4368470 02/03/2015
  • Sp1 regulates Raf/MEK/ERK-induced p21(CIP1) transcription in TP53-mutated cancer cells. (Karkhanis M, Park JI) Cell Signal 2015 Mar;27(3):479-86 PMID: 25595558 PMCID: PMC4333010 01/18/2015
  • Kinome sequencing reveals RET G691S polymorphism in human neuroendocrine lung cancer cell lines. (Sosonkina N, Hong SK, Starenki D, Park JI) Genes Genomics 2014 Dec;36(6):829-841 PMID: 25530832 PMCID: PMC4270057 12/23/2014
  • Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells. (Starenki D, Hong SK, Lloyd RV, Park JI) Oncogene 2015 Aug 27;34(35):4624-34 PMID: 25435367 PMCID: PMC4451452 12/02/2014
  • Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels. (Kim JH, Hong SK, Wu PK, Richards AL, Jackson WT, Park JI) Exp Cell Res 2014 Oct 1;327(2):340-52 PMID: 25128814 PMCID: PMC4164593 08/17/2014
  • Growth arrest signaling of the Raf/MEK/ERK pathway in cancer. (Park JI) Front Biol (Beijing) 2014 Feb;9(2):95-103 PMID: 24999356 PMCID: PMC4079089 07/08/2014
  • The Role of STAT3 in Thyroid Cancer. (Sosonkina N, Starenki D, Park JI) Cancers (Basel) 2014;6(1):526-44 PMID: 24662939 PMCID: PMC3980610 03/26/2014
  • Autophagy sensitivity of neuroendocrine lung tumor cells. (Hong SK, Kim JH, Starenki D, Park JI) Int J Oncol 2013 Dec;43(6):2031-8 PMID: 24126619 PMCID: PMC3834067 10/16/2013
  • A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase. (Wu PK, Hong SK, Veeranki S, Karkhanis M, Starenki D, Plaza JA, Park JI) Mol Cell Biol 2013 Oct;33(20):4051-67 PMID: 23959801 PMCID: PMC3811686 08/21/2013
  • Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice. (Starenki D, Singh NK, Jensen DR, Peterson FC, Park JI) Cancer Lett 2013 Oct 1;339(1):144-51 PMID: 23856028 PMCID: PMC3771534 07/17/2013
  • AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion. (Hong SK, Jeong JH, Chan AM, Park JI) Exp Cell Res 2013 Jul 15;319(12):1732-43 PMID: 23701950 PMCID: PMC3699957 05/25/2013
  • Mitochondria-targeted nitroxide, Mito-CP, suppresses medullary thyroid carcinoma cell survival in vitro and in vivo. (Starenki D, Park JI) J Clin Endocrinol Metab 2013 Apr;98(4):1529-40 PMID: 23509102 PMCID: PMC3615196 03/20/2013
  • Cooperative Cross-Talk between Neuroblastoma Subtypes Confers Resistance to Anaplastic Lymphoma Kinase Inhibition. (Yan X, Kennedy CR, Tilkens SB, Wiedemeier O, Guan H, Park JI, Chan AM) Genes Cancer 2011 May;2(5):538-49 PMID: 21901167 PMCID: PMC3161418 09/09/2011
  • The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells. (Hong SK, Kim JH, Lin MF, Park JI) Exp Cell Res 2011 Nov 1;317(18):2671-82 PMID: 21871886 PMCID: PMC3189339 08/30/2011
  • Leukemia inhibitory factor can mediate Ras/Raf/MEK/ERK-induced growth inhibitory signaling in medullary thyroid cancer cells. (Arthan D, Hong SK, Park JI) Cancer Lett 2010 Nov 1;297(1):31-41 PMID: 20570039 06/24/2010
  • Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling. (Hong SK, Yoon S, Moelling C, Arthan D, Park JI) J Biol Chem 2009 Nov 27;284(48):33006-18 PMID: 19805545 PMCID: PMC2785141 10/07/2009
  • Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. (Yin W, Park JI, Loeser RF) J Biol Chem 2009 Nov 13;284(46):31972-81 PMID: 19762915 PMCID: PMC2797269 09/19/2009
  • Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells. (Strock CJ, Park JI, Nakakura EK, Bova GS, Isaacs JT, Ball DW, Nelkin BD) Cancer Res 2006 Aug 1;66(15):7509-15 PMID: 16885348 08/04/2006
  • Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer. (Strock CJ, Park JI, Rosen DM, Ruggeri B, Denmeade SR, Ball DW, Nelkin BD) J Clin Endocrinol Metab 2006 Jan;91(1):79-84 PMID: 16263812 11/03/2005
  • The high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae is the major determinant of cAMP levels in stationary phase: involvement of different branches of the Ras-cyclic AMP pathway in stress responses. (Park JI, Grant CM, Dawes IW) Biochem Biophys Res Commun 2005 Feb 4;327(1):311-9 PMID: 15629464 01/05/2005
  • Interleukin-1beta can mediate growth arrest and differentiation via the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. (Park JI, Strock CJ, Ball DW, Nelkin BD) Cytokine 2005 Feb 7;29(3):125-34 PMID: 15613280 12/23/2004
  • Regulation and function of trefoil factor family 3 expression in the biliary tree. (Nozaki I, Lunz JG 3rd, Specht S, Park JI, Giraud AS, Murase N, Demetris AJ) Am J Pathol 2004 Dec;165(6):1907-20 PMID: 15579435 PMCID: PMC1618723 12/08/2004
  • IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. (Kim EJ, Park JI, Nelkin BD) J Biol Chem 2005 Feb 11;280(6):4913-20 PMID: 15572361 12/02/2004
  • GDNF-induced leukemia inhibitory factor can mediate differentiation via the MEK/ERK pathway in pheochromocytoma cells derived from nf1-heterozygous knockout mice. (Park JI, Powers JF, Tischler AS, Strock CJ, Ball DW, Nelkin BD) Exp Cell Res 2005 Feb 1;303(1):79-88 PMID: 15572029 12/02/2004
  • Rom2p, the Rho1 GTP/GDP exchange factor of Saccharomyces cerevisiae, can mediate stress responses via the Ras-cAMP pathway. (Park JI, Collinson EJ, Grant CM, Dawes IW) J Biol Chem 2005 Jan 28;280(4):2529-35 PMID: 15545276 11/17/2004
  • CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth. (Strock CJ, Park JI, Rosen M, Dionne C, Ruggeri B, Jones-Bolin S, Denmeade SR, Ball DW, Nelkin BD) Cancer Res 2003 Sep 1;63(17):5559-63 PMID: 14500395 09/23/2003
  • Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. (Sriuranpong V, Park JI, Amornphimoltham P, Patel V, Nelkin BD, Gutkind JS) Cancer Res 2003 Jun 1;63(11):2948-56 PMID: 12782602 06/05/2003
  • The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway. (Park JI, Strock CJ, Ball DW, Nelkin BD) Mol Cell Biol 2003 Jan;23(2):543-54 PMID: 12509453 PMCID: PMC151536 01/02/2003
  • The cytoplasmic Cu,Zn superoxide dismutase of saccharomyces cerevisiae is required for resistance to freeze-thaw stress. Generation of free radicals during freezing and thawing. (Park JI, Grant CM, Davies MJ, Dawes IW) J Biol Chem 1998 Sep 4;273(36):22921-8 PMID: 9722512 08/29/1998
  • The freeze-thaw stress response of the yeast Saccharomyces cerevisiae is growth phase specific and is controlled by nutritional state via the RAS-cyclic AMP signal transduction pathway. (Park JI, Grant CM, Attfield PV, Dawes IW) Appl Environ Microbiol 1997 Oct;63(10):3818-24 PMID: 9327544 PMCID: PMC168690 11/05/1997
  • Last update: 01/07/2016