Medical College of Wisconsin
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Wai-Meng Kwok PhD


Institution: Medical College of Wisconsin
Department: Anesthesiology
Division: Research

Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Comprehensive Injury Center


  • Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart. (Gadicherla AK, Wang N, Bulic M, Agullo-Pascual E, Lissoni A, De Smet M, Delmar M, Bultynck G, Krysko DV, Camara A, Schlüter KD, Schulz R, Kwok WM, Leybaert L) Basic Res Cardiol 2017 05;112(3):27 PMID: 28364353 04/02/2017       29 Citations
  • Identity and function of a cardiac mitochondrial small conductance Ca-activated K channel splice variant. (Yang M, Camara AKS, Aldakkak M, Kwok WM, Stowe DF) Biochim Biophys Acta Bioenerg 2017 Jun;1858(6):442-458 PMID: 28342809 PMCID: PMC5749404 03/28/2017       4 Citations
  • Association of TMTC2 With Human Nonsyndromic Sensorineural Hearing Loss. (Runge CL, Indap A, Zhou Y, Kent JW Jr, King E, Erbe CB, Cole R, Littrell J, Merath K, James R, Rüschendorf F, Kerschner JE, Marth G, Hübner N, Göring HH, Friedland DR, Kwok WM, Olivier M) JAMA Otolaryngol Head Neck Surg 2016 09 01;142(9):866-72 PMID: 27311106 PMCID: PMC5025373 06/17/2016       4 Citations
  • The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility. (Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ) J Biol Chem 2016 07 15;291(29):14939-53 PMID: 27226619 PMCID: PMC4946913 05/27/2016       4 Citations
  • Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction. (Raphael R, Purushotham D, Gastonguay C, Chesnik MA, Kwok WM, Wu HE, Shah SJ, Mirza SP, Strande JL) J Transl Med 2016 Jan 20;14:18 PMID: 26792056 PMCID: PMC4719542 01/23/2016       7 Citations
  • Markov chain Monte Carlo based analysis of post-translationally modified VDAC gating kinetics. (Tewari SG, Zhou Y, Otto BJ, Dash RK, Kwok WM, Beard DA) Front Physiol 2014;5:513 PMID: 25628567 PMCID: PMC4292549 01/30/2015    
  • Enhanced effects of isoflurane on the long QT syndrome 1-associated A341V mutant. (Mikuni I, Torres CG, Bakshi T, Tampo A, Carlson BE, Bienengraeber MW, Kwok WM) Anesthesiology 2015 Apr;122(4):806-20 PMID: 25585005 PMCID: PMC4366337 01/15/2015       4 Citations
  • High efficiency differentiation of human pluripotent stem cells to cardiomyocytes and characterization by flow cytometry. (Bhattacharya S, Burridge PW, Kropp EM, Chuppa SL, Kwok WM, Wu JC, Boheler KR, Gundry RL) J Vis Exp 2014 Sep 23(91):52010 PMID: 25286293 PMCID: PMC4448667 10/07/2014       24 Citations
  • Regulation of voltage-gated Ca(2+) currents by Ca(2+)/calmodulin-dependent protein kinase II in resting sensory neurons. (Kostic S, Pan B, Guo Y, Yu H, Sapunar D, Kwok WM, Hudmon A, Wu HE, Hogan QH) Mol Cell Neurosci 2014 Sep;62:10-8 PMID: 25064143 PMCID: PMC4187344 07/30/2014       5 Citations
  • Sigma-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. (Pan B, Guo Y, Kwok WM, Hogan Q, Wu HE) J Pharmacol Exp Ther 2014 Aug;350(2):290-300 PMID: 24891452 PMCID: PMC4109486 06/04/2014       13 Citations
  • Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membrane. (Stowe DF, Gadicherla AK, Zhou Y, Aldakkak M, Cheng Q, Kwok WM, Jiang MT, Heisner JS, Yang M, Camara AK) Biochim Biophys Acta 2013 Feb;1828(2):427-42 PMID: 22982251 PMCID: PMC3534888 09/18/2012       30 Citations
