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SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 1999 Sep 03;98(5):609-16

Date

09/18/1999

Pubmed ID

10490100

DOI

10.1016/s0092-8674(00)80048-3

Scopus ID

2-s2.0-0033520467   423 Citations

Abstract

SOCS1 is an SH2-containing protein that is primarily expressed in thymocytes in a cytokine- and T cell receptor-independent manner. SOCS1 deletion causes perinatal lethality with death by 2-3 weeks. During this period thymic changes include a loss of cellularity and a switch from predominantly CD4+ CD8+ to single positive cells. Peripheral T cells express activation antigens and proliferate to IL-2 in the absence of anti-CD3. In addition, IFNgamma is present in the serum. Reconstitution of the lymphoid lineage of JAK3-deficient mice with SOCS1-deficient stem cells recapitulates the lethality and T cell alterations. Introducing a RAG2 or IFNgamma deficiency eliminates lethality. The results demonstrate that lymphocytes are critical to SOCS1-associated perinatal lethality and implicate SOCS1 in lymphocyte differentiation or regulation.

Author List

Marine JC, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D, Yoshimura A, Ihle JN

Author

Demin Wang PhD Assistant Professor in the Microbiology and Immunology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Age Factors
Animals
Animals, Newborn
Carrier Proteins
DNA-Binding Proteins
Dose-Response Relationship, Drug
Flow Cytometry
Gene Expression Regulation, Developmental
Interferon-gamma
Janus Kinase 3
Lymphocytes
Mice
Mice, Mutant Strains
Protein-Tyrosine Kinases
Repressor Proteins
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling Proteins
T-Lymphocytes
Thymus Gland
Tissue Distribution
jenkins-FCD Prod-469 c3fc8ab87196149f9b23743c01b947d47e7319e5