Sensory TRP channels: the key transducers of nociception and pain. Prog Mol Biol Transl Sci 2015;131:73-118
Date
03/07/2015Pubmed ID
25744671Pubmed Central ID
PMC5903472DOI
10.1016/bs.pmbts.2015.01.002Scopus ID
2-s2.0-84924581659 (requires institutional sign-in at Scopus site) 114 CitationsAbstract
Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve fibers. The majority of such molecular detectors/transducers belong to the transient receptor potential (TRP) family of cation channels, which comprise both specific receptors for distinct nociceptive stimuli, as well as for multiple stimuli. This chapter discusses the classification, distribution, and functional properties of individual TRP channel types that have been implicated in various nociceptive and/or painful conditions.
Author List
Mickle AD, Shepherd AJ, Mohapatra DPAuthor
Aaron David Mickle PhD Associate Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsHumans
Models, Biological
Nociception
Pain
Sense Organs
Signal Transduction
Transient Receptor Potential Channels