  • Ca²⁺-dependent regulation of Ca²⁺ currents in rat primary afferent neurons: role of CaMKII and the effect of injury. (Tang Q, Bangaru ML, Kostic S, Pan B, Wu HE, Koopmeiners AS, Yu H, Fischer GJ, McCallum JB, Kwok WM, Hudmon A, Hogan QH) J Neurosci 2012 Aug 22;32(34):11737-49 PMID: 22915116 PMCID: PMC3723336 08/24/2012       20 Citations
  • Tyrosine nitration of voltage-dependent anion channels in cardiac ischemia-reperfusion: reduction by peroxynitrite scavenging. (Yang M, Camara AK, Wakim BT, Zhou Y, Gadicherla AK, Kwok WM, Stowe DF) Biochim Biophys Acta 2012 Nov;1817(11):2049-59 PMID: 22709907 PMCID: PMC3985433 06/20/2012       20 Citations
  • Partial restoration of the long QT syndrome associated KCNQ1 A341V mutant by the KCNE1 β-subunit. (Mikuni I, Torres CG, Bienengraeber MW, Kwok WM) Biochim Biophys Acta 2011 Dec;1810(12):1285-93 PMID: 21854832 PMCID: PMC3215802 08/23/2011       7 Citations
  • Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury. (Gemes G, Bangaru ML, Wu HE, Tang Q, Weihrauch D, Koopmeiners AS, Cruikshank JM, Kwok WM, Hogan QH) J Neurosci 2011 Mar 09;31(10):3536-49 PMID: 21389210 PMCID: PMC3565463 03/11/2011    
  • Subtype-specific reduction of voltage-gated calcium current in medium-sized dorsal root ganglion neurons after painful peripheral nerve injury. (McCallum JB, Wu HE, Tang Q, Kwok WM, Hogan QH) Neuroscience 2011 Apr 14;179:244-55 PMID: 21277351 PMCID: PMC3209503 02/01/2011       21 Citations
  • Survival of neurally induced mesenchymal cells may determine degree of motor recovery in injured spinal cord rats. (Alexanian AR, Kwok WM, Pravdic D, Maiman DJ, Fehlings MG) Restor Neurol Neurosci 2010;28(6):761-7 PMID: 21209491 01/07/2011       18 Citations
  • Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. (Cheng Q, Sedlic F, Pravdic D, Bosnjak ZJ, Kwok WM) FEBS Lett 2011 Jan 21;585(2):328-34 PMID: 21156174 PMCID: PMC3035949 12/16/2010       14 Citations
  • Mitochondrial matrix K+ flux independent of large-conductance Ca2+-activated K+ channel opening. (Aldakkak M, Stowe DF, Cheng Q, Kwok WM, Camara AK) Am J Physiol Cell Physiol 2010 Mar;298(3):C530-41 PMID: 20053924 PMCID: PMC2838564 01/08/2010       40 Citations
  • Suppressed Ca2+/CaM/CaMKII-dependent K(ATP) channel activity in primary afferent neurons mediates hyperalgesia after axotomy. (Kawano T, Zoga V, Gemes G, McCallum JB, Wu HE, Pravdic D, Liang MY, Kwok WM, Hogan Q, Sarantopoulos C) Proc Natl Acad Sci U S A 2009 May 26;106(21):8725-30 PMID: 19439665 PMCID: PMC2681318 05/15/2009       46 Citations
  • ATP-sensitive potassium currents in rat primary afferent neurons: biophysical, pharmacological properties, and alterations by painful nerve injury. (Kawano T, Zoga V, McCallum JB, Wu HE, Gemes G, Liang MY, Abram S, Kwok WM, Hogan QH, Sarantopoulos CD) Neuroscience 2009 Aug 18;162(2):431-43 PMID: 19422886 05/09/2009       30 Citations
  • Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. (Bodiga S, Zhang R, Jacobs DE, Larsen BT, Tampo A, Manthati VL, Kwok WM, Zeldin DC, Falck JR, Gutterman DD, Jacobs ER, Medhora MM) J Mol Cell Cardiol 2009 Jun;46(6):978-88 PMID: 19336274 PMCID: PMC2796716 04/02/2009       35 Citations
  • Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation. (Kawano T, Zoga V, Kimura M, Liang MY, Wu HE, Gemes G, McCallum JB, Kwok WM, Hogan QH, Sarantopoulos CD) Mol Pain 2009 Mar 14;5:12 PMID: 19284878 PMCID: PMC2673211 03/17/2009       72 Citations
