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Unraveling the biological roles of reactive oxygen species. Cell Metab 2011 Apr 06;13(4):361-366

Date

04/05/2011

Pubmed ID

21459321

Pubmed Central ID

PMC4445605

DOI

10.1016/j.cmet.2011.03.010

Scopus ID

2-s2.0-79953762174 (requires institutional sign-in at Scopus site)   670 Citations

Abstract

Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.

Author List

Murphy MP, Holmgren A, Larsson NG, Halliwell B, Chang CJ, Kalyanaraman B, Rhee SG, Thornalley PJ, Partridge L, Gems D, Nyström T, Belousov V, Schumacker PT, Winterbourn CC

Author

Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Antioxidants
Oxidative Stress
Reactive Oxygen Species
Signal Transduction