Differences that matter: major cytotoxic T cell-stimulating minor histocompatibility antigens. Immunity 2000 Sep;13(3):333-44
Date
10/06/2000Pubmed ID
11021531DOI
10.1016/s1074-7613(00)00033-9Scopus ID
2-s2.0-0033662243 (requires institutional sign-in at Scopus site) 76 CitationsAbstract
Despite thousands of genetic polymorphisms among MHC matched mouse strains, a few unknown histocompatibility antigens are targeted by the cytotoxic T cells specific for tissue grafts. We isolated the cDNA of a novel BALB.B antigen gene that defines the polymorphic H28 locus on chromosome 3 and yields the naturally processed ILENFPRL (IFL8) peptide for presentation by Kb MHC to C57BI/6 CTL. The CTL specific for the IFL8/Kb and our previously identified H60/Kb complexes represent a major fraction of the B6 anti-BALB.B immune response. The immunodominance of these antigens can be explained by their differential transcription in the donor versus the host strains and their expression in professional donor antigen-presenting cells.
Author List
Malarkannan S, Horng T, Eden P, Gonzalez F, Shih P, Brouwenstijn N, Klinge H, Christianson G, Roopenian D, Shastri NAuthor
Subramaniam Malarkannan PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Amino Acid SequenceAnimals
Antigen Presentation
Antigen-Presenting Cells
Base Sequence
Cell Line
Cytotoxicity, Immunologic
Epitopes, T-Lymphocyte
H-2 Antigens
Lymphocyte Activation
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Minor Histocompatibility Antigens
Minor Histocompatibility Loci
Molecular Sequence Data
Oligopeptides
Protein Binding
T-Lymphocytes, Cytotoxic
Transcription, Genetic
