Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Acute SARS-CoV-2 pneumonitis with cytotoxic CD8 positive T-lymphocytes: Case report and review of the literature. Pathol Res Pract 2021 Apr;220:153380

Date

03/07/2021

Pubmed ID

33676105

Pubmed Central ID

PMC7883708

DOI

10.1016/j.prp.2021.153380

Scopus ID

2-s2.0-85101878778   5 Citations

Abstract

As of October 2020, there are over 40 million confirmed cases, and more than 1 million confirmed deaths of Covid-19 worldwide. The main cause of death in hospitalized patients is a respiratory failure due to acute respiratory distress syndrome. It has been suggested that the very intense immune response induces diffuse alveolar damage that far exceeds the harm that would have been caused by virus replication per se, resulting in lethal tissue destruction. We present a detailed report of the histopathological findings on cryo transbronchial biopsy in the patient with persistent (3 months) interstitial pneumonitis and severe CD8 positive cell infiltration in the lungs due to SARS-CoV-2 infection. CD8 positive T-lymphocytes have a great potential to damage tissue either through direct cytotoxicity or through cytokines release.

Author List

Puzyrenko A, Felix JC, Sun Y, Rui H, Sheinin Y

Authors

Juan Felix MD Vice Chair, Director, Professor in the Pathology department at Medical College of Wisconsin
Hallgeir Rui MD, PhD Vice Chair, Professor in the Pathology department at Medical College of Wisconsin
Yuri M. Sheinin MD, PhD Assistant Professor in the Pathology department at Medical College of Wisconsin
Yunguang Sun MD, PhD Assistant Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Fatal Outcome
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Lung
Male
Middle Aged
T-Lymphocytes, Cytotoxic