  • Accelerated inactivation of cardiac L-type calcium channels triggered by anaesthetic-induced preconditioning. (Tampo A, Hogan CS, Sedlic F, Bosnjak ZJ, Kwok WM) Br J Pharmacol 2009 Feb;156(3):432-43 PMID: 19154423 PMCID: PMC2697672 01/22/2009    
  • The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel. (Wan TC, Ge ZD, Tampo A, Mio Y, Bienengraeber MW, Tracey WR, Gross GJ, Kwok WM, Auchampach JA) J Pharmacol Exp Ther 2008 Jan;324(1):234-43 PMID: 17906066 PMCID: PMC2435594 10/02/2007       62 Citations
  • Isoflurane activates human cardiac mitochondrial adenosine triphosphate-sensitive K+ channels reconstituted in lipid bilayers. (Jiang MT, Nakae Y, Ljubkovic M, Kwok WM, Stowe DF, Bosnjak ZJ) Anesth Analg 2007 Oct;105(4):926-32, table of contents PMID: 17898367 09/28/2007       23 Citations
  • Opposing effects of spinal nerve ligation on calcium-activated potassium currents in axotomized and adjacent mammalian primary afferent neurons. (Sarantopoulos CD, McCallum JB, Rigaud M, Fuchs A, Kwok WM, Hogan QH) Brain Res 2007 Feb 09;1132(1):84-99 PMID: 17184741 PMCID: PMC2692681 12/23/2006       33 Citations
  • Painful peripheral nerve injury decreases calcium current in axotomized sensory neurons. (McCallum JB, Kwok WM, Sapunar D, Fuchs A, Hogan QH) Anesthesiology 2006 Jul;105(1):160-8 PMID: 16810008 PMCID: PMC3725035 07/01/2006       48 Citations
  • Characterization of human cardiac mitochondrial ATP-sensitive potassium channel and its regulation by phorbol ester in vitro. (Jiang MT, Ljubkovic M, Nakae Y, Shi Y, Kwok WM, Stowe DF, Bosnjak ZJ) Am J Physiol Heart Circ Physiol 2006 May;290(5):H1770-6 PMID: 16361367 12/20/2005       28 Citations
  • The interaction of isoflurane and protein kinase C-activators on sarcolemmal KATP channels. (Turner LA, Fujimoto K, Suzuki A, Stadnicka A, Bosnjak ZJ, Kwok WM) Anesth Analg 2005 Jun;100(6):1680-6 PMID: 15920195 05/28/2005       8 Citations
  • Beta-escin diminishes voltage-gated calcium current rundown in perforated patch-clamp recordings from rat primary afferent neurons. (Sarantopoulos C, McCallum JB, Kwok WM, Hogan Q) J Neurosci Methods 2004 Oct 15;139(1):61-8 PMID: 15351522 09/08/2004       19 Citations
  • Preconditioning of the myocardium by volatile anesthetics. (Kwok WM, Aizawa K) Curr Med Chem Cardiovasc Hematol Agents 2004 Jul;2(3):249-55 PMID: 15320790 08/24/2004       9 Citations
  • Protein kinase C-epsilon primes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to modulation by isoflurane. (Aizawa K, Turner LA, Weihrauch D, Bosnjak ZJ, Kwok WM) Anesthesiology 2004 Aug;101(2):381-9 PMID: 15277921 07/28/2004       35 Citations
  • Contribution of reactive oxygen species to isoflurane-induced sensitization of cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to pinacidil. (An J, Stadnicka A, Kwok WM, Bosnjak ZJ) Anesthesiology 2004 Mar;100(3):575-80 PMID: 15108971 04/28/2004       12 Citations
  • ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin. (Sarantopoulos C, McCallum B, Sapunar D, Kwok WM, Hogan Q) Neurosci Lett 2003 Jun 12;343(3):185-9 PMID: 12770693 05/29/2003       32 Citations
  • The effects of isoflurane on the cardiac slowly activating delayed-rectifier potassium channel in Guinea pig ventricular myocytes. (Suzuki A, Bosnjak ZJ, Kwok WM) Anesth Analg 2003 May;96(5):1308-15, table of contents PMID: 12707124 04/23/2003       30 Citations
