Faculty Collaboration Database

Signaling by the cytokine receptor superfamily. Ann N Y Acad Sci 1998 Dec 11;865:1-9

Date

02/03/1999

Pubmed ID

9927991

DOI

10.1111/j.1749-6632.1998.tb11157.x

Scopus ID

2-s2.0-0032417376   92 Citations

Abstract

A variety of cytokines that regulate functions of multiple lineages share the utilization of receptors that are structurally and functionally related and are referred to as the cytokine receptor superfamily. These receptors associate with one or more of the four mammalian Janus kinases (Jaks) and ligand-induced receptor aggregation results in their activation. Critical roles for Jak3 and Jak2 are demonstrated by the phenotypes of mice that lack each gene. Among the substrates of the Jaks are one or more of the seven members of the signal transducers and activators of transcription (Stats). Each Stat family member plays a critical role in the biological functions of specific cytokines as demonstrated by the phenotype of mice lacking one or more of these genes.

Author List

Ihle JN, Thierfelder W, Teglund S, Stravopodis D, Wang D, Feng J, Parganas E

Author

Demin Wang PhD Assistant Professor in the Microbiology and Immunology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Cytokines
DNA-Binding Proteins
Humans
Janus Kinase 2
Janus Kinase 3
Mammals
Mice
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Receptors, Cytokine
STAT1 Transcription Factor
STAT2 Transcription Factor
Signal Transduction
Trans-Activators