Medical College of Wisconsin
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Yuri M. Sheinin MD, PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Administration


Publications (49)

  • Rat Models of Partial-body Irradiation with Bone Marrow-sparing (Leg-out PBI) Designed for FDA Approval of Countermeasures for Mitigation of Acute and Delayed Injuries by Radiation. (Fish BL, MacVittie TJ, Gao F, Narayanan J, Gasperetti T, Scholler D, Sheinin Y, Himburg HA, Hart B, Medhora M) Health Phys 2021 Oct 01;121(4):419-433 PMID: 34546222 09/22/2021    
  • Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies. (Puzyrenko A, Jacobs ER, Sun Y, Felix JC, Sheinin Y, Ge L, Lai S, Dai Q, Gantner BN, Nanchal R, North PE, Simpson PM, Rui H, Benjamin IJ) Cell Stress Chaperones 2021 Aug 12 PMID: 34382151 PMCID: PMC8357488 SCOPUS ID: 2-s2.0-85112285201 08/13/2021    
  • Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness. (Felix JC, Sheinin YM, Suster D, Ronen N, Ratiani M, Vanden Heuvel T, Winge E, Patton MD, Rau MJ, Ge L, Sun Y, Udhane SS, Langenheim JF, Rui H) Ann Diagn Pathol 2021 Aug;53:151744 PMID: 33991784 PMCID: PMC8053602 SCOPUS ID: 2-s2.0-85105597450 05/16/2021    
  • Amyloid Precursor-like Protein 2 Expression Increases during Pancreatic Cancer Development and Shortens the Survival of a Spontaneous Mouse Model of Pancreatic Cancer. (Poelaert BJ, Knoche SM, Larson AC, Pandey P, Seshacharyulu P, Khan N, Maurer HC, Olive KP, Sheinin Y, Ahmad R, Singh AB, Batra SK, Rachagani S, Solheim JC) Cancers (Basel) 2021 Mar 26;13(7) PMID: 33810510 PMCID: PMC8036577 SCOPUS ID: 2-s2.0-85102991803 04/04/2021    
  • Acute SARS-CoV-2 pneumonitis with cytotoxic CD8 positive T-lymphocytes: Case report and review of the literature. (Puzyrenko A, Felix JC, Sun Y, Rui H, Sheinin Y) Pathol Res Pract 2021 Apr;220:153380 PMID: 33676105 PMCID: PMC7883708 SCOPUS ID: 2-s2.0-85101878778 03/07/2021       1 Citation
  • Primary pulmonary mucoepidermoid carcinoma: Cyto-histologic correlation and review of the literature. (Puzyrenko A, Shponka V, Sheinin Y, Giorgadze T, Nomani L) Ann Diagn Pathol 2021 Apr;51:151698 PMID: 33450549 SCOPUS ID: 2-s2.0-85099174351 01/16/2021    
  • Utility of PD-L1 testing on non-small cell lung cancer cytology specimens: An institutional experience with interobserver variability analysis. (Kravtsov O, Hartley CP, Sheinin Y, Hunt BC, Felix JC, Giorgadze T) Ann Diagn Pathol 2020 Oct;48:151602 PMID: 32877833 SCOPUS ID: 2-s2.0-85089903657 09/03/2020       1 Citation
  • p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. (Wang F, Qi XM, Wertz R, Mortensen M, Hagen C, Evans J, Sheinin Y, James M, Liu P, Tsai S, Thomas J, Mackinnon A, Dwinell M, Myers CR, Bartrons Bach R, Fu L, Chen G) Cancer Res 2020 08 15;80(16):3251-3264 PMID: 32580961 SCOPUS ID: 2-s2.0-85089787021 06/26/2020       8 Citations
  • The p52 isoform of SHC1 is a key driver of breast cancer initiation. (Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A) Breast Cancer Res 2019 06 15;21(1):74 PMID: 31202267 PMCID: PMC6570928 SCOPUS ID: 2-s2.0-85067234098 06/17/2019       10 Citations
  • Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer. (Jahan R, Ganguly K, Smith LM, Atri P, Carmicheal J, Sheinin Y, Rachagani S, Natarajan G, Brand RE, Macha MA, Grandgenett PM, Kaur S, Batra SK) EBioMedicine 2019 Apr;42:375-385 PMID: 30956167 PMCID: PMC6491718 SCOPUS ID: 2-s2.0-85063916779 04/09/2019       9 Citations
  • FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis. (Seshacharyulu P, Rachagani S, Muniyan S, Siddiqui JA, Cruz E, Sharma S, Krishnan R, Killips BJ, Sheinin Y, Lele SM, Smith LM, Talmon GA, Ponnusamy MP, Datta K, Batra SK) Oncogene 2019 06;38(26):5265-5280 PMID: 30914801 PMCID: PMC6597298 SCOPUS ID: 2-s2.0-85063565187 03/28/2019       11 Citations
  • Correction to Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy. (Wang Y, Xie Y, Li J, Peng ZH, Sheinin Y, Zhou J, Oupický D) ACS Nano 2019 Apr 23;13(4):4855 PMID: 30888139 SCOPUS ID: 2-s2.0-85065343993 03/20/2019       2 Citations
  • Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease. (Kanvinde S, Chhonker YS, Ahmad R, Yu F, Sleightholm R, Tang W, Jaramillo L, Chen Y, Sheinin Y, Li J, Murry DJ, Singh AB, Oupický D) Acta Biomater 2018 12;82:158-170 PMID: 30342282 PMCID: PMC6258327 SCOPUS ID: 2-s2.0-85055279960 10/21/2018       9 Citations
  • Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. (Hsu AH, Lum MA, Shim KS, Frederick PJ, Morrison CD, Chen B, Lele SM, Sheinin YM, Daikoku T, Dey SK, Leone G, Black AR, Black JD) Cell Rep 2018 07 17;24(3):655-669 PMID: 30021163 PMCID: PMC6118133 SCOPUS ID: 2-s2.0-85049825453 07/19/2018       15 Citations
  • Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer. (Aithal A, Junker WM, Kshirsagar P, Das S, Kaur S, Orzechowski C, Gautam SK, Jahan R, Sheinin YM, Lakshmanan I, Ponnusamy MP, Batra SK, Jain M) PLoS One 2018;13(4):e0193907 PMID: 29708979 PMCID: PMC5927449 SCOPUS ID: 2-s2.0-85046277545 05/01/2018       11 Citations
  • Loss of the Nuclear Pool of Ubiquitin Ligase CHIP/STUB1 in Breast Cancer Unleashes the MZF1-Cathepsin Pro-oncogenic Program. (Luan H, Mohapatra B, Bielecki TA, Mushtaq I, Mirza S, Jennings TA, Clubb RJ, An W, Ahmed D, El-Ansari R, Storck MD, Mishra NK, Guda C, Sheinin YM, Meza JL, Raja S, Rakha EA, Band V, Band H) Cancer Res 2018 05 15;78(10):2524-2535 PMID: 29510992 PMCID: PMC5955821 SCOPUS ID: 2-s2.0-85047880767 03/08/2018       18 Citations
  • Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy. (Wang Y, Xie Y, Li J, Peng ZH, Sheinin Y, Zhou J, Oupický D) ACS Nano 2017 02 28;11(2):2227-2238 PMID: 28165223 PMCID: PMC5332348 SCOPUS ID: 2-s2.0-85014157600 02/07/2017       260 Citations
  • hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells. (Karmakar S, Seshacharyulu P, Lakshmanan I, Vaz AP, Chugh S, Sheinin YM, Mahapatra S, Batra SK, Ponnusamy MP) Oncotarget 2017 Feb 28;8(9):14806-14820 PMID: 28122356 PMCID: PMC5362445 SCOPUS ID: 2-s2.0-85014066886 01/26/2017       14 Citations
  • Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: clinical implication for improved colon surveillance. (Krishn SR, Kaur S, Sheinin YM, Smith LM, Gautam SK, Patel A, Jain M, Juvvigunta V, Pai P, Lazenby AJ, Roy HK, Batra SK) Oncotarget 2017 Jan 24;8(4):7025-7038 PMID: 27705923 PMCID: PMC5351688 SCOPUS ID: 2-s2.0-85010748415 10/06/2016       13 Citations
