Linezolid for the treatment of drug-resistant infections. Expert Rev Anti Infect Ther 2008 Dec;6(6):825-48
Date
12/05/2008Pubmed ID
19053895DOI
10.1586/14787210.6.6.825Scopus ID
2-s2.0-59449100218 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
Multidrug-resistant pathogens have become increasingly common in contemporary healthcare. Specific to Gram-positive pathogens, methicillin-resistant Staphylococcus aureus (MRSA) is of particular concern, as it has been associated with increased hospital length of stay, higher healthcare expenditures and poorer outcomes. To date, linezolid is the first and only oxazolidinone approved by the US FDA for the treatment of infections caused by Gram-positive pathogens, including MRSA. This article will serve as a comprehensive review of linezolid, including an overview of the current market and its in vitro activity, with an in-depth review of its pharmacokinetic and pharmacodynamic profile. Emphasis will be placed on clinical data for the drug, both on- and off-label. The article will conclude with a brief overview of linezolid's pharmacoeconomic implications and safety profile, followed by a commentary and 5-year prospective analysis remarking on the future of the antimicrobial field as it relates to MRSA.
Author List
Herrmann DJ, Peppard WJ, Ledeboer NA, Theesfeld ML, Weigelt JA, Buechel BJAuthors
Nathan A. Ledeboer PhD Vice Chair, Professor in the Pathology department at Medical College of WisconsinWilliam J. Peppard PharmD Trauma/Surgical Critical Care Pharmacist in the Pharmacy department at Froedtert Hospital
MESH terms used to index this publication - Major topics in bold
AcetamidesAnti-Bacterial Agents
Clinical Trials as Topic
Drug Resistance, Multiple, Bacterial
Economics, Pharmaceutical
Gram-Positive Bacterial Infections
Humans
Linezolid
Oxazolidinones