The Rat Genome Database pathway portal. Database (Oxford) 2011;2011:bar010
Date
04/12/2011Pubmed ID
21478484Pubmed Central ID
PMC3072770DOI
10.1093/database/bar010Scopus ID
2-s2.0-80052334281 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
The set of interacting molecules collectively referred to as a pathway or network represents a fundamental structural unit, the building block of the larger, highly integrated networks of biological systems. The scientific community's interest in understanding the fine details of how pathways work, communicate with each other and synergize, and how alterations in one or several pathways may converge into a disease phenotype, places heightened demands on pathway data and information providers. To meet such demands, the Rat Genome Database [(RGD) http://rgd.mcw.edu] has adopted a multitiered approach to pathway data acquisition and presentation. Resources and tools are continuously added or expanded to offer more comprehensive pathway data sets as well as enhanced pathway data manipulation, exploration and visualization capabilities. At RGD, users can easily identify genes in pathways, see how pathways relate to each other and visualize pathways in a dynamic and integrated manner. They can access these and other components from several entry points and effortlessly navigate between them and they can download the data of interest. The Pathway Portal resources at RGD are presented, and future directions are discussed. Database URL: http://rgd.mcw.edu.
Author List
Petri V, Shimoyama M, Hayman GT, Smith JR, Tutaj M, de Pons J, Dwinell MR, Munzenmaier DH, Twigger SN, Jacob HJ, RGD TeamAuthors
Melinda R. Dwinell PhD Professor in the Physiology department at Medical College of WisconsinG. Thomas Hayman PhD Research Scientist II in the Physiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsDatabases, Genetic
Gene Regulatory Networks
Genome
Humans
Internet
Male
Molecular Sequence Annotation
Prostatic Neoplasms
Rats
Signal Transduction