  • MUC4 is negatively regulated through the Wnt/β-catenin pathway via the Notch effector Hath1 in colorectal cancer. (Pai P, Rachagani S, Dhawan P, Sheinin YM, Macha MA, Qazi AK, Chugh S, Ponnusamy MP, Mallya K, Pothuraju R, Batra SK) Genes Cancer 2016 May;7(5-6):154-168 PMID: 27551331 PMCID: PMC4979589 SCOPUS ID: 2-s2.0-85028954545 08/24/2016       12 Citations
  • A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells. (Goetz B, An W, Mohapatra B, Zutshi N, Iseka F, Storck MD, Meza J, Sheinin Y, Band V, Band H) Oncotarget 2016 Aug 09;7(32):51107-51123 PMID: 27276677 PMCID: PMC5239462 SCOPUS ID: 2-s2.0-84982282558 06/09/2016       4 Citations
  • Loss of N-acetylgalactosaminyltransferase 3 in poorly differentiated pancreatic cancer: augmented aggressiveness and aberrant ErbB family glycosylation. (Chugh S, Meza J, Sheinin YM, Ponnusamy MP, Batra SK) Br J Cancer 2016 06 14;114(12):1376-86 PMID: 27187683 PMCID: PMC4984453 SCOPUS ID: 2-s2.0-84969194701 05/18/2016       24 Citations
  • RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment. (Hein AL, Post CM, Sheinin YM, Lakshmanan I, Natarajan A, Enke CA, Batra SK, Ouellette MM, Yan Y) Oncogene 2016 12 08;35(49):6319-6329 PMID: 27181206 PMCID: PMC5112160 SCOPUS ID: 2-s2.0-84968546959 05/18/2016       38 Citations
  • PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling. (Hein AL, Seshacharyulu P, Rachagani S, Sheinin YM, Ouellette MM, Ponnusamy MP, Mumby MC, Batra SK, Yan Y) Cancer Res 2016 04 15;76(8):2243-2253 PMID: 26893480 PMCID: PMC4873354 SCOPUS ID: 2-s2.0-84970954356 02/20/2016       37 Citations
  • The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma. (Pai P, Rachagani S, Lakshmanan I, Macha MA, Sheinin Y, Smith LM, Ponnusamy MP, Batra SK) Mol Oncol 2016 Feb;10(2):224-39 PMID: 26526617 PMCID: PMC4740200 SCOPUS ID: 2-s2.0-84958924067 11/04/2015       19 Citations
  • Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer. (Das S, Rachagani S, Sheinin Y, Smith LM, Gurumurthy CB, Roy HK, Batra SK) Oncogene 2016 05 19;35(20):2645-54 PMID: 26364605 PMCID: PMC5555307 SCOPUS ID: 2-s2.0-84941671033 09/15/2015       33 Citations
  • Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis. (Pandey P, Rachagani S, Das S, Seshacharyulu P, Sheinin Y, Naslavsky N, Pan Z, Smith BL, Peters HL, Radhakrishnan P, McKenna NR, Giridharan SS, Haridas D, Kaur S, Hollingsworth MA, MacDonald RG, Meza JL, Caplan S, Batra SK, Solheim JC) Oncotarget 2015 Feb 10;6(4):2064-75 PMID: 25576918 PMCID: PMC4385836 SCOPUS ID: 2-s2.0-84923013443 01/13/2015       19 Citations
  • B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis. (Mansfield AS, Roden AC, Peikert T, Sheinin YM, Harrington SM, Krco CJ, Dong H, Kwon ED) J Thorac Oncol 2014 Jul;9(7):1036-1040 PMID: 24926549 PMCID: PMC4058651 SCOPUS ID: 2-s2.0-84902522051 06/14/2014       158 Citations
  • Tissue microarrays: one size does not fit all. (Eckel-Passow JE, Lohse CM, Sheinin Y, Crispen PL, Krco CJ, Kwon ED) Diagn Pathol 2010 Jul 07;5:48 PMID: 20609235 PMCID: PMC2910003 SCOPUS ID: 2-s2.0-77954274042 07/09/2010       35 Citations
  • Evaluation of B7-H3 expression as a biomarker of biochemical recurrence after salvage radiation therapy for recurrent prostate cancer. (Parker AS, Heckman MG, Sheinin Y, Wu KJ, Hilton TW, Diehl NN, Pisansky TM, Schild SE, Kwon ED, Buskirk SJ) Int J Radiat Oncol Biol Phys 2011 Apr 01;79(5):1343-9 PMID: 20598810 SCOPUS ID: 2-s2.0-79952703623 07/06/2010       28 Citations
