Faculty Collaboration Database

Reactive oxygen species cerebral autoregulation in health and disease. Pediatr Clin North Am 2006 Oct;53(5):1029-37, xi

Date

10/10/2006

Pubmed ID

17027622

Pubmed Central ID

PMC2533262

DOI

10.1016/j.pcl.2006.08.003

Scopus ID

2-s2.0-33749260560 (requires institutional sign-in at Scopus site)   21 Citations

Abstract

Reactive oxygen species (ROS) are a family of oxygen-derived free radicals that are produced in mammalian cells under normal and pathologic conditions. Many ROS, such as the superoxide anion (O2-) and hydrogen peroxide (H2O2), act as cellular signaling molecules within blood vessels, altering mechanisms mediating mechanical signal transduction and autoregulation of cerebral blood flow. This article focuses on the actions of ROS, such as O2.- and H2O2, and how they influence mechanisms responsible for the modulation of pressure-induced myogenic tone in the cerebral circulation and blood flow autoregulation in response to elevated arterial pressure. ROS may be a key target for therapeutic interventions in pediatric patients who have hypoxic injury or altered cerebral metabolism induced by trauma or infection.

Author List

Terashvili M, Pratt PF, Gebremedhin D, Narayanan J, Harder DR

MESH terms used to index this publication - Major topics in bold

Cerebrovascular Circulation
Child
Cytochrome P-450 Enzyme System
Humans
Ion Channels
Reactive Oxygen Species
Signal Transduction