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Sensory TRP channels: the key transducers of nociception and pain. Prog Mol Biol Transl Sci 2015;131:73-118

Date

03/07/2015

Pubmed ID

25744671

Pubmed Central ID

PMC5903472

DOI

10.1016/bs.pmbts.2015.01.002

Scopus ID

2-s2.0-84924581659 (requires institutional sign-in at Scopus site)   108 Citations

Abstract

Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve fibers. The majority of such molecular detectors/transducers belong to the transient receptor potential (TRP) family of cation channels, which comprise both specific receptors for distinct nociceptive stimuli, as well as for multiple stimuli. This chapter discusses the classification, distribution, and functional properties of individual TRP channel types that have been implicated in various nociceptive and/or painful conditions.

Author List

Mickle AD, Shepherd AJ, Mohapatra DP

Author

Aaron D. Mickle PhD Associate Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Humans
Models, Biological
Nociception
Pain
Sense Organs
Signal Transduction
Transient Receptor Potential Channels