  • T-cell co-regulatory molecule expression in renal angiomyolipoma and pulmonary lymphangioleiomyomatosis. (Boorjian SA, Sheinin Y, Crispen PL, Lohse CM, Leibovich BC, Kwon ED) Urology 2009 Dec;74(6):1359-64 PMID: 19501877 PMCID: PMC2789880 SCOPUS ID: 2-s2.0-70849100014 06/09/2009       9 Citations
  • Development and evaluation of BioScore: a biomarker panel to enhance prognostic algorithms for clear cell renal cell carcinoma. (Parker AS, Leibovich BC, Lohse CM, Sheinin Y, Kuntz SM, Eckel-Passow JE, Blute ML, Kwon ED) Cancer 2009 May 15;115(10):2092-103 PMID: 19296514 PMCID: PMC2789398 SCOPUS ID: 2-s2.0-65649097342 03/20/2009       94 Citations
  • Expression of immunosuppresive B7-H3 ligand by hormone-treated prostate cancer tumors and metastases. (Chavin G, Sheinin Y, Crispen PL, Boorjian SA, Roth TJ, Rangel L, Blute ML, Sebo TJ, Tindall DJ, Kwon ED, Karnes RJ) Clin Cancer Res 2009 Mar 15;15(6):2174-80 PMID: 19276267 PMCID: PMC2676580 SCOPUS ID: 2-s2.0-63549150834 03/12/2009       65 Citations
  • Sirolimus affects cardiomyocytes to reduce left ventricular mass in heart transplant recipients. (Kushwaha SS, Raichlin E, Sheinin Y, Kremers WK, Chandrasekaran K, Brunn GJ, Platt JL) Eur Heart J 2008 Nov;29(22):2742-50 PMID: 18790727 PMCID: PMC2721707 SCOPUS ID: 2-s2.0-56449128027 09/16/2008       41 Citations
  • Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma. (Crispen PL, Sheinin Y, Roth TJ, Lohse CM, Kuntz SM, Frigola X, Thompson RH, Boorjian SA, Dong H, Leibovich BC, Blute ML, Kwon ED) Clin Cancer Res 2008 Aug 15;14(16):5150-7 PMID: 18694993 PMCID: PMC2789387 SCOPUS ID: 2-s2.0-52649160243 08/13/2008       186 Citations
  • T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival. (Boorjian SA, Sheinin Y, Crispen PL, Farmer SA, Lohse CM, Kuntz SM, Leibovich BC, Kwon ED, Frank I) Clin Cancer Res 2008 Aug 01;14(15):4800-8 PMID: 18676751 SCOPUS ID: 2-s2.0-51049096135 08/05/2008       202 Citations
  • Comparison of digital image analysis versus visual assessment to assess survivin expression as an independent predictor of survival for patients with clear cell renal cell carcinoma. (Parker AS, Lohse CM, Leibovich BC, Cheville JC, Sheinin YM, Kwon ED) Hum Pathol 2008 Aug;39(8):1176-84 PMID: 18538369 PMCID: PMC2789391 SCOPUS ID: 2-s2.0-47549103693 06/10/2008       13 Citations
  • Hormone receptor expression in renal angiomyolipoma: clinicopathologic correlation. (Boorjian SA, Sheinin Y, Crispen PL, Lohse CM, Kwon ED, Leibovich BC) Urology 2008 Oct;72(4):927-32 PMID: 18374399 PMCID: PMC2789392 SCOPUS ID: 2-s2.0-52949129082 04/01/2008       41 Citations
  • External validation of IMP3 expression as an independent prognostic marker for metastatic progression and death for patients with clear cell renal cell carcinoma. (Hoffmann NE, Sheinin Y, Lohse CM, Parker AS, Leibovich BC, Jiang Z, Kwon ED) Cancer 2008 Apr 01;112(7):1471-9 PMID: 18260086 PMCID: PMC2792740 SCOPUS ID: 2-s2.0-41149145266 02/09/2008       107 Citations
