Medical College of Wisconsin
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Julie K. Freed MD, PhD

Julie K. Freed MD, PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Anesthesiology
Division: Clinical
Program: Operating Room Service

Member of the Cardiovascular Center


  • An Unexpected Finding During Repair of An Ascending Aortic Aneurysm. (Boettcher BT, Mungara C, Manupipatpong KK, Freed JK, Kaiser M, Pagel PS) J Cardiothorac Vasc Anesth 2017 Feb 16 PMID: 28552298 05/30/2017
  • PGC-1α (Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure. (Kadlec AO, Chabowski DS, Ait-Aissa K, Hockenberry JC, Otterson MF, Durand MJ, Freed JK, Beyer AM, Gutterman DD) Hypertension 2017 Jul;70(1):166-173 PMID: 28533333 PMCID: PMC5485836 05/24/2017
  • Communication Is Key: Mechanisms of Intercellular Signaling in Vasodilation. (Freed JK, Gutterman DD) J Cardiovasc Pharmacol 2017 May;69(5):264-272 PMID: 28482351 PMCID: PMC5424612 05/10/2017
  • Moderate, Short-Term, Local Hyperglycemia Attenuates Forearm Endothelium-Dependent Vasodilation After Transient Ischemia-Reperfusion in Human Volunteers. (Ebert TJ, Novalija J, Barney JA, Uhrich TD, Arain SR, Freed JK, Pagel PS) J Cardiothorac Vasc Anesth 2017 Oct;31(5):1649-1655 PMID: 28284926 03/13/2017
  • Mitochondria-regulated formation of endothelium-derived extracellular vesicles shifts the mediator of flow-induced vasodilation. (Freed JK, Durand MJ, Hoffmann BR, Densmore JC, Greene AS, Gutterman DD) Am J Physiol Heart Circ Physiol 2017 May 01;312(5):H1096-H1104 PMID: 28213406 PMCID: PMC5451582 02/19/2017
  • A Rare Complication of Metastatic Osteosarcoma. (Pagel PS, Davidovich RM, Steck DT, Freed JK, Boettcher BT) J Cardiothorac Vasc Anesth 2017 08;31(4):1540-1541 PMID: 28094173 01/18/2017
  • Treatment of Vasoplegic Syndrome With Intravenous Hydroxocobalamin During Liver Transplantation. (Boettcher BT, Woehlck HJ, Reck SE, Hong JC, Zimmerman MA, Kim J, Zundel MT, Freed JK, Pagel PS) J Cardiothorac Vasc Anesth 2017 08;31(4):1381-1384 PMID: 28012726 12/26/2016
  • Short-Term Angiotensin Subtype 1 Receptor Blockade Does Not Alter the Circulatory Responses to Sympathetic Nervous System Modulation in Healthy Volunteers Before and During Sevoflurane Anesthesia: Results of a Pilot Study. (Arain SR, Freed JK, Novalija J, Pagel PS, Ebert TJ) J Cardiothorac Vasc Anesth 2016 Dec;30(6):1479-1484 PMID: 27751762 10/19/2016
  • A Rare Complication of Cardiopulmonary Resuscitation After Mitral Valve Replacement. (Pagel PS, Sethi P, Freed JK, Boettcher BT, Hossein Almassi G) J Cardiothorac Vasc Anesth 2017 04;31(2):770-772 PMID: 27693210 10/04/2016
  • Moderate Aortic Valvular Insufficiency Invalidates Vortex Formation Time as an Index of Left Ventricular Filling Efficiency in Patients With Severe Degenerative Calcific Aortic Stenosis Undergoing Aortic Valve Replacement. (Pagel PS, Boettcher BT, De Vry DJ, Freed JK, Iqbal Z) J Cardiothorac Vasc Anesth 2016 Oct;30(5):1260-5 PMID: 27474333 07/31/2016
  • Acute, Severe Pulmonary Arterial Hypertension During Off-Pump Coronary Artery Surgery: Is New Myocardial Ischemia, Cardiac Repositioning, or External Mitral Valve Compression the Culprit? (Khatib D, Boettcher BT, Freed JK, Pagel PS) J Cardiothorac Vasc Anesth 2016 Dec;30(6):1744-1747 PMID: 27431596 07/20/2016
  • The Human Microcirculation: Regulation of Flow and Beyond. (Gutterman DD, Chabowski DS, Kadlec AO, Durand MJ, Freed JK, Ait-Aissa K, Beyer AM) Circ Res 2016 Jan 08;118(1):157-72 PMID: 26837746 PMCID: PMC4742348 02/04/2016
  • Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. (Beyer AM, Freed JK, Durand MJ, Riedel M, Ait-Aissa K, Green P, Hockenberry JC, Morgan RG, Donato AJ, Peleg R, Gasparri M, Rokkas CK, Santos JH, Priel E, Gutterman DD) Circ Res 2016 Mar 04;118(5):856-66 PMID: 26699654 PMCID: PMC4772813 12/25/2015
  • Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation. (Freed JK, Beyer AM, LoGiudice JA, Hockenberry JC, Gutterman DD) Circ Res 2014 Aug 15;115(5):525-32 PMID: 24920698 PMCID: PMC4640193 06/13/2014
  • Mitochondrial reactive oxygen species and vascular function: less is more. (Freed JK, Gutterman DD) Arterioscler Thromb Vasc Biol 2013 Apr;33(4):673-5 PMID: 23486769 03/15/2013
  • Proteomic analysis of shear stress-mediated protection from TNF-alpha in endothelial cells. (Freed JK, Greene AS) Microcirculation 2010 May;17(4):259-70 PMID: 20536739 PMCID: PMC3712086 06/12/2010
  • Revealing the role of phosphatidylserine in shear stress-mediated protection in endothelial cells. (Freed JK, Shortreed MR, Kleefisch CJ, Smith LM, Greene AS) Endothelium 2008 Jul-Aug;15(4):225-30 PMID: 18663626 PMCID: PMC2579788 07/30/2008
  • Isolation of signal transduction complexes using biotin and crosslinking methodologies. (Freed JK, Smith JR, Li P, Greene AS) Proteomics 2007 Jul;7(14):2371-4 PMID: 17623297 07/12/2007
  • Last update: 11/16/2017
    jenkins-FCD Prod-153 3ca6710ea990189ceb85f4312e7298b5922ce1a6