  • Isoflurane activates rat mitochondrial ATP-sensitive K+ channels reconstituted in lipid bilayers. (Nakae Y, Kwok WM, Bosnjak ZJ, Jiang MT) Am J Physiol Heart Circ Physiol 2003 May;284(5):H1865-71 PMID: 12573994 02/08/2003       50 Citations
  • Loss of T-type calcium current in sensory neurons of rats with neuropathic pain. (McCallum JB, Kwok WM, Mynlieff M, Bosnjak ZJ, Hogan QH) Anesthesiology 2003 Jan;98(1):209-16 PMID: 12502999 12/28/2002       63 Citations
  • Isoflurane sensitizes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to pinacidil. (Gassmayr S, Stadnicka A, Suzuki A, Kwok WM, Bosnjak ZJ) Anesthesiology 2003 Jan;98(1):114-20 PMID: 12502987 12/28/2002       18 Citations
  • Biphasic effects of isoflurane on the cardiac action potential: an ionic basis for anesthetic-induced changes in cardiac electrophysiology. (Suzuki A, Aizawa K, Gassmayr S, Bosnjak ZJ, Kwok WM) Anesthesiology 2002 Nov;97(5):1209-17 PMID: 12411807 11/02/2002       19 Citations
  • Protein tyrosine kinase-dependent modulation of isoflurane effects on cardiac sarcolemmal K(ATP) channel. (Stadnicka A, Kwok WM, Warltier DC, Bosnjak ZJ) Anesthesiology 2002 Nov;97(5):1198-208 PMID: 12411806 11/02/2002       26 Citations
  • Isoflurane-induced facilitation of the cardiac sarcolemmal K(ATP) channel. (Fujimoto K, Bosnjak ZJ, Kwok WM) Anesthesiology 2002 Jul;97(1):57-65 PMID: 12131104 07/20/2002       58 Citations
  • Differential modulation of the cardiac adenosine triphosphate-sensitive potassium channel by isoflurane and halothane. (Kwok WM, Martinelli AT, Fujimoto K, Suzuki A, Stadnicka A, Bosnjak ZJ) Anesthesiology 2002 Jul;97(1):50-6 PMID: 12131103 07/20/2002       45 Citations
  • Gabapentin decreases membrane calcium currents in injured as well as in control mammalian primary afferent neurons. (Sarantopoulos C, McCallum B, Kwok WM, Hogan Q) Reg Anesth Pain Med 2002 Jan-Feb;27(1):47-57 PMID: 11799505 01/19/2002    
  • Differential modulation of the cardiac L- and T-type calcium channel currents by isoflurane. (Camara AK, Begic Z, Kwok WM, Bosnjak ZJ) Anesthesiology 2001 Aug;95(2):515-24 PMID: 11506128 08/17/2001    
  • Cannabinoid CB1 receptor-mediated inhibition of prolactin release and signaling mechanisms in GH4C1 cells. (Ho BY, Stadnicka A, Prather PL, Buckley AR, Current LL, Bosnjak ZJ, Kwok WM) Endocrinology 2000 May;141(5):1675-85 PMID: 10803576 05/10/2000       22 Citations
  • Painful neuropathy decreases membrane calcium current in mammalian primary afferent neurons. (Hogan QH, McCallum JB, Sarantopoulos C, Aason M, Mynlieff M, Kwok WM, Bosnjak ZJ) Pain 2000 May;86(1-2):43-53 PMID: 10779659 04/26/2000       77 Citations
  • Modulation of cardiac inward rectifier K(+)current by halothane and isoflurane. (Stadnicka A, Bosnjak ZJ, Kampine JP, Kwok WM) Anesth Analg 2000 Apr;90(4):824-33 PMID: 10735783 03/29/2000       36 Citations
  • Xenon does not alter cardiac function or major cation currents in isolated guinea pig hearts or myocytes. (Stowe DF, Rehmert GC, Kwok WM, Weigt HU, Georgieff M, Bosnjak ZJ) Anesthesiology 2000 Feb;92(2):516-22 PMID: 10691240 02/26/2000       61 Citations
  • Effects of halothane and isoflurane on fast and slow inactivation of human heart hH1a sodium channels. (Stadnicka A, Kwok WM, Hartmann HA, Bosnjak ZJ) Anesthesiology 1999 Jun;90(6):1671-83 PMID: 10360866 06/09/1999       22 Citations
  • Terikalant, an inward-rectifier potassium channel blocker, does not abolish the cardioprotection induced by ischemic preconditioning in the rat. (Schultz JE, Kwok WM, Hsu AK, Gross GJ) J Mol Cell Cardiol 1998 Sep;30(9):1817-25 PMID: 9769237 10/14/1998       6 Citations