  • Carbonic anhydrase IX is not an independent predictor of outcome for patients with clear cell renal cell carcinoma. (Leibovich BC, Sheinin Y, Lohse CM, Thompson RH, Cheville JC, Zavada J, Kwon ED) J Clin Oncol 2007 Oct 20;25(30):4757-64 PMID: 17947723 SCOPUS ID: 2-s2.0-36048987954 10/20/2007       151 Citations
  • B7-H3 ligand expression by prostate cancer: a novel marker of prognosis and potential target for therapy. (Roth TJ, Sheinin Y, Lohse CM, Kuntz SM, Frigola X, Inman BA, Krambeck AE, McKenney ME, Karnes RJ, Blute ML, Cheville JC, Sebo TJ, Kwon ED) Cancer Res 2007 Aug 15;67(16):7893-900 PMID: 17686830 SCOPUS ID: 2-s2.0-34548046956 08/10/2007       186 Citations
  • Ki-67 and coagulative tumor necrosis are independent predictors of poor outcome for patients with clear cell renal cell carcinoma and not surrogates for each other. (Tollefson MK, Thompson RH, Sheinin Y, Lohse CM, Cheville JC, Leibovich BC, Kwon ED) Cancer 2007 Aug 15;110(4):783-90 PMID: 17594714 SCOPUS ID: 2-s2.0-34547893437 06/28/2007       59 Citations
  • Induction of chondrocyte growth arrest by FGF: transcriptional and cytoskeletal alterations. (Rozenblatt-Rosen O, Mosonego-Ornan E, Sadot E, Madar-Shapiro L, Sheinin Y, Ginsberg D, Yayon A) J Cell Sci 2002 Feb 01;115(Pt 3):553-62 PMID: 11861762 SCOPUS ID: 2-s2.0-0036473018 02/28/2002       52 Citations
  • Protein phosphatase 2Calpha expression in normal human tissues: an immunohistochemical study. (Lifschitz-Mercer B, Sheinin Y, Ben-Meir D, Bramante-Schreiber L, Leider-Trejo L, Karby S, Smorodinsky NI, Lavi S) Histochem Cell Biol 2001 Jul;116(1):31-9 PMID: 11479720 SCOPUS ID: 2-s2.0-0034743213 08/02/2001       21 Citations
  • In situ mRNA hybridization analysis and immunolocalization of the vitamin D receptor in normal and carcinomatous human colonic mucosa: relation to epidermal growth factor receptor expression. (Sheinin Y, Kaserer K, Wrba F, Wenzl E, Kriwanek S, Peterlik M, Cross HS) Virchows Arch 2000 Nov;437(5):501-7 PMID: 11147170 SCOPUS ID: 2-s2.0-0033663826 01/09/2001       47 Citations
  • Immunocytochemical localization of the extracellular calcium-sensing receptor in normal and malignant human large intestinal mucosa. (Sheinin Y, Kállay E, Wrba F, Kriwanek S, Peterlik M, Cross HS) J Histochem Cytochem 2000 May;48(5):595-602 PMID: 10769043 SCOPUS ID: 2-s2.0-0342314479 04/18/2000       108 Citations
  • Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3(G380R) transgenic mice. (Segev O, Chumakov I, Nevo Z, Givol D, Madar-Shapiro L, Sheinin Y, Weinreb M, Yayon A) Hum Mol Genet 2000 Jan 22;9(2):249-58 PMID: 10607835 SCOPUS ID: 2-s2.0-0033970893 12/23/1999       85 Citations
  • Epidermal growth factor receptor expression in primary cultured human colorectal carcinoma cells. (Tong WM, Ellinger A, Sheinin Y, Cross HS) Br J Cancer 1998 Jun;77(11):1792-8 PMID: 9667648 PMCID: PMC2150335 SCOPUS ID: 2-s2.0-0031746337 07/17/1998       47 Citations
  • Establishment of primary cultures from human colonic tissue during tumor progression: vitamin-D responses and vitamin-D-receptor expression. (Tong WM, Bises G, Sheinin Y, Ellinger A, Genser D, Pötzi R, Wrba F, Wenzl E, Roka R, Neuhold N, Peterlik M, Cross HS) Int J Cancer 1998 Jan 30;75(3):467-72 PMID: 9455810 SCOPUS ID: 2-s2.0-0032579470 02/10/1998       29 Citations
  • Last update: 09/23/2021