FVIII/VWF ratio is not a reliable predictor of VWD in children. Pediatr Blood Cancer 2014 May;61(5):936-9
Date
11/28/2013Pubmed ID
24281894DOI
10.1002/pbc.24860Scopus ID
2-s2.0-84895764326 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Adults with von Willebrand Disease (VWD) are known to have a ratio of factor VIII activity (FVIII:C) to von Willebrand factor antigen (VWF:Ag) greater than 1. We, however, noted healthy children with ratios that are unexpectedly high. Though the FVIII:C/VWF:Ag ratio differs significantly between healthy children and VWD patients in some age groups, the substantial overlap of observed ranges suggests that a ratio threshold-based screening approach alone cannot reliably discriminate between these groups. The diagnostic performance of this ratio is poor for VWD in children, which may decrease its value as a screening tool in the pediatric population.
Author List
Branchford BR, Ruegg K, Villalobos-Menuey E, Jacobson LJ, Di Paola JA, Manco-Johnson MAuthor
Brian Branchford MD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultBiomarkers
Blood Coagulation Tests
Case-Control Studies
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Factor VIII
Female
Follow-Up Studies
Humans
Infant
Male
Middle Aged
Prognosis
Young Adult
von Willebrand Disease, Type 1
von Willebrand Factor
