Acute SARS-CoV-2 pneumonitis with cytotoxic CD8 positive T-lymphocytes: Case report and review of the literature. Pathol Res Pract 2021 Apr;220:153380
Date
03/07/2021Pubmed ID
33676105Pubmed Central ID
PMC7883708DOI
10.1016/j.prp.2021.153380Scopus ID
2-s2.0-85101878778 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
As of October 2020, there are over 40 million confirmed cases, and more than 1 million confirmed deaths of Covid-19 worldwide. The main cause of death in hospitalized patients is a respiratory failure due to acute respiratory distress syndrome. It has been suggested that the very intense immune response induces diffuse alveolar damage that far exceeds the harm that would have been caused by virus replication per se, resulting in lethal tissue destruction. We present a detailed report of the histopathological findings on cryo transbronchial biopsy in the patient with persistent (3 months) interstitial pneumonitis and severe CD8 positive cell infiltration in the lungs due to SARS-CoV-2 infection. CD8 positive T-lymphocytes have a great potential to damage tissue either through direct cytotoxicity or through cytokines release.
Author List
Puzyrenko A, Felix JC, Sun Y, Rui H, Sheinin YAuthors
Juan Felix MD Vice Chair, Director, Professor in the Pathology department at Medical College of WisconsinYuri M. Sheinin MD, PhD Associate Professor in the Pathology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Fatal OutcomeHumans
Leukemia, Lymphocytic, Chronic, B-Cell
Lung
Male
Middle Aged
T-Lymphocytes, Cytotoxic
