Medical College of Wisconsin
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Xiao Chen MD, PhD

Xiao Chen MD, PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology - Medicine
Program: Hematology

Member of the Cancer Center


Publications

  • Role of Vitamin A in Modulating Graft-versus-Host Disease. (Zheng J, Taylor B, Chen X) J Immunol Res Ther 2018;3(1):124-128 PMID: 30101210 PMCID: PMC6086377 08/14/2018    
  • Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors. (Pan P, Oshima K, Huang YW, Agle KA, Drobyski WR, Chen X, Zhang J, Yearsley MM, Yu J, Wang LS) Int J Cancer 2018 08 15;143(4):886-896 PMID: 29524208 PMCID: PMC6041131 03/11/2018       2 Citations
  • Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+ mice. (Pan P, W Skaer C, Wang HT, Oshima K, Huang YW, Yu J, Zhang J, M Yearsley M, A Agle K, R Drobyski W, Chen X, Wang LS) Carcinogenesis 2017 01;38(1):86-93 PMID: 27866157 PMCID: PMC5219051 11/21/2016       16 Citations
  • Effects of Donor Vitamin A Deficiency and Pharmacologic Modulation of Donor T Cell Retinoic Acid Pathway on the Severity of Experimental Graft-versus-Host Disease. (Dodge J, Stephans A, Lai J, Drobyski WR, Chen X) Biol Blood Marrow Transplant 2016 12;22(12):2141-2148 PMID: 27596131 09/07/2016       1 Citations
  • A colitogenic memory CD4+ T cell population mediates gastrointestinal graft-versus-host disease. (Zhou V, Agle K, Chen X, Beres A, Komorowski R, Belle L, Taylor C, Zhu F, Haribhai D, Williams CB, Verbsky J, Blumenschein W, Sadekova S, Bowman E, Ballantyne C, Weaver C, Serody DA, Vincent B, Serody J, Cua DJ, Drobyski WR) J Clin Invest 2016 09 01;126(9):3541-55 PMID: 27500496 PMCID: PMC5004941 08/09/2016       4 Citations
  • A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease. (Chen X, Dodge J, Komorowski R, Drobyski WR) Blood 2013 May 09;121(19):3970-80 PMID: 23529927 PMCID: PMC3650708 03/27/2013       11 Citations
  • Phosphatidylserine inhibits NFκB and p38 MAPK activation in human monocyte derived dendritic cells. (Doffek K, Chen X, Sugg SL, Shilyansky J) Mol Immunol 2011 Sep;48(15-16):1771-7 PMID: 21628073 06/02/2011       11 Citations
  • Interleukin 17 is not required for autoimmune-mediated pathologic damage during chronic graft-versus-host disease. (Chen X, Das R, Komorowski R, van Snick J, Uyttenhove C, Drobyski WR) Biol Blood Marrow Transplant 2010 Jan;16(1):123-8 PMID: 19772944 PMCID: PMC2804961 09/24/2009       13 Citations
  • Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease. (Chen X, Das R, Komorowski R, Beres A, Hessner MJ, Mihara M, Drobyski WR) Blood 2009 Jul 23;114(4):891-900 PMID: 19491393 PMCID: PMC2716024 06/06/2009       162 Citations
  • Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease. (Das R, Chen X, Komorowski R, Hessner MJ, Drobyski WR) Blood 2009 Mar 05;113(10):2352-62 PMID: 19059877 PMCID: PMC2652376 12/09/2008       51 Citations
  • Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease. (Chen X, Vodanovic-Jankovic S, Johnson B, Keller M, Komorowski R, Drobyski WR) Blood 2007 Nov 15;110(10):3804-13 PMID: 17693581 PMCID: PMC2077325 08/19/2007       158 Citations
  • Homeostatic expansion and repertoire regeneration of donor T cells during graft versus host disease is constrained by the host environment. (Gorski J, Chen X, Gendelman M, Yassai M, Krueger A, Tivol E, Logan B, Komorowski R, Vodanovic-Jankovic S, Drobyski WR) Blood 2007 Jun 15;109(12):5502-10 PMID: 17347406 PMCID: PMC1890817 03/10/2007       13 Citations
  • In-vivo generation of leukaemia-derived dendritic cells. (Kolb HJ, Rank A, Chen X, Woiciechowsky A, Roskrow M, Schmid C, Tischer J, Ledderose G) Best Pract Res Clin Haematol 2004 Sep;17(3):439-51 PMID: 15498715 10/23/2004       14 Citations
  • Phosphatidylserine regulates the maturation of human dendritic cells. (Chen X, Doffek K, Sugg SL, Shilyansky J) J Immunol 2004 Sep 01;173(5):2985-94 PMID: 15322157 08/24/2004       85 Citations
  • Adoptive immunotherapy in chimeras with donor lymphocytes. (Kolb HJ, Schmid C, Chen X, Woiciechowski A, Roskrow M, Weber M, Guenther W, Ledderose G, Schleuning M) Acta Haematol 2003;110(2-3):110-20 PMID: 14583671 10/30/2003       18 Citations
  • Neuroblastoma cells inhibit the immunostimulatory function of dendritic cells. (Chen X, Doffek K, Sugg SL, Shilyansky J) J Pediatr Surg 2003 Jun;38(6):901-5 PMID: 12778389 06/05/2003       6 Citations
  • Ex vivo generation of cytotoxic T lymphocytes specific for one or two distinct viruses for the prophylaxis of patients receiving an allogeneic bone marrow transplant. (Regn S, Raffegerst S, Chen X, Schendel D, Kolb HJ, Roskrow M) Bone Marrow Transplant 2001 Jan;27(1):53-64 PMID: 11244438 03/13/2001       45 Citations
  • Interferon alpha in combination with GM-CSF induces the differentiation of leukaemic antigen-presenting cells that have the capacity to stimulate a specific anti-leukaemic cytotoxic T-cell response from patients with chronic myeloid leukaemia. (Chen X, Regn S, Raffegerst S, Kolb HJ, Roskrow M) Br J Haematol 2000 Nov;111(2):596-607 PMID: 11122108 12/21/2000       50 Citations
  • Impaired expression of the CD3-zeta chain in peripheral blood T cells of patients with chronic myeloid leukaemia results in an increased susceptibility to apoptosis. (Chen X, Woiciechowsky A, Raffegerst S, Schendel D, Kolb HJ, Roskrow M) Br J Haematol 2000 Dec;111(3):817-25 PMID: 11122143 12/21/2000       51 Citations
  • Last update: 11/28/2018
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