Medical College of Wisconsin
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Cell biological regulation of division fate in vertebrate neuroepithelial cells. Dev Dyn 2011 Aug;240(8):1865-79



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2-s2.0-79960366363   23 Citations


The developing nervous system derives from neuroepithelial progenitor cells that divide to generate all of the mature neuronal types. For the proper complement of cell types to form, the progenitors must produce postmitotic cells, yet also replenish the progenitor pool. Progenitor divisions can be classified into three general types: symmetric proliferative (producing two progenitors), asymmetric neurogenic (producing one progenitor and one postmitotic cell), and symmetric neurogenic (producing two postmitotic cells). The appropriate ratios for these modes of cell division require intrinsic polarity, which is one of the characteristics that define neuroepithelial progenitor cells. The type of division an individual progenitor undergoes can be influenced by cellular features, or behaviors, which are heterogeneous within the population of progenitors. Here we review three key cellular parameters, asymmetric inheritance, cell cycle kinetics, and interkinetic nuclear migration, and the possible mechanisms for how these features influence progenitor fates.

Author List

Willardsen MI, Link BA


Brian A. Link PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Cell Differentiation
Cell Division
Cell Lineage
Cell Nucleus
Cell Polarity
Cell Proliferation
Neuroepithelial Cells
Signal Transduction
Stem Cells
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0