  • Sensitization of the cardiac Na channel to alpha1-adrenergic stimulation by inhalation anesthetics: evidence for distinct modulatory pathways. (Weigt HU, Kwok WM, Rehmert GC, Bosnjak ZJ) Anesthesiology 1998 Jan;88(1):125-33 PMID: 9447865 02/03/1998       13 Citations
  • Modulation of the cardiac sodium current by inhalational anesthetics in the absence and presence of beta-stimulation. (Weigt HU, Kwok WM, Rehmert GC, Bosnjak ZJ) Anesthesiology 1998 Jan;88(1):114-24 PMID: 9447864 02/03/1998       21 Citations
  • Modulation of cardiac sodium current by alpha1-stimulation and volatile anesthetics. (Weigt HU, Kwok WM, Rehmert GC, Turner LA, Bosnjak ZJ) Anesthesiology 1997 Dec;87(6):1507-16 PMID: 9416736 01/07/1998       12 Citations
  • Conformational state-dependent effects of halothane on cardiac Na+ current. (Weigt HU, Rehmert GC, Bosnjak ZJ, Kwok WM) Anesthesiology 1997 Dec;87(6):1494-506 PMID: 9416735 01/07/1998       14 Citations
  • Effects of sevoflurane on inward rectifier K+ current in guinea pig ventricular cardiomyocytes. (Stadnicka A, Bosnjak ZJ, Kampine JP, Kwok WM) Am J Physiol 1997 Jul;273(1 Pt 2):H324-32 PMID: 9249507 07/01/1997       22 Citations
  • Voltage-dependent effects of volatile anesthetics on cardiac sodium current. (Weigt HU, Kwok WM, Rehmert GC, Turner LA, Bosnjak ZJ) Anesth Analg 1997 Feb;84(2):285-93 PMID: 9024016 02/01/1997       45 Citations
  • Study of quantum anharmonic oscillators by state-dependent diagonalization. (Ho KC, Liu YT, Lo CF, Liu KL, Kwok WM, Shiu ML) Phys Rev A 1996 Mar;53(3):1280-1284 PMID: 9913016 03/01/1996    
  • Inhibition of pinacidil induced IK(ATP) in heart by changes in extracellular pH. (Kwok WM, Kass RS) Cardiovasc Res 1994 Jun;28(6):836-40 PMID: 7923288 06/01/1994       4 Citations
  • Block of cardiac ATP-sensitive K+ channels by external divalent cations is modulated by intracellular ATP. Evidence for allosteric regulation of the channel protein. (Kwok WM, Kass RS) J Gen Physiol 1993 Oct;102(4):693-712 PMID: 8270910 PMCID: PMC2229174 10/01/1993       17 Citations
  • Phosphorylation-independent regulation of cardiac IK by guanine nucleotides and isoproterenol. (Freeman LC, Kwok WM, Kass RS) Am J Physiol 1992 Apr;262(4 Pt 2):H1298-302 PMID: 1314511 04/01/1992       15 Citations
  • Delayed rectification in single cells isolated from guinea pig sinoatrial node. (Anumonwo JM, Freeman LC, Kwok WM, Kass RS) Am J Physiol 1992 Mar;262(3 Pt 2):H921-5 PMID: 1558202 03/01/1992       58 Citations
  • Calcium-induced inactivation of calcium release from the sarcoplasmic reticulum of skeletal muscle. (Kwok WM, Best PM) Pflugers Arch 1991 Sep;419(2):166-76 PMID: 1961687 09/01/1991       6 Citations
  • Delayed-rectifier potassium channel activity in isolated membrane patches of guinea pig ventricular myocytes. (Walsh KB, Arena JP, Kwok WM, Freeman L, Kass RS) Am J Physiol 1991 Apr;260(4 Pt 2):H1390-3 PMID: 1849375 04/01/1991       31 Citations
  • The influence of ion species on phosphatidylcholine bilayer structure and packing. (Cunningham BA, Shimotake JE, Tamura-Lis W, Mastran T, Kwok WM, Kauffman JW, Lis LJ) Chem Phys Lipids 1986 Jan;39(1-2):135-43 PMID: 3753902 01/01/1986       40 Citations
  • Last update: 05/27/2016
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6