Signaling by the cytokine receptor superfamily. Ann N Y Acad Sci 1998 Dec 11;865:1-9
Date
02/03/1999Pubmed ID
9927991DOI
10.1111/j.1749-6632.1998.tb11157.xScopus ID
2-s2.0-0032417376 (requires institutional sign-in at Scopus site) 98 CitationsAbstract
A variety of cytokines that regulate functions of multiple lineages share the utilization of receptors that are structurally and functionally related and are referred to as the cytokine receptor superfamily. These receptors associate with one or more of the four mammalian Janus kinases (Jaks) and ligand-induced receptor aggregation results in their activation. Critical roles for Jak3 and Jak2 are demonstrated by the phenotypes of mice that lack each gene. Among the substrates of the Jaks are one or more of the seven members of the signal transducers and activators of transcription (Stats). Each Stat family member plays a critical role in the biological functions of specific cytokines as demonstrated by the phenotype of mice lacking one or more of these genes.
Author List
Ihle JN, Thierfelder W, Teglund S, Stravopodis D, Wang D, Feng J, Parganas EAuthor
Demin Wang PhD Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCytokines
DNA-Binding Proteins
Humans
Janus Kinase 2
Janus Kinase 3
Mammals
Mice
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Receptors, Cytokine
STAT1 Transcription Factor
STAT2 Transcription Factor
Signal Transduction
Trans-Activators
